Infectivity and expression of the early adenovirus proteins are important regulators of wild-type and DeltaE1B adenovirus replication in human cells.

abstract：:Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platform...

journal_title：Oncogene

authors： Launay S,Hermine O,Fontenay M,Kroemer G,Solary E,Garrido C

更新日期：2005-08-04 00:00:00

abstract：:Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH+ subpopulations, decreases stemness-re...

journal_title：Oncogene

authors： Peng F,Wang JH,Fan WJ,Meng YT,Li MM,Li TT,Cui B,Wang HF,Zhao Y,An F,Guo T,Liu XF,Zhang L,Lv L,Lv DK,Xu LZ,Xie JJ,Lin WX,Lam EW,Xu J,Liu Q

更新日期：2018-02-22 00:00:00

abstract：:Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial-mesenchymal transition (EMT) with cells exhibiting enhanced migration and invasion potential in vit...

journal_title：Oncogene

authors： Gu G,Tian L,Herzog SK,Rechoum Y,Gelsomino L,Gao M,Du L,Kim JA,Dustin D,Lo HC,Beyer AR,Edwards DG,Gonzalez T,Tsimelzon A,Huang HJ,Fernandez NM,Grimm SL,Hilsenbeck SG,Liu D,Xu J,Alaniz A,Li S,Mills GB,Janku F

更新日期：2020-12-15 00:00:00

abstract：:Human carcinomas frequently express high levels of receptors in the EGF receptor family, and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely related ErbB2, has been associated with a more aggressive clinical behavior. Further, transfection or activation of high levels of these tw...

journal_title：Oncogene

authors： Mendelsohn J,Baselga J

更新日期：2000-12-27 00:00:00

abstract：:Mouse malignant T-lymphoma CS-21 cells grow in vitro in the presence of CA-12 lymph node stromal cells, but they undergo apoptotic cell death when separated from CA-12 stromal cells. In the course of examining the nursing effects of CA-12 stromal cells, we found that these cells provided some soluble factors that supp...

journal_title：Oncogene

authors： Lee SH,Fujita N,Mashima T,Tsuruo T

更新日期：1996-11-21 00:00:00

abstract：:Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes are peppered with mutations. Although most somatic tumour mutations are unlikely to have any role in the cancer process per se, the spectra of DNA sequence changes in tumour mutation catalogues have the potential to identify the mutag...

journal_title：Oncogene

authors： Hollstein M,Alexandrov LB,Wild CP,Ardin M,Zavadil J

更新日期：2017-01-12 00:00:00

abstract：:DNA double-strand breaks (DSBs), the most hazardous DNA lesions, may result in genomic instability, a hallmark of cancer cells. The main DSB repair pathways are non-homologous end joining (NHEJ) and homologous recombination (HR). In mammalian cells, NHEJ, which can lead to inaccurate repair, predominates. HR repair (H...

journal_title：Oncogene

authors： Shahar OD,Raghu Ram EV,Shimshoni E,Hareli S,Meshorer E,Goldberg M

更新日期：2012-07-26 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to play an important role in melanoma development and progression. However, the downstream targets of BMPs have not been investigated thus far. Therefore, we treated melanoma cell lines with the Smad-specific BMP inhibitor Dorsomorphin and performed a cDNA microarray. We id...

journal_title：Oncogene

authors： Braig S,Bosserhoff AK

更新日期：2013-02-14 00:00:00

abstract：:Multiple endocrine neoplasia type 2 (MEN 2) is an inherited cancer syndrome that includes pheochromocytoma. Germline mutations in RET are responsible for MEN 2 but the precise pathogenetic mechanisms of tumorigenesis are unknown. We have recently identified possible mechanisms of tumor formation in patients with MEN 2...

journal_title：Oncogene

authors： Koch CA,Huang SC,Zhuang Z,Stolle C,Azumi N,Chrousos GP,Vortmeyer AO,Pacak K

更新日期：2002-01-17 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R...

journal_title：Oncogene

authors： Frieling JS,Shay G,Izumi V,Aherne ST,Saul RG,Budzevich M,Koomen J,Lynch CC

更新日期：2017-08-01 00:00:00

abstract：:Hypoxic microenvironment supports cancer stem cell survival, causes poor response to anticancer therapy and tumor recurrence. Inhibition of Notch-1 signaling in adenocarcinoma of the lung (ACL) cells causes apoptosis specifically under hypoxia. Here, we found that Akt-1 activation is a key mediator of Notch-1 pro-surv...

journal_title：Oncogene

authors： Eliasz S,Liang S,Chen Y,De Marco MA,Machek O,Skucha S,Miele L,Bocchetta M

更新日期：2010-04-29 00:00:00

abstract：:VEGFR-1 (Flt-1), VEGFR-2 (KDR) and VEGFR-3 (Flt4) are endothelial specific receptor tyrosine kinases, regulated by members of the vascular endothelial growth factor family. VEGFRs are indispensable for embryonic vascular development, and are involved in the regulation of many aspects of physiological and pathological ...

journal_title：Oncogene

authors： Karkkainen MJ,Petrova TV

更新日期：2000-11-20 00:00:00

abstract：:Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion in invasive breast carcinoma. OSM stimulation promotes spontaneous lung metastasis of MCF-7 xenografts in nude mice. A conspicuous epig...

journal_title：Oncogene

authors： Guo L,Chen C,Shi M,Wang F,Chen X,Diao D,Hu M,Yu M,Qian L,Guo N

更新日期：2013-11-07 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progression. Here, we report that PAK4 activation promotes PC progression through the EMT regulator Slug. We find tha...

journal_title：Oncogene

authors： Park JJ,Park MH,Oh EH,Soung NK,Lee SJ,Jung JK,Lee OJ,Yun SJ,Kim WJ,Shin EY,Kim EG

更新日期：2018-09-01 00:00:00

abstract：:BTK is a cytoplasmic protein-tyrosine kinase, whose corresponding gene was isolated in the early 1990s. BTK was initially identified by positional cloning of the gene causing X-linked agammaglobulinemia and independently in a search for new kinases. Given the phenotype of affected patients, namely lack of B-lymphocyte...

journal_title：Oncogene

authors： Smith CI

更新日期：2017-04-01 00:00:00

abstract：:To investigate the role of individual Jun proteins in cell growth and transformation, we have used a doxycycline-inducible retroviral vector to regulate their expression in rat fibroblasts. AP-1 complexes enriched with cJun and JunB result in morphological alterations and anchorage-independent cell growth consistent w...

journal_title：Oncogene

authors： Leaner VD,Kinoshita I,Birrer MJ

更新日期：2003-08-28 00:00:00

abstract：:The ability of tumour cells to resist apoptosis-inducing signals by cytotoxic T cells may decide the success or failure of tumour elimination. An important effector of apoptosis is the CD95/CD95 ligand system (APO-1/Fas) that mediates perforin-independent cytotoxic T-cell killing of tumour cells. We propose a new stra...

journal_title：Oncogene

authors： Strand S,Vollmer P,van den Abeelen L,Gottfried D,Alla V,Heid H,Kuball J,Theobald M,Galle PR,Strand D

更新日期：2004-04-29 00:00:00

abstract：:Gene expression patterns in normal and v-myc-transformed quail embryo fibroblasts were compared by mRNA differential display. Displaying approximately 2500 mRNA species by reverse transcription/PCR, reamplification of 73 differential cDNA fragments and rescreening by Northern analysis led to the isolation of a clone, ...

journal_title：Oncogene

authors： Oberst C,Weiskirchen R,Hartl M,Bister K

更新日期：1997-03-06 00:00:00

abstract：:Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is elevated in cancer cells and its expression is highly correlated with poor prognosis in many human tumors. We demonstrate that PRMT5-MEP50 is essential for tran...

journal_title：Oncogene

authors： Chen H,Lorton B,Gupta V,Shechter D

更新日期：2017-01-19 00:00:00

abstract：:Rho GTPases are critical signal transducers of multiple pathways. They have been proposed to be useful anti-neoplastic targets for over two decades, especially in Ras-driven cancers. Until recently, however, few in vivo studies had been carried out to test this premise. Several recent mouse model studies have verified...

journal_title：Oncogene

authors： Zandvakili I,Lin Y,Morris JC,Zheng Y

更新日期：2017-06-08 00:00:00

abstract：:Growth arrest after u.v. damage was investigated in C3H mouse primary cultured hepatocytes, spontaneously immortalized liver epithelial cells and their H-ras-transformed derivatives. All cells except for one of the transformed lines had the wild type p53 gene considered necessary for the G1-S checkpoint. Growth arrest...

journal_title：Oncogene

authors： Kadohama T,Tsuji K,Ogawa K

更新日期：1994-10-01 00:00:00

abstract：:DOI: 10.1038/sj/onc/1205119 ...

journal_title：Oncogene

authors： Brennan PJ,Kumagai T,Berezov A,Murali R,Greene MI

更新日期：2002-01-10 00:00:00

abstract：:The present study was designed to elucidate the relationship between p53 and ceramide, both of which are involved in apoptotic signaling. Treatment of human glioma cells with etoposide caused apoptosis only in cells expressing functional p53. p53 activation was followed by the formation of reactive oxygen species (ROS...

journal_title：Oncogene

authors： Sawada M,Nakashima S,Kiyono T,Nakagawa M,Yamada J,Yamakawa H,Banno Y,Shinoda J,Nishimura Y,Nozawa Y,Sakai N

更新日期：2001-03-15 00:00:00

abstract：:Tek/Tie2 is an endothelial cell-specific receptor tyrosine kinase that has been shown to play a role in vascular development of the mouse. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathway(s) mediated by this rec...

journal_title：Oncogene

authors： Jones N,Dumont DJ

更新日期：1998-09-03 00:00:00

abstract：:Observations that genome-wide DNA hypomethylation induces genome instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2'-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that allows the quantifi...

journal_title：Oncogene

authors： Maslov AY,Lee M,Gundry M,Gravina S,Strogonova N,Tazearslan C,Bendebury A,Suh Y,Vijg J

更新日期：2012-12-13 00:00:00

abstract：:Tamoxifen (Tam), besides its action as an anti-estrogen, also inhibits cell proliferation of estrogen receptor (ER)-negative cancer cells by an unknown mechanism. In this study, we used ER-negative lung cancer cells to clarify such ER-independent inhibitory effect of Tam. We found that Tam induced G1 growth arrest in ...

journal_title：Oncogene

authors： Lee TH,Chuang LY,Hung WC

更新日期：1999-07-22 00:00:00

abstract：:Induction of apoptosis in tumor cells is an important mechanism of chemotherapy-induced cell death. The tumor-suppressor gene p53 is required for the efficient activation of apoptosis following chemotherapy. However, the molecular mechanism regulating p53-associated apoptosis remains controversial. In this study, we s...

journal_title：Oncogene

authors： Kondo S,Barnett GH,Hara H,Morimura T,Takeuchi J

更新日期：1995-05-18 00:00:00

abstract：:The tumor suppressor protein, p53, plays a critical role as a transcriptional activator of downstream target genes involved in the cellular response to DNA damaging agents. We examined the cell cycle checkpoint response of human mammary epithelial cells (HMEC) and their isogenic fibroblast counterparts to ionizing (IR...

journal_title：Oncogene

authors： Meyer KM,Hess SM,Tlsty TD,Leadon SA

更新日期：1999-10-14 00:00:00

abstract：:Using Southern blot analysis of DNA from mouse-hamster somatic cell hybrids, we have mapped Lmyc and Bmyc, two members of the myc family of genes, to mouse chromosomes 4 and 2, respectively. Furthermore, we have compared the regulation of Lmyc and Bmyc expression under different growth conditions and during in vitro d...

journal_title：Oncogene

authors： Ingvarsson S,Sundaresan S,Jin P,Francke U,Asker C,Sümegi J,Klein G,Sejersen T

更新日期：1988-12-01 00:00:00

abstract：:The stress-activated protein kinases (SAPKs), also known as c-Jun amino-terminal kinases (JNKs), are activated in response to diverse stimuli including DNA damage, heat shock, interleukin-1, tumor necrosis factor-alpha and Fas. Although all these inducers cause apoptosis, whether SAPK/JNK activation is required for ap...

journal_title：Oncogene

authors： Chauhan D,Pandey P,Ogata A,Teoh G,Treon S,Urashima M,Kharbanda S,Anderson KC

更新日期：1997-08-14 00:00:00