Abstract:
:Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.
journal_name
Oncogenejournal_title
Oncogeneauthors
Kim SW,Kim HJ,Jung DJ,Lee SK,Kim YS,Kim JH,Kim TS,Lee JWdoi
10.1038/sj.onc.1204695subject
Has Abstractpub_date
2001-10-04 00:00:00pages
6638-42issue
45eissn
0950-9232issn
1476-5594journal_volume
20pub_type
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