Abstract：
:Pdcd4 is a novel transformation suppressor that is highly expressed in promotion-resistant (P-) mouse epidermal JB6 cells but not in susceptible (P+) cells. Overexpression of pdcd4 cDNA in stably transfected P+ cells rendered cells resistant to tumor promoter-induced transformation, indicating that elevated expression of Pdcd4 protein is sufficient to suppress neoplastic transformation. To determine whether Pdcd4 suppresses neoplastic transformation through inhibiting known transformation required events, we examined the possibility that pdcd4 inhibited the activation of AP-1 or NF-kappaB dependent transcription or of ornithine decarboxylase (ODC) activity. Activation of AP-1-dependent transcriptional activity was inhibited by pdcd4 expression in a concentration dependent manner. In contrast, Pdcd4 slightly increased NF-kappaB-dependent transcription and did not alter ODC enzymatic activity. Previous studies suggested that activation of AP-1 was required for P+ cell transformation as well as for tumor promotion in vivo. These results indicate that Pdcd4 functions as a transformation suppressor, possibly through inhibiting AP-1 activation in combination with other factors such as enhancing NF-kappaB activation. Pdcd4 may thus constitute a useful molecular target for cancer prevention.
journal_name
Oncogenejournal_title
Oncogeneauthors
Yang HS,Jansen AP,Nair R,Shibahara K,Verma AK,Cmarik JL,Colburn NHdoi
10.1038/sj.onc.1204137subject
Has Abstractpub_date
2001-02-08 00:00:00pages
669-76issue
6eissn
0950-9232issn
1476-5594journal_volume
20pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon ti...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-11-16 00:00:00
abstract：:An adenovirus mutant lacking the expression of the large E1B protein (DeltaE1B) has been reported to replicate selectively in cells lacking the expression of functionally wild-type (wt) p53. Based on these results the DeltaE1B or ONYX-015 virus has been proposed to be an oncolytic virus which might be useful to treat ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202886
更新日期：1999-09-09 00:00:00
abstract：:Transformed cells express high levels of non-telomeric reverse-transcriptase (RT) activity of retrotransposon and endogenous retrovirus origin. We previously reported that RT inhibition, either pharmacological or through transient silencing of RT-encoding LINE-1 (L1) elements by RNA interference (RNAi), reduced prolif...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210214
更新日期：2007-06-21 00:00:00
abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209541
更新日期：2006-09-07 00:00:00
abstract：:In lung cancer, frequent loss of one allele of chromosome 3p is seen in both small cell lung cancer and non-small cell lung cancer (NSCLC), providing evidence of tumor suppressor genes (TSGs) in this chromosomal region. The mechanism of Fus1 tumor suppressor activity is unknown. We have found that a Fus1 peptide inhib...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210500
更新日期：2007-10-25 00:00:00
abstract：:Many p53 mutants found in human cancer have an altered ability to bind DNA and transactivate gene expression. Re-expression of functional p53 in cells in which the endogenous TP53 gene is inactivated has been demonstrated to restore a non-tumorigenic phenotype. Pharmacological modulation of p53 mutant conformation may...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204428
更新日期：2001-06-14 00:00:00
abstract：:We have evaluated the transcriptional activation of a human p21 promoter reporter construct by transfection of BRCA1 expression constructs into tumorigenic and nontumorigenic human breast cell lines. Two cell lines with wildtype p53 (MCF-7 and MCF10A) demonstrated transcriptional activation of the p21 promoter by full...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204025
更新日期：2000-12-14 00:00:00
abstract：:NIH sponsored a meeting of medical and veterinary pathologists with mammary gland expertise in Annapolis in March 1999. Rapid development of mouse mammary models has accentuated the need for definitions of the mammary lesions in genetically engineered mice (GEM) and to assess their usefulness as models of human breast...
journal_title：Oncogene
pub_type： 共识发展会议,杂志文章,评审
doi：10.1038/sj.onc.1203277
更新日期：2000-02-21 00:00:00
abstract：:Members of the ErbB family of receptors have been implicated in regulation of androgen receptor (AR) activity. Ebp1, an ErbB-3 binding protein recently cloned in our laboratory, possesses an LXXLL motif important in mediating interactions with nuclear hormone receptors. Therefore, we sought to determine if Ebp1 could ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205638
更新日期：2002-08-15 00:00:00
abstract：:Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81 results in hypersensitivity to DNA-damaging agents, defects on both t...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.16
更新日期：2016-09-15 00:00:00
abstract：:The Interleukin-1beta converting enzyme (ICE) family of proteins, homologs of the C elegans cell death gene product CED-3, play important roles in controlling vertebrate programmed cell death. Because inhibition of apoptosis may be an essential step in tumorigenesis, we investigated the interaction of the simian virus...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1200943
更新日期：1997-03-13 00:00:00
abstract：:A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1202749
更新日期：1999-05-13 00:00:00
abstract：:Germline LKB1 mutations cause Peutz-Jeghers syndrome, a hereditary disorder that predisposes to gastrointestinal hamartomatous polyposis and several types of malignant tumors. Somatic LKB1 alterations are rare in sporadic cancers, however, a few reports showed the presence of somatic alterations in a considerable frac...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210418
更新日期：2007-08-30 00:00:00
abstract：:Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0586-4
更新日期：2019-03-01 00:00:00
abstract：:TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5 (DR5). TRAIL preferentially induces apoptosis in transformed cells and the identification of mechanisms by which TRAIL-induced apoptosis can be enhanced may lead to novel cancer chemotherape...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204842
更新日期：2001-10-18 00:00:00
abstract：:To identify potential microRNA (miRNA) links between Smad3, a mediator of TGF-β (transforming growth factor-β) signaling, and E-cadherin, we characterized the miRNA profiles of two gastric cancer cell lines: SNU484-LPCX, which does not express Smad3, and SNU484-Smad3, in which Smad3 is overexpressed. We found that amo...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.484
更新日期：2012-06-21 00:00:00
abstract：:The heterodimeric nuclear factor (NF) 90/NF45 complex (NF90/NF45) binds nucleic acids and is a multifunctional regulator of gene expression. Here we report that depletion of NF90/NF45 restores the expression of the p53 and p21 proteins in cervical carcinoma cells infected with high-risk human papillomaviruses (HPVs). ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.533
更新日期：2013-10-24 00:00:00
abstract：:Pin1 regulates a subset of phosphoproteins by isomerizing phospho-Ser/Thr-Pro motifs via a 'post-phosphorylation' mechanism. Here, we characterize TR3 as a novel Pin1 substrate, and the mitogenic function of TR3 depends on Pin1-induced isomerization. There are at least three phospho-Ser-Pro motifs on TR3 that bind to ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.463
更新日期：2012-06-07 00:00:00
abstract：:Simian virus 40 (SV40) is a small DNA tumor virus whose early region gene product, large T antigen, is sufficient to immortalize primary rodent cells and transform established rodent cell lines. Three functional domains of large T antigen are required for transformation of the rat embryo fibroblast REF 52 cell line: t...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-12-07 00:00:00
abstract：:Skeletrophin (mindbomb homolog 2 (MIB2)) is a RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands. A previous immunohistochemical study demonstrated that skeletrophin was downregulated in many melanomas. In the present study, we have identified ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209688
更新日期：2006-11-09 00:00:00
abstract：:The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pe...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.214
更新日期：2017-11-02 00:00:00
abstract：:The regulation of cell adhesion and motility in human prostate is not well understood. We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion. Endoglin is a transmembrane transforming growth factor beta binding protein typically expressed by endothelial cells....
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206117
更新日期：2002-11-28 00:00:00
abstract：:Neuroendocrine prostate cancer (NEPC) has increasingly become a clinical challenge. The mechanisms by which neuroendocrine (NE) cells arises from prostate adenocarcinoma cells are poorly understood. FOXA1 is a transcription factor of the forkhead family that is required for prostate epithelial differentiation. In this...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.50
更新日期：2017-07-13 00:00:00
abstract：:Nuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show that oncogenic β-ca...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0170-y
更新日期：2018-06-01 00:00:00
abstract：:A locus in feline DNA, termed flvi-1, has been identified as harboring retroviral integrations commonly found in natural feline lymphomas induced by infection with feline leukemia virus (FeLV). Southern blot analysis of human and murine DNA using restriction fragments representing flvi-1 demonstrates its phylogenetic ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Chronic inflammation has been associated with a variety of human cancers including prostate cancer. Interleukin-17 (IL-17) is a critical pro-inflammatory cytokine, which has been demonstrated to promote development of prostate cancer, colon cancer, skin cancer, breast cancer, lung cancer and pancreas cancer. IL-17 pro...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.240
更新日期：2017-02-02 00:00:00
abstract：:Using a combination of raf and myc oncogenes co-expressed by the recombinant retrovirus J-2 we have generated and characterized a cell line which very efficiently supports the growth of B-cells and B-cell hybridomas. Murine spleen cells were cultured under in vitro immunization conditions favoring the short term proli...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:EBP1 was identified as a protein that interacts with the ErbB-3 receptor and possibly contributes to transducing growth regulatory signals. The existence of EBP1 homologs across species from simple eukaryotes to humans and its wide tissue expression pattern suggest that EBP1 acts as a general signaling molecule. We pr...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207579
更新日期：2004-05-27 00:00:00
abstract：:Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.261
更新日期：2012-02-02 00:00:00
abstract：:MSH2 and MLH1 have a central role in correcting mismatches in DNA occurring during DNA replication and have been implicated in the engagement of apoptosis induced by a number of cytotoxic anticancer agents. The function of MLH1 is not clearly defined, although it is required for mismatch repair (MMR) and engagement of...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206252
更新日期：2003-02-13 00:00:00
