Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding.

abstract：:The nucleolus is one of the functional nuclear compartments in which the ribosome biogenesis takes place. Proteomic analysis revealed a large number of nucleolar proteins that are involved in diverse cellular processes, including biogenesis of ribonucleoprotein particles, stress responses, cell proliferation and cell ...

journal_title：Oncogene

authors： Yao Z,Duan S,Hou D,Wang W,Wang G,Liu Y,Wen L,Wu M

更新日期：2010-03-25 00:00:00

abstract：:High frequencies of allelic loss on the short arm of chromosome 3 in small cell lung cancer (SCLC) and a number of other tumors suggest the existence of a tumor suppressor gene(s) within the deleted regions. Two small cell lung cancer lines, NCI H740 and GLC20, have been described which have homozygous deletions in th...

journal_title：Oncogene

authors： Todd MC,Xiang RH,Garcia DK,Kerbacher KE,Moore SL,Hensel CH,Liu P,Siciliano MJ,Kok K,van den Berg A,Veldhuis P,Buys CH,Killary AM,Naylor SL

更新日期：1996-12-05 00:00:00

abstract：:Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by eliminating Chk1-mediated checkpoint responses. Using mouse models, we...

journal_title：Oncogene

authors： Origanti S,Cai SR,Munir AZ,White LS,Piwnica-Worms H

更新日期：2013-01-31 00:00:00

abstract：:Reexpression of hypermethylated tumor suppressor genes using DNA methyltransferase (DNMT) and histone deacetylase inhibitors occurs by a mechanism whereby promoter demethylation is the dominant event. In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promot...

journal_title：Oncogene

authors： Lakshmikuttyamma A,Scott SA,DeCoteau JF,Geyer CR

更新日期：2010-01-28 00:00:00

abstract：:The antifolates were the first class of antimetabolites to enter the clinics more than 50 years ago. Over the following decades, a full understanding of their mechanisms of action and chemotherapeutic potential evolved along with the mechanisms by which cells develop resistance to these drugs. These principals served ...

journal_title：Oncogene

authors： Zhao R,Goldman ID

更新日期：2003-10-20 00:00:00

abstract：:The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast cancer. ATM signalling is constitutively activated in early stages of diverse types of human malignancies and c...

journal_title：Oncogene

authors： Tommiska J,Bartkova J,Heinonen M,Hautala L,Kilpivaara O,Eerola H,Aittomäki K,Hofstetter B,Lukas J,von Smitten K,Blomqvist C,Ristimäki A,Heikkilä P,Bartek J,Nevanlinna H

更新日期：2008-04-10 00:00:00

abstract：:Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements in tumors. Different DNA damage response proteins were shown to regul...

journal_title：Oncogene

authors： Ozeri-Galai E,Schwartz M,Rahat A,Kerem B

更新日期：2008-04-03 00:00:00

abstract：:The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss als...

journal_title：Oncogene

authors： Hunter JE,Butterworth JA,Zhao B,Sellier H,Campbell KJ,Thomas HD,Bacon CM,Cockell SJ,Gewurz BE,Perkins ND

更新日期：2016-06-30 00:00:00

abstract：:The transcription factor PU.1 is essential for terminal myeloid differentiation, B- and T-cell development, erythropoiesis and hematopoietic stem cell maintenance. PU.1 functions as oncogene in Friend virus-induced erythroleukemia and as tumor suppressor in acute myeloid leukemias. Moreover, Friend virus-induced eryth...

journal_title：Oncogene

authors： Tschan MP,Reddy VA,Ress A,Arvidsson G,Fey MF,Torbett BE

更新日期：2008-05-29 00:00:00

abstract：:Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not. Serine, glutamic acid, and prolin...

journal_title：Oncogene

authors： Roussel MF,Downing JR,Sherr CJ

更新日期：1990-01-01 00:00:00

abstract：:Detachment of non-malignant epithelial cells from the extracellular matrix causes their apoptosis, a phenomenon called anoikis. By contrast, carcinoma cells are anoikis-resistant, and this resistance is thought to be critical for tumor progression. Many oncogenes trigger not only anti- but also pr-apoptotic signals. T...

journal_title：Oncogene

authors： Yoo BH,Masson O,Li Y,Khan IA,Gowda PS,Rosen KV

更新日期：2015-09-17 00:00:00

abstract：:We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...

journal_title：Oncogene

authors： Kuga H,Morisaki T,Nakamura K,Onishi H,Noshiro H,Uchiyama A,Tanaka M,Katano M

更新日期：2003-10-30 00:00:00

abstract：:To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease proc...

journal_title：Oncogene

authors： Peng WX,Koirala P,Mo YY

更新日期：2017-10-12 00:00:00

abstract：:Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81 results in hypersensitivity to DNA-damaging agents, defects on both t...

journal_title：Oncogene

authors： Ghamrasni SE,Cardoso R,Li L,Guturi KK,Bjerregaard VA,Liu Y,Venkatesan S,Hande MP,Henderson JT,Sanchez O,Hickson ID,Hakem A,Hakem R

更新日期：2016-09-15 00:00:00

abstract：:MSH2 and MLH1 have a central role in correcting mismatches in DNA occurring during DNA replication and have been implicated in the engagement of apoptosis induced by a number of cytotoxic anticancer agents. The function of MLH1 is not clearly defined, although it is required for mismatch repair (MMR) and engagement of...

journal_title：Oncogene

authors： Mac Partlin M,Homer E,Robinson H,McCormick CJ,Crouch DH,Durant ST,Matheson EC,Hall AG,Gillespie DA,Brown R

更新日期：2003-02-13 00:00:00

abstract：:Hepatocyte growth factor (HGF) is an important multifunctional cytokine whose gene expression is regulated mainly at the transcriptional level. Previous studies using transgenic mice as well as in vitro analyses showed that a potential regulatory element(s) exists between -260 to -230 bp in the upstream region of the ...

journal_title：Oncogene

authors： Jiang JG,Gao B,Zarnegar R

更新日期：2000-05-25 00:00:00

abstract：:Recent studies suggest that medulloblastoma, the most common malignant brain tumor of childhood, is comprised of four disease variants. The WIP1 oncogene is overexpressed in Group 3 and 4 tumors, which contain medulloblastomas with the most aggressive clinical behavior. Our data demonstrate increased WIP1 expression i...

journal_title：Oncogene

authors： Buss MC,Remke M,Lee J,Gandhi K,Schniederjan MJ,Kool M,Northcott PA,Pfister SM,Taylor MD,Castellino RC

更新日期：2015-02-26 00:00:00

abstract：:Tumor recurrence following treatment remains a major clinical challenge in oral cavity cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been considered as the driving force of tumor recurrence and metastasis. However, it still remains unclear whether targeting CSCs in oral cancer is a cl...

journal_title：Oncogene

authors： Hu J,Mirshahidi S,Simental A,Lee SC,De Andrade Filho PA,Peterson NR,Duerksen-Hughes P,Yuan X

更新日期：2019-07-01 00:00:00

abstract：:Inhibition of apoptosis or abnormal cell survival can result in tumorigenesis by facilitating the insurgence of various mutations. Immediate-early response gene X-1 (IEX-1), protects T cells from apoptosis induced by the ligation of Fas or the T-cell receptor (TCR)/CD3 complex in Emu-IEX-1 mice that direct the gene ex...

journal_title：Oncogene

authors： Zhang Y,Finegold MJ,Porteu F,Kanteti P,Wu MX

更新日期：2003-10-09 00:00:00

abstract：:The epidermis is continually exposed to harmful mutagens that have the potential to cause DNA damage. To protect the skin from accumulating mutated cells, keratinocytes have developed a highly regulated mechanism of eliminating damaged cells through apoptosis. Bcl-xL is a well-described cell survival protein that when...

journal_title：Oncogene

authors： Taylor JK,Zhang QQ,Monia BP,Marcusson EG,Dean NM

更新日期：1999-08-05 00:00:00

abstract：:Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms, including by mediating tumor-promoting inflammation. Immune modulation in the tumor microenvironment plays a central role in determining disease outcome. Howe...

journal_title：Oncogene

authors： Cohen N,Shani O,Raz Y,Sharon Y,Hoffman D,Abramovitz L,Erez N

更新日期：2017-08-01 00:00:00

abstract：:Telomeres are stabilized, and telomeric DNA is replenished, by the action of the ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the ability of telomeres to protect chromosome ends from cellular DNA-damage responses such as cell cycle arrest or apoptosis. This property of telomer...

journal_title：Oncogene

authors： Chan SW,Blackburn EH

更新日期：2002-01-21 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT), marked by the dissolution of cell-cell junctions, loss of cell polarity and increased cell motility, is one of the essential steps for prostate cancer metastasis. However, the underlying mechanism has not been fully explored. We report in this study that Shp2 is upregulated ...

journal_title：Oncogene

authors： Zhang K,Zhao H,Ji Z,Zhang C,Zhou P,Wang L,Chen Q,Wang J,Zhang P,Chen Z,Zhu HH,Gao WQ

更新日期：2016-03-10 00:00:00

abstract：:Cancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells (GSCs). However, little is known about the molecular mechanisms of cell cycle regulation that discriminate between GSCs an...

journal_title：Oncogene

authors： Koyama-Nasu R,Nasu-Nishimura Y,Todo T,Ino Y,Saito N,Aburatani H,Funato K,Echizen K,Sugano H,Haruta R,Matsui M,Takahashi R,Manabe E,Oda T,Akiyama T

更新日期：2013-08-15 00:00:00

abstract：:Tumor necrosis factor (TNF) induces both cell death and survival signals. NF-kappaB, a transcription factor activated by TNF, is critical for controlling survival signals through trans-activation of downstream target genes. However, few NF-kappaB target survival genes have been identified with direct roles in oncogene...

journal_title：Oncogene

authors： Au PY,Martin N,Chau H,Moemeni B,Chia M,Liu FF,Minden M,Yeh WC

更新日期：2005-04-28 00:00:00

abstract：:Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly understood. The purpose of this study was to elucidate mechanisms by which PXN affects cancer growth and progression, which we addressed using cancer patient data, cell l...

journal_title：Oncogene

authors： Noh K,Bach DH,Choi HJ,Kim MS,Wu SY,Pradeep S,Ivan C,Cho MS,Bayraktar E,Rodriguez-Aguayo C,Dasari SK,Stur E,Mangala LS,Lopez-Berestein G,Sood AK

更新日期：2021-01-01 00:00:00

abstract：:Individuals affected with the Gorlin syndrome inherit a germ-line mutation of the patched (Ptc1) developmental gene and, analogously to Ptc1 heterozygous mice, show an increased susceptibility to spontaneous tumor development. Human and mouse Ptc1 heterozygotes (Ptc1(+/-)) are also hypersensitive to ionizing radiation...

journal_title：Oncogene

authors： Pazzaglia S,Mancuso M,Atkinson MJ,Tanori M,Rebessi S,Majo VD,Covelli V,Hahn H,Saran A

更新日期：2002-10-24 00:00:00

abstract：:Ataxia Telangiectasia Mutated (ATM) kinase, a central regulator of the DNA damage response, regulates the activity of several E3-ubiquitin ligases, and the ubiquitination-proteasome system is a consistent target of ATM. ITCH is an E3-ubiquitin ligase that modulates the ubiquitination of several targets, therefore part...

journal_title：Oncogene

authors： Santini S,Stagni V,Giambruno R,Fianco G,Di Benedetto A,Mottolese M,Pellegrini M,Barilà D

更新日期：2014-02-27 00:00:00

abstract：:Despite the fact that objective response rates to 5-FU are as low as 20%, 5-FU remains the most commonly used drug for the treatment of colorectal cancer. The lack of understanding of resistance to 5-FU, therefore, remains a significant impediment in maximizing its efficacy. We used intestinal epithelial cells with an...

journal_title：Oncogene

authors： Klampfer L,Swaby LA,Huang J,Sasazuki T,Shirasawa S,Augenlicht L

更新日期：2005-06-02 00:00:00

abstract：:A Rho GTPase-activating protein (RhoGAP), deleted in liver cancer 1 (DLC1), is known to function as a tumor suppressor in various cancer types; however, whether DLC1 is a tumor-suppressor gene or an oncogene in melanoma remains to be clarified. Here we revealed that high DLC1 expression was detected in most of the mel...

journal_title：Oncogene

authors： Yang X,Hu F,Liu JA,Yu S,Cheung MPL,Liu X,Ng IO,Guan XY,Wong KKW,Sharma R,Lung HL,Jiao Y,Lee LTO,Cheung M

更新日期：2020-05-01 00:00:00