Rb may act as a transcriptional co-activator in undifferentiated F9 cells.

abstract：:The activities of E2F transcription factors are inhibited by interactions with members of the retinoblastoma (RB) tumor suppressor family, p105RB, p107 and p130. In cycling cells p107 and p130 also interact with heterodimers comprised of Cdk2 and either A or E cyclins. We characterized E2F complexes present in C2C12 a...

journal_title：Oncogene

authors： Corbeil HB,Whyte P,Branton PE

更新日期：1995-09-07 00:00:00

abstract：:The product of the retinoblastoma susceptibility gene, pRb, is a negative regulator of cell growth. It functions by regulating the activity of transcription factors. Rb represses some genes by sequestering or inactivating the positive transcription factor E2F and seems to activate some others by interacting with facto...

journal_title：Oncogene

authors： Rohde M,Warthoe P,Gjetting T,Lukas J,Bartek J,Strauss M

更新日期：1996-06-06 00:00:00

abstract：:A locus in feline DNA, termed flvi-1, has been identified as harboring retroviral integrations commonly found in natural feline lymphomas induced by infection with feline leukemia virus (FeLV). Southern blot analysis of human and murine DNA using restriction fragments representing flvi-1 demonstrates its phylogenetic ...

journal_title：Oncogene

authors： Levesque KS,Mattei MG,Levy LS

更新日期：1991-08-01 00:00:00

abstract：:p53 plays a central role in the induction of apoptosis of spermatogonia in response to ionizing radiation. In p53(-/-) testes, however, spermatogonial apoptosis still can be induced by ionizing radiation, so p53 independent apoptotic pathways must exist in spermatogonia. Here we show that the p53 homologues p63 and p7...

journal_title：Oncogene

authors： Hamer G,Gademan IS,Kal HB,de Rooij DG

更新日期：2001-07-19 00:00:00

abstract：:Although p73alpha induces many of the same cellular events as p53, it is structurally distinct from p53 in that it possesses a unique COOH-terminal domain. To dissect the function of this domain, we performed yeast two-hybrid screening of a HeLa cDNA library using residues 552-636 of p73alpha as bait. Among the clones...

journal_title：Oncogene

authors： Lee YG,Lee SW,Sin HS,Kim EJ,Um SJ

更新日期：2009-02-19 00:00:00

abstract：:Breast carcinoma invasion is associated with prominent alterations in stromal fibroblasts. Carcinoma-associated fibroblasts (CAF) support and promote tumorigenesis, whereas normal mammary fibroblasts (NF) are thought to suppress tumor progression. Little is known about the difference in gene expression between CAF and...

journal_title：Oncogene

authors： Bauer M,Su G,Casper C,He R,Rehrauer W,Friedl A

更新日期：2010-03-25 00:00:00

abstract：:In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a specialized checkpoint protein that does not participate in the control of normal cell cycle progression. How...

journal_title：Oncogene

authors： Bianchi T,Rufer N,MacDonald HR,Migliaccio M

更新日期：2006-07-06 00:00:00

abstract：:Telomerase expression is the hallmark of tumor cells in which this ribonucleoprotein complex preserves chromosome integrity by maintaining telomere length and thereby prevents cell death. However, recent data support a role of the combination of p53 and telomerase inactivation in initiating genetic instability that pr...

journal_title：Oncogene

authors： Gabet AS,Mortreux F,Charneau P,Riou P,Duc-Dodon M,Wu Y,Jeang KT,Wattel E

更新日期：2003-06-12 00:00:00

abstract：:In order to examine the role of p53 expression on the sensitivity of cells to radiation-induced reproductive failure, we examined the radiosensitivity of a human diploid fibroblast cell strain (AG1521) before and after transfection with the E6 or E6/E7 genes of human papillomavirus 16 (HPV16)3. HPV E6 binds to p53, pr...

journal_title：Oncogene

authors： Tsang NM,Nagasawa H,Li C,Little JB

更新日期：1995-06-15 00:00:00

abstract：:Better understanding of the underlying biology of malignant gliomas is critical for the development of early detection strategies and new therapeutics. This study aimed to define genes associated with survival. We investigated whether genes coupled with a class prediction model could be used to define subgroups of hig...

journal_title：Oncogene

authors： Yamanaka R,Arao T,Yajima N,Tsuchiya N,Homma J,Tanaka R,Sano M,Oide A,Sekijima M,Nishio K

更新日期：2006-09-28 00:00:00

abstract：:Transforming Growth Factor-beta1 (TGF-beta1) inhibits the proliferation of most cells, but stimulates some mesenchymal cell types, including murine NIH3T3 fibroblasts. We show here that TGF-beta1 growth stimulation of NIH3T3 fibroblasts is reversed when these cells are transformed by SV40 or are transfected with a pla...

journal_title：Oncogene

authors： Dkhissi F,Raynal S,Jullien P,Lawrence DA

更新日期：1999-01-21 00:00:00

abstract：:A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance t...

journal_title：Oncogene

authors： Casazza A,Di Conza G,Wenes M,Finisguerra V,Deschoemaeker S,Mazzone M

更新日期：2014-04-03 00:00:00

abstract：:Low oxygen tension (hypoxia) is a common feature of solid tumors and stimulates the expressions of a variety of genes including those related to angiogenesis, apoptosis and endoplasmic reticulum (ER) stress response. Here we show a close correlation between metastatic potential and the resistance to hypoxia- and ER st...

journal_title：Oncogene

authors： Koshikawa N,Maejima C,Miyazaki K,Nakagawara A,Takenaga K

更新日期：2006-02-09 00:00:00

abstract：:E2F transcription factors are important regulators of the cell cycle, and unrestrained activation of E2F-dependent transcription is considered to be an important driver of tumor formation and progression. Although highly expressed in normal skin and skin cancer, the role of the atypical E2Fs, E2F7 and E2F8, in keratin...

journal_title：Oncogene

authors： Thurlings I,Martínez-López LM,Westendorp B,Zijp M,Kuiper R,Tooten P,Kent LN,Leone G,Vos HJ,Burgering B,de Bruin A

更新日期：2017-02-09 00:00:00

abstract：:To identify genes that are differentially over-expressed in Small Cell Lung Carcinoma (SCLC) we have used a combination of suppression subtractive hybridization and cDNA microarray to analyse the expression profiles of 2400 cDNAs clones. Genes that are over-expressed in SCLC were identified using 32 pairs of fluoresce...

journal_title：Oncogene

authors： Bangur CS,Switzer A,Fan L,Marton MJ,Meyer MR,Wang T

更新日期：2002-05-23 00:00:00

abstract：:Fanconi anemia is a hereditary cancer susceptibility disorder characterized at the cellular level by spontaneous chromosomal instability and specific hypersensitivity to DNA cross-linking agents such as mitomycin C. This phenotype suggests a possible role for the Fanconi anemia proteins in the repair of DNA lesions in...

journal_title：Oncogene

authors： Godthelp BC,Artwert F,Joenje H,Zdzienicka MZ

更新日期：2002-07-25 00:00:00

abstract：:The forkhead transcription factor FOXO1, a downstream target of phosphatidylinositol-3-kinase/Akt signalling pathway, regulates cyclic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis is unknown. Screening of endometrial cancer cell lines demonstrated that FOXO1 is expres...

journal_title：Oncogene

authors： Goto T,Takano M,Albergaria A,Briese J,Pomeranz KM,Cloke B,Fusi L,Feroze-Zaidi F,Maywald N,Sajin M,Dina RE,Ishihara O,Takeda S,Lam EW,Bamberger AM,Ghaem-Maghami S,Brosens JJ

更新日期：2008-01-03 00:00:00

abstract：:We have examined the possibility that the E7 proteins of the high-risk human papillomavirus (HPV) type 16 and 18 and the oncogenic adenovirus (Ad) type 12 E1A protein share the ability to down-regulate the expression of components of the antigen processing and presentation pathway, as a common strategy in the evasion ...

journal_title：Oncogene

authors： Georgopoulos NT,Proffitt JL,Blair GE

更新日期：2000-10-05 00:00:00

abstract：:Helicobacter pylori induces a strong motogenic response in infected gastric epithelial host cells, which is enhanced by translocation of the pathogenic factor cytotoxin-associated gene A (CagA) into host cells via a specialized type IV secretion system. Once injected into the cytosol CagA is rapidly tyrosine phosphory...

journal_title：Oncogene

authors： Poppe M,Feller SM,Römer G,Wessler S

更新日期：2007-05-24 00:00:00

abstract：:The transcriptional activity of the androgen receptor (AR) is regulated by both ligand binding and post-translational modifications, including acetylation and small ubiquitin-like modifier (SUMO)ylation. Histone deacetylases (HDACs) are known to catalyze the removal of acetyl groups from both histones and non-histone ...

journal_title：Oncogene

authors： Yang Y,Tse AK,Li P,Ma Q,Xiang S,Nicosia SV,Seto E,Zhang X,Bai W

更新日期：2011-05-12 00:00:00

abstract：:Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma membrane invaginations (caveolae). Cav1 regulates multiple cancer-associated processes. In breast cancer, a tumor suppressive role for Cav1 has been suggested; however, Cav1 is frequently overexpressed in aggressive breast cancer subtypes, ...

journal_title：Oncogene

authors： Rao X,Evans J,Chae H,Pilrose J,Kim S,Yan P,Huang RL,Lai HC,Lin H,Liu Y,Miller D,Rhee JK,Huang YW,Gu F,Gray JW,Huang TM,Nephew KP

更新日期：2013-09-19 00:00:00

abstract：:Aggrus (also known as T1alpha/podoplanin) is a membrane sialoglycoprotein whose function in tumors is unknown. We recently determined that Aggrus possessed the ability of inducing platelet aggregation and that its expression was frequently upregulated in colorectal tumors. Thus, Aggrus expression might be associated w...

journal_title：Oncogene

authors： Kato Y,Sasagawa I,Kaneko M,Osawa M,Fujita N,Tsuruo T

更新日期：2004-11-04 00:00:00

abstract：:Pdcd4 is a novel transformation suppressor that is highly expressed in promotion-resistant (P-) mouse epidermal JB6 cells but not in susceptible (P+) cells. Overexpression of pdcd4 cDNA in stably transfected P+ cells rendered cells resistant to tumor promoter-induced transformation, indicating that elevated expression...

journal_title：Oncogene

authors： Yang HS,Jansen AP,Nair R,Shibahara K,Verma AK,Cmarik JL,Colburn NH

更新日期：2001-02-08 00:00:00

abstract：:Intrinsic and acquired resistance to anti-EGFR antibody therapy, frequently mediated by a mutant or amplified KRAS oncogene, is a significant challenge in the treatment of colorectal cancer (CRC). However, the mechanism of KRAS-mediated therapeutic resistance is not well understood. In this study, we demonstrate that ...

journal_title：Oncogene

authors： Knickelbein K,Tong J,Chen D,Wang YJ,Misale S,Bardelli A,Yu J,Zhang L

更新日期：2018-08-01 00:00:00

abstract：:Bloom's syndrome (BS) is an autosomal recessive disorder associated with an elevated incidence of cancers. The gene mutated in BS, BLM, encodes a RecQ helicase family member. BS cells exhibit genomic instability, including excessive homologous recombination and chromosomal aberrations. We reported previously that BS c...

journal_title：Oncogene

authors： Rassool FV,North PS,Mufti GJ,Hickson ID

更新日期：2003-11-27 00:00:00

abstract：:The W locus of mice encodes the c-kit receptor tyrosine kinase. Recently, we characterized a novel mutant allele, Wn, and demonstrated that the c-kit protein synthesized in Wn/Wn cultured mast cells (CMC) was reduced in size and not expressed on their surface (Tsujimura et al., 1993). In this study, we further examine...

journal_title：Oncogene

authors： Koshimizu U,Tsujimura T,Isozaki K,Nomura S,Furitsu T,Kanakura Y,Kitamura Y,Nishimune Y

更新日期：1994-01-01 00:00:00

abstract：:Prothymosin alpha (PT-alpha) is a nuclear protein involved in cell proliferation. Transcription of PT-alpha has been reported to be regulated by the c-myc gene in vitro. We identified PT-alpha as being overexpressed in a human colon cancer minus normal mucosa subtraction cDNA library. Northern blot (messenger RNA) ana...

journal_title：Oncogene

authors： Mori M,Barnard GF,Staniunas RJ,Jessup JM,Steele GD Jr,Chen LB

更新日期：1993-10-01 00:00:00

abstract：:Hepatocyte Growth Factor (HGF) exerts its biological effects via binding and activating a transmembrane protein tyrosine kinase receptor known as c-Met. Previous studies from our laboratory demonstrated that c-met gene expression is inducible by its own ligand (HGF). However, the molecular mechanism(s) involved in thi...

journal_title：Oncogene

authors： Seol DW,Chen Q,Zarnegar R

更新日期：2000-02-24 00:00:00

abstract：:Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory co...

journal_title：Oncogene

authors： Fonsatti E,Altomonte M,Nicotra MR,Natali PG,Maio M

更新日期：2003-09-29 00:00:00

abstract：:Caspase-8 is a key effector of death-receptor-triggered apoptosis. In a previous study, we demonstrated, however, that caspase-8 can also be activated in a death receptor-independent manner via the mitochondrial apoptosis pathway, downstream of caspase-3. Here, we show that caspases-3 and -8 mediate a mitochondrial am...

journal_title：Oncogene

authors： von Haefen C,Wieder T,Essmann F,Schulze-Osthoff K,Dörken B,Daniel PT

更新日期：2003-04-17 00:00:00