Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN.

abstract：:TSG101 has been identified as a candidate tumor suppressor gene and abnormal transcripts have been identified in a substantial fraction of breast cancers. To determine whether TSG101 expression is commonly altered in other tumors, a series of 15 primary and metastatic prostate cancers were analysed by reverse transcri...

journal_title：Oncogene

authors： Sun Z,Pan J,Bubley G,Balk SP

更新日期：1997-12-18 00:00:00

abstract：:Transforming growth factor beta1 (TGF-beta1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of mammalian cells. Although solid data established the role of TGF-beta's as suppressor factors in tumorigenic processes, in the context of an advanced stage of di...

journal_title：Oncogene

authors： Murillo MM,del Castillo G,Sánchez A,Fernández M,Fabregat I

更新日期：2005-06-30 00:00:00

abstract：:A distinctive property of Hepatocyte Growth Factor (HGF) is its ability to induce differentiation of tubular structures from epithelial and endothelial cells (branching tubulogenesis). The HGF receptor directly activates PI3 kinase, Ras and STAT signalling pathways and phosphorylates the adaptator GRB2 Associated Bind...

journal_title：Oncogene

authors： Gual P,Giordano S,Williams TA,Rocchi S,Van Obberghen E,Comoglio PM

更新日期：2000-03-16 00:00:00

abstract：:There is a large body of evidence suggesting the connexin gap junction proteins appear to act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main function of cell coupling through gap junctions. However, some cancer cells (e.g. the rat bladder carcinoma BC31 cell line) are cell-...

journal_title：Oncogene

authors： Krutovskikh VA,Troyanovsky SM,Piccoli C,Tsuda H,Asamoto M,Yamasaki H

更新日期：2000-01-27 00:00:00

abstract：:ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...

journal_title：Oncogene

authors： Li Y,Zhou Z,Alimandi M,Chen C

更新日期：2009-08-20 00:00:00

abstract：:The product of the RB susceptibility gene has been shown to be differentially phosphorylated during the cell cycle, suggesting a role in the regulation of cell cycle progression. We examined the expression and phosphorylation status of the RB protein in senescent Syrian hamster embryo cells. Both phosphorylated and un...

journal_title：Oncogene

authors： Futreal PA,Barrett JC

更新日期：1991-07-01 00:00:00

abstract：:SIAH-1 and SIAH-2 are the human members of an evolutionary highly conserved E3 ligase family. SIAH-1 is a p53 and p21(Waf-1/Cip-1) induced gene during apoptosis and tumor suppression. In stable-transfected clones of MCF-7 cells, SIAH-1 overexpression was associated with apoptosis, mitotic alterations and p21(Waf-1/Cip...

journal_title：Oncogene

authors： Germani A,Prabel A,Mourah S,Podgorniak MP,Di Carlo A,Ehrlich R,Gisselbrecht S,Varin-Blank N,Calvo F,Bruzzoni-Giovanelli H

更新日期：2003-12-04 00:00:00

abstract：:The E2F1 transcription factor, which is deregulated in most human cancers by mutations in the p16-cyclin D-Rb pathway, has both oncogenic and tumor-suppressive properties. This is dramatically illustrated by the phenotype of an E2F1 transgenic mouse model that spontaneously develops tumors in the skin and other epithe...

journal_title：Oncogene

authors： Russell JL,Weaks RL,Berton TR,Johnson DG

更新日期：2006-02-09 00:00:00

abstract：:The acute contractile function of the heart is controlled by the effects of released nonepinephrine (NE) on cardiac adrenergic receptors. NE can also act in a more chronic fashion to induce cardiomyocyte growth, characterized by cell enlargement (hypertrophy), increased protein synthesis, alterations in gene expressio...

journal_title：Oncogene

authors： Adams JW,Brown JH

更新日期：2001-03-26 00:00:00

abstract：:Rho small GTP-binding protein regulates various cell functions, such as formation of stress fibers and focal adhesions, cell motility, membrane ruffling, cytokinesis and smooth muscle contraction in mammalian cells and bud formation in the yeast Saccharomyces cerevisiae. As to the functioning sites of Rho in Saccharom...

journal_title：Oncogene

authors： Takaishi K,Sasaki T,Kameyama T,Tsukita S,Tsukita S,Takai Y

更新日期：1995-07-06 00:00:00

abstract：:Infection by HTLV-1 has been correlated with the appearance of various proliferative or degenerative diseases. Some of these disorders have been observed in transgenic mice expressing the Tax protein, which is known to transactivate various viral and cellular promoters through interactions with several transcription f...

journal_title：Oncogene

authors： Rousset R,Fabre S,Desbois C,Bantignies F,Jalinot P

更新日期：1998-02-05 00:00:00

abstract：:In colorectal tumorigenesis, loss of function of the mismatch repair genes is closely associated with genomic instability at the nucleotide level whereas p53 deficiency has been linked with gross chromosomal instability. We have addressed the contribution of these two forms of genetic instability to tumorigenesis usin...

journal_title：Oncogene

authors： Toft NJ,Curtis LJ,Sansom OJ,Leitch AL,Wyllie AH,te Riele H,Arends MJ,Clarke AR

更新日期：2002-09-12 00:00:00

abstract：:The myb proto oncogene product (c-Myb) is a transcriptional regulator and its expression and function are tightly linked to the cellular entry into S phase and DNA synthesis. It has been shown [Venturelli, D., Travali, S. & Calabretta, B. (1990). Proc. Natl. Acad. Sci. USA, 87, 5963-5967] that inhibition of T-cell pro...

journal_title：Oncogene

authors： Sudo T,Miyazawa H,Hanaoka F,Ishii S

更新日期：1992-10-01 00:00:00

abstract：:LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion a...

journal_title：Oncogene

authors： Reiss K,Wang JY,Romano G,Tu X,Peruzzi F,Baserga R

更新日期：2001-01-25 00:00:00

abstract：:Mouse Developmental Kinase 1 (MDK1) is a receptor tyrosine kinase of the eck/eph subfamily expressed in a variety of tissues during early mouse embryogenesis. To obtain further insight into the function of MDK1, we determined identity and localisation of its physiological ligand(s). Staining whole embryos with fusion ...

journal_title：Oncogene

authors： Ciossek T,Ullrich A

更新日期：1997-01-09 00:00:00

abstract：:MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, but their role in head and neck cancer development and progression is not well defined. We aimed to determine whether specific miRNAs and their target mRNAs contribute to head and neck cancer pathogenesis and progression. To ide...

journal_title：Oncogene

authors： Nakanishi H,Taccioli C,Palatini J,Fernandez-Cymering C,Cui R,Kim T,Volinia S,Croce CM

更新日期：2014-02-06 00:00:00

abstract：:P21waf1/cip1 is a potent inhibitor of cell cycle progression and can inhibit the growth of both normal cells and cells transformed by a number of oncogenes. However, the ability of p21waf1/cip1 to inhibit the growth of cells that overexpress the transcriptional transactivator E2F1 is controversial: it has been reporte...

journal_title：Oncogene

authors： Givol I,Givol D,Hughes SH

更新日期：1998-06-18 00:00:00

abstract：:An integrative functional genomics study of multiple forms of data are vital for discovering molecular drivers of cancer development and progression. Here, we present an integrated genomic strategy utilizing DNA methylation and transcriptome profile data to discover epigenetically regulated genes implicated in cancer ...

journal_title：Oncogene

authors： Mondal B,Patil V,Shwetha SD,Sravani K,Hegde AS,Arivazhagan A,Santosh V,Kanduri M,Somasundaram K

更新日期：2017-01-05 00:00:00

abstract：:Germline LKB1 mutations cause Peutz-Jeghers syndrome, a hereditary disorder that predisposes to gastrointestinal hamartomatous polyposis and several types of malignant tumors. Somatic LKB1 alterations are rare in sporadic cancers, however, a few reports showed the presence of somatic alterations in a considerable frac...

journal_title：Oncogene

authors： Matsumoto S,Iwakawa R,Takahashi K,Kohno T,Nakanishi Y,Matsuno Y,Suzuki K,Nakamoto M,Shimizu E,Minna JD,Yokota J

更新日期：2007-08-30 00:00:00

abstract：:We have isolated a human cDNA clone encoding a novel protein of 22 kDa that is a human counterpart of the rat oncoprotein PTTG. We show that the corresponding gene (hpttg) is overexpressed in Jurkat cells (a human T lymphoma cell line) and in samples from patients with different kinds of hematopoietic malignancies. An...

journal_title：Oncogene

authors： Domínguez A,Ramos-Morales F,Romero F,Rios RM,Dreyfus F,Tortolero M,Pintor-Toro JA

更新日期：1998-10-29 00:00:00

abstract：:Overexpression of hepatocyte growth factor (HGF), also called scatter factor (SF), and its receptor c-Met are associated with poor prognosis for cancer patients. In particular, breast cancer cells can produce HGF that acts in a paracrine as well as in an autocrine manner. Therefore, HGF and c-Met are putative targets ...

journal_title：Oncogene

authors： Gallego MI,Bierie B,Hennighausen L

更新日期：2003-11-20 00:00:00

abstract：:The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...

journal_title：Oncogene

authors： O'Neil J,Look AT

更新日期：2007-10-15 00:00:00

abstract：:RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas. We used RasGRP1 trans...

journal_title：Oncogene

authors： Klinger MB,Guilbault B,Goulding RE,Kay RJ

更新日期：2005-04-14 00:00:00

abstract：:Keratinocyte growth factor is a potent and specific mitogen for different types of epithelial cells, including keratinocytes of the skin. Furthermore, it has been implicated in morphogenetic processes of several organs. To further define the mechanisms of KGF action in the skin, we attempted to identify genes which ar...

journal_title：Oncogene

authors： Frank S,Munz B,Werner S

更新日期：1997-02-27 00:00:00

abstract：:A single heat shock factor (HSF), mediating the heat shock response, exists from yeast to Drosophila, whereas several related HSFs have been found in mammals. This raises the question of the specific or redundant functions of the different members of the HSF family and in particular of HSF1 and HSF2, which are both ub...

journal_title：Oncogene

authors： Lecomte S,Desmots F,Le Masson F,Le Goff P,Michel D,Christians ES,Le Dréan Y

更新日期：2010-07-22 00:00:00

abstract：:Ovarian endometrioid adenocarcinomas (OEAs) frequently exhibit constitutive activation of canonical WNT signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the β-catenin protein. In previous work, we used microarray-based methods to compare gene expression in OEAs with and without dysr...

journal_title：Oncogene

authors： Zhai Y,Iura A,Yeasmin S,Wiese AB,Wu R,Feng Y,Fearon ER,Cho KR

更新日期：2011-10-06 00:00:00

abstract：:Intrinsic and acquired resistance to anti-EGFR antibody therapy, frequently mediated by a mutant or amplified KRAS oncogene, is a significant challenge in the treatment of colorectal cancer (CRC). However, the mechanism of KRAS-mediated therapeutic resistance is not well understood. In this study, we demonstrate that ...

journal_title：Oncogene

authors： Knickelbein K,Tong J,Chen D,Wang YJ,Misale S,Bardelli A,Yu J,Zhang L

更新日期：2018-08-01 00:00:00

abstract：:The MAP kinase pathway impinging on ERK2 has been shown to be integrally associated with mitogenic signalling in many cell types. Previously, we and others have demonstrated that oncogenic forms of Raf-1 kinase, when expressed in fibroblasts, lead to the constitutive activation of ERK2, the de-regulation of c-fos expr...

journal_title：Oncogene

authors： Kortenjann M,Shaw PE

更新日期：1995-11-16 00:00:00

abstract：:Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of...

journal_title：Oncogene

authors： Kauffman MG,Rose PA,Kelly TJ

更新日期：1991-08-01 00:00:00

abstract：:Prolonged activation of protein kinase Cs (PKCs) by long-term treatment of cells with phorbol ester tumor promoters down-regulates the expression of many PKCs. To investigate the molecular mechanisms involved in the down-regulation of PKC eta, we expressed the novel PKCs eta and θ and various mutant forms in bab...

journal_title：Oncogene

authors： Kang BS,French OG,Sando JJ,Hahn CS

更新日期：2000-08-31 00:00:00