Genetics of melanoma predisposition.


:Predisposition to melanoma is genetically heterogeneous. Two high penetrance susceptibility genes, CDKN2A and CDK4, have so far been identified and mapping is ongoing to localize and identify others. With the advent of a catalogue of millions of potential DNA polymorphisms, attention is now also being focused on identification of genes that confer a more modest contribution to melanoma risk, such as those encoding proteins involved in pigmentation, DNA repair, cell growth and differentiation or detoxification of metabolites. One such pigmentation gene, MC1R, has not only been found to be a low penetrance melanoma gene but has also been shown to act as a genetic modifier of melanoma risk in individuals carrying CDKN2A mutations. Most recently, an environmental agent, ultraviolet radiation, has also been established as a modifier of melanoma risk in CDKN2A mutation carriers. Hence, melanoma is turning out to be an excellent paradigm for studying gene-gene and gene-environment interactions.






Hayward NK




Has Abstract


2003-05-19 00:00:00
















  • Interferon-gamma suppresses transforming growth factor-beta-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model.

    abstract::We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...


    pub_type: 杂志文章


    authors: Kuga H,Morisaki T,Nakamura K,Onishi H,Noshiro H,Uchiyama A,Tanaka M,Katano M

    更新日期:2003-10-30 00:00:00

  • Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.

    abstract::dMax, a naturally occurring splice variant of the Myc binding protein Max, lacks the DNA binding basic region and helix 1 of the Helix-Loop-Helix domain; dMax interacts with c-Myc in vitro and in vivo, and inhibits E-box Myc site driven transcription in transient transfection assays. Here we have investigated the expr...


    pub_type: 杂志文章


    authors: FitzGerald MJ,Arsura M,Bellas RE,Yang W,Wu M,Chin L,Mann KK,DePinho RA,Sonenshein GE

    更新日期:1999-04-15 00:00:00

  • Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis.

    abstract::Despite the fact that objective response rates to 5-FU are as low as 20%, 5-FU remains the most commonly used drug for the treatment of colorectal cancer. The lack of understanding of resistance to 5-FU, therefore, remains a significant impediment in maximizing its efficacy. We used intestinal epithelial cells with an...


    pub_type: 杂志文章


    authors: Klampfer L,Swaby LA,Huang J,Sasazuki T,Shirasawa S,Augenlicht L

    更新日期:2005-06-02 00:00:00

  • Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

    abstract::In this study we have surveyed by immunoblotting the protein levels of Cyclin D1, D2, D3 and their catalytic partners, Cdk4 and Cdk6 in normal and transformed human cells. We found that all these proteins were differentially expressed in diploid cells derived from different tissues, in contrast to Cyclin E, Cyclin A a...


    pub_type: 杂志文章


    authors: Tam SW,Theodoras AM,Shay JW,Draetta GF,Pagano M

    更新日期:1994-09-01 00:00:00

  • Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC.

    abstract::Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of th...


    pub_type: 杂志文章


    authors: John B,Naczki C,Patel C,Ghoneum A,Qasem S,Salih Z,Said N

    更新日期:2019-05-01 00:00:00

  • Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.

    abstract::Anaplastic lymphoma kinase (ALK) is a transmembrane receptor tyrosine kinase in the insulin receptor superfamily. We recently demonstrated that the growth factors pleiotrophin (PTN) and midkine (MK) are ligands for ALK and that upon ALK activation, insulin receptor substrate-1 (IRS-1) and other substrates are phosphor...


    pub_type: 杂志文章


    authors: Kuo AH,Stoica GE,Riegel AT,Wellstein A

    更新日期:2007-02-08 00:00:00

  • A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity.

    abstract::Bcl-2 and Bcl-XL serve as critical inhibitors of apoptosis triggered by a broad range of stimuli, mainly acting on the mitochondria. We identified two members of the reticulon (RTN) family as Bcl-XL binding proteins, i.e., NSP-C (RTN1-C) and a new family member, RTN-XS, both of which did not belong to the Bcl-2 family...


    pub_type: 杂志文章


    authors: Tagami S,Eguchi Y,Kinoshita M,Takeda M,Tsujimoto Y

    更新日期:2000-11-23 00:00:00

  • Radiation-induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells.

    abstract::The p53 protein is known to play a central role in mediating G1 arrest or apoptosis in response to ionizing radiation in some cell types. It has been proposed that the link between p53 and induction of apoptosis is provided in part by p53-mediated upregulation of BAX. In this study, we used the human SW626 ovarian can...


    pub_type: 杂志文章


    authors: Strobel T,Swanson L,Korsmeyer S,Cannistra SA

    更新日期:1997-06-12 00:00:00

  • Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters.

    abstract::Different diagnostic and prognostic groups of colorectal carcinoma (CRC) have been defined. However, accurate diagnosis and prediction of survival are sometimes difficult. Gene expression profiling might improve these classifications and bring new insights into underlying molecular mechanisms. We profiled 50 cancerous...


    pub_type: 杂志文章


    authors: Bertucci F,Salas S,Eysteries S,Nasser V,Finetti P,Ginestier C,Charafe-Jauffret E,Loriod B,Bachelart L,Montfort J,Victorero G,Viret F,Ollendorff V,Fert V,Giovaninni M,Delpero JR,Nguyen C,Viens P,Monges G,Birnbaum D,

    更新日期:2004-02-19 00:00:00

  • Essential roles of Crk and CrkL in fibroblast structure and motility.

    abstract::Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...


    pub_type: 杂志文章


    authors: Park TJ,Curran T

    更新日期:2014-10-23 00:00:00

  • Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression.

    abstract::Alu sequences are the most abundant short interspersed repeated elements in the human genome. Here we show that in a cell culture model of colorectal cancer (CRC) progression, we observe accumulation of Alu RNA that is associated with reduced DICER1 levels. Alu RNA induces epithelial-to-mesenchymal transition (EMT) by...


    pub_type: 杂志文章


    authors: Di Ruocco F,Basso V,Rivoire M,Mehlen P,Ambati J,De Falco S,Tarallo V

    更新日期:2018-02-01 00:00:00

  • Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase.

    abstract::We screened cdc2 kinase inhibitors from cultured mediums of micro organisms using purified mouse cyclin B-cdc2 kinase and a specific substrate peptide for cdc2 kinase. A selective inhibitor of cdc2 kinase was isolated from the cultured medium of Aspergillus species F-25799, and identified as butyrolactone I. Butyrolac...


    pub_type: 杂志文章


    authors: Kitagawa M,Okabe T,Ogino H,Matsumoto H,Suzuki-Takahashi I,Kokubo T,Higashi H,Saitoh S,Taya Y,Yasuda H

    更新日期:1993-09-01 00:00:00

  • Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis.

    abstract::Although it has been demonstrated that transformed progenitor cell population can contribute to tumor initiation, factors contributing to this malignant transformation are poorly known. Using in vitro and xenograft-based models, previous studies demonstrated that miR-489 acts as a tumor suppressor miRNA by targeting v...


    pub_type: 杂志文章


    authors: Patel Y,Soni M,Awgulewitsch A,Kern MJ,Liu S,Shah N,Singh UP,Chen H

    更新日期:2019-01-01 00:00:00

  • Depletion of PDGF from serum inhibits growth of AIDS-related and sporadic Kaposi's sarcoma cells in culture.

    abstract::We have examined the mitogenic potential of platelet-derived growth factor (PDGF) on AIDS (acquired immune deficiency syndrome)-related and sporadic Kaposi's sarcoma cells in comparison to fibroblasts at physiological and subphysiological calcium concentrations of the culture medium. At low calcium concentrations in t...


    pub_type: 杂志文章


    authors: Roth WK,Werner S,Schirren CG,Hofschneider PH

    更新日期:1989-04-01 00:00:00

  • Dominant negative Met reduces tumorigenicity-metastasis and increases tubule formation in mammary cells.

    abstract::Activation of the Met tyrosine kinase growth factor receptor by its ligand HGF/SF has been shown to increase in vitro invasiveness in epithelial cell lines. To study the effect of Met-HGF/SF signaling in breast cancer cells, we transfected met, hgf/sf and dominant negative (DN) forms of met into the poorly differentia...


    pub_type: 杂志文章


    authors: Firon M,Shaharabany M,Altstock RT,Horev J,Abramovici A,Resau JH,Vande Woude GF,Tsarfaty I

    更新日期:2000-05-11 00:00:00

  • Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay.

    abstract::Many p53 mutants found in human cancer have an altered ability to bind DNA and transactivate gene expression. Re-expression of functional p53 in cells in which the endogenous TP53 gene is inactivated has been demonstrated to restore a non-tumorigenic phenotype. Pharmacological modulation of p53 mutant conformation may...


    pub_type: 杂志文章


    authors: Maurici D,Monti P,Campomenosi P,North S,Frebourg T,Fronza G,Hainaut P

    更新日期:2001-06-14 00:00:00

  • High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.

    abstract::Pilocytic astrocytomas (PAs, WHO grade I) are the most common brain tumors in the pediatric and adolescent population, accounting for approximately one-fifth of central nervous system tumors. Because few consistent molecular alterations have been identified in PAs compared to higher grade gliomas, we performed array c...


    pub_type: 杂志文章


    authors: Deshmukh H,Yeh TH,Yu J,Sharma MK,Perry A,Leonard JR,Watson MA,Gutmann DH,Nagarajan R

    更新日期:2008-08-07 00:00:00

  • Molecular pathology in basal cell cancer with p53 as a genetic marker.

    abstract::Human basal cell cancer (BCC) has unique growth characteristics with virtual inability to metastasize. We investigated clonality and genetic progression using p53 mutations as marker. Sampling was done through microdissection of frozen immunohistochemically stained 16 microm slices of tumors. From 11 BCC tumors 78 sam...


    pub_type: 杂志文章


    authors: Pontén F,Berg C,Ahmadian A,Ren ZP,Nistér M,Lundeberg J,Uhlén M,Pontén J

    更新日期:1997-08-28 00:00:00

  • Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.

    abstract::Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cell...


    pub_type: 杂志文章


    authors: Nakamura N,Fujii M,Tsukahara T,Arai M,Ohashi T,Wakao H,Kannagi M,Yamamoto N

    更新日期:1999-04-29 00:00:00

  • Induction of a complex between rasGAP and a novel 110 kD protein is required for immortalization of primary epithelial cells by the E1A 12S oncoprotein of adenovirus.

    abstract::Although established cell lines can be transformed with oncogenic ras, primary epithelial cells cannot, but require the coexpression of an immortalizing oncogene, such as the E1A region of adenovirus. We have previously shown that immortalization of primary epithelial cells by E1A 12S requires the expression of five r...


    pub_type: 杂志文章


    authors: Gopalakrishnan S,Fischer RS,Quinlan MP

    更新日期:1996-12-19 00:00:00

  • Elevated expression of v-mos is correlated with altered differentiation of carcinoma cells.

    abstract::Permanent alterations of the epithelial differentiation pattern were investigated after infection of HH-16 cl. 4 adenocarcinoma cells with Moloney murine sarcoma virus (MoMuSV). Transformed cell clones with fibroblastoid morphology were isolated and compared with clones of unchanged epithelioid phenotype. Southern blo...


    pub_type: 杂志文章


    authors: Scherdin U,Steffen M,Dietel M,Boecker W,Breindl M,Hölzel F

    更新日期:1990-11-01 00:00:00

  • EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation.

    abstract::Tyrosine kinase receptors have an essential role in various aspects of tumor progression. In particular, epidermal growth factor receptor (EGFR) and its ligands have been implicated in the growth and dissemination of a wide array of human carcinomas. Here, we describe an EGFR-mediated signaling pathway that regulates ...


    pub_type: 杂志文章


    authors: Huang M,Anand S,Murphy EA,Desgrosellier JS,Stupack DG,Shattil SJ,Schlaepfer DD,Cheresh DA

    更新日期:2012-05-31 00:00:00

  • Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.

    abstract::Heterozygous germline mutations in PHOX2B, a transcriptional regulator of sympathetic neuronal differentiation, predispose to diseases of the sympathetic nervous system, including neuroblastoma and congenital central hypoventilation syndrome (CCHS). Although the PHOX2B variants in CCHS largely involve expansions of th...


    pub_type: 杂志文章


    authors: Wang W,Zhong Q,Teng L,Bhatnagar N,Sharma B,Zhang X,Luther W 2nd,Haynes LP,Burgoyne RD,Vidal M,Volchenboum S,Hill DE,George RE

    更新日期:2014-06-19 00:00:00

  • Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.

    abstract::Granulocyte macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5 belong to a family of cytokines that regulate proliferation, differentiation and function of haematopoietic cells. Their receptor consists of a ligand specific alpha-chain and a signal transducing beta-chain (betac)...


    pub_type: 杂志文章


    authors: Geijsen N,Spaargaren M,Raaijmakers JA,Lammers JW,Koenderman L,Coffer PJ

    更新日期:1999-09-09 00:00:00

  • GRIM-19 inhibits v-Src-induced cell motility by interfering with cytoskeletal restructuring.

    abstract::GRIM-19 (Gene associated with Retinoid-Interferon-induced Mortality 19) is a novel tumor suppressor regulated by interferon/retinoid combination. We have recently shown that GRIM-19 inhibits v-Src-induced oncogenic transformation and metastatic behavior of cells. Oncogenic v-Src induces cell motility by cytoskeletal r...


    pub_type: 杂志文章


    authors: Sun P,Nallar SC,Kalakonda S,Lindner DJ,Martin SS,Kalvakolanu DV

    更新日期:2009-03-12 00:00:00

  • Effects of hTERT on metal ion-induced genomic instability.

    abstract::There is currently a great interest in delayed chromosomal and other damaging effects of low-dose exposure to a variety of pollutants which appear collectively to act through induction of stress-response pathways related to oxidative stress and ageing. These have been studied mostly in the radiation field but evidence...


    pub_type: 杂志文章


    authors: Glaviano A,Nayak V,Cabuy E,Baird DM,Yin Z,Newson R,Ladon D,Rubio MA,Slijepcevic P,Lyng F,Mothersill C,Case CP

    更新日期:2006-06-08 00:00:00

  • Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells.

    abstract::A potential role for 1-oleoyl-sn-glycero-3-phosphate or lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) in the regulation of malignant diseases has been widely considered. In this study, we found that in transformed astroglial cells, the expression profile of lysophospholipid receptor mRNA and the action...


    pub_type: 杂志文章


    authors: Malchinkhuu E,Sato K,Horiuchi Y,Mogi C,Ohwada S,Ishiuchi S,Saito N,Kurose H,Tomura H,Okajima F

    更新日期:2005-10-06 00:00:00

  • The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells.

    abstract::Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell...


    pub_type: 杂志文章


    authors: Tada Y,Yamaguchi Y,Kinjo T,Song X,Akagi T,Takamura H,Ohta T,Yokota T,Koide H

    更新日期:2015-02-05 00:00:00

  • Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer.

    abstract::The microtubule-targeting antineoplastic agent, paclitaxel, is highly efficacious against a wide spectrum of human cancers. However, dose-limiting toxicity and development of drug resistance limit its clinical application. Development of novel strategies that overcome chemoresistance and sensitize cancer cells to pacl...


    pub_type: 杂志文章


    authors: Sreekanth CN,Bava SV,Sreekumar E,Anto RJ

    更新日期:2011-07-14 00:00:00

  • Specific DNA binding by different classes of human p53 mutants.

    abstract::The p53 protein is a multifunctional transcription factor which orchestrates cellular responses to DNA damage, so helping to conserve genomic stability. It may also regulate genes involved in intercellular signalling, such as thrombospondin, a negative regulator of angiogenesis and metastatic spread. Activation of p53...


    pub_type: 杂志文章


    authors: Rolley N,Butcher S,Milner J

    更新日期:1995-08-17 00:00:00