Abstract:
:Protection from detachment-induced cell death, termed anoikis, facilitates metastasis. Though anoikis is largely attributed to the loss of integrin-related 'outside-in' survival signals, Terada and colleagues demonstrate a novel 'inside-out' attachment sensing role for the adapter protein p66(Shc) in promoting anoikis and suppressing metastasis via Ras-dependent control of proliferation and survival.
journal_name
Oncogenejournal_title
Oncogeneauthors
Debnath Jdoi
10.1038/onc.2010.347subject
Has Abstractpub_date
2010-10-14 00:00:00pages
5556-8issue
41eissn
0950-9232issn
1476-5594pii
onc2010347journal_volume
29pub_type
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