Abstract：
:The RAD17 gene product of S. Pombe is an essential component of the checkpoint control pathway which responds to both DNA damage and disruption of replication. We have identified a human cDNA that encodes a polypeptide which is structurally conserved with the S. Pombe Rad17 protein. The human gene, designated hRAD17, predicts an encoded protein of 590 amino acids and a molecular weight of 69 kD. Amino acid sequence alignment revealed that hRadl7 has 28.3% and 52.5% similarity with the S. Pombe Rad17 protein, and 21.8% identity and 45.8% similarity to the budding yeast cell cycle checkpoint protein, Rad 24. When introduced into the S. Pombe rad17 mutant, hRAD17 was able to partially revert its hydroxyurea and ionizing radiation hypersensitivity, but not its UV hypersensitivity. Permanent overexpression of the hRAD17 gene in human fibrosarcoma cells resulted in p53 activation and a significant reduction of S- and G2/M-phase cells accompanied by an accumulation of the G1-phase population, suggesting that hRAD17 may have a role in cell cycle checkpoint control. Immunostaining of HT-1080 cells transiently transfected with a hRAD17 construct confirmed the nuclear accumulation of p53, which mimics the induction caused by DNA damage. Using FISH analysis, we have mapped the hRAD17 locus to human chromosome 5q11.2.
journal_name
Oncogenejournal_title
Oncogeneauthors
Li L,Peterson CA,Kanter-Smoler G,Wei YF,Ramagli LS,Sunnerhagen P,Siciliano MJ,Legerski RJdoi
10.1038/sj.onc.1202469subject
Has Abstractpub_date
1999-03-04 00:00:00pages
1689-99issue
9eissn
0950-9232issn
1476-5594journal_volume
18pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Epithelial-mesenchymal transition (EMT) is a process during which normal epithelial cells acquire mesenchymal characteristics. EMT has a critical role in various human diseases especially in cancer. EMT facilitates tumor initiation and progression by mediating cancer cell stemness and motility. Zinc finger transcripti...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.370
更新日期：2018-02-08 00:00:00
abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209541
更新日期：2006-09-07 00:00:00
abstract：:We report chromosome 3p deletion mapping of 32 cervical carcinoma (CC) biopsies using 26 microsatellite markers located in frequently deleted 3p regions to detect loss of heterozygosity and homozygous loss. In addition, two STS markers (NLJ-003 and NL3-001) located in the 3p21.3 telomeric (3p21.3T) and 3p21.3 centrome...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206429
更新日期：2003-05-15 00:00:00
abstract：:Integrin α3β1 regulates adhesive interactions of cells with laminins and have a critical role in adhesion-dependent cellular responses. Here, we examined the role of α3β1-integrin in ErbB2-dependent proliferation of breast cancer cells in three-dimensional laminin-rich extracellular matrix (3D lr-ECM). Depletion of α3...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.231
更新日期：2014-05-22 00:00:00
abstract：:LIM domain factors and associated cofactors are important developmental regulators in pattern formation and organogenesis. In addition, overexpression of two LIM-only factors (LMOs) causes acute lymphocytic leukemia. The more recently discovered LMO factor LMO4 is highly expressed in proliferating epithelial cells, an...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207288
更新日期：2004-02-26 00:00:00
abstract：:Germline mutations of the RET proto-oncogene are responsible for the familial tumor syndrome called multiple endocrine neoplasia type 2 (MEN 2) that includes medullary thyroid carcinoma (MTC). Although inherited mutations of RET lead to tumor formation in patients with MEN 2, it is not understood why only selected cel...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204991
更新日期：2001-11-22 00:00:00
abstract：:While screening a chicken kidney cDNA library for the normal homolog of the yes oncogene, we isolated a clone that encodes a novel non-receptor type protein tyrosine kinase of the Src family. We named this gene product Yrk (York), as an acronym for Yes-related kinase. As predicted from the cDNA sequence, the Yrk prote...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:Expression of viral proteins may result in susceptibility of cells to the cytotoxic effect of Tumor Necrosis Factor Alpha (TNF). While murine C127 cells containing the bovine papillomavirus type 1 (BPV-1) genome were reported to exhibit increased TNF sensitivity, the gene(s) responsible was not identified. The BPV-1 E...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202373
更新日期：1999-01-21 00:00:00
abstract：:Fallopian tube carcinoma (FTC) is a rare, poorly studied and aggressive cancer, associated with poor survival. Since tumorigenesis is related to the acquisition of genetic changes, we used genome-wide array comparative genomic hybridization to analyse copy number aberrations occurring in FTC in order to obtain a bette...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206621
更新日期：2003-07-03 00:00:00
abstract：:Growth factor receptor-mediated signal transduction has been implicated in conferring resistance to conventional chemotherapy on cancer cells. In this study, we delineated a pathway that involves HER2/PI-3K/Akt in mediating multidrug resistance in human breast cancer cells. We found that the cell lines that express bo...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206394
更新日期：2003-05-22 00:00:00
abstract：:The BTB/POZ family of proteins has been implicated in multiple biological processes, including tumourigenesis, DNA damage responses and cell cycle progression and development. MIZ-1 (Myc-interacting zinc-finger protein 1) is known to activate transcription of CDKN1A. We recently found that a kidney cancer-related POK ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.331
更新日期：2012-03-15 00:00:00
abstract：:SHPTP2 is a ubiquitously-expressed SH2-containing tyrosine phosphatase that is tyrosine phosphorylated in response to activation of various receptor and nonreceptor tyrosine kinases. SHPTP2 associates with the platelet-derived growth factor (PDGF) receptor after ligand stimulation, and binding of SHPTP2 to this recept...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-04-04 00:00:00
abstract：:Using Southern blot analysis of DNA from mouse-hamster somatic cell hybrids, we have mapped Lmyc and Bmyc, two members of the myc family of genes, to mouse chromosomes 4 and 2, respectively. Furthermore, we have compared the regulation of Lmyc and Bmyc expression under different growth conditions and during in vitro d...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：:High-risk papillomavirus type 18 (HPV18) is one of the less represented HPV types in low-grade lesions of the anogenital tract, whereas it occupies the second place in cervical cancer, where it can be found in 16% of the cases worldwide, after HPV16 present in 54% of them. These epidemiological data indicate that HPV1...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.246
更新日期：2010-09-09 00:00:00
abstract：:Histone modifications such as acetylation, methylation and phosphorylation have been implicated in fundamental cellular processes such as epigenetic regulation of gene expression, organization of chromatin structure, chromosome segregation, DNA replication and DNA repair. Males absent on the first (MOF) is responsible...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1210607
更新日期：2007-08-13 00:00:00
abstract：:CD44 is a transmembrane glycoprotein known to bind hyaluronic acid (HA) in its extracellular domain and to contain at least one ankyrin-binding site in its cytoplasmic domain. In this study we have examined CD44 expression in a mouse fibroblast cell line transfected with the pl85(neu) oncogene cDNA. The results of RT-...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-06-06 00:00:00
abstract：:Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members rem...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209473
更新日期：2006-07-27 00:00:00
abstract：:H1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-coupled receptors. Recent studies have shown that H1HR expression is increased in several types of cancer. However, its functional roles in tumor progression remain largely unknown, especially in hepatocellular carcinoma (HCC). We found tha...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-019-1093-y
更新日期：2020-02-01 00:00:00
abstract：:Oncolytic adenoviruses, such as Delta-24-RGD (Δ24RGD), are replication-competent viruses that are genetically engineered to induce selective cancer cell lysis. In cancer cells, Δ24RGD induces massive autophagy, which is required for efficient cell lysis and adenoviral spread. Understanding the cellular mechanisms unde...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.452
更新日期：2015-10-08 00:00:00
abstract：:The 2;13 chromosomal translocation occurs in most cases of the cancer alveolar rhabdomyosarcoma (ARMS), and juxtaposes the genes encoding the PAX3 and FKHR transcription factors. The resulting chimeric protein PAX3-FKHR is a potent transcriptional activator, and is hypothesized to function as a dominant acting oncogen...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207850
更新日期：2004-09-09 00:00:00
abstract：:The high incidence of loss of chromosome 10 alleles in glioblastoma multiforme suggests the presence on this chromosome of a tumor suppressor gene that is important in glioma tumorigenesis and progression. Our initial deletion mapping studies using restriction fragment length polymorphism markers indicated a common de...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:The simian double strand DNA tumor virus SV40 encodes the 90-kDa multi-functional protein, large T antigen (LT). LT functions by binding to DNA, as well as to many cellular target proteins such as p53 and retinoblastoma protein (pRB). We report here the identification of a cellular heat shock protein, HSP90, as a prev...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203475
更新日期：2000-03-09 00:00:00
abstract：:D-type cyclins are important cell cycle regulators that promote cellular proliferation in response to growth factors by inactivation of the retinoblastoma protein (Rb). Cyclin D1 has been shown to be overexpressed in several cancer types and to act as an oncogene in breast cancers. As D-type cyclins are rate limiting ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202511
更新日期：1999-03-18 00:00:00
abstract：:Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201658
更新日期：1998-03-26 00:00:00
abstract：:c-Myc overexpression has been associated with several types of human cancers. To study the role of c-myc in epidermal differentiation and carcinogenesis, a transgenic mouse model was created to overexpress c-Myc in the epidermis. Human c-myc 2 cDNA was subcloned into a 6.5 kb mouse loricrin expression vector, ML.myc2....
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203040
更新日期：1999-08-26 00:00:00
abstract：:Previous reports have demonstrated that E7 is the major transforming gene of HPV-16 and that continued expression of the gene is required to maintain the transformed phenotype of primary baby rat kidney cells transformed by HPV-16 E7 and EJ-ras. To investigate the point of action of E7 in the cell cycle we have utilis...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Mutations in the transmembrane receptor patched1 (ptc1) are responsible for the majority of basal cell carcinoma (BCC) cases. Many of these mutations, including ptc1-Q688X, result in premature truncation of the ptc1 protein. ptc1-Q688X has been identified in patients with both BCC and nevoid basal cell carcinoma syndr...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208240
更新日期：2005-01-27 00:00:00
abstract：:RRR-alpha-tocopheryl succinate (alpha-vitamin E succinate, VES), one of the vitamin E derivatives, can effectively inhibit the proliferation of human prostate cancer cells. However, little is known about its effect on prostate cancer cell invasive ability. Tumor metastasis is a complex process and the extracellular ma...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207435
更新日期：2004-04-15 00:00:00
abstract：:The Notch ligand delta-like ligand 4 (DLL4) is an essential component expressed by endothelial tip cells during angiogenic sprouting. We have described a conceptually novel therapeutic strategy for targeting tumor angiogenesis and endothelial tip cells based on DNA vaccination against DLL4. Immunization with DLL4-enco...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.176
更新日期：2010-07-29 00:00:00
abstract：:Mechanisms underlying multidrug resistance (MDR), one of the major causes of cancer treatment failure, are still poorly understood. We selected the osteosarcoma MDR HosDXR150 cell line by culturing Hos cells in the presence of increasing doxorubicin doses and showed that it is crossresistant to vinblastine. Similarly ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206487
更新日期：2003-06-05 00:00:00
