Abstract：
:H1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-coupled receptors. Recent studies have shown that H1HR expression is increased in several types of cancer. However, its functional roles in tumor progression remain largely unknown, especially in hepatocellular carcinoma (HCC). We found that H1HR is frequently unregulated in HCC, which is significantly associated with both recurrence-free survival and overall survival in HCC patients. Functional experiments revealed that H1HR promoted both the growth and metastasis of HCC cells by inducing cell cycle progression, formation of lamellipodia, production of matrix metalloproteinase 2, and suppression of cell apoptosis. Activation of cyclic adenosine monophosphate-dependent protein kinase A was found to be involved in H1HR-mediated HCC cell growth and metastasis. In addition, we found that overexpression of H1HR was mainly due to the downregulation of miR-940 in HCC cells. Moreover, the H1HR inhibitor terfenadine significantly suppressed tumor growth and metastasis in an HCC xenograft nude mice model. Our findings demonstrate that H1HR plays a critical role in the growth and metastasis of HCC cells, which provides experimental evidence supporting H1HR as a potential drug target for the treatment of HCC.
journal_name
Oncogenejournal_title
Oncogeneauthors
Zhao J,Hou Y,Yin C,Hu J,Gao T,Huang X,Zhang X,Xing J,An J,Wan S,Li Jdoi
10.1038/s41388-019-1093-ysubject
Has Abstractpub_date
2020-02-01 00:00:00pages
1724-1738issue
8eissn
0950-9232issn
1476-5594pii
10.1038/s41388-019-1093-yjournal_volume
39pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:One-carbon metabolism plays a central role in a broad array of metabolic processes required for the survival and growth of tumor cells. However, the molecular basis of how one-carbon metabolism may influence RNA methylation and tumorigenesis remains largely unknown. Here we show MTHFD2, a mitochondrial enzyme involved...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-019-0869-4
更新日期：2019-08-01 00:00:00
abstract：:p27 restrains normal cell growth, but PI3K-dependent C-terminal phosphorylation of p27 at threonine 157 (T157) and T198 promotes cancer cell invasion. Here, we describe an oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator of transcription 3) ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.473
更新日期：2015-10-01 00:00:00
abstract：:Skin carcinogenesis is known to be a multi-step process with several stages along its malignant evolution. We hypothesized that transformation of normal epidermis to cutaneous squamous cell carcinoma (cSCC) is causally linked to alterations in microRNAs (miRNA) expression. For this end we decided to evaluate their alt...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.315
更新日期：2018-01-11 00:00:00
abstract：:To identify potential microRNA (miRNA) links between Smad3, a mediator of TGF-β (transforming growth factor-β) signaling, and E-cadherin, we characterized the miRNA profiles of two gastric cancer cell lines: SNU484-LPCX, which does not express Smad3, and SNU484-Smad3, in which Smad3 is overexpressed. We found that amo...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.484
更新日期：2012-06-21 00:00:00
abstract：:The family of tripartite-motif (TRIM) proteins are involved in diverse cellular processes, but are often characterized by critical protein-protein interactions necessary for their function. TRIM16 is induced in different cancer types, when the cancer cell is forced to proceed down a differentiation pathway. We have id...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.340
更新日期：2010-11-18 00:00:00
abstract：:Hexokinase-II (HK2) is a key enzyme involved in glycolysis, which is required for breast cancer progression. However, the underlying post-translational mechanisms of HK2 activity are poorly understood. Here, we showed that Proviral Insertion in Murine Lymphomas 2 (PIM2) directly bound to HK2 and phosphorylated HK2 on ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0386-x
更新日期：2018-11-01 00:00:00
abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with proper treatment. Antiangiogenic therapy is the most effective medical treatment for metastatic ccRCC. Thus, exploration of novel approaches t...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-020-01428-3
更新日期：2020-09-01 00:00:00
abstract：:Previous studies have demonstrated that activation of Kit by stem cell factor (SCF), its natural ligand, or by gain-of-function point mutation in its intracellular domain, confers significant protection against apoptosis induced by growth factor deprivation or radiation. However, the effects of Kit activation on the c...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204877
更新日期：2001-10-11 00:00:00
abstract：:The RNA-binding protein (RBP) RNPC1 is a target of the p53 family and forms a feedback regulatory loop with the p53 family proteins. The murine double minute-2 (MDM2) oncogene, a key negative regulator of p53, has a critical role in a variety of fundamental cellular processes. MDM2 expression is found to be regulated ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.238
更新日期：2013-04-25 00:00:00
abstract：:Provirus modifications which can occur in tumors may lead to tumor antigenic variants. To investigate this possibility we compared the restriction fragment length patterns of mouse mammary tumor virus (MMTV), murine leukemia virus and xenotropic and mink cell-focus inducing (MCF)-related sequences, using Southern blot...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:Long-lived species Homo sapiens have evolved robust protection mechanisms against cancer by repressing telomerase and maintaining short telomeres, thereby delaying the onset of the majority of cancer types until post-reproductive age. Indeed, telomerase is silent in most differentiated human cells, predominantly due t...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/s41388-019-0872-9
更新日期：2019-08-01 00:00:00
abstract：:The human c-rel gene (REL), encoding an NF-kappaB transcription factor, is amplified or mutated in several human B-cell lymphomas and can transform chicken lymphoid cells in vitro. We have previously shown that certain deletions of C-terminal transactivation sequences enhance REL's transforming ability in chicken sple...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208902
更新日期：2005-11-10 00:00:00
abstract：:VEGFR-1 (Flt-1), VEGFR-2 (KDR) and VEGFR-3 (Flt4) are endothelial specific receptor tyrosine kinases, regulated by members of the vascular endothelial growth factor family. VEGFRs are indispensable for embryonic vascular development, and are involved in the regulation of many aspects of physiological and pathological ...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1203855
更新日期：2000-11-20 00:00:00
abstract：:Neuroblastoma (Nb) is a malignancy of the sympathetic nervous system which affects children in their first decade. It is the most common extra-cranial solid tumor in children with an incidence of approximately 1 in 8-10 000 live births annually and accounts for approximately 10% of all children's cancers. Ganglioneuro...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205734
更新日期：2002-08-29 00:00:00
abstract：:Polyomavirus infection of adolescent athymic female mice causes a high incidence of mammary adenocarcinomas. We have examined the role of ovarian hormones, age and mammary gland developmental stage at infection on subsequent tumor induction, viral replication and gene expression. Ovariectomy (OVX) of adolescent mice 1...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-11-02 00:00:00
abstract：:Growth factor receptor-mediated signal transduction has been implicated in conferring resistance to conventional chemotherapy on cancer cells. In this study, we delineated a pathway that involves HER2/PI-3K/Akt in mediating multidrug resistance in human breast cancer cells. We found that the cell lines that express bo...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206394
更新日期：2003-05-22 00:00:00
abstract：:Ovarian cancer is the leading cause of death among all gynecological malignancies due to the development of acquired chemoresistance and disease relapse. Although the role of cancer stem cells (CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therapeutic resistance is beginning...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.320
更新日期：2017-03-01 00:00:00
abstract：:In lung cancer, frequent loss of one allele of chromosome 3p is seen in both small cell lung cancer and non-small cell lung cancer (NSCLC), providing evidence of tumor suppressor genes (TSGs) in this chromosomal region. The mechanism of Fus1 tumor suppressor activity is unknown. We have found that a Fus1 peptide inhib...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210500
更新日期：2007-10-25 00:00:00
abstract：:We have shown earlier that overexpression of Calreticulin (CRT) contributed to a poor prognosis for patients with esophageal squamous cell carcinoma (ESCC). Here, we have shown an important role of CRT in tumorigenesis through enhancing cell motility and anoikis resistance. SiRNA-mediated knockdown of CRT caused impai...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.237
更新日期：2009-10-22 00:00:00
abstract：:Previous studies have shown that the cell cycle-regulated B-myb promoter contains a conserved E2F binding site that is critical for repressing transcription in quiescent cells. To investigate its significance for permanent promoter silencing, we have inactivated this binding site in the mouse genome. Mice homozygous f...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210087
更新日期：2007-04-26 00:00:00
abstract：:Assessment of the genetic instability of a microsatellite has indicated a new mechanism in human carcinogenesis. Examination was made to determine whether microsatellite instability is associated with the onset of prostate cancer. Twenty-nine DNA samples from 24 primary prostate cancer, two metastatic lymph-node and t...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-03-02 00:00:00
abstract：:The current model for colorectal tumorigenesis defines four specific mutations (activation of a ras proto-oncogene and inactivation of the APC, p53 and DCC tumor-suppressor genes) that accumulate in a colonic epithelial cell as it progresses towards a carcinoma. However, further mutations must be needed for progressio...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:We have cloned a cDNA from the Drosophila elg gene, a new member of the ets family of genes. The D-elg gene is located at 97D on chromosome 3R and is expressed as a 2.0kb RNA in the embryos, pupae and adults, with no detectable expression in third instar larvae. D-elg expression is observed in all cells of early stage...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Radicicol, an inhibitor of Src-family protein-tyrosine kinases, causes morphological reversion of v-src- and v-Ha-ras-transformed fibroblasts and arrest of the cell cycle at both the G1 and the G2 phases. Radicicol was found to inhibit the growth of several other oncogene-transformed cell lines and human carcinoma cel...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201443
更新日期：1997-11-20 00:00:00
abstract：:Degradation of chromosomal DNA into nucleosome-sized fragments is one of the characteristics of apoptotic cell death. Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposid...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202868
更新日期：1999-08-05 00:00:00
abstract：:Promyelocytic leukemia (PML) nuclear bodies (PML NBs) are discrete subnuclear domains organized by the promyelocytic leukemia protein PML, a tumor suppressor essential for multiple apoptotic pathways. We have recently described a novel family of cellular factors, the THAP proteins, characterized by the presence at the...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206271
更新日期：2003-04-24 00:00:00
abstract：:Oncostatin M (OM) is a polypeptide cytokine that induces autocrine and paracrine effects on AIDS-Kaposi's sarcoma (KS) cells (Nair et al., Science, 255, 1430-1432, 1992; Miles et al., Science, 255, 1432-1434, 1992). The signalling pathways underlying this activation are largely unknown. We have found that OM binding t...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical modulator in liver TIC self-renewal. However, the molecular mechanism of Wnt/β-catenin initiation in liver tumori...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0203-6
更新日期：2018-06-01 00:00:00
abstract：:A transgenic mouse family expressing the middle T antigen of polyoma virus under control of the immunoglobulin heavy chain (IgE) enhancer showed the frequent occurrence of carcinomas in various organs, predominantly in females. Most frequently affected were the salivary and thyroid glands, but mammary tumours, liver h...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:The C-terminal src kinase (Csk) is responsible for the phosphorylation of the carboxy-terminal tyrosine of several tyrosine kinases of the Src family. This phosphorylation site has a negative regulatory function. Csk is unique among the members of the protein tyrosine kinase family because it lacks the conserved tyros...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
