Abstract:
:Dependence receptors (DRs) now form a family of more than a dozen membrane receptors that are not linked by their structure, but by common functional traits. The most notable is their ability to trigger two opposite signaling pathways: in the presence of ligand, these receptors activate classic signaling pathways implicated in cell survival, migration and differentiation. In the absence of ligand, they do not stay inactive, rather they elicit an apoptotic signal. Thus, cells expressing this kind of receptor are dependent on the presence of ligand in the extracellular environment to survive. This review will recapitulate the increasing data regarding the molecular mechanisms associated with DRs, their potential implication during development, as well as their deregulation during tumorigenesis and, finally, their emergence as new possible therapeutic targets for cancer treatment.
journal_name
Oncogenejournal_title
Oncogeneauthors
Goldschneider D,Mehlen Pdoi
10.1038/onc.2010.13subject
Has Abstractpub_date
2010-04-01 00:00:00pages
1865-82issue
13eissn
0950-9232issn
1476-5594pii
onc201013journal_volume
29pub_type
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