Abstract：
:The cellular response to ionizing radiation (IR) includes the induction of apoptosis. The p300/CBP proteins possess histone acetyltransferase activity and function as transcriptional coactivators of p53. We have prepared cells deficient in p300 or CBP to define the roles of these proteins in the cellular response to DNA damage. The present results demonstrate that p300, but not CBP, contributes to IR sensitivity of cells. The results also demonstrate that IR-induced apoptosis is impaired in the p300-, but not CBP-, deficient cells. These findings indicate that p300 functions in the apoptotic response to DNA damage.
journal_name
Oncogenejournal_title
Oncogeneauthors
Yuan ZM,Huang Y,Ishiko T,Nakada S,Utsugisawa T,Shioya H,Utsugisawa Y,Shi Y,Weichselbaum R,Kufe Ddoi
10.1038/sj.onc.1202930subject
Has Abstractpub_date
1999-10-07 00:00:00pages
5714-7issue
41eissn
0950-9232issn
1476-5594journal_volume
18pub_type
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