Characterization of transcription factor E2F complexes during muscle and neuronal differentiation.

abstract：:Constitutive NF-kappaB activity varies widely among cancer cell lines. In this report, we studied the expression and the role of different I kappaB inhibitors in adenocarcinoma cell lines. High constitutive NF-kappaB activity and low I kappaB-alpha expression was found in a number of these cell lines. Moreover, some o...

journal_title：Oncogene

authors： Dejardin E,Deregowski V,Chapelier M,Jacobs N,Gielen J,Merville MP,Bours V

更新日期：1999-04-22 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a kind of adult stem cells that can be isolated easily from bone marrow, adipose tissue, umbilical cord and many other tissues. MSCs have been shown to specifically migrate to inflammatory sites, including tumors, and hold great promise as tumor-specific vectors to deliver antitumor a...

journal_title：Oncogene

authors： Xu C,Lin L,Cao G,Chen Q,Shou P,Huang Y,Han Y,Wang Y,Shi Y

更新日期：2014-10-16 00:00:00

abstract：:The p21WAF1/CIP1/SDI1 gene is an important regulator of crucial cellular processes, including cell cycle control, cellular differentiation, and the response to genotoxic stress. Induction of p21 gene expression upon DNA damage is widely believed to be p53-dependent. In the present study we analysed the expression of p...

journal_title：Oncogene

authors： Butz K,Geisen C,Ullmann A,Zentgraf H,Hoppe-Seyler F

更新日期：1998-08-13 00:00:00

abstract：:We have used two different, but complementary assays to characterize functions of SV40 T antigen that are necessary for its ability to immortalize rat embryo fibroblasts. In accordance with previous work, we found that several functions were required. These include activities that map to the p53 binding domain and the...

journal_title：Oncogene

authors： Powell AJ,Darmon AJ,Gonos ES,Lam EW,Peden KW,Jat PS

更新日期：1999-12-02 00:00:00

abstract：:Bone morphogenetic protein 3B (BMP3B) is a member of the TGF-beta superfamily. The BMP3B promoter sequence was previously identified as a target for aberrant DNA methylation in non-small-cell lung cancer (NSCLC). Aberrant DNA hypermethylation in the BMP3B promoter is associated with downregulation of BMP3B transcripti...

journal_title：Oncogene

authors： Dai Z,Popkie AP,Zhu WG,Timmers CD,Raval A,Tannehill-Gregg S,Morrison CD,Auer H,Kratzke RA,Niehans G,Amatschek S,Sommergruber W,Leone GW,Rosol T,Otterson GA,Plass C

更新日期：2004-04-29 00:00:00

abstract：:Oncogenesis results from changes in kinetics or in abundance of proteins in signal transduction networks. Recently, it was shown that control of signalling cannot reside in a single gene product, and might well be dispersed over many components. Which of the reactions in these complex networks are most important, and ...

journal_title：Oncogene

authors： Hornberg JJ,Binder B,Bruggeman FJ,Schoeberl B,Heinrich R,Westerhoff HV

更新日期：2005-08-25 00:00:00

abstract：:A flow cytometric assay was developed to examine the expression of the cellular myc oncogene in relation to cell cycle in individual cells. C-myc-oncoprotein was detected by indirect immunofluorescence using a purified sheep polyclonal antibody, anti-human-myc. Specific binding of anti-human-myc was measured by flow c...

journal_title：Oncogene

authors： Mohamed AN,Nakeff A,Mohammad RM,KuKuruga M,al-Katib A

更新日期：1988-10-01 00:00:00

abstract：:In this study we have investigated DNA-protein interactions at an AP1-like motif of the neuropeptide tyrosine (NPY) promoter during in vitro differentiation of human neuroblastoma cells SH-SY5Y to mature nonproliferative sympathetic neuron-like cells. These neuroblast-like cells originate from the parental cell line S...

journal_title：Oncogene

authors： Jalava A,Mai S

更新日期：1994-08-01 00:00:00

abstract：:DAL-1 (differentially expressed in adenocarcinoma of the lung)/4.1B is a tumor suppressor gene on human chromosome 18p11.3 whose expression is lost in >50% of primary non-small-cell lung carcinomas. Based on sequence similarity, DAL-1/4.1B has been assigned to the Protein 4.1 superfamily whose members interact with pl...

journal_title：Oncogene

authors： Singh V,Miranda TB,Jiang W,Frankel A,Roemer ME,Robb VA,Gutmann DH,Herschman HR,Clarke S,Newsham IF

更新日期：2004-10-14 00:00:00

abstract：:Many components of the Wnt/β-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3α and GSK-3β) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion of GSK-3 in the mammary epit...

journal_title：Oncogene

authors： Dembowy J,Adissu HA,Liu JC,Zacksenhaus E,Woodgett JR

更新日期：2015-07-01 00:00:00

abstract：:A distinctive property of Hepatocyte Growth Factor (HGF) is its ability to induce differentiation of tubular structures from epithelial and endothelial cells (branching tubulogenesis). The HGF receptor directly activates PI3 kinase, Ras and STAT signalling pathways and phosphorylates the adaptator GRB2 Associated Bind...

journal_title：Oncogene

authors： Gual P,Giordano S,Williams TA,Rocchi S,Van Obberghen E,Comoglio PM

更新日期：2000-03-16 00:00:00

abstract：:There is a large body of evidence suggesting the connexin gap junction proteins appear to act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main function of cell coupling through gap junctions. However, some cancer cells (e.g. the rat bladder carcinoma BC31 cell line) are cell-...

journal_title：Oncogene

authors： Krutovskikh VA,Troyanovsky SM,Piccoli C,Tsuda H,Asamoto M,Yamasaki H

更新日期：2000-01-27 00:00:00

abstract：:In colorectal tumorigenesis, loss of function of the mismatch repair genes is closely associated with genomic instability at the nucleotide level whereas p53 deficiency has been linked with gross chromosomal instability. We have addressed the contribution of these two forms of genetic instability to tumorigenesis usin...

journal_title：Oncogene

authors： Toft NJ,Curtis LJ,Sansom OJ,Leitch AL,Wyllie AH,te Riele H,Arends MJ,Clarke AR

更新日期：2002-09-12 00:00:00

abstract：:The quail Pax-6 gene is expressed from two promoters named P0 and P1. P0 promoter is under the control of a neuroretina-specific enhancer (EP). This enhancer activates the P0 promoter specifically in neuroretina cells and in a developmental stage-dependent manner. The EP enhancer binds efficiently, as revealed by sout...

journal_title：Oncogene

authors： Plaza S,Aumercier M,Bailly M,Dozier C,Saule S

更新日期：1999-01-28 00:00:00

abstract：:The tumor suppressor gene Pdcd4 (programmed cell death gene 4) has drawn considerable attention because its downregulation is involved in the development of several types of cancer. Because Pdcd4 interacts with the translation initiation factor eIF4A and inhibits its helicase activity, Pdcd4 has been implicated in the...

journal_title：Oncogene

authors： Biyanee A,Ohnheiser J,Singh P,Klempnauer KH

更新日期：2015-03-12 00:00:00

abstract：:RAS-driven malignancies remain a major therapeutic challenge. The two-stage 7,12-dimethylbenz(a)anthracene (DMBA)/12-o-tetradecanoylphorbol-13-acetate (TPA) model of mouse skin carcinogenesis has been used to study mechanisms of epithelial tumor development by oncogenic Hras. We used mice with an Hras(G12V) knock-in a...

journal_title：Oncogene

authors： Chen X,Makarewicz JM,Knauf JA,Johnson LK,Fagin JA

更新日期：2014-11-20 00:00:00

abstract：:Neuroendocrine prostate cancer (NEPC) has increasingly become a clinical challenge. The mechanisms by which neuroendocrine (NE) cells arises from prostate adenocarcinoma cells are poorly understood. FOXA1 is a transcription factor of the forkhead family that is required for prostate epithelial differentiation. In this...

journal_title：Oncogene

authors： Kim J,Jin H,Zhao JC,Yang YA,Li Y,Yang X,Dong X,Yu J

更新日期：2017-07-13 00:00:00

abstract：:Embryonic stem (ES) cells have provided a valid model to understand early events of mammalian lineage specification and differentiation, leading to important insights into the mechanisms that control embryogenesis at the molecular and cellular levels. Furthermore, ES cells have recently evoked great scientific interes...

journal_title：Oncogene

authors： Minchiotti G

更新日期：2005-08-29 00:00:00

abstract：:Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...

journal_title：Oncogene

authors： Gooding AJ,Zhang B,Gunawardane L,Beard A,Valadkhan S,Schiemann WP

更新日期：2019-03-01 00:00:00

abstract：:Metastatic growth in breast cancer (BC) has been proposed as an exclusive property of cancer stem cells (CSCs). However, formal proof of their identity as cells of origin of recurrences at distant sites and the molecular events that may contribute to tumor cell dissemination and metastasis development are yet to be el...

journal_title：Oncogene

authors： Bartucci M,Dattilo R,Moriconi C,Pagliuca A,Mottolese M,Federici G,Benedetto AD,Todaro M,Stassi G,Sperati F,Amabile MI,Pilozzi E,Patrizii M,Biffoni M,Maugeri-Saccà M,Piccolo S,De Maria R

更新日期：2015-02-05 00:00:00

abstract：:The Mucin 1 (MUC1) protein is overexpressed in various cancers and mediates chemotherapy resistance. However, the mechanism is not fully understood. Given that most chemotherapeutic drugs disrupt ER homeostasis as part of their toxicity, and MUC1 expression is regulated by proteins involved in ER homeostasis, we inves...

journal_title：Oncogene

authors： Olou AA,King RJ,Yu F,Singh PK

更新日期：2020-04-01 00:00:00

abstract：:Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a histori...

journal_title：Oncogene

authors： Ferreira LM,Hebrant A,Dumont JE

更新日期：2012-09-06 00:00:00

abstract：:T-cell lymphoproliferative diseases are often associated with recurrent chromosomal translocations involving T cell receptor genes (TCR) and genes that are thought to play a role in the pathogenesis of these diseases. Whereas numerous such genes have already been identified in acute T cell leukemias, no candidate gene...

journal_title：Oncogene

authors： Stern MH,Soulier J,Rosenzwajg M,Nakahara K,Canki-Klain N,Aurias A,Sigaux F,Kirsch IR

更新日期：1993-09-01 00:00:00

abstract：:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box,...

journal_title：Oncogene

authors： Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MP

更新日期：1998-07-16 00:00:00

abstract：:The p53 tumour suppressor induces cell cycle arrest and apoptosis in response to cellular stresses. p53 is inactivated by various cellular and viral factors. We set out to generate regulatable p53 derivatives that are highly inducible by synthetic ligands, escape inactivation and efficiently induce apoptosis. We have ...

journal_title：Oncogene

authors： Sengupta S,Ralhan R,Wasylyk B

更新日期：2000-01-20 00:00:00

abstract：:We have compared the DNase I hypersensitivity of the regulatory region of two estrogen-regulated genes, pS2 and cathepsin D in hormone-dependent and -independent breast carcinoma cell lines. This strategy allowed the identification of two important control regions, one in pS2 and the other in cathepsin D genes. In the...

journal_title：Oncogene

authors： Giamarchi C,Solanas M,Chailleux C,Augereau P,Vignon F,Rochefort H,Richard-Foy H

更新日期：1999-01-14 00:00:00

abstract：:Chromosomal translocation t(X;14)(q28;q11) has been observed in patients with pro-lymphocytic T-cell leukaemia (T-PLL). In two cases of T-PLL, one of which was associated with Ataxia telangiectasia (AT), the chromosomal break occurred in two different introns of a gene c6.1A, located at the Xq28 locus. Fusion transcri...

journal_title：Oncogene

authors： Fisch P,Forster A,Sherrington PD,Dyer MJ,Rabbitts TH

更新日期：1993-12-01 00:00:00

abstract：:The p160 nuclear receptor co-activators represent a family of molecules, which are recruited by steroid nuclear receptors as well as other transcription factors that are overexpressed in several tumors. We investigated the role of one member of this family on the sensitivity of cells to apoptosis. We observed that ove...

journal_title：Oncogene

authors： Colo GP,Rubio MF,Nojek IM,Werbajh SE,Echeverría PC,Alvarado CV,Nahmod VE,Galigniana MD,Costas MA

更新日期：2008-04-10 00:00:00

abstract：:The p53 gene has been implicated as a tumor suppressor gene with mutations found in common human cancers. We examined 51 early stage, primary, resected non-small cell lung cancer specimens using an RNAase protection assay and cDNA sequencing. Mutations changing the p53 coding sequence were found in 23/51 (45%) tumor s...

journal_title：Oncogene

authors： Chiba I,Takahashi T,Nau MM,D'Amico D,Curiel DT,Mitsudomi T,Buchhagen DL,Carbone D,Piantadosi S,Koga H

更新日期：1990-10-01 00:00:00

abstract：:Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas af...

journal_title：Oncogene

authors： Wang Y,Sugiyama H,Axelson H,Panda CK,Babonits M,Ma A,Steinberg JM,Alt FW,Klein G,Wiener F

更新日期：1992-06-01 00:00:00