Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 alpha-directed invasion of human basal cell carcinoma cells.

abstract：:Reovirus is a naturally oncolytic virus that preferentially replicates in Ras-transformed cells and is currently undergoing clinical trials as a cancer therapeutic. Ras transformation promotes reovirus oncolysis by enhancing virion disassembly during entry, viral progeny production, and virus release through apoptosis...

journal_title：Oncogene

authors： Garant KA,Shmulevitz M,Pan L,Daigle RM,Ahn DG,Gujar SA,Lee PW

更新日期：2016-02-11 00:00:00

abstract：:Bone morphogenetic protein 3B (BMP3B) is a member of the TGF-beta superfamily. The BMP3B promoter sequence was previously identified as a target for aberrant DNA methylation in non-small-cell lung cancer (NSCLC). Aberrant DNA hypermethylation in the BMP3B promoter is associated with downregulation of BMP3B transcripti...

journal_title：Oncogene

authors： Dai Z,Popkie AP,Zhu WG,Timmers CD,Raval A,Tannehill-Gregg S,Morrison CD,Auer H,Kratzke RA,Niehans G,Amatschek S,Sommergruber W,Leone GW,Rosol T,Otterson GA,Plass C

更新日期：2004-04-29 00:00:00

abstract：:The c-myc proto-oncogene has been shown to cause blockages to differentiation in many cell lineages. Although the mechanism by which c-Myc affects this process remains unknown, it is considered that it might result indirectly as an outcome of the continued cell-cycle progression invoked by c-Myc in cells which must gr...

journal_title：Oncogene

authors： Ryan KM,Birnie GD

更新日期：1997-06-12 00:00:00

abstract：:Loss of the DNA mismatch repair (MMR) protein MSH3 leads to the development of a variety of tumors in mice without significantly affecting survival rates, suggesting a modulating role for the MutSβ (MSH2-MSH3) complex in late-onset tumorigenesis. To better study the role of MSH3 in tumor progression, we crossed Msh3(-...

journal_title：Oncogene

authors： van Oers JM,Edwards Y,Chahwan R,Zhang W,Smith C,Pechuan X,Schaetzlein S,Jin B,Wang Y,Bergman A,Scharff MD,Edelmann W

更新日期：2014-07-24 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) all signal through the transmembrane receptor tyrosine kinase RET. The signalling complex consists of GFLs, GPI-anchored ligand binding GDNF family receptor alphas (GFRalphas) and RET. Signalling via RET is required for the development of the ner...

journal_title：Oncogene

authors： Yang J,Runeberg-Roos P,Leppänen VM,Saarma M

更新日期：2007-05-31 00:00:00

abstract：:The DNA methylation pattern of a cell is exquisitely controlled during early development resulting in distinct methylation patterns. The tight control of DNA methylation is released in the cancer cell characterized by a reversal of methylation states. CpG island associated genes, in particular tumour suppressor or rel...

journal_title：Oncogene

authors： Clark SJ,Melki J

更新日期：2002-08-12 00:00:00

abstract：:Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In this study we demonstrate that inhibition of hypoxia-inducible factor (...

journal_title：Oncogene

authors： Zhang H,Wong CC,Wei H,Gilkes DM,Korangath P,Chaturvedi P,Schito L,Chen J,Krishnamachary B,Winnard PT Jr,Raman V,Zhen L,Mitzner WA,Sukumar S,Semenza GL

更新日期：2012-04-05 00:00:00

abstract：:The osteogenic transcription factor, Runx2, is abnormally expressed in prostate cancer (PCa) and associated with metastatic disease. During bone development, Runx2 is activated by signals known to be hyperactive in PCa including the RAS/MAP kinase pathway, which phosphorylates Runx2 on multiple serine residues includi...

journal_title：Oncogene

authors： Ge C,Zhao G,Li Y,Li H,Zhao X,Pannone G,Bufo P,Santoro A,Sanguedolce F,Tortorella S,Mattoni M,Papagerakis S,Keller ET,Franceschi RT

更新日期：2016-01-21 00:00:00

abstract：:The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this elusive 'TGF-β paradox'. Herein, we identify a mechanism by which Six1 ...

journal_title：Oncogene

authors： Smith AL,Iwanaga R,Drasin DJ,Micalizzi DS,Vartuli RL,Tan AC,Ford HL

更新日期：2012-12-13 00:00:00

abstract：:In this study we have surveyed by immunoblotting the protein levels of Cyclin D1, D2, D3 and their catalytic partners, Cdk4 and Cdk6 in normal and transformed human cells. We found that all these proteins were differentially expressed in diploid cells derived from different tissues, in contrast to Cyclin E, Cyclin A a...

journal_title：Oncogene

authors： Tam SW,Theodoras AM,Shay JW,Draetta GF,Pagano M

更新日期：1994-09-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a cytokine that regulates the proliferation of some tumor cells including multiple myeloma (MM). Ectopic expression of fibroblast growth factor receptor 3 (FGFR 3) associated with the chromosomal translocation, t(4;14)(p16.3;q32), is frequently found in MM, and therefore, has been implicated in...

journal_title：Oncogene

authors： Ishikawa H,Tsuyama N,Liu S,Abroun S,Li FJ,Otsuyama K,Zheng X,Ma Z,Maki Y,Iqbal MS,Obata M,Kawano MM

更新日期：2005-09-15 00:00:00

abstract：:Protection from detachment-induced cell death, termed anoikis, facilitates metastasis. Though anoikis is largely attributed to the loss of integrin-related 'outside-in' survival signals, Terada and colleagues demonstrate a novel 'inside-out' attachment sensing role for the adapter protein p66(Shc) in promoting anoikis...

journal_title：Oncogene

authors： Debnath J

更新日期：2010-10-14 00:00:00

abstract：:We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog (hTERT), and the presence of reverse transcriptase and telomerase specific motifs. Furthermore, we show functional interchangeability with hTERT in in vitro telomeras...

journal_title：Oncogene

authors： Greenberg RA,Allsopp RC,Chin L,Morin GB,DePinho RA

更新日期：1998-04-02 00:00:00

abstract：:The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to mesenchymal transition and promote colorectal cancer. However, due to its essential role in gut homeostasis, therapeutic targeting of this pathway has proven challenging. Additionally, IL-6/Stat-3 signaling, activated by microbial tran...

journal_title：Oncogene

authors： Ahmad R,Kumar B,Chen Z,Chen X,Müller D,Lele SM,Washington MK,Batra SK,Dhawan P,Singh AB

更新日期：2017-11-23 00:00:00

abstract：:EBP1 was identified as a protein that interacts with the ErbB-3 receptor and possibly contributes to transducing growth regulatory signals. The existence of EBP1 homologs across species from simple eukaryotes to humans and its wide tissue expression pattern suggest that EBP1 acts as a general signaling molecule. We pr...

journal_title：Oncogene

authors： Squatrito M,Mancino M,Donzelli M,Areces LB,Draetta GF

更新日期：2004-05-27 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by overexpression of cyclin D1 due to the t(11;14) chromosomal translocation. While expression of cyclin D1 correlates with MCL development, expression of wild-type (WT) cyclin D1 transgene in murine lymphocytes is unable to drive B-cell lymphoma. As cyclin...

journal_title：Oncogene

authors： Gladden AB,Woolery R,Aggarwal P,Wasik MA,Diehl JA

更新日期：2006-02-16 00:00:00

abstract：:Tbx3 is a member of the T-box family of transcription factors. Mutations in Tbx3 cause ulnar-mammary syndrome, an autosomal dominant disorder characterized by upper limb defects, apocrine-gland defects including mammary hypoplasia, and tooth, hair and genital defects. In cell culture, Tbx3 and its close relative Tbx2 ...

journal_title：Oncogene

authors： Carlson H,Ota S,Song Y,Chen Y,Hurlin PJ

更新日期：2002-05-30 00:00:00

abstract：:Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic. These e...

journal_title：Oncogene

authors： Krokan HE,Drabløs F,Slupphaug G

更新日期：2002-12-16 00:00:00

abstract：:The most common genetic alteration identified in transitional cell carcinoma (TCC) of the bladder is loss of heterozygosity (LOH) on chromosome 9. However, localization of tumor suppressor genes on 9q has been hampered by the low frequency of subchromosomal deletions. We have analysed 139 primary, initial low stage TC...

journal_title：Oncogene

authors： Simoneau M,Aboulkassim TO,LaRue H,Rousseau F,Fradet Y

更新日期：1999-01-07 00:00:00

abstract：:In the search for retinoids active against Burkitt's lymphoma (BL), we found that the arotinoid mofarotene (Ro 40-8757) induced strong antiproliferative and apoptotic responses in most established BL cell lines as well as in primary BL cells. Ro 40-8757-induced apoptosis is associated with mitochondrial membrane depol...

journal_title：Oncogene

authors： Cariati R,Zancai P,Righetti E,Rizzo S,De Rossi A,Boiocchi M,Dolcetti R

更新日期：2003-02-13 00:00:00

abstract：:Tumors consistently mimic wound-generating chronic inflammation; however, why they do not heal like wounds with fibrotic scars remains unknown. The components of the tumor microenvironment, such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGFs), may account for this phenomenon. Tumor formati...

journal_title：Oncogene

authors： Zhang HR,Wang XD,Yang X,Chen D,Hao J,Cao R,Wu XZ

更新日期：2017-07-06 00:00:00

abstract：:Better understanding of the underlying biology of malignant gliomas is critical for the development of early detection strategies and new therapeutics. This study aimed to define genes associated with survival. We investigated whether genes coupled with a class prediction model could be used to define subgroups of hig...

journal_title：Oncogene

authors： Yamanaka R,Arao T,Yajima N,Tsuchiya N,Homma J,Tanaka R,Sano M,Oide A,Sekijima M,Nishio K

更新日期：2006-09-28 00:00:00

abstract：:A search for protein tyrosine kinases expressed during murine cardiogenesis resulted in the isolation of a novel tyrosine kinase, designated tek, which maps to mouse chromosome 4 between the brown and pmv-23 loci. The deduced amino acid sequence of tek predicts that it encodes a putative receptor tyrosine kinase that ...

journal_title：Oncogene

authors： Dumont DJ,Yamaguchi TP,Conlon RA,Rossant J,Breitman ML

更新日期：1992-08-01 00:00:00

abstract：:The human c-rel gene (REL), encoding an NF-kappaB transcription factor, is amplified or mutated in several human B-cell lymphomas and can transform chicken lymphoid cells in vitro. We have previously shown that certain deletions of C-terminal transactivation sequences enhance REL's transforming ability in chicken sple...

journal_title：Oncogene

authors： Starczynowski DT,Reynolds JG,Gilmore TD

更新日期：2005-11-10 00:00:00

abstract：:Mel-18 has been implicated in several processes in tumor progression, in which the Akt pathway is involved as an important key molecular event. However, the function of Mel-18 in human cancers has not been fully established yet. Here, we examined the effect of Mel-18 on tumor angiogenesis in human breast cancer, and f...

journal_title：Oncogene

authors： Park JH,Lee JY,Shin DH,Jang KS,Kim HJ,Kong G

更新日期：2011-11-10 00:00:00

abstract：:We have previously determined that the amplified DNA present in the HL60 promyelocytic leukaemia cell line contained 70 kb of continuous DNA sequences around the c-myc gene. In the work presented here we have further defined the HL60 amplicon and find it to be of the order of 160 kb and to contain a large region of DN...

journal_title：Oncogene

authors： Feo S,Di Liegro C,Mangano R,Read M,Fried M

更新日期：1996-10-03 00:00:00

abstract：:RET/PTC1 is a chimeric oncogene created by the fusion of the tyrosine kinase domain of RET to the 5'-terminal region of another gene named H4. So far, this oncogene has been found activated only in human papillary thyroid carcinomas. In order to investigate its transforming properties in vivo, we have produced transge...

journal_title：Oncogene

authors： Portella G,Salvatore D,Botti G,Cerrato A,Zhang L,Mineo A,Chiappetta G,Santelli G,Pozzi L,Vecchio G,Fusco A,Santoro M

更新日期：1996-11-07 00:00:00

abstract：:Structural rearrangements involving chromosome 13 are frequently seen in B-cell chronic lymphocytic leukaemia. The presence of reciprocal translocations involving 13q14 in 10-15% of cases pinpoints the location of a gene important in leukaemogenesis. In order to characterise the exact location of the 13q14 breakpoint,...

journal_title：Oncogene

authors： Hawthorn LA,Chapman R,Oscier D,Cowell JK

更新日期：1993-06-01 00:00:00

abstract：:Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and caspase 8 upon death stimuli has been studied in detail, posttranslationa...

journal_title：Oncogene

authors： Seo J,Lee EW,Shin J,Seong D,Nam YW,Jeong M,Lee SH,Lee C,Song J

更新日期：2018-09-01 00:00:00

abstract：:Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaire...

journal_title：Oncogene

authors： Sari IN,Yang YG,Wijaya YT,Jun N,Lee S,Kim KS,Bajaj J,Oehler VG,Kim SH,Choi SY,Park SH,Kim DW,Reya T,Han J,Kwon HY

更新日期：2021-01-01 00:00:00