Uncoupling of p21WAF1/CIP1/SDI1 mRNA and protein expression upon genotoxic stress.

abstract：:Sp1 is important for the transcription of many genes. Our previous studies have shown that Sp1 is degraded in normal cell, but it is preserved in cancer cells during mitosis and exists a priori in the daughter cells, ready to engage in gene transcription and thereby contributes to the proliferation and survival of can...

journal_title：Oncogene

authors： Chuang JY,Wang SA,Yang WB,Yang HC,Hung CY,Su TP,Chang WC,Hung JJ

更新日期：2012-11-22 00:00:00

abstract：:Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link betwee...

journal_title：Oncogene

authors： Zhou W,Sun W,Yung MMH,Dai S,Cai Y,Chen CW,Meng Y,Lee JB,Braisted JC,Xu Y,Southall NT,Shinn P,Huang X,Song Z,Chen X,Kai Y,Cai X,Li Z,Hao Q,Cheung ANY,Ngan HYS,Liu SS,Barak S,Hao J,Dai Z,Tzatsos A,Peng W

更新日期：2018-07-01 00:00:00

abstract：:Tumor suppressor Pdcd4 has recently been shown to inhibit invasion by activating activator protein-1 (AP-1); however, little is known of the functionally significant Pdcd4-target genes. The urokinase receptor (u-PAR) promotes invasion/metastasis, and is associated with poor cancer-patient survival. The present study w...

journal_title：Oncogene

authors： Leupold JH,Yang HS,Colburn NH,Asangani I,Post S,Allgayer H

更新日期：2007-07-05 00:00:00

abstract：:Although it has been demonstrated that transformed progenitor cell population can contribute to tumor initiation, factors contributing to this malignant transformation are poorly known. Using in vitro and xenograft-based models, previous studies demonstrated that miR-489 acts as a tumor suppressor miRNA by targeting v...

journal_title：Oncogene

authors： Patel Y,Soni M,Awgulewitsch A,Kern MJ,Liu S,Shah N,Singh UP,Chen H

更新日期：2019-01-01 00:00:00

abstract：:A yeast two-hybrid screen has identified HBP1 as a transcription factor capable of interacting with the pocket protein family. We show that HBP1 can interact with one of these, RB, both in vitro and in mammalian cells. Two distinct RB binding sites are present within HBP1--a high affinity binding site, mediated by an ...

journal_title：Oncogene

authors： Lavender P,Vandel L,Bannister AJ,Kouzarides T

更新日期：1997-06-05 00:00:00

abstract：:The biological outcome of TMPRSS2:ERG chromosomal translocations in prostate cancer (PC) remains poorly understood. To address this, we compared the transcriptional effects of TMPRSS2:ERG expression in a transgenic mouse model with those of ERG knockdown in a TMPRSS2:ERG-positive PC cell line. This reveals that ERG re...

journal_title：Oncogene

authors： Mounir Z,Lin F,Lin VG,Korn JM,Yu Y,Valdez R,Aina OH,Buchwalter G,Jaffe AB,Korpal M,Zhu P,Brown M,Cardiff RD,Rocnik JL,Yang Y,Pagliarini R

更新日期：2015-07-01 00:00:00

abstract：:This study addresses the question of whether loss of p16INK4 expression contributes to the immortalization of human cells. In vitro immortalization usually proceeds through two phases. In the first phase (lifespan extension), cells continue proliferating and their telomeres continue shortening beyond the point at whic...

journal_title：Oncogene

authors： Noble JR,Rogan EM,Neumann AA,Maclean K,Bryan TM,Reddel RR

更新日期：1996-09-19 00:00:00

abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

journal_title：Oncogene

authors： Sachsenmaier C,Sadowski HB,Cooper JA

更新日期：1999-06-17 00:00:00

abstract：:Melanoma-associated antigen A1 (MAGEA1) is member of the MAGE gene family that is expressed in male germ line cells and placenta under normal physiological conditions. Although MAGEA1's expression levels have been evaluated as one of the cancer testis (CT) antigens for immunotherapy in melanoma and several other cance...

journal_title：Oncogene

authors： Zhao J,Wang Y,Mu C,Xu Y,Sang J

更新日期：2017-08-31 00:00:00

abstract：:Expression of polyomavirus middle-T antigen (middle-T) is involved in the formation of various tumors in vivo, e.g. hemangiomas and mammary gland tumors. Several genes have been shown to be activated in middle-T-expressing cells, but the underlying mechanisms have only been partially elucidated. Among the genes regula...

journal_title：Oncogene

authors： Besser D,Urich M,Sakaue M,Messerschmitt A,Ballmer-Hofer K,Nagamine Y

更新日期：1995-12-07 00:00:00

abstract：:Latent membrane protein 1 (LMP1), an oncoprotein encoded by Epstein-Barr virus (EBV), is an integral membrane protein, which acts like a constitutively active receptor. LMP1 is critical for some facet of EBV's induction and maintenance of proliferation of infected B cells. It, in part, mimics signaling by the CD40 rec...

journal_title：Oncogene

authors： Dirmeier U,Hoffmann R,Kilger E,Schultheiss U,Briseño C,Gires O,Kieser A,Eick D,Sugden B,Hammerschmidt W

更新日期：2005-03-03 00:00:00

abstract：:Atypical protein kinase C (aPKC) and Lethal giant larvae (Lgl) regulate apical-basal polarity in Drosophila and mammalian epithelia. At the apical domain, aPKC phosphorylates and displaces Lgl that, in turn, maintains aPKC inactive at the basolateral region. The mutual exclusion of these two proteins seems to be cruci...

journal_title：Oncogene

authors： Grifoni D,Garoia F,Bellosta P,Parisi F,De Biase D,Collina G,Strand D,Cavicchi S,Pession A

更新日期：2007-08-30 00:00:00

abstract：:We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking change in cell morphology characterized by outgrowth of filopodia and processes. A similar morphological response...

journal_title：Oncogene

authors： Haapasalo A,Saarelainen T,Moshnyakov M,Arumäe U,Kiema TR,Saarma M,Wong G,Castrén E

更新日期：1999-02-11 00:00:00

abstract：:Resistance to anti-HER2 (human epithelial growth factor receptor 2) trastuzumab therapy occurs commonly in HER2-positive breast cancer and involves overactivation of HER2 and/or AKT1. Using the model of trastuzumab-sensitive or trastuzumab-resistant HER2-positive cells with wild-type PTEN, negative regulator of AKT1, ...

journal_title：Oncogene

authors： Kulkarni S,Reddy KB,Esteva FJ,Moore HC,Budd GT,Tubbs RR

更新日期：2010-03-04 00:00:00

abstract：:The heterogeneous breast cancers can be classified into different subtypes according to their histopathological characteristics and molecular signatures. Foxa1 expression is linked with luminal breast cancer (LBC) with good prognosis, whereas Twist1 expression is associated with basal-like breast cancer (BLBC) with po...

journal_title：Oncogene

authors： Xu Y,Qin L,Sun T,Wu H,He T,Yang Z,Mo Q,Liao L,Xu J

更新日期：2017-02-23 00:00:00

abstract：:As tumors grow and invade beyond their homeostatic limits, the tumor cells are subjected to insufficient nutrient and oxygen supplies because of excessive demand for nutrition and oxygen, and insufficient vascularization. We therefore hypothesized that tolerance to nutrient deprivation as well as angiogenesis may be c...

journal_title：Oncogene

authors： Kato K,Ogura T,Kishimoto A,Minegishi Y,Nakajima N,Miyazaki M,Esumi H

更新日期：2002-09-05 00:00:00

abstract：:Epidermal squamous cell carcinoma (SCC) is a common and highly invasive form of cancer. SCC arises due to ultraviolet light exposure and is associated with increased expression of pro-cancer genes and reduced expression of cancer suppressors. Actin-Like Protein 6A (ACTL6A, BAF53a) is an important protein subunit of th...

journal_title：Oncogene

authors： Shrestha S,Adhikary G,Xu W,Kandasamy S,Eckert RL

更新日期：2020-09-01 00:00:00

abstract：:The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor growth due to loss...

journal_title：Oncogene

authors： Dong H,Ma L,Gan J,Lin W,Chen C,Yao Z,Du L,Zheng L,Ke C,Huang X,Song H,Kumar R,Yeung SC,Zhang H

更新日期：2017-01-19 00:00:00

abstract：:Mammalian nuclear Dbf2-related (NDR) kinases (LATS1 and 2, NDR1 and 2) play a role in cell proliferation, apoptosis and morphological changes. These kinases are regulated by mammalian sterile 20-like kinases (MSTs) and Mps one binder (MOB) 1. Okadaic acid (OA), which activates MST2, facilitates the complex formation o...

journal_title：Oncogene

authors： Hirabayashi S,Nakagawa K,Sumita K,Hidaka S,Kawai T,Ikeda M,Kawata A,Ohno K,Hata Y

更新日期：2008-07-17 00:00:00

abstract：:Recognition and elimination of malignant cells by cytotoxic T lymphocytes depends on antigenic peptides generated by proteasomes. It has been established that impairment of the immunoproteasome subunits, that is, PSMB8, PSMB9 and PSMB10 (PSMBs), is critical for malignant cells to escape immune recognition. We report h...

journal_title：Oncogene

authors： Yang XW,Wang P,Liu JQ,Zhang H,Xi WD,Jia XH,Wang KK

更新日期：2014-05-22 00:00:00

abstract：:The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous cell carcinoma cell lines following irradiation. Isogenic p53-null radioresistant cancer cells established through cumulative irradi...

journal_title：Oncogene

authors： Chang HW,Kim MR,Lee HJ,Lee HM,Kim GC,Lee YS,Nam HY,Lee M,Jang HJ,Lee KE,Lee JC,Byun Y,Kim SW,Kim SY

更新日期：2019-05-01 00:00:00

abstract：:The effect of p53-dependent cell-cycle arrest and senescence on Emu-myc-induced B-cell lymphoma development remains controversial. To address this question, we crossed Emu-myc mice with the p53(515C) mutant mouse, encoding the mutant p53R172P protein that retains the ability to activate the cell-cycle inhibitor and se...

journal_title：Oncogene

authors： Post SM,Quintás-Cardama A,Terzian T,Smith C,Eischen CM,Lozano G

更新日期：2010-03-04 00:00:00

abstract：:Deletion or loss-of-function mutation of LKB1, frequently occurring in non-small cell lung cancers (NSCLCs), is a predominant caution of NSCLC initiation and progression. However, the upstream signaling pathways governing LKB1 activation are largely unknown. Here, we report that LKB1 undergoes Aurora kinase A (AURKA)-...

journal_title：Oncogene

authors： Zheng X,Chi J,Zhi J,Zhang H,Yue D,Zhao J,Li D,Li Y,Gao M,Guo J

更新日期：2018-01-25 00:00:00

abstract：:In order to assess the functional contribution of the human c-myc promoter region in the expression of the c-myc gene, transgenic mouse lines containing a bacterial lac Z gene encoding beta-galactosidase under the control of the human c-myc protooncogene promoter were generated. Transgenic mouse embryos heterozygous f...

journal_title：Oncogene

authors： Jones DE Jr,Cui DM,Miller DM

更新日期：1995-06-15 00:00:00

abstract：:Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid modulator of allergic and inflammatory reactions, is diverse and functions as a modulator of a variety of physiological and pathological events in many cell types and tissues. Its role (if any) in modulating the prolifera...

journal_title：Oncogene

authors： Wang H,Chakrabarty S

更新日期：2003-04-10 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse human cancers, this kinase is a key therapeutic target. Redd1 is a negative regulator of mTOR, mediati...

journal_title：Oncogene

authors： Jin HO,Seo SK,Kim YS,Woo SH,Lee KH,Yi JY,Lee SJ,Choe TB,Lee JH,An S,Hong SI,Park IC

更新日期：2011-09-01 00:00:00

abstract：:Chromosome 8 loss of heterozygosity (LOH) in cancer of the urinary bladder is associated with high tumour grade and stage. We have screened 193 cases of transitional cell carcinoma (TCC) of the bladder using 30 microsatellite polymorphisms on chromosome 8. Forty three cases (22%) showed LOH on 8p, the majority of whic...

journal_title：Oncogene

authors： Takle LA,Knowles MA

更新日期：1996-03-07 00:00:00

abstract：:Myeloid differentiation is a highly regulated process governed by various cytokines, such as EPO, TPO, G-CSF, IL-3, IL-5 and GM-CSF. These cytokines act in part through activation of the STAT transcription factor family. In particular, various isoforms of STAT3 and STAT5 are activated during myeloid differentiation in...

journal_title：Oncogene

authors： Coffer PJ,Koenderman L,de Groot RP

更新日期：2000-05-15 00:00:00

abstract：:Endothelial cells expressing fibroblast growth factor receptor-1 (FGFR-1) migrate and proliferate in response to treatment with FGF. We analysed ligand-induced migration and proliferation of porcine aortic endothelial cells expressing wild-type FGFR-1, point-mutated Y766F FGFR-1, unable to activate phospholipase C-gam...

journal_title：Oncogene

authors： Landgren E,Klint P,Yokote K,Claesson-Welsh L

更新日期：1998-07-23 00:00:00

abstract：:PTEN, encoding a lipid phosphatase, is a tumor suppressor gene and is mutated in various types of cancers. It is reported to regulate G1 to S phase transition of the cell cycle by influencing the expression, protein stability and subcellular location of cyclin D1. Here, we provide evidence that PTEN modulates the tran...

journal_title：Oncogene

authors： Huang W,Chang HY,Fei T,Wu H,Chen YG

更新日期：2007-04-12 00:00:00