Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins.

abstract：:The FOXO family of Forkhead transcription factors, regulated by the phosphoinositide-3-kinase-Akt pathway, is involved in cell cycle regulation and apoptosis. Strong expression of HER2, a receptor tyrosine kinase oncogene, in cancers has been associated with a poor prognosis. Recently, FOXO4 was shown to regulate the ...

journal_title：Oncogene

authors： Yang H,Zhao R,Yang HY,Lee MH

更新日期：2005-03-10 00:00:00

abstract：:We have recently isolated the erythroleukemic cell line, HB60-5, that proliferates in the presence of erythropoietin (Epo) and stem cell factor (SCF), but undergoes terminal differentiation in the presence of Epo alone. Ectopic expression of the ets related transcription factor Fli-1 in these cells resulted in the est...

journal_title：Oncogene

authors： Zochodne B,Truong AH,Stetler K,Higgins RR,Howard J,Dumont D,Berger SA,Ben-David Y

更新日期：2000-05-04 00:00:00

abstract：:Expression of the c-myc gene is often elevated in human colorectal tumors, but reported amplification of the locus is rare. Here we demonstrate that modest amplification of c-myc is frequently found in aggressive subtypes of colorectal cancer. Careful quantitation of c-myc copy number has shown amplification in 53.8% ...

journal_title：Oncogene

authors： Heerdt BG,Molinas S,Deitch D,Augenlicht LH

更新日期：1991-01-01 00:00:00

abstract：:The SCL/TAL1 gene was originally identified by virtue of its rearrangement and transcriptional activation in patients with T cell acute lymphoblastic leukaemia. It encodes a helix-loop-helix transcription factor, is not normally expressed in T cells, but is expressed in erythroid, mast, megakaryocytic and progenitor c...

journal_title：Oncogene

authors： Murrell AM,Bockamp EO,Göttgens B,Chan YS,Cross MA,Heyworth CM,Green AR

更新日期：1995-07-06 00:00:00

abstract：:Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes are peppered with mutations. Although most somatic tumour mutations are unlikely to have any role in the cancer process per se, the spectra of DNA sequence changes in tumour mutation catalogues have the potential to identify the mutag...

journal_title：Oncogene

authors： Hollstein M,Alexandrov LB,Wild CP,Ardin M,Zavadil J

更新日期：2017-01-12 00:00:00

abstract：:TNFα is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNFα exerts its diverse effects on breast cancer subtypes remains elusive. Using in vitro assays and mouse xenografts, ...

journal_title：Oncogene

authors： Lee E,Ouzounova M,Piranlioglu R,Ma MT,Guzel M,Marasco D,Chadli A,Gestwicki JE,Cowell JK,Wicha MS,Hassan KA,Korkaya H

更新日期：2019-01-01 00:00:00

abstract：:Two thirds of breast cancers express estrogen receptors (ER). ER alpha (ERα) mediates breast cancer cell proliferation, and expression of ERα is the standard choice to indicate adjuvant endocrine therapy. ERbeta (ERβ) inhibits growth in vitro; its effects in vivo have been incompletely investigated and its role in bre...

journal_title：Oncogene

authors： Cotrim CZ,Fabris V,Doria ML,Lindberg K,Gustafsson JÅ,Amado F,Lanari C,Helguero LA

更新日期：2013-05-09 00:00:00

abstract：:Adenovirus E4orf4 protein is a multifunctional viral regulator, which is involved in down regulation of virally-modulated signal transduction, in control of alternative splicing of viral mRNAs, and in induction of apoptosis in transformed cells. It has been previously shown that E4orf4 interacts with protein phosphata...

journal_title：Oncogene

authors： Shtrichman R,Sharf R,Kleinberger T

更新日期：2000-08-03 00:00:00

abstract：:Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...

journal_title：Oncogene

authors： Varga AE,Stourman NV,Zheng Q,Safina AF,Quan L,Li X,Sossey-Alaoui K,Bakin AV

更新日期：2005-07-28 00:00:00

abstract：:We identified IFIX as a new member of the hematopoietic interferon (IFN)-inducible nuclear protein with the 200-amino-acid repeat (HIN-200) family. Six different alternatively spliced forms of mRNA are transcribed from the IFIX gene, which are predicted to encode six different isoforms of IFIX proteins (IFIXalpha1, al...

journal_title：Oncogene

authors： Ding Y,Wang L,Su LK,Frey JA,Shao R,Hunt KK,Yan DH

更新日期：2004-06-03 00:00:00

abstract：:This report describes a new polymorphism, in intron 3 of the p53 gene, which consists of a single repeat of 16 nucleotides, absent in the published wild-type p53 gene sequence. In the Caucasian population tested (n = 82), 28% of individuals were heterozygotes for this polymorphism. Using PCR-based analysis, we were ab...

journal_title：Oncogene

authors： Lazar V,Hazard F,Bertin F,Janin N,Bellet D,Bressac B

更新日期：1993-06-01 00:00:00

abstract：:Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...

journal_title：Oncogene

authors： Chen Y,Xu L,Lin RY,Müschen M,Koeffler HP

更新日期：2020-10-01 00:00:00

abstract：:TCR-mediated activation of T cell hybridomas induces programmed cell death by a Fas-dependent pathway. We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-ind...

journal_title：Oncogene

authors： Ivanov VN,Lee RK,Podack ER,Malek TR

更新日期：1997-05-22 00:00:00

abstract：:The most common genetic alteration identified in transitional cell carcinoma (TCC) of the bladder is loss of heterozygosity (LOH) on chromosome 9. However, localization of tumor suppressor genes on 9q has been hampered by the low frequency of subchromosomal deletions. We have analysed 139 primary, initial low stage TC...

journal_title：Oncogene

authors： Simoneau M,Aboulkassim TO,LaRue H,Rousseau F,Fradet Y

更新日期：1999-01-07 00:00:00

abstract：:We previously reported the development of a src-specific tumor regression system in chickens in which preinfection with rASV1702, a mutant of Rous sarcoma virus (RSV) encoding non-myristylated src product with a novel N-terminal domain, results in the immune suppression of challenge tumors induced by RSV. In order to ...

journal_title：Oncogene

authors： Gelman IH,Khan S,Hanafusa H

更新日期：1993-11-01 00:00:00

abstract：:To study the interplay of steroid hormones and oncogenes in the control of endometrial cell proliferation and differentiation we have generated cell lines derived from rat endometrium by expressing the immortalizing oncogenes adeno E1A or SV40 large T antigen. These lines are positive for mesenchymal markers and conta...

journal_title：Oncogene

authors： Helftenbein G,Alvarez CV,Tuohimaa P,Beato M

更新日期：1993-08-01 00:00:00

abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

journal_title：Oncogene

authors： Sachsenmaier C,Sadowski HB,Cooper JA

更新日期：1999-06-17 00:00:00

abstract：:Evidence from murine fibroblast models and human breast cancer cells indicates that c-Src and human EGF receptor (HER1) synergize to enhance neoplastic growth of mammary epithelial cells. To investigate whether interactions between c-Src and other HER family members may also play a role in breast tumor progression, we...

journal_title：Oncogene

authors： Belsches-Jablonski AP,Biscardi JS,Peavy DR,Tice DA,Romney DA,Parsons SJ

更新日期：2001-03-22 00:00:00

abstract：:The mechanisms involved in the p53-dependent control of gene expression following DNA damage have not been completely elucidated. Here, we show that the p53 C terminus associates with factors that are required for the ultraviolet (UV)-induced inhibition of the mRNA 3' cleavage step of the polyadenylation reaction, suc...

journal_title：Oncogene

authors： Nazeer FI,Devany E,Mohammed S,Fonseca D,Akukwe B,Taveras C,Kleiman FE

更新日期：2011-07-07 00:00:00

abstract：:Hox gene products, initially characterized as master regulators of embryonic patterning, are also required for proper functioning of adult tissues. There is also a growing body of evidence that links Hox proteins to regulation of cellular proliferation/transformation. However, the underlying molecular mechanisms of Ho...

journal_title：Oncogene

authors： Krosl J,Sauvageau G

更新日期：2000-10-26 00:00:00

abstract：:The most common mutations in the familial breast and ovarian cancer susceptibility gene BRCA1 are frameshift and nonsense mutations, which lead to the synthesis of truncated proteins. On this ground, we have analysed BRCA1 exon 11, which includes about 61% of coding region, in germline DNA from 70 Italian breast and/o...

journal_title：Oncogene

authors： De Benedetti VM,Radice P,Mondini P,Spatti G,Conti A,Illeni MT,Caligo MA,Cipollini G,Bevilaqua G,Pilotti S,Pierotti MA

更新日期：1996-09-19 00:00:00

abstract：:In the present study we investigated the frequency of p16 gene exon 2 mutations in 35 malignant gliomas, using either direct sequencing of the PCR products or cloning into the pCRII vector and sequencing of the cloned PCR products. No mutations were detected during direct sequencing of the PCR products. However, after...

journal_title：Oncogene

authors： Kyritsis AP,Zhang B,Zhang W,Xiao M,Takeshima H,Bondy ML,Cunningham JE,Levin VA,Bruner J

更新日期：1996-01-04 00:00:00

abstract：:von Hippel-Lindau (VHL) disease is a dominantly inherited family cancer syndrome characterized by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma (RCC) and phaeochromocytoma. Specific germline VHL mutations may predispose to haemangioblastomas, RCC and phaeochromocytoma t...

journal_title：Oncogene

authors： Abdulrahman M,Maina EN,Morris MR,Zatyka M,Raval RR,Banks RE,Wiesener MS,Richards FM,Johnson CM,Latif F,Maher ER

更新日期：2007-03-08 00:00:00

abstract：:The cdk2 gene has been identified as a human cdc2/CDC28-related gene that encodes a protein kinase essential for the G1/S transition in mammalian cells, but not for the G2/M transition, which requires Cdk1, another p34cdc2/CDC28 homolog. Novel potential functions of Cdk2 have been uncovered by using two potent and spe...

journal_title：Oncogene

authors： David-Pfeuty T

更新日期：1999-12-09 00:00:00

abstract：:Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle. Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary. In this study, ...

journal_title：Oncogene

authors： Ohtani K,Iwanaga R,Nakamura M,Ikeda M,Yabuta N,Tsuruga H,Nojima H

更新日期：1999-04-08 00:00:00

abstract：:The degree of DNA methylation in the c-fos gene and its vicinity in liver, brain and spleen of mice of different ages was examined using methylation-sensitive restriction endonucleases. The gene had an invariable unmethylated domain from 1.8kb upstream of the cap site to the first intron. The domain was flanked on bot...

journal_title：Oncogene

authors： Uehara Y,Ono T,Kurishita A,Kokuryu H,Okada S

更新日期：1989-08-01 00:00:00

abstract：:Blockade of the mitogen-activated protein (MAP) kinase pathway suppresses growth of colon cancer in vivo. Here we demonstrate a direct link between the extracellular signal-regulated kinase ERK2 and the growth-promoting cell adhesion molecule, integrin alphavbeta6, in colon cancer cells. Down-regulation of beta6 integ...

journal_title：Oncogene

authors： Ahmed N,Niu J,Dorahy DJ,Gu X,Andrews S,Meldrum CJ,Scott RJ,Baker MS,Macreadie IG,Agrez MV

更新日期：2002-02-21 00:00:00

abstract：:Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27. These pivotal epigenetic marks are altered in many cancers, including melanoma, as a result of EZH2 overexpression. Here, we show that the non-canonical-NF-kB pathway accounts for mo...

journal_title：Oncogene

authors： De Donatis GM,Le Pape E,Pierron A,Cheli Y,Hofman V,Hofman P,Allegra M,Zahaf K,Bahadoran P,Rocchi S,Bertolotto C,Ballotti R,Passeron T

更新日期：2016-05-01 00:00:00

abstract：:The recent identification of the mouse White spotting and Steel loci as genes encoding the c-kit receptor and its ligand, respectively, has shed light on the importance of this ligand and receptor in embryogenesis, melanogenesis and hematopoiesis. In order to determine if the c-kit proto-oncogene is involved in human ...

journal_title：Oncogene

authors： Vandenbark GR,deCastro CM,Taylor H,Dew-Knight S,Kaufman RE

更新日期：1992-07-01 00:00:00

abstract：:Malignant mesotheliomas (MMs) are very aggressive tumors that respond poorly to standard chemotherapeutic approaches. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been implicated in tumor aggressiveness, in part by mediating cell survival and reducing sensitivity to chemotherapy. Using antibodies recognizi...

journal_title：Oncogene

authors： Altomare DA,You H,Xiao GH,Ramos-Nino ME,Skele KL,De Rienzo A,Jhanwar SC,Mossman BT,Kane AB,Testa JR

更新日期：2005-09-08 00:00:00