Transactivation of host and viral genes by the adenovirus E1B 19K tumor antigen.

abstract：:Previous studies have documented that Tumor necrosis factor alpha (TNFalpha) is a potent negative regulator of normal hematopoiesis. However, the mechanism by which TNFalpha acts at the cellular level is not totally understood. Although apoptotic cell killing appears to be the most common cellular effect of TNFalpha, ...

journal_title：Oncogene

authors： Beyne-Rauzy O,Recher C,Dastugue N,Demur C,Pottier G,Laurent G,Sabatier L,Mansat-De Mas V

更新日期：2004-09-30 00:00:00

abstract：:Raf-1 is a serine-threonine protein kinase that functions as a central component of the mitogen-activated protein kinase signal transduction pathway. Raf-1 activity is currently assayed in vitro by either measuring 32P incorporation into MEK, Raf-1's only characterized substrate, or by using the phosphorylated MEK to ...

journal_title：Oncogene

authors： Bondzi C,Grant S,Krystal GW

更新日期：2000-10-12 00:00:00

abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

journal_title：Oncogene

authors： Sachsenmaier C,Sadowski HB,Cooper JA

更新日期：1999-06-17 00:00:00

abstract：:In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5'-up...

journal_title：Oncogene

authors： Munnes M,Patrone G,Schmitz B,Romeo G,Doerfler W

更新日期：1998-11-19 00:00:00

abstract：:Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77 translocation is induced by certain apoptotic stimuli, including the synthetic retinoid-related 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid...

journal_title：Oncogene

authors： Han YH,Cao X,Lin B,Lin F,Kolluri SK,Stebbins J,Reed JC,Dawson MI,Zhang XK

更新日期：2006-05-18 00:00:00

abstract：:O-linked glycans of secreted and membrane-bound proteins have an important role in the pathogenesis of pancreatic cancer by modulating immune responses, inflammation and tumorigenesis. A critical aspect of O-glycosylation, the position at which proteins are glycosylated with N-acetyl-galactosamine on serine and threon...

journal_title：Oncogene

authors： Taniuchi K,Cerny RL,Tanouchi A,Kohno K,Kotani N,Honke K,Saibara T,Hollingsworth MA

更新日期：2011-12-08 00:00:00

abstract：:Small-cell lung cancer (SCLC) is an aggressive, rapidly metastasizing neoplasm. The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is constitutively secreted by marrow stromal cells and plays a key role for homing of hematopoietic cells to the marrow. Here, we report that tumor cells from patients with SCLC ex...

journal_title：Oncogene

authors： Burger M,Glodek A,Hartmann T,Schmitt-Gräff A,Silberstein LE,Fujii N,Kipps TJ,Burger JA

更新日期：2003-11-06 00:00:00

abstract：:Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platform...

journal_title：Oncogene

authors： Launay S,Hermine O,Fontenay M,Kroemer G,Solary E,Garrido C

更新日期：2005-08-04 00:00:00

abstract：:Alpha-fetoprotein (AFP) producing gastric cancer (AFP-GC) is very malignant and highly metastatic compared with common gastric cancer. However, the causal relationship between AFP production and the high malignancy of AFP-GC is unclear. We investigated AFP gene regulation in AFP-GC by an active transcription factor, H...

journal_title：Oncogene

authors： Kataoka H,Miura Y,Joh T,Seno K,Tada T,Tamaoki T,Nakabayashi H,Kawaguchi M,Asai K,Kato T,Itoh M

更新日期：2001-02-15 00:00:00

abstract：:Our previous work with primary bovine fibroblasts demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 and G2/M, in correlation with p53 activation. The expression of bovine papillomavirus type 4 (BPV-4) E7 overcame this arrest and lead to the d...

journal_title：Oncogene

authors： Beniston RG,Campo MS

更新日期：2003-08-21 00:00:00

abstract：:Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived...

journal_title：Oncogene

authors： Qiao Y,Zhang C,Li A,Wang D,Luo Z,Ping Y,Zhou B,Liu S,Li H,Yue D,Zhang Z,Chen X,Shen Z,Lian J,Li Y,Wang S,Li F,Huang L,Wang L,Zhang B,Yu J,Qin Z,Zhang Y

更新日期：2018-02-15 00:00:00

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:In Dictyostelium discoideum, three ras genes (rasD, rasG and rasB) and one ras-related gene (rap1) have been previously isolated and characterized, and the deduced amino acid sequence of their predicted protein products share at least 50% sequence identity with the human H-Ras protein. We have now cloned and character...

journal_title：Oncogene

authors： Daniel J,Bush J,Cardelli J,Spiegelman GB,Weeks G

更新日期：1994-02-01 00:00:00

abstract：:The reversible interaction of the retinoblastoma susceptibility gene product (Rb) with the cellular transcription factor E2F has recently been demonstrated. Activation of the adenovirus E2a promoter by the products of the viral E1a gene correlates with the ability of both early E1a proteins to sequester Rb, thereby re...

journal_title：Oncogene

authors： Bocco JL,Reimund B,Chatton B,Kedinger C

更新日期：1993-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer-related mortality in the United States. Exploring the mechanism of HCC and identifying ideal targets is critical. In the present study, we demonstrated metabolism dysfunction might be a key diver for the development of HCC. The mitochondrial amidoxime...

journal_title：Oncogene

authors： Wu D,Wang Y,Yang G,Zhang S,Liu Y,Zhou S,Guo H,Liang S,Cui Y,Zhang B,Ma K,Zhang C,Liu Y,Sun L,Wang J,Liu L

更新日期：2020-09-01 00:00:00

abstract：:Chromosomal translocation t(X;14)(q28;q11) has been observed in patients with pro-lymphocytic T-cell leukaemia (T-PLL). In two cases of T-PLL, one of which was associated with Ataxia telangiectasia (AT), the chromosomal break occurred in two different introns of a gene c6.1A, located at the Xq28 locus. Fusion transcri...

journal_title：Oncogene

authors： Fisch P,Forster A,Sherrington PD,Dyer MJ,Rabbitts TH

更新日期：1993-12-01 00:00:00

abstract：:Low molecular weight protein tyrosine phosphatases (LMW-PTPs) are an enzyme family that plays a key role in cell proliferation control by dephosphorylating/inactivating both tyrosine kinase receptors (such as PDGF, insulin, and ephrin receptors) and docking proteins (such, as beta-catenin) endowed with both adhesion a...

journal_title：Oncogene

authors： Chiarugi P,Taddei ML,Schiavone N,Papucci L,Giannoni E,Fiaschi T,Capaccioli S,Raugei G,Ramponi G

更新日期：2004-05-13 00:00:00

abstract：:We compared the mitogenic and signaling pathways of three Fibroblast Growth Factor Receptors (FGFRs), FGFR1, KGFR and FGFR4 in the same cell line. Each receptor was expressed in L6E9 rat myoblasts that do not normally express detectable levels of FGFRs and clones that express comparable levels of each receptor were se...

journal_title：Oncogene

authors： Shaoul E,Reich-Slotky R,Berman B,Ron D

更新日期：1995-04-20 00:00:00

abstract：:The mixed lineage leukemia (MLL) gene at chromosome band 11q23 is commonly involved in reciprocal translocations that are detected in acute leukemias. Evidence suggests that the resulting MLL fusion genes contribute to leukemogenesis. AF9 is a common MLL fusion partner in acute myeloid leukemia. The AF9 protein functi...

journal_title：Oncogene

authors： Srinivasan RS,de Erkenez AC,Hemenway CS

更新日期：2003-05-29 00:00:00

abstract：:Apoptin, a protein of the chicken anemia virus (CAV), represents a novel potential anticancer therapeutic, because it induces apoptotic death specifically in tumor but not normal cells. The cellular localization appears to be crucial for apoptin's selective toxicity. In normal cells apoptin remains in the cytoplasm, w...

journal_title：Oncogene

authors： Janssen K,Hofmann TG,Jans DA,Hay RT,Schulze-Osthoff K,Fischer U

更新日期：2007-03-08 00:00:00

abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. BAG-1 exists as three major isoforms, BAG-1L, BAG-1M and BAG-1S. BAG-1L contains a nuclear localization signal, which is not present in the other isoforms, and is pr...

journal_title：Oncogene

authors： Cutress RI,Townsend PA,Sharp A,Maison A,Wood L,Lee R,Brimmell M,Mullee MA,Johnson PW,Royle GT,Bateman AC,Packham G

更新日期：2003-08-07 00:00:00

abstract：:Fos protein heterodimerizes through one surface of an alpha-helical domain called the leucine zipper. We have investigated the effect of destabilizing this domain by multiply substituting small residues of its non-interacting surface with glycine. Ternary complex formation between mutated Fos, Jun and DNA was determin...

journal_title：Oncogene

authors： Nicklin MJ,Zechner D,Kislyakova T

更新日期：1993-07-01 00:00:00

abstract：:To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease proc...

journal_title：Oncogene

authors： Peng WX,Koirala P,Mo YY

更新日期：2017-10-12 00:00:00

abstract：:Both chemokine receptors (CXCRs) 7 and 4 can facilitate immune cell migration and mediate a vast array of physiological and pathological events. Herein we report, in both human and animal studies, that these two CXCRs can form heterodimers in vivo and promote colorectal tumorigenesis through histone demethylation. Com...

journal_title：Oncogene

authors： Song ZY,Wang F,Cui SX,Gao ZH,Qu XJ

更新日期：2019-02-01 00:00:00

abstract：:The Ewing sarcoma is the second most common bone tumor in children and young adults. Despite the advances in therapy, the 5-year survival rate for patients with metastatic disease is poor, indicating the need for alternative treatments. Here, we report that 2-methoxy-estradiol (2-Me), a natural estrogen metabolite, in...

journal_title：Oncogene

authors： Djavaheri-Mergny M,Wietzerbin J,Besançon F

更新日期：2003-05-01 00:00:00

abstract：:Murine double minute (MDM2) binding protein (MTBP) has been implicated in cancer progression. Here, we demonstrate one mechanism by which MTBP inhibits cancer metastasis. Overexpression of MTBP in human osteosarcoma cell lines lacking wild-type p53 did not alter primary tumor growth in mice, but significantly inhibite...

journal_title：Oncogene

authors： Agarwal N,Adhikari AS,Iyer SV,Hekmatdoost K,Welch DR,Iwakuma T

更新日期：2013-01-24 00:00:00

abstract：:As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiat...

journal_title：Oncogene

authors： Kim KW,Moretti L,Mitchell LR,Jung DK,Lu B

更新日期：2010-06-03 00:00:00

abstract：:MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the go...

journal_title：Oncogene

authors： Galland F,Pirisi V,de Lapeyriere O,Birnbaum D

更新日期：1991-05-01 00:00:00

abstract：:The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival and glucose transport, and is implicated in various disease states, such as cancer and diabetes. Although there have been numerous studies dissecting the role of PI3K signaling in different c...

journal_title：Oncogene

authors： Ling LS,Voskas D,Woodgett JR

更新日期：2013-11-21 00:00:00

abstract：:Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to rep...

journal_title：Oncogene

authors： Kasinski AL,Kelnar K,Stahlhut C,Orellana E,Zhao J,Shimer E,Dysart S,Chen X,Bader AG,Slack FJ

更新日期：2015-07-01 00:00:00