Correction: ASPM promotes prostate cancer stemness and progression by augmenting Wnt-Dvl-3-β-catenin signaling.

abstract：:Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosin...

journal_title：Oncogene

authors： Kiyoi H,Ohno R,Ueda R,Saito H,Naoe T

更新日期：2002-04-11 00:00:00

abstract：:Polyomavirus large T-antigen (PyLT-Ag), a nucleophosphoprotein essential for regulating viral gene expression, modulates the cell cycle by binding to the Rb tumor suppressor gene product. PyLT-Ag/Rb binding is essential for in vitro immortalization. However, the effect of PyLT-Ag on apoptosis has not been extensively ...

journal_title：Oncogene

authors： Rodier F,Bertrand R,Bossolasco M,Mes-Masson AM

更新日期：2000-12-14 00:00:00

abstract：:BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA). Here we report that transcription inhibition can be alleviated by interferon treatment and the degradati...

journal_title：Oncogene

authors： Marchetti B,Ashrafi GH,Dornan ES,Araibi EH,Ellis SA,Campo MS

更新日期：2006-04-06 00:00:00

abstract：:Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor s...

journal_title：Oncogene

authors： Strano S,Dell'Orso S,Di Agostino S,Fontemaggi G,Sacchi A,Blandino G

更新日期：2007-04-02 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) is a nuclear encoded and mitochondrial matrix-localized redox enzyme that is known to regulate the cellular redox environment. Cellular redox environment changes during transitions between quiescent and proliferative cycles. Human MnSOD has two poly(A) sites resulting in two tran...

journal_title：Oncogene

authors： Chaudhuri L,Nicholson AM,Kalen AL,Goswami PC

更新日期：2012-03-08 00:00:00

abstract：:P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of epidermis and other epithelia in human...

journal_title：Oncogene

authors： Zhang Y,Yan W,Chen X

更新日期：2014-03-20 00:00:00

abstract：:Bracken fern is the environmental co-carcinogen of BPV-4 in the induction of neoplasias of the upper alimentary canal of cattle. The flavonoid quercetin is one of the most potent and best characterised mutagens present in the fern. We have shown that transfection with BPV-4 DNA and exposure to a single dose of quercet...

journal_title：Oncogene

authors： Connolly JA,Morgan IM,Jackson ME,Campo MS

更新日期：1998-05-28 00:00:00

abstract：:Liver metastasis remains a serious problem in the management of gastric cancer (GC). Our aims were to identify through transcriptome analysis a molecule that mediates hepatic metastasis in GC, and to evaluate its potential as a diagnostic marker and a therapeutic target. The effects of knocking out a relevant molecule...

journal_title：Oncogene

authors： Kanda M,Tanaka H,Shimizu D,Miwa T,Umeda S,Tanaka C,Kobayashi D,Hattori N,Suenaga M,Hayashi M,Iwata N,Yamada S,Fujiwara M,Kodera Y

更新日期：2018-09-01 00:00:00

abstract：:The balance between acetylation and deacetylation of histone and nonhistone proteins controls gene expression in a variety of cellular processes, with transcription being activated by acetyltransferases and silenced by deacetylases. We report here the formation and enzymatic characterization of a complex between the a...

journal_title：Oncogene

authors： Simone C,Stiegler P,Forcales SV,Bagella L,De Luca A,Sartorelli V,Giordano A,Puri PL

更新日期：2004-03-18 00:00:00

abstract：:Diffuse intrinsic pontine glioma (or DIPG) are pediatric high-grade gliomas associated with a dismal prognosis. They harbor specific substitution in histone H3 at position K27 that induces major epigenetic dysregulations. Most clinical trials failed so far to increase survival, and radiotherapy remains the most effici...

journal_title：Oncogene

authors： Silva-Evangelista C,Barret E,Ménez V,Merlevede J,Kergrohen T,Saccasyn A,Oberlin E,Puget S,Beccaria K,Grill J,Castel D,Debily MA

更新日期：2019-09-01 00:00:00

abstract：:The status of the p53 gene in lymphoblastoid cell lines (LCLs) and Burkitt lymphoma cell lines (BLs) was investigated. Southern blot analysis demonstrated that no major deletions or rearrangements had occurred in the p53 gene in any of the cell lines. The p53 protein was examined by immunoprecipitation using two monoc...

journal_title：Oncogene

authors： Wiman KG,Magnusson KP,Ramqvist T,Klein G

更新日期：1991-09-01 00:00:00

abstract：:We have examined the presence of p16MTS1/CDK4I gene deletions, mutations and methylation status, and 9p21-23 deletions in a series of 46 squamous cell carcinomas of the larynx and paired normal mucosa previously characterized for cyclin D1 gene amplification and overexpression. pRb expression was also examined by immu...

journal_title：Oncogene

authors： Jares P,Fernández PL,Nadal A,Cazorla M,Hernández L,Pinyol M,Hernández S,Traserra J,Cardesa A,Campo E

更新日期：1997-09-18 00:00:00

abstract：:The RAF-mitogen-activated protein kinase kinase 1/2-extracellular signal-regulated kinase 1/2 (RAF-MEK1/2-ERK1/2) pathway is activated in many human tumours and can protect cells against growth factor deprivation; however, most such studies have relied upon overexpression of RAF or MEK constructs that are not found in...

journal_title：Oncogene

authors： Wickenden JA,Jin H,Johnson M,Gillings AS,Newson C,Austin M,Chell SD,Balmanno K,Pritchard CA,Cook SJ

更新日期：2008-12-04 00:00:00

abstract：:The transforming potential of adenovirus E1A oncogene products derives largely from the formation of complexes with cellular proteins, including the p105Rb tumor suppressor and a related p107 species, p130 and p300 proteins, and cyclin A (p60cycA). Extensive quantitative analyses using E1A deletion mutants identified ...

journal_title：Oncogene

authors： Barbeau D,Charbonneau R,Whalen SG,Bayley ST,Branton PE

更新日期：1994-02-01 00:00:00

abstract：:Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation of oncogenic signaling cascades. We previously reported activation of a key oncogenic signaling ...

journal_title：Oncogene

authors： Lone MU,Baghel KS,Kanchan RK,Shrivastava R,Malik SA,Tewari BN,Tripathi C,Negi MP,Garg VK,Sharma M,Bhatt ML,Bhadauria S

更新日期：2017-03-30 00:00:00

abstract：:Protein kinase C (PKC)ɛ, a member of the novel PKC family, has key roles in mitogenesis and survival in normal and cancer cells. PKCɛ is frequently overexpressed in epithelial cancers, particularly in lung cancer. Using a short-hairpin RNA approach, here we established that PKCɛ is required for non-small cell lung car...

journal_title：Oncogene

authors： Caino MC,Lopez-Haber C,Kim J,Mochly-Rosen D,Kazanietz MG

更新日期：2012-05-17 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non-PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that ...

journal_title：Oncogene

authors： Totani H,Shinjo K,Suzuki M,Katsushima K,Mase S,Masaki A,Ito A,Ri M,Kusumoto S,Komatsu H,Ishida T,Inagaki H,Iida S,Kondo Y

更新日期：2020-08-01 00:00:00

abstract：:The genetic instability driving tumorigenesis is fueled by DNA damage and by errors made by the DNA replication. Upon DNA damage the cell organizes an integrated response not only by the classical DNA repair mechanisms but also involving mechanisms of replication, transcription, chromatin structure dynamics, cell cycl...

journal_title：Oncogene

authors： Ceruti JM,Scassa ME,Fló JM,Varone CL,Cánepa ET

更新日期：2005-06-09 00:00:00

abstract：:The human papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected cells. In order to understand the mechanisms by which E6 contributes to ...

journal_title：Oncogene

authors： Mantovani F,Banks L

更新日期：2001-11-26 00:00:00

abstract：:TGF-beta/Smads regulate a wide variety of biological responses through transcriptional regulation of target genes. ELF, a beta-spectrin, plays a key role in the transmission of TGF-beta-mediated transcriptional response through Smads. ELF was originally identified as a key protein involved in endodermal stem/progenito...

journal_title：Oncogene

authors： Katuri V,Tang Y,Marshall B,Rashid A,Jogunoori W,Volpe EA,Sidawy AN,Evans S,Blay J,Gallicano GI,Premkumar Reddy E,Mishra L,Mishra B

更新日期：2005-12-01 00:00:00

abstract：:The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects approximately 1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tube...

journal_title：Oncogene

authors： Rosner M,Freilinger A,Hengstschläger M

更新日期：2007-01-25 00:00:00

abstract：:An altered protein expression of Ca(2+)-dependent protein kinase C (PKC) isoforms and a point mutation in the PKC alpha cDNA (position 908 of the nucleotide sequence, position 294 of the amino acid sequence, substitution of an aspartic acid by a glycine) have been previously described in a subpopulation of human pitui...

journal_title：Oncogene

authors： Prévostel C,Alvaro V,de Boisvilliers F,Martin A,Jaffiol C,Joubert D

更新日期：1995-08-17 00:00:00

abstract：:Several motifs are conserved in the extracellular domain of the cloned chains of the recently described cytokine receptor superfamily. One of them, usually close to the transmembrane region, is the 'WS motif'. Its function remains unknown, but it has been recently shown that the integrity of this motif is essential fo...

journal_title：Oncogene

authors： Bénit L,Charon M,Cocault L,Wendling F,Gisselbrecht S

更新日期：1993-03-01 00:00:00

abstract：:Inactivation of the transforming growth factor-beta (TGF-beta) pathway occurs often in malignancies of the gastrointestinal (GI) system. However, only a fraction of sporadic GI tumors exhibit inactivating mutations in early stages of cancer formation, suggesting that other mechanisms play a critical role in the inacti...

journal_title：Oncogene

authors： Katuri V,Tang Y,Li C,Jogunoori W,Deng CX,Rashid A,Sidawy AN,Evans S,Reddy EP,Mishra B,Mishra L

更新日期：2006-03-23 00:00:00

abstract：:Grb2 is an adaptor protein that links receptor and cytoplasmic tyrosine kinases to the Ras signalling pathway by binding the Ras-specific guanine nucleotide exchange factor, Sos1, through its SH3 domains. The Grb2-SH3 domain binding has been localized to the carboxy-terminal two hundred amino acids of Sos1 (Sos1-c). B...

journal_title：Oncogene

authors： Sastry L,Lin W,Wong WT,Di Fiore PP,Scoppa CA,King CR

更新日期：1995-09-21 00:00:00

abstract：:Telomeres are stabilized, and telomeric DNA is replenished, by the action of the ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the ability of telomeres to protect chromosome ends from cellular DNA-damage responses such as cell cycle arrest or apoptosis. This property of telomer...

journal_title：Oncogene

authors： Chan SW,Blackburn EH

更新日期：2002-01-21 00:00:00

abstract：:Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans and is usually characterized by local aggressiveness with little metastatic potential, although deep invasion, recurrence, and regional and distant metastases may occur. Here, we studied the mechanism of BCC invasion. We found that human BCC...

journal_title：Oncogene

authors： Chu CY,Cha ST,Chang CC,Hsiao CH,Tan CT,Lu YC,Jee SH,Kuo ML

更新日期：2007-04-12 00:00:00

abstract：:While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...

journal_title：Oncogene

authors： Morris SM,Mhyre AJ,Carmack SS,Myers CH,Burns C,Ye W,Ferrer M,Olson JM,Klinghoffer RA

更新日期：2018-08-01 00:00:00

abstract：:Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor of children and young adults in which finding effective new targeted therapies is imperative. Here, we report an in-depth preclinical study of the investigational cullin-RING ubiquitin ligase (CRL) inhibitor MLN4924 in ES, as we have recently demonstrated ...

journal_title：Oncogene

authors： Mackintosh C,García-Domínguez DJ,Ordóñez JL,Ginel-Picardo A,Smith PG,Sacristán MP,de Álava E

更新日期：2013-03-14 00:00:00

abstract：:Twenty five human glial tumours of different grades of malignancy were examined by Southern blotting and polymerase chain reaction (PCR) for alterations (rearrangements, amplification and deletions) in the c-myc gene. Number of c-myc positive cells per thousand cells were also counted in all the tumours after immunohi...

journal_title：Oncogene

authors： Chattopadhyay P,Banerjee M,Sarkar C,Mathur M,Mohapatra AK,Sinha S

更新日期：1995-12-21 00:00:00