Retroviral heterogeneity in mouse lymphomas.

abstract：:Fusion proteins involving the BRAF serine/threonine kinase occur in many cancers. The oncogenic potential of BRAF fusions has been attributed to the loss of critical N-terminal domains that mediate BRAF autoinhibition. We used whole-exome and RNA sequencing in a patient with glioblastoma multiforme to identify a rearr...

journal_title：Oncogene

authors： Weinberg F,Griffin R,Fröhlich M,Heining C,Braun S,Spohr C,Iconomou M,Hollek V,Röring M,Horak P,Kreutzfeldt S,Warsow G,Hutter B,Uhrig S,Neumann O,Reuss D,Heiland DH,von Kalle C,Weichert W,Stenzinger A,Brors B,Gli

更新日期：2020-01-01 00:00:00

abstract：:Mdm2 is the major negative regulator of p53 tumor-suppressor activity. This oncoprotein is overexpressed in many human tumors that retain the wild-type p53 allele. As such, targeted inhibition of Mdm2 is being considered as a therapeutic anticancer strategy. The N-terminal hydrophobic pocket of Mdm2 binds to p53 and t...

journal_title：Oncogene

authors： Wade M,Li YC,Matani AS,Braun SM,Milanesi F,Rodewald LW,Wahl GM

更新日期：2012-11-08 00:00:00

abstract：:The marine alkaloid ascididemin (ASC) was shown to exert cytotoxicity even against multidrug-resistant cancer cells. Here, we address the signaling pathways utilized by ASC to trigger apoptosis in Jurkat leukemia T cells. We show that ASC (0.5-20 microM) induces a mitochondrial pathway that requires the activation of ...

journal_title：Oncogene

authors： Dirsch VM,Kirschke SO,Estermeier M,Steffan B,Vollmar AM

更新日期：2004-02-26 00:00:00

abstract：:Axl is a receptor that induces proliferation, migration and invasion in cancer. In this study, we show that specific microRNAs (miRNAs) target the 3'-UTR of Axl. Luciferase-reporter assays with wild-type and deleted miR-34 and miR-199a/b seed sequences of Axl 3'-UTR confirmed the specificity of targeting. An inverse c...

journal_title：Oncogene

authors： Mudduluru G,Ceppi P,Kumarswamy R,Scagliotti GV,Papotti M,Allgayer H

更新日期：2011-06-23 00:00:00

abstract：:To investigate the effect of p33(ING1) on wild-type p53 gene therapy, T.Tn human esophageal carcinoma cells were stably transfected with p33(ING1) cDNA. Infection with Ad-p53 (recombinant adenovirus containing wild-type p53) into p33-transfected cells reduced cell viability, while infection with empty vector had littl...

journal_title：Oncogene

authors： Shimada H,Liu TL,Ochiai T,Shimizu T,Haupt Y,Hamada H,Abe T,Oka M,Takiguchi M,Hiwasa T

更新日期：2002-02-14 00:00:00

abstract：:Cytokines can influence the interactions between members of the integrin cell adhesion receptor family and the extracellular matrix thereby potentially affecting cell function and promoting cell adhesion, growth and migration of malignant astrocytoma tumor cells. As malignant astrocytoma cells synthesize TGF-beta1 in ...

journal_title：Oncogene

authors： Han X,Stewart JE Jr,Bellis SL,Benveniste EN,Ding Q,Tachibana K,Grammer JR,Gladson CL

更新日期：2001-11-29 00:00:00

abstract：:The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the ability of avian myeloblastosis virus (AMV) to transform myelomonocytic cells. v-Myb is thought to disrupt the differentiation of myelomonocytic cells by affecting the expression of specific target genes. To identify such...

journal_title：Oncogene

authors： Schlichter U,Burk O,Worpenberg S,Klempnauer KH

更新日期：2001-01-11 00:00:00

abstract：:Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteostasis is regulated ...

journal_title：Oncogene

authors： German P,Bai S,Liu XD,Sun M,Zhou L,Kalra S,Zhang X,Minelli R,Scott KL,Mills GB,Jonasch E,Ding Z

更新日期：2016-09-22 00:00:00

abstract：:Large cancer projects measure somatic mutations in thousands of samples, gradually assembling a catalog of recurring mutations in cancer. Many methods analyze these data jointly with auxiliary information with the aim of identifying subtype-specific results. Here, we show that somatic gene mutations alone can reliably...

journal_title：Oncogene

authors： Amar D,Izraeli S,Shamir R

更新日期：2017-06-15 00:00:00

abstract：:Targeting Bruton tyrosine kinase (BTK) by ibrutinib is an effective treatment for patients with relapsed/refractory mantle cell lymphoma (MCL). However, both primary and acquired resistance to ibrutinib have developed in a significant number of these patients. A combinatory strategy targeting multiple oncogenic pathwa...

journal_title：Oncogene

authors： Li Y,Bouchlaka MN,Wolff J,Grindle KM,Lu L,Qian S,Zhong X,Pflum N,Jobin P,Kahl BS,Eickhoff JC,Wuerzberger-Davis SM,Miyamoto S,Thomas CJ,Yang DT,Capitini CM,Rui L

更新日期：2016-12-01 00:00:00

abstract：:A cDNA encoding a complete human c-fos protein was isolated and inserted into two different murine MoMuLV-derived recombinant retroviruses allowing expression of c-fos protein in different cell types. One c-fos-expressing retrovirus, chosen for its ability to express high levels of proteins in fibroblast-like cells, w...

journal_title：Oncogene

authors： Roux P,Verrier B,Klein B,Niccolino M,Marty L,Alexandre C,Piechaczyk M

更新日期：1991-11-01 00:00:00

abstract：:A mouse gene encoding a receptor tyrosine kinase, designated Embryonic receptor kinase (EmRK2), was isolated from embryoid bodies (EBs) generated by differentiating embryonic stem (ES) cells in culture for 6 days. Sequence analysis of EmRK2 cDNA clones predicts a receptor with a 755 amino acid extracellular region wit...

journal_title：Oncogene

authors： Choi K,Wall C,Hanratty R,Keller G

更新日期：1994-04-01 00:00:00

abstract：:The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has been reported that SIRT1 is upregulated in various kinds of tumors and is associated with cell growth and metastasis. However, the factors a...

journal_title：Oncogene

authors： Yu L,Dong L,Li H,Liu Z,Luo Z,Duan G,Dai X,Lin Z

更新日期：2020-05-01 00:00:00

abstract：:PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase activity in a guanine nucleotide-dependent manner. PIKE-A is one of the components of the CDK4 amplicon that is amplified in numerous human cancers. However, whether ...

journal_title：Oncogene

authors： Liu X,Hu Y,Hao C,Rempel SA,Ye K

更新日期：2007-07-26 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors induce growth arrest and apoptosis in a variety of human cancer cells. Sodium butyrate (NaB), a short chain fatty acid, is a HDAC inhibitor and is produced in the colonic lumen as a consequence of microbial degradation of dietary fibers. In order to dissect out the mechanism of Na...

journal_title：Oncogene

authors： Joseph J,Mudduluru G,Antony S,Vashistha S,Ajitkumar P,Somasundaram K

更新日期：2004-08-19 00:00:00

abstract：:The p53 tumor suppressor protein activates transcription and induces cell death. A close homologue of p53, termed p73, is expressed in transactivating (TA) forms that induce growth arrest and apoptosis much like p53. However, the p73 gene contains a second promoter, giving rise to the expression of p73 Delta N, a spec...

journal_title：Oncogene

authors： Kartasheva NN,Contente A,Lenz-Stöppler C,Roth J,Dobbelstein M

更新日期：2002-07-18 00:00:00

abstract：:Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally expos...

journal_title：Oncogene

authors： Napolitano A,Pellegrini L,Dey A,Larson D,Tanji M,Flores EG,Kendrick B,Lapid D,Powers A,Kanodia S,Pastorino S,Pass HI,Dixit V,Yang H,Carbone M

更新日期：2016-04-14 00:00:00

abstract：:The MLL (HRX/ALL-1 gene is frequently disrupted in infantile leukemias and therapy-related leukemias and fused to various translocation partner genes. We previously showed that chimeric MLL proteins localize in the nuclei in a fashion similar to that of MLL protein even if the partner gene encodes a cytoplasmic protei...

journal_title：Oncogene

authors： Joh T,Hosokawa Y,Suzuki R,Takahashi T,Seto M

更新日期：1999-01-28 00:00:00

abstract：:Activating mutations of the N-ras gene occur at relatively high frequency in acute myeloid leukemia and myelodysplastic syndrome. Somewhat paradoxically, ectopic expression of activated N-ras in primary hematopoietic cells and myeloid cell lines (in some cases) can lead to inhibition of proliferation. Expression of mu...

journal_title：Oncogene

authors： Passioura T,Shen S,Symonds G,Dolnikov A

更新日期：2005-11-10 00:00:00

abstract：:Mouse Developmental Kinase 1 (MDK1) is a receptor tyrosine kinase of the eck/eph subfamily expressed in a variety of tissues during early mouse embryogenesis. To obtain further insight into the function of MDK1, we determined identity and localisation of its physiological ligand(s). Staining whole embryos with fusion ...

journal_title：Oncogene

authors： Ciossek T,Ullrich A

更新日期：1997-01-09 00:00:00

abstract：:Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through cyclin-dependent kinase (CDK) inhibition has therefore emerged as an attractive option in the development of targ...

journal_title：Oncogene

authors： Johnson J,Thijssen B,McDermott U,Garnett M,Wessels LF,Bernards R

更新日期：2016-09-15 00:00:00

abstract：:Keratinocyte growth factor is a potent and specific mitogen for different types of epithelial cells, including keratinocytes of the skin. Furthermore, it has been implicated in morphogenetic processes of several organs. To further define the mechanisms of KGF action in the skin, we attempted to identify genes which ar...

journal_title：Oncogene

authors： Frank S,Munz B,Werner S

更新日期：1997-02-27 00:00:00

abstract：:The RCAS retroviral vector was used to express chicken and mouse cellular Jun proteins in chicken embryo fibroblasts. Both mouse and chicken proteins induced foci of transformed cells with low to moderate efficiency compared with viral Jun, but were as effective as the viral protein in promoting anchorage-independent ...

journal_title：Oncogene

authors： Wong WY,Håvarstein LS,Morgan IM,Vogt PK

更新日期：1992-10-01 00:00:00

abstract：:p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2). Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism. In this st...

journal_title：Oncogene

authors： Zhang Y,Feng X,Zhang J,Chen M,Huang E,Chen X

更新日期：2019-08-01 00:00:00

abstract：:Osteopontin (OPN) is a phosphorylated glycoprotein that binds to alpha v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization between mRNAs isolated from the Rama 37 (R37) rat mammary cell line and a subclone rendered invasive ...

journal_title：Oncogene

authors： Kurisetty VV,Johnston PG,Johnston N,Erwin P,Crowe P,Fernig DG,Campbell FC,Anderson IP,Rudland PS,El-Tanani MK

更新日期：2008-12-04 00:00:00

abstract：:Matrix metalloprotease-1 (MMP1) is an important mediator of tumorigenesis, inflammation and tissue remodeling through its ability to degrade critical matrix components. Recent studies indicate that stromal-derived MMP1 may exert direct oncogenic activity by signaling through protease-activated receptor-1 (PAR1) in car...

journal_title：Oncogene

authors： Foley CJ,Fanjul-Fernández M,Bohm A,Nguyen N,Agarwal A,Austin K,Koukos G,Covic L,López-Otín C,Kuliopulos A

更新日期：2014-04-24 00:00:00

abstract：:B7-H4, a member of B7 family, is a transmembrane protein and inhibits T-cells immunity. However, in a variety of tumor cells, B7-H4 was detected predominantly in intracellular compartments with unknown mechanism and functions. In this study, we analyzed B7-H4 expression and subcellular distribution by immunohistochemi...

journal_title：Oncogene

authors： Zhang L,Wu H,Lu D,Li G,Sun C,Song H,Li J,Zhai T,Huang L,Hou C,Wang W,Zhou B,Chen S,Lu B,Zhang X

更新日期：2013-11-14 00:00:00

abstract：:The growth and progression of prostate cancer are dependent on androgens and androgen receptor (AR), which act by modulating gene expression. Utilizing a gene microarray approach, we have identified the alpha1-subunit gene of soluble guanylyl cyclase (sGC) as a novel androgen-regulated gene. A heterodimeric cytoplasmi...

journal_title：Oncogene

authors： Cai C,Chen SY,Zheng Z,Omwancha J,Lin MF,Balk SP,Shemshedini L

更新日期：2007-03-08 00:00:00

abstract：:Vascular endothelial (VE)-cadherin is exclusively expressed at interendothelial junctions of normal and tumour vessels. In this report, we characterized the transcriptional activity of the human VE-cadherin promoter. Transient transfection assays revealed that sequences at positions --1135/-744 and -166/-5 base pairs ...

journal_title：Oncogene

authors： Prandini MH,Dreher I,Bouillot S,Benkerri S,Moll T,Huber P

更新日期：2005-04-21 00:00:00

abstract：:Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned (Gilks et al., 1993; Zoring et al; 1996). This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes ...

journal_title：Oncogene

authors： Roberts T,Cowell JK

更新日期：1997-02-27 00:00:00