Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells.

abstract：:Obesity is a highly prevalent and modifiable breast cancer risk factor. While the role of obesity in fueling breast cancer progression is well established, the mechanisms linking obesity to breast cancer initiation are poorly understood. A hallmark of breast cancer initiation is the disruption of apical polarity in ma...

journal_title：Oncogene

authors： Tenvooren I,Jenks MZ,Rashid H,Cook KL,Muhlemann JK,Sistrunk C,Holmes J,Wang K,Bonin K,Hodges K,Lo HW,Shaikh A,Camarillo IG,Lelièvre SA,Seewaldt V,Vidi PA

更新日期：2019-05-01 00:00:00

abstract：:Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metastasis. Based on this evidence, the pharmaceutical industry produced several well tolerated, orally active MMP inhibitors (MMPIs...

journal_title：Oncogene

authors： Zucker S,Cao J,Chen WT

更新日期：2000-12-27 00:00:00

abstract：:A33 antigen is a membrane-bound protein that is expressed only in intestinal epithelium and in most human colon cancers. Thus, A33 antigen has been explored as a potential therapeutic target for the treatment of colon cancers. However, little is known about the mechanism responsible for the tissue-specific pattern of ...

journal_title：Oncogene

authors： Mao Z,Song S,Zhu Y,Yi X,Zhang H,Shang Y,Tong T

更新日期：2003-07-10 00:00:00

abstract：:Exposure of cells to DNA damaging agents results in a G2 arrest. Exposure of HeLa cells to camptothecin, etoposide or nitrogen mustard for 1 h in S phase resulted in delayed expression of cyclin B1 mRNA during the G2 arrest. Initially the levels of cyclin B1 protein were low as well; however, with extended time the ce...

journal_title：Oncogene

authors： Maity A,Hwang A,Janss A,Phillips P,McKenna WG,Muschel RJ

更新日期：1996-10-17 00:00:00

abstract：:Human basal-like breast cancer (BLBC) is an enigmatic and aggressive malignancy with a poor prognosis. There is an urgent need to identify therapeutic targets for BLBC, because current treatment modalities are limited and not effective. The forkhead box transcription factor FOXC1 has recently been identified as a crit...

journal_title：Oncogene

authors： Wang J,Ray PS,Sim MS,Zhou XZ,Lu KP,Lee AV,Lin X,Bagaria SP,Giuliano AE,Cui X

更新日期：2012-11-08 00:00:00

abstract：:Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in...

journal_title：Oncogene

authors： Fuchs SY,Spiegelman VS,Kumar KG

更新日期：2004-03-15 00:00:00

abstract：:Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect ...

journal_title：Oncogene

authors： Fåhraeus R,Marin M,Olivares-Illana V

更新日期：2016-07-21 00:00:00

abstract：:Tumor recurrence following treatment remains a major clinical challenge in oral cavity cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been considered as the driving force of tumor recurrence and metastasis. However, it still remains unclear whether targeting CSCs in oral cancer is a cl...

journal_title：Oncogene

authors： Hu J,Mirshahidi S,Simental A,Lee SC,De Andrade Filho PA,Peterson NR,Duerksen-Hughes P,Yuan X

更新日期：2019-07-01 00:00:00

abstract：:Individuals with germline mutations in the tumour-suppressor gene CYLD are at high risk of developing disfiguring cutaneous appendageal tumours, the defining tumour being the highly organised cylindroma. Here, we analysed CYLD mutant tumour genomes by array comparative genomic hybridisation and gene expression microar...

journal_title：Oncogene

authors： Rajan N,Elliott R,Clewes O,Mackay A,Reis-Filho JS,Burn J,Langtry J,Sieber-Blum M,Lord CJ,Ashworth A

更新日期：2011-10-13 00:00:00

abstract：:We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concen...

journal_title：Oncogene

authors： Kristjuhan A,Jaks V,Rimm I,Tooming T,Maimets T

更新日期：1998-05-07 00:00:00

abstract：:The RASSF8 gene, which maps close to the KRAS2 gene, contains a RAS-associated domain and encodes a protein that is evolutionarily conserved from fish to humans. Analysis of the RASSF8 transcript revealed a complex expression pattern of 5'-UTR mRNA isoforms in normal lung and in lung adenocarcinomas (ADCAs), with no a...

journal_title：Oncogene

authors： Falvella FS,Manenti G,Spinola M,Pignatiello C,Conti B,Pastorino U,Dragani TA

更新日期：2006-06-29 00:00:00

abstract：:Atypical protein kinase C (aPKC) and Lethal giant larvae (Lgl) regulate apical-basal polarity in Drosophila and mammalian epithelia. At the apical domain, aPKC phosphorylates and displaces Lgl that, in turn, maintains aPKC inactive at the basolateral region. The mutual exclusion of these two proteins seems to be cruci...

journal_title：Oncogene

authors： Grifoni D,Garoia F,Bellosta P,Parisi F,De Biase D,Collina G,Strand D,Cavicchi S,Pession A

更新日期：2007-08-30 00:00:00

abstract：:The chromatin state is finely tuned to regulate function and specificity for transcription factors such as oestrogen receptor alpha (ER), which contributes to cell growth in breast cancer. ER transcriptional potential is mediated, in large part, by the specific associated proteins and co-factors that interact with it....

journal_title：Oncogene

authors： Serandour AA,Mohammed H,Miremadi A,Mulder KW,Carroll JS

更新日期：2018-09-01 00:00:00

abstract：:MET, the receptor tyrosine kinase (RTK) for hepatocyte growth factor, is a proto-oncogene involved in embryonic development and throughout life in homeostasis and tissue regeneration. Deregulation of MET signaling has been reported in numerous malignancies, prompting great interest in MET targeting for cancer therapy....

journal_title：Oncogene

authors： Koch JP,Aebersold DM,Zimmer Y,Medová M

更新日期：2020-04-01 00:00:00

abstract：:The initiation, magnitude and duration of an immune response against antigens are a tightly regulated process involving a dynamic, orchestrated balance of pro- and anti-inflammatory pathways in immune cells. Such a delicate balance is critical for allowing efficient immune response against foreign antigens while preve...

journal_title：Oncogene

authors： Villagra A,Sotomayor EM,Seto E

更新日期：2010-01-14 00:00:00

abstract：:As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional co-activator, whereas the SSX proteins are thought to act as transcriptional co...

journal_title：Oncogene

authors： de Bruijn DR,van Dijk AH,Willemse MP,van Kessel AG

更新日期：2008-01-24 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT), marked by the dissolution of cell-cell junctions, loss of cell polarity and increased cell motility, is one of the essential steps for prostate cancer metastasis. However, the underlying mechanism has not been fully explored. We report in this study that Shp2 is upregulated ...

journal_title：Oncogene

authors： Zhang K,Zhao H,Ji Z,Zhang C,Zhou P,Wang L,Chen Q,Wang J,Zhang P,Chen Z,Zhu HH,Gao WQ

更新日期：2016-03-10 00:00:00

abstract：:Prostate cancer is the most common malignancy of elderly men in the United States. Since there is no curative treatment for advanced prostate cancer, exploration of novel modalities of treatment is essential. Telomerase, a ribonucleoprotein, is detected in the vast majority of prostate cancer, but not in normal or ben...

journal_title：Oncogene

authors： Kondo Y,Koga S,Komata T,Kondo S

更新日期：2000-04-27 00:00:00

abstract：:Tek/Tie2 is an endothelial cell-specific receptor tyrosine kinase that has been shown to play a role in vascular development of the mouse. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathway(s) mediated by this rec...

journal_title：Oncogene

authors： Jones N,Dumont DJ

更新日期：1998-09-03 00:00:00

abstract：:Chromosome 8 loss of heterozygosity (LOH) in cancer of the urinary bladder is associated with high tumour grade and stage. We have screened 193 cases of transitional cell carcinoma (TCC) of the bladder using 30 microsatellite polymorphisms on chromosome 8. Forty three cases (22%) showed LOH on 8p, the majority of whic...

journal_title：Oncogene

authors： Takle LA,Knowles MA

更新日期：1996-03-07 00:00:00

abstract：:Although cell invasion is a necessary early step in cancer metastasis, its regulation is not well understood. We have previously shown, in human prostate cancer, that transforming growth factor beta (TGFbeta)-mediated increases in cell invasion are dependent upon activation of the serine/threonine kinase, p38 MAP kina...

journal_title：Oncogene

authors： Xu L,Chen S,Bergan RC

更新日期：2006-05-18 00:00:00

abstract：:Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Since surviving patients experience severe neurocognitive disabilities, better and more effective treatments are needed to enhance their quality of life. Casein kinase 2 (CK2) is known to regulate cell growth and survival in multiple cancers; how...

journal_title：Oncogene

authors： Nitta RT,Bolin S,Luo E,Solow-Codero DE,Samghabadi P,Purzner T,Aujla PS,Nwagbo G,Cho YJ,Li G

更新日期：2019-10-01 00:00:00

abstract：:Most normal cells require both mitogens and integrin-mediated attachment for growth. It is generally accepted that the p42/p44 MAP kinase module, which can be activated by both growth factors and adhesion, plays a critical role in G0 to S phase progression of quiescent cells. Studies on various cultured fibroblasts ha...

journal_title：Oncogene

authors： Le Gall M,Grall D,Chambard JC,Pouysségur J,Van Obberghen-Schilling E

更新日期：1998-09-10 00:00:00

abstract：:Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to elucidate intracellular signaling, the cytoplasmic moiety of Ufo/Axl was used to screen an expression library according to the CORT (cloning of receptor targets) m...

journal_title：Oncogene

authors： Braunger J,Schleithoff L,Schulz AS,Kessler H,Lammers R,Ullrich A,Bartram CR,Janssen JW

更新日期：1997-06-05 00:00:00

abstract：:We have previously reported the isolation of several temperature-sensitive (ts) mutants of F9 cells. Further investigations showed that some mutants were induced to differentiate at non-permissive temperature of cell growth, accompanied by changes in the expression of various genes, whereas others were not. During the...

journal_title：Oncogene

authors： Kosaka M,Iwai SA,Nishina Y,Sumi T,Nishimune Y

更新日期：1992-12-01 00:00:00

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid modulator of allergic and inflammatory reactions, is diverse and functions as a modulator of a variety of physiological and pathological events in many cell types and tissues. Its role (if any) in modulating the prolifera...

journal_title：Oncogene

authors： Wang H,Chakrabarty S

更新日期：2003-04-10 00:00:00

abstract：:LIM domain factors and associated cofactors are important developmental regulators in pattern formation and organogenesis. In addition, overexpression of two LIM-only factors (LMOs) causes acute lymphocytic leukemia. The more recently discovered LMO factor LMO4 is highly expressed in proliferating epithelial cells, an...

journal_title：Oncogene

authors： Wang N,Kudryavtseva E,Ch'en IL,McCormick J,Sugihara TM,Ruiz R,Andersen B

更新日期：2004-02-26 00:00:00

abstract：:The v-src gene of Rous sarcoma virus (RSV) encodes pp60v-src, a tyrosine kinase that can initiate cellular transformation. High levels of v-src gene expression can either be cytotoxic or the cause of altered expression of cellular genes. Examination of cytotoxic thresholds is difficult because cells expressing high le...

journal_title：Oncogene

authors： Wu LW,Hackett PB

更新日期：1995-10-19 00:00:00

abstract：:Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LN...

journal_title：Oncogene

authors： Urbanucci A,Sahu B,Seppälä J,Larjo A,Latonen LM,Waltering KK,Tammela TL,Vessella RL,Lähdesmäki H,Jänne OA,Visakorpi T

更新日期：2012-04-26 00:00:00