Abstract:
:Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory component of the transforming growth factor -beta receptor complex and is involved in vascular development and remodelling. Quantification of intratumoral microvessel density by CD105 staining and of circulating soluble CD105 has been suggested to have prognostic significance in selected neoplasias. In addition, the potential usefulness of CD105 in tumor imaging and antiangiogenetic therapy has been well documented utilizing different animal models.
journal_name
Oncogenejournal_title
Oncogeneauthors
Fonsatti E,Altomonte M,Nicotra MR,Natali PG,Maio Mdoi
10.1038/sj.onc.1206813subject
Has Abstractpub_date
2003-09-29 00:00:00pages
6557-63issue
42eissn
0950-9232issn
1476-5594pii
1206813journal_volume
22pub_type
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