A new candidate site for a tumor suppressor gene involved in mouse thymic lymphomagenesis is located on the distal part of chromosome 4.

abstract：:Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE) is clearly occupied in a cyclic manner in vivo, whereas the 3' eleme...

journal_title：Oncogene

authors： Philips A,Chambeyron S,Lamb N,Vié A,Blanchard JM

更新日期：1999-11-04 00:00:00

abstract：:Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region that contains one or two Polo-boxes. For Polo-like kinase 1, 2, and 3, and their homologs, the entire C-terminal region, including ...

journal_title：Oncogene

authors： Lowery DM,Lim D,Yaffe MB

更新日期：2005-01-10 00:00:00

abstract：:Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaire...

journal_title：Oncogene

authors： Sari IN,Yang YG,Wijaya YT,Jun N,Lee S,Kim KS,Bajaj J,Oehler VG,Kim SH,Choi SY,Park SH,Kim DW,Reya T,Han J,Kwon HY

更新日期：2021-01-01 00:00:00

abstract：:Bcl-2 and Bcl-XL serve as critical inhibitors of apoptosis triggered by a broad range of stimuli, mainly acting on the mitochondria. We identified two members of the reticulon (RTN) family as Bcl-XL binding proteins, i.e., NSP-C (RTN1-C) and a new family member, RTN-XS, both of which did not belong to the Bcl-2 family...

journal_title：Oncogene

authors： Tagami S,Eguchi Y,Kinoshita M,Takeda M,Tsujimoto Y

更新日期：2000-11-23 00:00:00

abstract：:Studies on human papillomavirus type 16 have demonstrated that the product of the early gene, E7, plays a key role in the immortalization and malignant transformation of the host cell. Several of the biological activities of HPV16 E7 are mediated by inactivation of the members of the pocket protein family, pRb, p107 a...

journal_title：Oncogene

authors： Caldeira S,de Villiers EM,Tommasino M

更新日期：2000-02-10 00:00:00

abstract：:Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor known to regulate a large number of genes in hepatocytes and pancreatic beta cells. Although HNF4alpha is highly expressed in some sections of the kidney, little is known about its role in this organ and about HNF4alpha-regulated ge...

journal_title：Oncogene

authors： Lucas B,Grigo K,Erdmann S,Lausen J,Klein-Hitpass L,Ryffel GU

更新日期：2005-09-22 00:00:00

abstract：:The mouse pancreatic amylase Amy-2.2 gene was fused to the structural gene for SV40 T antigen, and 51 independent transgenic founder mice carrying the fusion gene were generated. The majority of the founders and 100% of their offspring in the derived transgenic lines developed pancreatic acinar cell carcinomas and sto...

journal_title：Oncogene

authors： Ceci JD,Kovatch RM,Swing DA,Jones JM,Snow CM,Rosenberg MP,Jenkins NA,Copeland NG,Meisler MH

更新日期：1991-02-01 00:00:00

abstract：:The c-fos proto-oncogene is found to be overexpressed at least 30-fold in SMS-SB, a pre-B leukemic cell line compared to other cell types. No gross alteration of the c-fos gene structure in SMS-SB cells can be detected by karyotypic or Southern analyses. C-fos in SMS-SB cells can still be induced by serum, TPA and the...

journal_title：Oncogene

authors： Tsai LH,Nanu L,Smith RG,Ozanne B

更新日期：1991-01-01 00:00:00

abstract：:In colorectal tumorigenesis, loss of function of the mismatch repair genes is closely associated with genomic instability at the nucleotide level whereas p53 deficiency has been linked with gross chromosomal instability. We have addressed the contribution of these two forms of genetic instability to tumorigenesis usin...

journal_title：Oncogene

authors： Toft NJ,Curtis LJ,Sansom OJ,Leitch AL,Wyllie AH,te Riele H,Arends MJ,Clarke AR

更新日期：2002-09-12 00:00:00

abstract：:Activation of the Met tyrosine kinase growth factor receptor by its ligand HGF/SF has been shown to increase in vitro invasiveness in epithelial cell lines. To study the effect of Met-HGF/SF signaling in breast cancer cells, we transfected met, hgf/sf and dominant negative (DN) forms of met into the poorly differentia...

journal_title：Oncogene

authors： Firon M,Shaharabany M,Altstock RT,Horev J,Abramovici A,Resau JH,Vande Woude GF,Tsarfaty I

更新日期：2000-05-11 00:00:00

abstract：:The p160 nuclear receptor co-activators represent a family of molecules, which are recruited by steroid nuclear receptors as well as other transcription factors that are overexpressed in several tumors. We investigated the role of one member of this family on the sensitivity of cells to apoptosis. We observed that ove...

journal_title：Oncogene

authors： Colo GP,Rubio MF,Nojek IM,Werbajh SE,Echeverría PC,Alvarado CV,Nahmod VE,Galigniana MD,Costas MA

更新日期：2008-04-10 00:00:00

abstract：:DNA double-stranded breaks (DSBs) elicit a checkpoint response that causes a delay in cell cycle progression. Early in the checkpoint response, histone H2AX is phosphorylated in the chromatin region flanking the DSB by ATM/ATR and DNA-PK kinases. The resulting foci of phosphorylated H2AX (gamma-H2AX) serve as a platfo...

journal_title：Oncogene

authors： Macůrek L,Lindqvist A,Voets O,Kool J,Vos HR,Medema RH

更新日期：2010-04-15 00:00:00

abstract：:Acute myeloid leukemia 1 (AML1) gene on chromosome 21 is involved in several chromosomal translocations, including t(8;21) and t(16;21), that produce chimeric fusion proteins AML1-eight twenty-one (ETO) and AML-myeloid transforming gene chromosome 16 (MTG16), which contribute to leukemogenesis. The molecular basis for...

journal_title：Oncogene

authors： Qiu J,Wong J,Tweardy DJ,Dong S

更新日期：2006-06-29 00:00:00

abstract：:Signature abnormalities in the cell cycle and apoptotic pathway have been identified in mantle cell lymphoma (MCL), affording the opportunity to develop targeted therapies. In this study, we tested a novel class of kinase inhibitors, styryl sulfones, which differ from prior cell cycle inhibitors in that they are not r...

journal_title：Oncogene

authors： Park IW,Reddy MV,Reddy EP,Groopman JE

更新日期：2007-08-16 00:00:00

abstract：:The B-raf/c-Rmil proto-oncogene belongs to the raf/mil family of serine/threonine protein kinases. It encodes multiple protein isoforms resulting from alternative splicing of two exons located upstream of the kinase domain. Recent studies suggested that B-Raf could be the intermediate molecule between Ras and Mek-1 (M...

journal_title：Oncogene

authors： Papin C,Eychène A,Brunet A,Pagès G,Pouysségur J,Calothy G,Barnier JV

更新日期：1995-04-20 00:00:00

abstract：:Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, ne...

journal_title：Oncogene

authors： Tanaka S,Sugimachi K,Saeki H,Kinoshita J,Ohga T,Shimada M,Maehara Y,Sugimachi K

更新日期：2001-09-06 00:00:00

abstract：:We have optimized the conditions for efficient NIH3T3 focus formation by calcium phosphate transfection of proviral Abelson-murine leukemia virus (A-MuLV) plasmid DNA. Linearized pA-MuLV, P120 or P160 strains, when transfected with calf thymus carrier DNA, will produce 40-50 foci/100 ng pA-MuLV without co-transfecting...

journal_title：Oncogene

authors： Shore SK,Reddy EP

更新日期：1989-11-01 00:00:00

abstract：:The role of cyclooxygenase-2 (COX-2) in cancer remains controversial. Using cervical carcinoma cells (HeLa), the present study investigates the involvement of COX-2 in apoptosis elicited by the chemotherapeutics paclitaxel, cisplatin and 5-fluorouracil. Each compound led to a profound induction of COX-2 expression and...

journal_title：Oncogene

authors： Eichele K,Ramer R,Hinz B

更新日期：2008-05-08 00:00:00

abstract：:Within the superfamily of ras-related GTP-binding proteins, only ras itself has been shown to act as an oncogene. Seven other proteins, however, have greater than 50% amino acid identity to ras and one of them, rap1A, has been shown to interact with the ras GTPase activating protein, ras-GAP, and to inhibit ras functi...

journal_title：Oncogene

authors： Rey I,Taylor-Harris P,van Erp H,Hall A

更新日期：1994-03-01 00:00:00

abstract：:Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect ...

journal_title：Oncogene

authors： Fåhraeus R,Marin M,Olivares-Illana V

更新日期：2016-07-21 00:00:00

abstract：:Matrix metalloprotease-1 (MMP1) is an important mediator of tumorigenesis, inflammation and tissue remodeling through its ability to degrade critical matrix components. Recent studies indicate that stromal-derived MMP1 may exert direct oncogenic activity by signaling through protease-activated receptor-1 (PAR1) in car...

journal_title：Oncogene

authors： Foley CJ,Fanjul-Fernández M,Bohm A,Nguyen N,Agarwal A,Austin K,Koukos G,Covic L,López-Otín C,Kuliopulos A

更新日期：2014-04-24 00:00:00

abstract：:The cysteinyl leukotriene1 (CysLT1) receptor (CysLT1R) enhances survival and proliferation of intestinal cells via distinct pathways. Here, we have demonstrated that there is significant endogenous production of CysLTs from both non-tumour- and tumour-derived intestinal epithelial cells. Treatment of two non-tumour ce...

journal_title：Oncogene

authors： Paruchuri S,Mezhybovska M,Juhas M,Sjölander A

更新日期：2006-10-26 00:00:00

abstract：:We have determined the genomic structure of the mouse fra-1 gene, which consists of four exons and three introns at positions also found in the other members of the fos gene family. Fra-1 is expressed rather highly in the brain and testes of adult mice, and at low levels in most other tissues. Absence of c-Fos leads t...

journal_title：Oncogene

authors： Schreiber M,Poirier C,Franchi A,Kurzbauer R,Guenet JL,Carle GF,Wagner EF

更新日期：1997-09-04 00:00:00

abstract：:Here we report that ALDH1L1 (FDH, a folate enzyme with tumor suppressor-like properties) inhibits cell motility. The underlying mechanism involves F-actin stabilization, re-distribution of cytoplasmic actin toward strong preponderance of filamentous actin and formation of actin stress fibers. A549 cells expressing FDH...

journal_title：Oncogene

authors： Oleinik NV,Krupenko NI,Krupenko SA

更新日期：2010-11-25 00:00:00

abstract：:Although there is indirect genetic evidence that MEN1, the gene for multiple endocrine neoplasia type 1, is a tumor suppressor gene, little is known about the MEN1-encoded protein, menin. Menin was stably overexpressed in a well-characterized murine tumor cell line, (valine-12)-RAS-transformed NIH3T3 cells. Menin over...

journal_title：Oncogene

authors： Kim YS,Burns AL,Goldsmith PK,Heppner C,Park SY,Chandrasekharappa SC,Collins FS,Spiegel AM,Marx SJ

更新日期：1999-10-21 00:00:00

abstract：:Vascular endothelial (VE)-cadherin is exclusively expressed at interendothelial junctions of normal and tumour vessels. In this report, we characterized the transcriptional activity of the human VE-cadherin promoter. Transient transfection assays revealed that sequences at positions --1135/-744 and -166/-5 base pairs ...

journal_title：Oncogene

authors： Prandini MH,Dreher I,Bouillot S,Benkerri S,Moll T,Huber P

更新日期：2005-04-21 00:00:00

abstract：:Telomeres are stabilized, and telomeric DNA is replenished, by the action of the ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the ability of telomeres to protect chromosome ends from cellular DNA-damage responses such as cell cycle arrest or apoptosis. This property of telomer...

journal_title：Oncogene

authors： Chan SW,Blackburn EH

更新日期：2002-01-21 00:00:00

abstract：:Apoptin, a small protein from the chicken anemia virus, has attracted attention because of its specificity in killing tumor cells. Localization of apoptin in the nucleus of tumor cells has been shown to be vital for proapoptotic activity, however, targeted expression of apoptin in the nucleus of normal cells does not ...

journal_title：Oncogene

authors： Maddika S,Wiechec E,Ande SR,Poon IK,Fischer U,Wesselborg S,Jans DA,Schulze-Osthoff K,Los M

更新日期：2008-05-08 00:00:00

abstract：:Drug-resistant clones selected from FR3T3 rat cells after transfer of neo-BPV1 (Bovine Papillomavirus Type 1) DNA constructs became phenotypically transformed (focal transformation, growth in suspension and tumor formation) soon after selection (approximately 5 generations in culture). A frameshift mutation in ORF E5 ...

journal_title：Oncogene

authors： Binétruy B,Schiller J,Lowy D,Cerni C,Cuzin F

更新日期：1990-11-01 00:00:00

abstract：:To understand the mechanism for resistance of primary cultures of rat embryo fibroblasts (REFs) to oncogene-induced transformation, we studied the transforming ability of a recombinant retrovirus, ZSV, containing v-src and neo genes in REFs and in the rat cell line F2408. The susceptibility of REFs to p60v-src transfo...

journal_title：Oncogene

authors： Inoue H,Tavoloni N,Hanafusa H

更新日期：1995-07-20 00:00:00