Transformation of NIH3T3 cells by A-MuLV proviral DNA: effect of plasmid linearization and carrier DNA on transformation efficiency.

abstract：:Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are unresectable at diagnosis and minimally responsive to conventional treatment, lending urgency to the identification of new pathway dependencies and ...

journal_title：Oncogene

authors： Ki DH,Oppel F,Durbin AD,Look AT

更新日期：2019-09-01 00:00:00

abstract：:Mutant p53 proteins were shown to exert complex DNA-interactions in vitro, like binding to MAR-DNA, but so far it is unknown whether such interactions also occur in vivo. Therefore we analysed the binding of mutant (mut) p53 (Gly245-->Ser) in Onda 11 glioma cells to cellular DNA in vivo, using p53-specific chromatin i...

journal_title：Oncogene

authors： Koga H,Deppert W

更新日期：2000-08-24 00:00:00

abstract：:Imbalances in chromosome 11q occur in approximately 30% of primary neuroblastoma and are associated with poor outcome. It has been suggested that 11q loss constitutes a distinct clinico-genetic neuroblastoma subgroup by affecting expression levels of corresponding genes. This study analysed the relationship of 11q los...

journal_title：Oncogene

authors： Fischer M,Bauer T,Oberthür A,Hero B,Theissen J,Ehrich M,Spitz R,Eils R,Westermann F,Brors B,König R,Berthold F

更新日期：2010-02-11 00:00:00

abstract：:The Ewing sarcoma is the second most common bone tumor in children and young adults. Despite the advances in therapy, the 5-year survival rate for patients with metastatic disease is poor, indicating the need for alternative treatments. Here, we report that 2-methoxy-estradiol (2-Me), a natural estrogen metabolite, in...

journal_title：Oncogene

authors： Djavaheri-Mergny M,Wietzerbin J,Besançon F

更新日期：2003-05-01 00:00:00

abstract：:Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional respon...

journal_title：Oncogene

authors： Choudhry H,Albukhari A,Morotti M,Haider S,Moralli D,Smythies J,Schödel J,Green CM,Camps C,Buffa F,Ratcliffe P,Ragoussis J,Harris AL,Mole DR

更新日期：2015-08-20 00:00:00

abstract：:Individuals affected with the Gorlin syndrome inherit a germ-line mutation of the patched (Ptc1) developmental gene and, analogously to Ptc1 heterozygous mice, show an increased susceptibility to spontaneous tumor development. Human and mouse Ptc1 heterozygotes (Ptc1(+/-)) are also hypersensitive to ionizing radiation...

journal_title：Oncogene

authors： Pazzaglia S,Mancuso M,Atkinson MJ,Tanori M,Rebessi S,Majo VD,Covelli V,Hahn H,Saran A

更新日期：2002-10-24 00:00:00

abstract：:Expression of the c-myc gene is often elevated in human colorectal tumors, but reported amplification of the locus is rare. Here we demonstrate that modest amplification of c-myc is frequently found in aggressive subtypes of colorectal cancer. Careful quantitation of c-myc copy number has shown amplification in 53.8% ...

journal_title：Oncogene

authors： Heerdt BG,Molinas S,Deitch D,Augenlicht LH

更新日期：1991-01-01 00:00:00

abstract：:Genetic mutations of oncogenes often underlie deranged cell growth and altered differentiation pathways leading to malignant transformation of B-lymphocytes. However, addiction to oncogenes is not the only drive to lymphoid tumor pathogenesis. Dependence on non-oncogenes, which act by propelling basic mechanisms of ce...

journal_title：Oncogene

authors： Mandato E,Manni S,Zaffino F,Semenzato G,Piazza F

更新日期：2016-11-24 00:00:00

abstract：:One-carbon metabolism plays a central role in a broad array of metabolic processes required for the survival and growth of tumor cells. However, the molecular basis of how one-carbon metabolism may influence RNA methylation and tumorigenesis remains largely unknown. Here we show MTHFD2, a mitochondrial enzyme involved...

journal_title：Oncogene

authors： Green NH,Galvan DL,Badal SS,Chang BH,LeBleu VS,Long J,Jonasch E,Danesh FR

更新日期：2019-08-01 00:00:00

abstract：:Microarray RNA gene expression profiling analysis has shown that Sox4 (Sry-related high mobility group (HMG) box 4) is one of the most upregulated genes in adenoid cystic carcinoma (ACC), relative to non-neoplastic tissue of origin. Here, we show that Sox4 protein is similarly upregulated in ACC by immunohistochemistr...

journal_title：Oncogene

authors： Pramoonjago P,Baras AS,Moskaluk CA

更新日期：2006-09-14 00:00:00

abstract：:In the published version of this paper the author Shu-Pin Huang's surname was incorrectly given as Hwang instead of Huang. This has now been corrected in the HTML and PDF versions of the paper. ...

journal_title：Oncogene

authors： Pai VC,Hsu CC,Chan TS,Liao WY,Chuu CP,Chen WY,Li CR,Lin CY,Huang SP,Chen LT,Tsai KK

更新日期：2019-02-01 00:00:00

abstract：:BALB/c mice heterozygous for Trp53 develop a high proportion of spontaneous mammary tumors, a phenotype distinct from other mouse strains. BALB/c-Trp53+/- female mice, thus, resemble the hereditary Li-Fraumeni syndrome (LFS) characterized by early-onset of breast cancer, even though LFS involves TP53 mutations, which ...

journal_title：Oncogene

authors： Böhringer M,Obermeier K,Griner N,Waldraff D,Dickinson E,Eirich K,Schindler D,Hagen M,Jerry DJ,Wiesmüller L

更新日期：2013-11-28 00:00:00

abstract：:Transformed cells express high levels of non-telomeric reverse-transcriptase (RT) activity of retrotransposon and endogenous retrovirus origin. We previously reported that RT inhibition, either pharmacological or through transient silencing of RT-encoding LINE-1 (L1) elements by RNA interference (RNAi), reduced prolif...

journal_title：Oncogene

authors： Oricchio E,Sciamanna I,Beraldi R,Tolstonog GV,Schumann GG,Spadafora C

更新日期：2007-06-21 00:00:00

abstract：:The regulation of cell adhesion and motility in human prostate is not well understood. We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion. Endoglin is a transmembrane transforming growth factor beta binding protein typically expressed by endothelial cells....

journal_title：Oncogene

authors： Liu Y,Jovanovic B,Pins M,Lee C,Bergan RC

更新日期：2002-11-28 00:00:00

abstract：:There is an emerging body of evidence implicating iron in carcinogenesis and in particular colorectal cancer, but whether this involves Wnt signalling, a major oncogenic signalling pathway has not been studied. We aimed to determine the effect of iron loading on Wnt signalling using mutant APC (Caco-2 and SW480) and w...

journal_title：Oncogene

authors： Brookes MJ,Boult J,Roberts K,Cooper BT,Hotchin NA,Matthews G,Iqbal T,Tselepis C

更新日期：2008-02-07 00:00:00

abstract：:Inhibition of the chaperone heat-shock protein 90 (HSP90) induces apoptosis, and it is a promising anti-cancer strategy. The mechanisms underpinning apoptosis activation following HSP90 inhibition and how they are modified during acquired drug resistance are unknown. We show for the first time that, to induce apoptosi...

journal_title：Oncogene

authors： Busacca S,Law EW,Powley IR,Proia DA,Sequeira M,Le Quesne J,Klabatsa A,Edwards JM,Matchett KB,Luo JL,Pringle JH,El-Tanani M,MacFarlane M,Fennell DA

更新日期：2016-03-24 00:00:00

abstract：:p53 and DNA methylation play key roles in the maintenance of genome stability. In this work, we demonstrate that the two mechanisms are linked and that p53 plays a role in the maintenance of the DNA methylation levels. The loss of p53 was shown to induce loss of DNA methylation in the TROP1 gene, a human cancer-expres...

journal_title：Oncogene

authors： Nasr AF,Nutini M,Palombo B,Guerra E,Alberti S

更新日期：2003-03-20 00:00:00

abstract：:To investigate the possible role of the product of the retinoblastoma susceptibility gene, pRB, in leukemogenesis, we examined fresh leukemia cells from 56 cases of primary leukemia (AML, 32; ALL, 12; CML-BC, 9; CLL, 3) for expression of pRB by using an immunoblotting assay with anti-pRB monoclonal antibodies PMG 3-24...

journal_title：Oncogene

authors： Furukawa Y,DeCaprio JA,Belvin M,Griffin JD

更新日期：1991-08-01 00:00:00

abstract：:p66(Shc), an isoform of Shc adaptor proteins, is shown to mediate various signals, including cellular stress. However, little is known about its involvement in carcinogenesis. We previously showed that p66(Shc) protein level is upregulated by steroid hormones in human carcinoma cells and is higher in prostate cancer (...

journal_title：Oncogene

authors： Veeramani S,Igawa T,Yuan TC,Lin FF,Lee MS,Lin JS,Johansson SL,Lin MF

更新日期：2005-11-03 00:00:00

abstract：:The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...

journal_title：Oncogene

authors： O'Neil J,Look AT

更新日期：2007-10-15 00:00:00

abstract：:PI3K/AKT pathway activation is thought to be a driving force in metastatic melanomas. Members of the pleckstrin homology (PH) domain leucine-rich repeat protein Ser/Thr specific phosphatase family (PHLPP1 and PHLPP2) can regulate AKT activation. By dephosphorylating specific serine residues in the hydrophobic motif, P...

journal_title：Oncogene

authors： Yu Y,Dai M,Lu A,Yu E,Merlino G

更新日期：2018-04-01 00:00:00

abstract：:The c-myc proto-oncogene has been shown to cause blockages to differentiation in many cell lineages. Although the mechanism by which c-Myc affects this process remains unknown, it is considered that it might result indirectly as an outcome of the continued cell-cycle progression invoked by c-Myc in cells which must gr...

journal_title：Oncogene

authors： Ryan KM,Birnie GD

更新日期：1997-06-12 00:00:00

abstract：:Homeodomain interacting protein kinase-2 (HIPK2) is a member of the HIPK family of stress-responsive kinases that modulates cell growth, apoptosis, proliferation and development. HIPK2 has several well-characterised tumour suppressor roles, but recent studies suggest it can also contribute to tumour progression, altho...

journal_title：Oncogene

authors： Torrente L,Sanchez C,Moreno R,Chowdhry S,Cabello P,Isono K,Koseki H,Honda T,Hayes JD,Dinkova-Kostova AT,de la Vega L

更新日期：2017-11-02 00:00:00

abstract：:Gut-enriched Krüppel-like factor (GKLF or KLF4) is a zinc finger-containing, epithelial-specific transcription factor, that functions as a suppressor of cell proliferation. We previously showed that GKLF expression is decreased in intestinal and colonic adenomas, respectively, from multiple intestinal neoplasia (Min) ...

journal_title：Oncogene

authors： Dang DT,Mahatan CS,Dang LH,Agboola IA,Yang VW

更新日期：2001-08-09 00:00:00

abstract：:Accumulating evidences have shown the association between aberrantly expressed microRNAs (miRs) and cancer, where these small regulatory RNAs appear to dictate the cell fate by regulating all the main biological processes. We demonstrated the responsibility of the circuitry connecting the oncomiR-221&222 with the tumo...

journal_title：Oncogene

authors： Felli N,Errico MC,Pedini F,Petrini M,Puglisi R,Bellenghi M,Boe A,Felicetti F,Mattia G,De Feo A,Bottero L,Tripodo C,Carè A

更新日期：2016-06-09 00:00:00

abstract：:The viral mitochondrial inhibitor of apoptosis (vMIA) encoded by the human cytomegalovirus exerts cytopathic effects and neutralizes the proapoptotic endogenous Bcl-2 family member Bax by recruiting it to mitochondria, inducing its oligomerization and membrane insertion. Using a combination of computational modeling a...

journal_title：Oncogene

authors： Pauleau AL,Larochette N,Giordanetto F,Scholz SR,Poncet D,Zamzami N,Goldmacher VS,Kroemer G

更新日期：2007-11-01 00:00:00

abstract：:The Ste20-like kinase, SLK, is involved in the control of cell motility through its effects on actin reorganization and focal adhesion turnover. Here we investigated the role of SLK in chemotaxis downstream of the tyrosine kinase receptor, HER2/ErbB2/Neu, which is frequently overexpressed in human breast cancers. Our ...

journal_title：Oncogene

authors： Roovers K,Wagner S,Storbeck CJ,O'Reilly P,Lo V,Northey JJ,Chmielecki J,Muller WJ,Siegel PM,Sabourin LA

更新日期：2009-08-06 00:00:00

abstract：:We have characterized a chromosomal translocation in a cell line (SU-DUL5) established from a patient with lymphoblastic lymphoma in which the c-myc gene on chromosome 8 was juxtaposed to a t(14;18). Cytogenetic analysis of this cell line showed 14q+, 18q-, and 8p+q+ marker chromosomes in the absence of t(14;18). Geno...

journal_title：Oncogene

authors： Kiem HP,Nourse J,Saltman DL,Blume KG,Cleary ML

更新日期：1990-12-01 00:00:00

abstract：:Lung cancer is the most widely diagnosed malignancy in the world. Understanding early-stage disease will give insight into its pathogenesis. Despite the fact that pre-invasive lesions are challenging to isolate, and often yield insufficient DNA for the analysis of multiple loci, genomic profiling of such lesions will ...

journal_title：Oncogene

authors： Garnis C,Davies JJ,Buys TP,Tsao MS,MacAulay C,Lam S,Lam WL

更新日期：2005-07-14 00:00:00

abstract：:Constitutive NF-kappaB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of different I kappaB inhibitors in adenocarcinoma cell lines. High constitutive NF-kappaB activity and low I kappaB-alpha expression was found in a number of these cell lines. Moreover, some o...

journal_title：Oncogene

authors： Dejardin E,Deregowski V,Chapelier M,Jacobs N,Gielen J,Merville MP,Bours V

更新日期：1999-04-22 00:00:00