Retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha.

abstract：:We previously reported that overexpression of the 24 kDa basic fibroblast factor (or FGF-2) isoform provides protection from the cytotoxic effect of ionizing radiation (IR). DNA double-strand breaks (DSB), the IR-induced lethal lesions, are mainly repaired in human cells by non-homologous end joining system (NHEJ). NH...

journal_title：Oncogene

authors： Ader I,Muller C,Bonnet J,Favre G,Cohen-Jonathan E,Salles B,Toulas C

更新日期：2002-09-19 00:00:00

abstract：:The W locus of mice encodes the c-kit receptor tyrosine kinase. Recently, we characterized a novel mutant allele, Wn, and demonstrated that the c-kit protein synthesized in Wn/Wn cultured mast cells (CMC) was reduced in size and not expressed on their surface (Tsujimura et al., 1993). In this study, we further examine...

journal_title：Oncogene

authors： Koshimizu U,Tsujimura T,Isozaki K,Nomura S,Furitsu T,Kanakura Y,Kitamura Y,Nishimune Y

更新日期：1994-01-01 00:00:00

abstract：:We recently reported the cloning and overexpression of full-length forms of human fibroblast growth factor (FGF) receptors, bek and flg. These receptors contain three immunoglobulin (Ig)-like domains and an unusual acidic motif in the extracellular region, a single transmembrane segment and a protein tyrosine kinase c...

journal_title：Oncogene

authors： Crumley G,Bellot F,Kaplow JM,Schlessinger J,Jaye M,Dionne CA

更新日期：1991-12-01 00:00:00

abstract：:A single heat shock factor (HSF), mediating the heat shock response, exists from yeast to Drosophila, whereas several related HSFs have been found in mammals. This raises the question of the specific or redundant functions of the different members of the HSF family and in particular of HSF1 and HSF2, which are both ub...

journal_title：Oncogene

authors： Lecomte S,Desmots F,Le Masson F,Le Goff P,Michel D,Christians ES,Le Dréan Y

更新日期：2010-07-22 00:00:00

abstract：:Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon ti...

journal_title：Oncogene

authors： Mossie K,Jallal B,Alves F,Sures I,Plowman GD,Ullrich A

更新日期：1995-11-16 00:00:00

abstract：:The transcription factor activator protein-1 (AP-1) has been implicated in a large variety of biological processes including cell differentiation, proliferation, apoptosis and oncogenic transformation. It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation ...

journal_title：Oncogene

authors： Li J,Ma C,Huang Y,Luo J,Huang C

更新日期：2003-01-16 00:00:00

abstract：:Wild-type p53 is stabilized and accumulates in the nucleus of DNA damaged cells. The effect of stabilizing p53 is to inhibit cell growth, either through a G1 cell cycle arrest or apoptotic cell death. MDM2 can inhibit p53 activity, in part, by promoting its rapid degradation through the ubiquitin proteolysis pathway. ...

journal_title：Oncogene

authors： Yu ZK,Geyer RK,Maki CG

更新日期：2000-11-30 00:00:00

abstract：:In this study we have investigated DNA-protein interactions at an AP1-like motif of the neuropeptide tyrosine (NPY) promoter during in vitro differentiation of human neuroblastoma cells SH-SY5Y to mature nonproliferative sympathetic neuron-like cells. These neuroblast-like cells originate from the parental cell line S...

journal_title：Oncogene

authors： Jalava A,Mai S

更新日期：1994-08-01 00:00:00

abstract：:ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix-loop-helix transcription factors. Certain human primary breast cancers reportedly have low or no expression of ID4 protein, but its role in carcinogenesis and cancer progression is unknown. To determine its poss...

journal_title：Oncogene

authors： Umetani N,Mori T,Koyanagi K,Shinozaki M,Kim J,Giuliano AE,Hoon DS

更新日期：2005-07-07 00:00:00

abstract：:p73 and p63 are two recently discovered p53 homologs. Like p53, these proteins can recognize canonical p53 DNA-binding sites and, when overproduced, can activate p53-responsive target genes and induce apoptosis. Unlike p53, these genes undergo complex alternative splicing which, at least in the case of p63, yields pro...

journal_title：Oncogene

authors： Kaelin WG Jr

更新日期：1999-12-13 00:00:00

abstract：:The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA (lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer. In this study, we show that upregulation of HOTAIR induced platinum resistance in ovarian cancer, and increased HOTAIR levels were observed in recu...

journal_title：Oncogene

authors： Özeş AR,Miller DF,Özeş ON,Fang F,Liu Y,Matei D,Huang T,Nephew KP

更新日期：2016-10-13 00:00:00

abstract：:Chromatin remodeling proteins regulate multiple aspects of cell homeostasis, making them ideal candidates for misregulation in transformed cells. Here, we explore Sin3A, a member of the Sin3 family of proteins linked to tumorigenesis that are thought to regulate gene expression through their role as histone deacetylas...

journal_title：Oncogene

authors： Das TK,Sangodkar J,Negre N,Narla G,Cagan RL

更新日期：2013-06-27 00:00:00

abstract：:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...

journal_title：Oncogene

authors： Olmeda D,Jordá M,Peinado H,Fabra A,Cano A

更新日期：2007-03-22 00:00:00

abstract：:P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of epidermis and other epithelia in human...

journal_title：Oncogene

authors： Zhang Y,Yan W,Chen X

更新日期：2014-03-20 00:00:00

abstract：:Millions of somatic mutations have recently been discovered in cancer genomes. These mutations in cancer genomes occur due to internal and external mutagenesis forces. Decoding the mutational processes by examining their unique patterns has successfully revealed many known and novel signatures from whole exome data, b...

journal_title：Oncogene

authors： Pei G,Hu R,Dai Y,Zhao Z,Jia P

更新日期：2020-07-01 00:00:00

abstract：:Loss of heterozygosity on chromosome 10p was observed frequently in human prostate cancers. Studies have demonstrated that the introduction of the short arm of human chromosome 10 into a human prostate cancer cell line, PPC-1, by microcell-mediated chromosome transfer (MMCT), suppressed the malignant phenotype, sugges...

journal_title：Oncogene

authors： Fukuhara H,Maruyama T,Nomura S,Oshimura M,Kitamura T,Sekiya T,Murakami Y

更新日期：2001-01-18 00:00:00

abstract：:Two rare cases of chronic lymphocytic leukemia (CLL) in children, patients AS and LH, have been found to be associated with a unique chromosomal translocation, t(2;14)(p13;q32). Previous studies have shown the breakpoints of this translocation to be in the gamma 2 switch region of the Ig heavy-chain locus on chromosom...

journal_title：Oncogene

authors： Richardson AL,Humphries CG,Tucker PW

更新日期：1992-05-01 00:00:00

abstract：:Topors was identified recently as a human protein that binds to topoisomerase I and p53. Topors contains a highly conserved RING domain and localizes in promyelocytic leukemia nuclear bodies. Relatively little is known regarding topors expression patterns or function. We now demonstrate that topors mRNA and protein ar...

journal_title：Oncogene

authors： Saleem A,Dutta J,Malegaonkar D,Rasheed F,Rasheed Z,Rajendra R,Marshall H,Luo M,Li H,Rubin EH

更新日期：2004-07-08 00:00:00

abstract：:The simian double strand DNA tumor virus SV40 encodes the 90-kDa multi-functional protein, large T antigen (LT). LT functions by binding to DNA, as well as to many cellular target proteins such as p53 and retinoblastoma protein (pRB). We report here the identification of a cellular heat shock protein, HSP90, as a prev...

journal_title：Oncogene

authors： Miyata Y,Yahara I

更新日期：2000-03-09 00:00:00

abstract：:An Ets-related E1A-F has been characterized as an enhancer-binding protein for the adenovirus E1A gene. Here we show, in transient expression assays, that E1A-F can activate three different subclasses of the matrix metalloproteinase gene promoters. Expressions of the chloramphenicol acetyltransferase (CAT) reporter ge...

journal_title：Oncogene

authors： Higashino F,Yoshida K,Noumi T,Seiki M,Fujinaga K

更新日期：1995-04-06 00:00:00

abstract：:To identify tyrosine kinases that may regulate regeneration of the mammalian intestinal epithelium, we amplified portions of the catalytic domains of protein kinases expressed in intestinal crypt cells, using the polymerase chain reaction technique with primers directed against two invariant amino acid sequence motifs...

journal_title：Oncogene

authors： Siyanova EY,Serfas MS,Mazo IA,Tyner AL

更新日期：1994-07-01 00:00:00

abstract：:Rad51 protein plays a pivotal role in homologous recombination (HR), which is involved in double-strand break repair and in genome maintenance. Despite interactions with tumor suppressor proteins, the role of mammalian Rad51 and more generally of HR in tumor prevention is not clearly established. Indeed, both high and...

journal_title：Oncogene

authors： Bertrand P,Lambert S,Joubert C,Lopez BS

更新日期：2003-10-23 00:00:00

abstract：:The anti-p185(her2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhumAb 4D5 (h4D5). AHNP mimics many but not all of the antitumor characteristics exhibited by h4D5. However, the pharmacokinetic profiles of AHNP are less than optimal for therapeutic or diagnostic purposes...

journal_title：Oncogene

authors： Masuda K,Richter M,Song X,Berezov A,Masuda K,Murali R,Greene MI,Zhang H

更新日期：2006-12-14 00:00:00

abstract：:Omi is a mammalian serine protease that is localized in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the X-chromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies o...

journal_title：Oncogene

authors： Junqueira D,Cilenti L,Musumeci L,Sedivy JM,Zervos AS

更新日期：2003-05-08 00:00:00

abstract：:Senescence is an irreversible growth arrest phenotype adopted by cells that has a key role in protecting organisms from cancer. There is now considerable interest in therapeutic strategies that reactivate this process to control the growth of cancer cells. Protein kinase-Cι (PKCι) is a member of the atypical PKC famil...

journal_title：Oncogene

authors： Paget JA,Restall IJ,Daneshmand M,Mersereau JA,Simard MA,Parolin DA,Lavictoire SJ,Amin MS,Islam S,Lorimer IA

更新日期：2012-08-02 00:00:00

abstract：:Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally expos...

journal_title：Oncogene

authors： Napolitano A,Pellegrini L,Dey A,Larson D,Tanji M,Flores EG,Kendrick B,Lapid D,Powers A,Kanodia S,Pastorino S,Pass HI,Dixit V,Yang H,Carbone M

更新日期：2016-04-14 00:00:00

abstract：:In a previous work we provided preliminary evidence of the existence of a putative tumor suppressor gene region on the distal part of chromosome 4 in gamma-radiation-induced T-cell lymphomas of (C57BL/6J x RF/J) F1 hybrid mice. This region, named as TLSR2 (Thymic Lymphoma Suppressor Region 2), was located centered at ...

journal_title：Oncogene

authors： Santos J,Herranz M,Pérez de Castro I,Pellicer A,Fernández-Piqueras J

更新日期：1998-08-20 00:00:00

abstract：:Oncolytic adenoviruses, such as Delta-24-RGD (Δ24RGD), are replication-competent viruses that are genetically engineered to induce selective cancer cell lysis. In cancer cells, Δ24RGD induces massive autophagy, which is required for efficient cell lysis and adenoviral spread. Understanding the cellular mechanisms unde...

journal_title：Oncogene

authors： Klein SR,Piya S,Lu Z,Xia Y,Alonso MM,White EJ,Wei J,Gomez-Manzano C,Jiang H,Fueyo J

更新日期：2015-10-08 00:00:00

abstract：:The genetic instability driving tumorigenesis is fueled by DNA damage and by errors made by the DNA replication. Upon DNA damage the cell organizes an integrated response not only by the classical DNA repair mechanisms but also involving mechanisms of replication, transcription, chromatin structure dynamics, cell cycl...

journal_title：Oncogene

authors： Ceruti JM,Scassa ME,Fló JM,Varone CL,Cánepa ET

更新日期：2005-06-09 00:00:00

abstract：:Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human m...

journal_title：Oncogene

authors： Filippou PS,Karagiannis GS,Constantinidou A

更新日期：2020-03-01 00:00:00