Abstract：
:Previous studies have shown that increased expression of oncogenes from the myc-family can down-regulate the level of MHC class I antigens in tumor cells. This has suggested a mechanism by which amplification/overexpression of myc-genes may contribute to the malignancy development of certain tumors. Earlier published data from the murine SEWA tumor, a polyomavirus-induced osteosarcoma, have correlated the degree of tumorigenicity of different sublines to their level of c-myc amplification. Here I present a quantitative and qualitative analysis of MHC class I antigens from five sublines of this tumor system. No differences could be found, between sublines with different degrees of tumorigenicity, regarding MHC class I antigen expression. Thus, in the SEWA tumor, the enhancement of the tumorigenicity caused by c-myc amplification is not mediated through down-regulation of MHC class I antigens.
journal_name
Oncogenejournal_title
Oncogeneauthors
Dahllöf Bsubject
Has Abstractpub_date
1990-03-01 00:00:00pages
433-5issue
3eissn
0950-9232issn
1476-5594journal_volume
5pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on the role of Stat activation in the development of myeloid cells in response to hemat...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1203477
更新日期：2000-05-15 00:00:00
abstract：:Fas-associated death domain (FADD) is an adaptor protein recruiting complexes of caspase 8 to death ligand receptors to induce extrinsic apoptotic cell death in response to a TNF superfamily member. Although, formation of the complex of FADD and caspase 8 upon death stimuli has been studied in detail, posttranslationa...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0323-z
更新日期：2018-09-01 00:00:00
abstract：:Interferon (IFN)-beta induces S-phase slowing and apoptosis in human papilloma virus (HPV)-positive cervical carcinoma cell line ME-180. Here, we show that apoptosis is a consequence of the S-phase lengthening imposed by IFN-beta, demonstrating the functional correlation between S-phase alteration and apoptosis induct...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208403
更新日期：2005-04-07 00:00:00
abstract：:Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) in about 5% of carriers after a long latent period. After its infection, HTLV-I promotes the clonal proliferation of HTLV-I infected cells in vivo by actions of encoded viral proteins, including Tax. However, leukemic cells frequently lack ...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1206551
更新日期：2003-08-11 00:00:00
abstract：:Ovarian cancer is the leading cause of death among all gynecological malignancies due to the development of acquired chemoresistance and disease relapse. Although the role of cancer stem cells (CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therapeutic resistance is beginning...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.320
更新日期：2017-03-01 00:00:00
abstract：:p73 is a member of the p53 family. Recent studies have shown that DNA damage can stabilize p73 protein and enhance p73-mediated apoptosis in a c-Abl dependent manner. To determine what regulates p73 transcriptionally, we analysed the expression of p73 in several cell lines following genotoxic stresses. We found that p...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204149
更新日期：2001-02-08 00:00:00
abstract：:Tumor metastasis, but not primary overgrowth, is the leading cause of mortality for cancer patients. During the past decade, Drosophila melanogaster has been well-accepted as an excellent model to address the intrinsic mechanism of different aspects of cancer progression, ranging from tumor initiation to metastasis. I...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.463
更新日期：2017-06-01 00:00:00
abstract：:Liver kinase B1 (LKB1) is mutationally inactivated in Peutz-Jeghers syndrome and in a variety of cancers including human papillomavirus (HPV)-caused cervical cancer. However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. Herein, we demonstrated that, in mouse embr...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.290
更新日期：2017-03-02 00:00:00
abstract：:The Epstein-Barr virus latency-associated membrane protein LMP2A has been shown to activate the survival kinase Akt in epithelial and B cells in a phosphoinositide 3-kinase-dependent fashion. In this study, we demonstrate that the signalling scaffold Shb associates through SH2 and PTB domain interactions with phosphor...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210298
更新日期：2007-07-26 00:00:00
abstract：:Rad23 proteins function in both DNA repair and protein stability regulation. As ubiquitinated forms of p53 are stabilized after DNA damage in concert with p53 functional activation, and human Rad23 proteins (hHR23A and B) regulate p53 stability in unstressed cells, the role of hHR23B in post-genotoxin regulation of p5...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209865
更新日期：2007-02-22 00:00:00
abstract：:To investigate the possible role of the product of the retinoblastoma susceptibility gene, pRB, in leukemogenesis, we examined fresh leukemia cells from 56 cases of primary leukemia (AML, 32; ALL, 12; CML-BC, 9; CLL, 3) for expression of pRB by using an immunoblotting assay with anti-pRB monoclonal antibodies PMG 3-24...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208956
更新日期：2005-12-08 00:00:00
abstract：:Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human m...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/s41388-019-1124-8
更新日期：2020-03-01 00:00:00
abstract：:In many differentiating cells, a reduction of c-myc proto-oncogene expression is a prerequisite for terminal differentiation. The downmodulation of c-myc in differentiating cells is due to at least two different mechanisms: (i) an elongation block to c-myc transcription activated during an early phase of differentiati...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:Bloom syndrome and ataxia-telangiectasia are autosomal recessive human disorders characterized by immunodeficiency, genome instability and predisposition to develop cancer. Recent data reveal that the products of these two genes, BLM and ATM, interact and function together in recognizing abnormal DNA structures. To in...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207276
更新日期：2004-02-26 00:00:00
abstract：:Better understanding of the underlying biology of malignant gliomas is critical for the development of early detection strategies and new therapeutics. This study aimed to define genes associated with survival. We investigated whether genes coupled with a class prediction model could be used to define subgroups of hig...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209585
更新日期：2006-09-28 00:00:00
abstract：:MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of critical cell processes such as apoptosis, cell proliferation and differentiation. A small set of miRNAs is differentially expressed in hematopoietic cells and seemingly has an important role in granulopoiesis and lineage differentiation. In th...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.255
更新日期：2009-11-12 00:00:00
abstract：:Migration and invasion inhibitory protein (MIIP) is recently identified as an inhibitor in tumor development. However, the regulatory mechanism and biological contributions of MIIP in pancreatic cancer (PC) have been not elucidated. In this study, we demonstrated a negative feedback of MIIP and hypoxia-induced factor-...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-017-0082-2
更新日期：2018-03-01 00:00:00
abstract：:We isolated three related cDNA clones from a mouse cerebellar library; the type I cDNA was identical to the gene encoding the apoptosis-associated tyrosine kinase (AATYK), whose expression in myeloid precursor cells is increased during growth arrest or apoptosis. Low levels of AATYK mRNA expression were seen in adult ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204210
更新日期：2001-03-01 00:00:00
abstract：:Here we report that ALDH1L1 (FDH, a folate enzyme with tumor suppressor-like properties) inhibits cell motility. The underlying mechanism involves F-actin stabilization, re-distribution of cytoplasmic actin toward strong preponderance of filamentous actin and formation of actin stress fibers. A549 cells expressing FDH...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.356
更新日期：2010-11-25 00:00:00
abstract：:To explore the mechanism of estrogen-induced growth of normal endometrium, the transactivation system of the cyclin D1 gene was analysed using cultured normal endometrial glandular cells. Estradiol (E2) treatment of cultured normal endometrial glandular cells induced upregulation of c-Jun, and then cyclin D1 proteins,...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207849
更新日期：2004-11-11 00:00:00
abstract：:Heregulins are a group of growth factors that play diverse and critical roles in the signaling network of the human epidermal growth factor receptor (HER or EGFR) superfamily. Our earlier studies have shown that recombinant heregulinbeta1 (HRG) induces apoptosis in SKBr3 breast cancer cells that overexpress HER2. Here...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205039
更新日期：2001-12-13 00:00:00
abstract：:The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has a significant role in initiating EBV-associated lymphoproliferative disease and EBV-related malignancies. In view of clinical features related to the type of EBV latency, LMP1 may influence invasiveness of EBV associated tumors categorized as ty...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203502
更新日期：2000-03-30 00:00:00
abstract：:In previous studies we changed five conserved amino acid residues in the catalytic domain of the yeast Ras-specific guanine nucleotide exchange factor CDC25GEF (Park et al., 1994). One of the substitutions (R1489E) resulted in a molecule which could bind Ras but was catalytically inactive. These observations suggested...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1200893
更新日期：1997-02-20 00:00:00
abstract：:Loss of RASSF1A leads to several mitotic abnormalities, including cytokinesis failure and tetraploidization. Uncontrolled proliferation of tetraploid cells is known to trigger genomic instability and tumor development and is normally prevented through activation of a p53-dependent tetraploidy checkpoint. RASSF1A is th...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.440
更新日期：2011-02-10 00:00:00
abstract：:Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB recepto...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2015.220
更新日期：2016-03-24 00:00:00
abstract：:A hallmark of cancer is the deregulation of cell-cycle machinery, ultimately facilitating aberrant proliferation that fuels tumorigenesis and disease progression. Particularly, in breast cancers, cyclin D1 has a crucial role in the development of disease. Recently, a highly specific inhibitor of CDK4/6 activity (PD-03...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.154
更新日期：2010-07-15 00:00:00
abstract：:Aggrus (also known as T1alpha/podoplanin) is a membrane sialoglycoprotein whose function in tumors is unknown. We recently determined that Aggrus possessed the ability of inducing platelet aggregation and that its expression was frequently upregulated in colorectal tumors. Thus, Aggrus expression might be associated w...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207869
更新日期：2004-11-04 00:00:00
abstract：:We previously reported the development of a src-specific tumor regression system in chickens in which preinfection with rASV1702, a mutant of Rous sarcoma virus (RSV) encoding non-myristylated src product with a novel N-terminal domain, results in the immune suppression of challenge tumors induced by RSV. In order to ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:In previous studies examining the role of pp60c-src in cellular proliferation, we demonstrated that overexpression of wild type (wt) but not mutated c-src in C3H10T1/2 murine embryo fibroblasts resulted in a 2 to 5 fold enhancement of DNA synthesis in response to epidermal growth factor (EGF). Using phosphotyrosine an...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
