Abstract：
:Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect the functional properties of the encoded protein. We describe how mRNAs exert control of cell biological processes governed by the encoded proteins via translation kinetics, protein folding, mRNA stability, spatio-temporal protein expression and by direct interactions with cellular factors. These examples illustrate how additional levels of information lie within the coding sequences and that the degenerative genetic code is not redundant and have co-evolved with the encoded proteins. Hence, so called synonymous mutations are not always silent but 'whisper'.
journal_name
Oncogenejournal_title
Oncogeneauthors
Fåhraeus R,Marin M,Olivares-Illana Vdoi
10.1038/onc.2015.454subject
Has Abstractpub_date
2016-07-21 00:00:00pages
3753-9issue
29eissn
0950-9232issn
1476-5594pii
onc2015454journal_volume
35pub_type
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