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ONCOGENE文献大全abstract::Expression of oncogenic H-Ras in 23A2 myoblasts (A2:H-Ras cells) is sufficient to induce both a transformed phenotype and a differentiation-defective phenotype. Because oncogenic Ras is known to induce the secretion of several different growth factors involved in maintaining the transformed phenotype of both fibroblas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201423
更新日期:1997-11-20 00:00:00
abstract::Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younger people. Compared with most other skin cancers, a feature of melanoma is its high metastatic capacity, although the mechanisms that confer this are not well understood. The Hippo pathway i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1362-9
更新日期:2020-07-01 00:00:00
abstract::The transcription factor NF-kappa-B is normally sequestered in the cytoplasm by its inhibitory subunit IkappaB. Most extracellular signals activate NF-kappa-B through a mechanism involving the phosphorylation and proteasome-dependent degradation of IkappaB. EGF activates NF-kappaB in A-431 carcinoma cells, which overe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201731
更新日期:1998-04-23 00:00:00
abstract::Ras-GRF, a guanine-nucleotide exchange factor that activates Ras p21, was tested for its ability to couple to either tyrosine kinase or heterotrimeric G protein signal transduction pathways. Ras-GRF failed to bind the SH2 and SH3 containing adaptor protein Grb2, either in vitro or in vivo. Furthermore, Ras-GRF did not...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-05-18 00:00:00
abstract::dMax, a naturally occurring splice variant of the Myc binding protein Max, lacks the DNA binding basic region and helix 1 of the Helix-Loop-Helix domain; dMax interacts with c-Myc in vitro and in vivo, and inhibits E-box Myc site driven transcription in transient transfection assays. Here we have investigated the expr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202611
更新日期:1999-04-15 00:00:00
abstract::The Cdk inhibitor p21(WAF1/CIP1) is a negative regulator of the cell cycle, although its expression is induced by a number of mitogens that promote cell proliferation. We have found that E2F1 and E2F3, transcription factors that activate genes required for cell cycle progression, are strong activators of the p21 promo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202240
更新日期:1998-12-31 00:00:00
abstract::Prostate stem cell antigen (PSCA) is a recently defined homologue of the Thy-1/Ly-6 family of glycosylphosphatidylinositol (GPI)-anchored cell surface antigens. PSCA mRNA is expressed in the basal cells of normal prostate and in more than 80% of prostate cancers. The purpose of the present study was to examine PSCA pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203426
更新日期:2000-03-02 00:00:00
abstract::Although cell invasion is a necessary early step in cancer metastasis, its regulation is not well understood. We have previously shown, in human prostate cancer, that transforming growth factor beta (TGFbeta)-mediated increases in cell invasion are dependent upon activation of the serine/threonine kinase, p38 MAP kina...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209337
更新日期:2006-05-18 00:00:00
abstract::The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding act...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Predisposition to melanoma is genetically heterogeneous. Two high penetrance susceptibility genes, CDKN2A and CDK4, have so far been identified and mapping is ongoing to localize and identify others. With the advent of a catalogue of millions of potential DNA polymorphisms, attention is now also being focused on ident...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1206445
更新日期:2003-05-19 00:00:00
abstract::Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched fun...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205370
更新日期:2002-04-18 00:00:00
abstract::Protection from detachment-induced cell death, termed anoikis, facilitates metastasis. Though anoikis is largely attributed to the loss of integrin-related 'outside-in' survival signals, Terada and colleagues demonstrate a novel 'inside-out' attachment sensing role for the adapter protein p66(Shc) in promoting anoikis...
journal_title:Oncogene
pub_type: 评论,杂志文章
doi:10.1038/onc.2010.347
更新日期:2010-10-14 00:00:00
abstract::The nucleolus is one of the functional nuclear compartments in which the ribosome biogenesis takes place. Proteomic analysis revealed a large number of nucleolar proteins that are involved in diverse cellular processes, including biogenesis of ribonucleoprotein particles, stress responses, cell proliferation and cell ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.473
更新日期:2010-03-25 00:00:00
abstract::Mitochondria have been classically characterized as organelles with responsibility for cellular energy production in the form of ATP, but they are also the organelles through which apoptotic signaling occurs. Cell stress stimuli can result in outer membrane permeabilization, after which mitochondria release numerous p...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.348
更新日期:2013-05-30 00:00:00
abstract::Multiple endocrine neoplasia type 2 (MEN 2) is an inherited cancer syndrome that includes pheochromocytoma. Germline mutations in RET are responsible for MEN 2 but the precise pathogenetic mechanisms of tumorigenesis are unknown. We have recently identified possible mechanisms of tumor formation in patients with MEN 2...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205133
更新日期:2002-01-17 00:00:00
abstract::While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0274-4
更新日期:2018-08-01 00:00:00
abstract::In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5'-up...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202165
更新日期:1998-11-19 00:00:00
abstract::The epidermis is continually exposed to harmful mutagens that have the potential to cause DNA damage. To protect the skin from accumulating mutated cells, keratinocytes have developed a highly regulated mechanism of eliminating damaged cells through apoptosis. Bcl-xL is a well-described cell survival protein that when...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202836
更新日期:1999-08-05 00:00:00
abstract::Although it has been demonstrated that transformed progenitor cell population can contribute to tumor initiation, factors contributing to this malignant transformation are poorly known. Using in vitro and xenograft-based models, previous studies demonstrated that miR-489 acts as a tumor suppressor miRNA by targeting v...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0439-1
更新日期:2019-01-01 00:00:00
abstract::The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. The retinoblastoma family includes three members, Rb/p105, p107 ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1209615
更新日期:2006-08-28 00:00:00
abstract::The FoxO family of Forkhead transcription factors plays an important role in longevity and tumor suppression by upregulating target genes involved in stress resistance, metabolism, cell cycle arrest and apoptosis. FoxO transcription factors translate a variety of environmental stimuli, including insulin, growth factor...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2008.21
更新日期:2008-04-07 00:00:00
abstract::The rodent S100-related calcium-binding protein, S100A4 induces metastasis in non-metastatic rat and mouse benign mammary cells and co-operates with benign-tumour-inducing changes in two transgenic mouse models, to yield metastatic mammary tumours. Co-transfection of the human gene for S100A4 with pSV2neo into the ben...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201948
更新日期:1998-07-30 00:00:00
abstract::MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of human cancer cell lines showed that miR-330 is a potential tumor-suppressor gene. However, the function and molec...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.192
更新日期:2009-09-24 00:00:00
abstract::Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208081
更新日期:2004-10-18 00:00:00
abstract::In order to examine the role of p53 expression on the sensitivity of cells to radiation-induced reproductive failure, we examined the radiosensitivity of a human diploid fibroblast cell strain (AG1521) before and after transfection with the E6 or E6/E7 genes of human papillomavirus 16 (HPV16)3. HPV E6 binds to p53, pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-06-15 00:00:00
abstract::We have cloned the rat homolog of the human leukocyte common antigen-related gene (LAR), which encodes a transmembrane receptor phosphotyrosine phosphatase, and raised antibodies against its protein product. We present evidence here for a processing event resulting in a two-chain structure of the mature receptor on th...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::To achieve a better understanding of mechanisms that underlie hepatocarcinogenesis and to identify novel target molecules for diagnosis and therapy of hepatocellular carcinoma (HCC), we previously analysed gene-expression profiles of 20 HCC tissues on a cDNA microarray. Among the genes upregulated in the tumor tissues...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209517
更新日期:2006-08-17 00:00:00
abstract::The v-Myb oncogene causes monoblastic leukemia and transforms only myelomonocytic cells in culture. The v-Myb protein is nuclear and binds to specific DNA sequences. To identify genes regulated by v-Myb, we utilized primary cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein. The E...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209868
更新日期:2007-02-22 00:00:00
abstract::Resistance to detachment-induced apoptosis, a process commonly referred as anoikis, is emerging as a hallmark of metastatic malignancies, mainly because it can ensure anchorage-independent growth and survival during organ colonization. Besides, a sustained oxidative stress has been associated with several steps of car...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.77
更新日期:2009-05-21 00:00:00
abstract::Max is a small helix-loop-helix protein which forms heterodimers with members of the Myc protein family. Myc/Max heterodimers exhibit sequence-specific DNA binding with much greater affinity than Myc homodimers. The Xenopus laevis homologue of Max, XMax, is shorter than the equivalent mammalian protein. This differenc...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00