Involvement of poly (ADP-ribose)-polymerase in the Pax-6 gene regulation in neuroretina.

abstract：:p73 is a member of the p53 family. Recent studies have shown that DNA damage can stabilize p73 protein and enhance p73-mediated apoptosis in a c-Abl dependent manner. To determine what regulates p73 transcriptionally, we analysed the expression of p73 in several cell lines following genotoxic stresses. We found that p...

journal_title：Oncogene

authors： Chen X,Zheng Y,Zhu J,Jiang J,Wang J

更新日期：2001-02-08 00:00:00

abstract：:Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small inter...

journal_title：Oncogene

authors： Rzymski T,Milani M,Pike L,Buffa F,Mellor HR,Winchester L,Pires I,Hammond E,Ragoussis I,Harris AL

更新日期：2010-08-05 00:00:00

abstract：:Deregulated expression of c-Myc has been shown to induce or enhance apoptosis in various different cell types. c-Myc requires p53 for apoptosis in some but not all the cell types, indicating heterogeneous mechanisms for c-Myc-induced apoptosis. In B lymphoma line WEHI-231, stable expression of c-Myc has been demonstra...

journal_title：Oncogene

authors： Hagiyama H,Adachi T,Yoshida T,Nomura T,Miyasaka N,Honjo T,Tsubata T

更新日期：1999-07-15 00:00:00

abstract：:Alterations affecting the epidermal growth factor (EGF)/transforming growth factor alpha (TGF alpha)-responsive mitogenic pathway are frequently detected in malignancies. In particular, the EGF-receptor (EGFR) molecule has been found overexpressed in a number of human tumors, and TGF alpha is produced by a large array...

journal_title：Oncogene

authors： Di Marco E,Pierce JH,Fleming TP,Kraus MH,Molloy CJ,Aaronson SA,Di Fiore PP

更新日期：1989-07-01 00:00:00

abstract：:Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an important role in the development of cancer, including HPV-related tum...

journal_title：Oncogene

authors： Peta E,Sinigaglia A,Masi G,Di Camillo B,Grassi A,Trevisan M,Messa L,Loregian A,Manfrin E,Brunelli M,Martignoni G,Palù G,Barzon L

更新日期：2018-03-01 00:00:00

abstract：:Mouse embryonal carcinoma (EC) cells of the P19 line can be induced to differentiate into neurons, astrocytes and fibroblasts by exposure to retinoic acid (RA), whereas treatment of the EC cells with dimethyl sulfoxide (DMSO) leads to differentiation into mesodermal tissues, including cardiac and skeletal muscle. In R...

journal_title：Oncogene

authors： St-Arnaud R,Nepveu A,Marcu KB,McBurney MW

更新日期：1988-11-01 00:00:00

abstract：:Ovarian endometrioid adenocarcinomas (OEAs) frequently exhibit constitutive activation of canonical WNT signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the β-catenin protein. In previous work, we used microarray-based methods to compare gene expression in OEAs with and without dysr...

journal_title：Oncogene

authors： Zhai Y,Iura A,Yeasmin S,Wiese AB,Wu R,Feng Y,Fearon ER,Cho KR

更新日期：2011-10-06 00:00:00

abstract：:E1A of human adenovirus type 5 (Ad5) encodes proteins of 289 and 243 residues (289R and 243R) which differ only by the 46 amino acid CR3 region known to activate expression of certain cellular and early viral genes. E1A proteins also induce DNA synthesis and cell transformation, but as well can stimulate apoptosis. Tw...

journal_title：Oncogene

authors： Teodoro JG,Shore GC,Branton PE

更新日期：1995-08-03 00:00:00

abstract：:Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a histori...

journal_title：Oncogene

authors： Ferreira LM,Hebrant A,Dumont JE

更新日期：2012-09-06 00:00:00

abstract：:Rapamycin, a natural product inhibitor of the Raptor-mammalian target of rapamycin complex (mTORC1), is known to induce Protein kinase B (Akt/PKB) Ser-473 phosphorylation in a subset of human cancer cell lines through inactivation of S6K1, stabilization of insulin receptor substrate (IRS)-1, and increased signaling th...

journal_title：Oncogene

authors： Han EK,Leverson JD,McGonigal T,Shah OJ,Woods KW,Hunter T,Giranda VL,Luo Y

更新日期：2007-08-16 00:00:00

abstract：:The role of poly (ADP-ribose) polymerase 1 (PARP1) in cancer has been extensively studied in the context of DNA repair, leading to clinical trials of PARP1 inhibitors in cancers defective in homologous recombination. However, the DNA repair-independent roles of PARP1 in carcinogenesis and metastasis, particularly in l...

journal_title：Oncogene

authors： Choi EB,Yang AY,Kim SC,Lee J,Choi JK,Choi C,Kim MY

更新日期：2016-09-01 00:00:00

abstract：:Ectopic expression of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse melanocytes induces melanoma formation. Although requirement of mGluR1 for development of melanoma in the initial stage has been demonstrated, its role in melanoma growth in vivo remains unclear. In this study, we developed novel transge...

journal_title：Oncogene

authors： Ohtani Y,Harada T,Funasaka Y,Nakao K,Takahara C,Abdel-Daim M,Sakai N,Saito N,Nishigori C,Aiba A

更新日期：2008-12-04 00:00:00

abstract：:The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to mesenchymal transition and promote colorectal cancer. However, due to its essential role in gut homeostasis, therapeutic targeting of this pathway has proven challenging. Additionally, IL-6/Stat-3 signaling, activated by microbial tran...

journal_title：Oncogene

authors： Ahmad R,Kumar B,Chen Z,Chen X,Müller D,Lele SM,Washington MK,Batra SK,Dhawan P,Singh AB

更新日期：2017-11-23 00:00:00

abstract：:Previous work by others has revealed homology between the rel oncogene and the transcription factor NF-kappa B. Further, in vitro-translated v-rel protein and c-rel protein are able to bind to an oligonucleotide containing the kappa B binding site. Unlike the in vitro-translated product, cellular Rel protein exists in...

journal_title：Oncogene

authors： Kochel T,Rice NR

更新日期：1992-03-01 00:00:00

abstract：:The epidermal growth factor (EGF)/EGF-receptor (ErbB1-4) family is involved in the biology of multiple myeloma (MM). In particular, ErbB-specific inhibitors induce strong apoptosis of myeloma cells (MMC) in vitro. To delineate the contribution of the 10 EGF-family ligands to the pathogenesis of MM, we have assessed th...

journal_title：Oncogene

authors： Mahtouk K,Cremer FW,Rème T,Jourdan M,Baudard M,Moreaux J,Requirand G,Fiol G,De Vos J,Moos M,Quittet P,Goldschmidt H,Rossi JF,Hose D,Klein B

更新日期：2006-11-16 00:00:00

abstract：:The genes for the M2 subunit of ribonucleotide reductase (RRM2), ornithine decarboxylase (ODC1), and 55,000-Daltons protein (P5), are amplified in hydroxyurea-resistant hamster and human cell lines. These genomic sequences have been mapped to hamster chromosome 7 and to human chromosome 2p24-25 near the cytogenetic lo...

journal_title：Oncogene

authors： Tonin PN,Yeger H,Stallings RL,Srinivasan PR,Lewis WH

更新日期：1989-09-01 00:00:00

abstract：:An Ets-related E1A-F has been characterized as an enhancer-binding protein for the adenovirus E1A gene. Here we show, in transient expression assays, that E1A-F can activate three different subclasses of the matrix metalloproteinase gene promoters. Expressions of the chloramphenicol acetyltransferase (CAT) reporter ge...

journal_title：Oncogene

authors： Higashino F,Yoshida K,Noumi T,Seiki M,Fujinaga K

更新日期：1995-04-06 00:00:00

abstract：:Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial growth factor signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via subsequent activation of alternative pathways. Through genome-scale i...

journal_title：Oncogene

authors： Chen CH,Fong LWR,Yu E,Wu R,Trott JF,Weiss RH

更新日期：2017-06-22 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (G(i), G(q) and G(12/1...

journal_title：Oncogene

authors： Kranenburg O,Moolenaar WH

更新日期：2001-03-26 00:00:00

abstract：:cDNA clones of the ski-related gene, sno, were isolated from a chicken cDNA library and sequenced. In contrast to the human system, from which two forms of sno cDNAs have been isolated, we obtained only one type of chicken sno cDNA, that encoding snoN. The coding region for chicken snoN was inserted into the retrovira...

journal_title：Oncogene

authors： Boyer PL,Colmenares C,Stavnezer E,Hughes SH

更新日期：1993-02-01 00:00:00

abstract：:We have developed a new yeast-based assay for the detection of PTEN nonsense mutation, and applied it to a total of 42 astrocytic tumors. The assay utilizes homologous recombination of PCR-amplified PTEN cDNA samples to a yeast vector which expresses an in-frame PTEN::ADE2 chimera protein. An allele of nonsense mutati...

journal_title：Oncogene

authors： Zhang CL,Tada M,Kobayashi H,Nozaki M,Moriuchi T,Abe H

更新日期：2000-09-07 00:00:00

abstract：:The oncoprotein Qin is a member of the winged helix family of transcriptional regulators. The region C-terminal to its winged helix DNA-binding domain is required for transformation of chicken embryo fibroblasts. We isolated the corepressor TLE1 as a binding partner for Qin in a yeast two-hybrid screen and localized t...

journal_title：Oncogene

authors： Sonderegger CK,Vogt PK

更新日期：2003-03-27 00:00:00

abstract：:Centrosome hyperamplification and the consequential mitotic defects contribute to chromosome instability in cancers. Loss or mutational inactivation of p53 has been shown to induce chromosome instability through centrosome hyperamplification. It has recently been found that Cdk2-cyclin E is involved in the initiation ...

journal_title：Oncogene

authors： Mussman JG,Horn HF,Carroll PE,Okuda M,Tarapore P,Donehower LA,Fukasawa K

更新日期：2000-03-23 00:00:00

abstract：:Loss of p53 function is associated with the acquisition of cisplatin resistance in the human ovarian adenocarcinoma A2780 cell line. Selection for cisplatin resistance of A2780 cells was used to isolate genetic suppressor elements (GSEs) from a retroviral library expressing random fragments of human or murine TP53 cDN...

journal_title：Oncogene

authors： Gallagher WM,Cairney M,Schott B,Roninson IB,Brown R

更新日期：1997-01-16 00:00:00

abstract：:One-carbon metabolism plays a central role in a broad array of metabolic processes required for the survival and growth of tumor cells. However, the molecular basis of how one-carbon metabolism may influence RNA methylation and tumorigenesis remains largely unknown. Here we show MTHFD2, a mitochondrial enzyme involved...

journal_title：Oncogene

authors： Green NH,Galvan DL,Badal SS,Chang BH,LeBleu VS,Long J,Jonasch E,Danesh FR

更新日期：2019-08-01 00:00:00

abstract：:Receptor crosstalk is an emerging and recurrent theme in cytokine and growth factor signaling; however, insight into the mechanism(s) underlying these interactions remains limited. Recently, we reported that crosstalk occurs between ErbB3 and the interferon alpha (IFN-alpha) signaling complex in the myeloma cell line ...

journal_title：Oncogene

authors： Walters DK,Jelinek DF

更新日期：2004-02-12 00:00:00

abstract：:The reversible interaction of the retinoblastoma susceptibility gene product (Rb) with the cellular transcription factor E2F has recently been demonstrated. Activation of the adenovirus E2a promoter by the products of the viral E1a gene correlates with the ability of both early E1a proteins to sequester Rb, thereby re...

journal_title：Oncogene

authors： Bocco JL,Reimund B,Chatton B,Kedinger C

更新日期：1993-11-01 00:00:00

abstract：:Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway emerges as a critical modulator in liver TIC self-renewal. However, the molecular mechanism of Wnt/β-catenin initiation in liver tumori...

journal_title：Oncogene

authors： Chen Z,Gao Y,Yao L,Liu Y,Huang L,Yan Z,Zhao W,Zhu P,Weng H

更新日期：2018-06-01 00:00:00

abstract：:Cellular adhesion to extracellular matrix is a central phenomenon for the maintenance of tissue integrity and cellular movement. Collectively, these processes are regulated by a fine-tuned balance between the formation and loosening of adhesive contacts, a process involving integrins, and the elevation and diminution ...

journal_title：Oncogene

authors： Sales KJ,Boddy SC,Jabbour HN

更新日期：2008-04-10 00:00:00

abstract：:Members of the Myc proto-oncogene family encode transcription factors that function in multiple aspects of cell behavior, including proliferation, differentiation, transformation and apoptosis. Recent studies have shown that MYC activities are modulated by a network of nuclear bHLH-Zip proteins. The MAX protein is at ...

journal_title：Oncogene

authors： Quéva C,Hurlin PJ,Foley KP,Eisenman RN

更新日期：1998-02-26 00:00:00