Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas.

abstract：:Proliferating cell nuclear antigen (PCNA) has no intrinsic enzymatic function, but functions as a sliding platform to mediate protein interactions with the DNA strand. Many proteins interact with PCNA through a small conserved motif with consensus QxxLxxFF. This work uses Schizosaccharomyces pombe and human cells to a...

journal_title：Oncogene

authors： Warbrick E

更新日期：2006-05-11 00:00:00

abstract：:Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheless mitigated by breast cancer-associated fibroblasts (bCAFs) in a manner that defines MCL-1 as another critical...

journal_title：Oncogene

authors： Louault K,Bonneaud TL,Séveno C,Gomez-Bougie P,Nguyen F,Gautier F,Bourgeois N,Loussouarn D,Kerdraon O,Barillé-Nion S,Jézéquel P,Campone M,Amiot M,Juin PP,Souazé F

更新日期：2019-04-01 00:00:00

abstract：:Procollagen lysyl hydroxylase 1 (PLOD1) is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer. Bioinformatics analysis revealed that PLOD1 is associated with the progression of GBM, particularly the most malignant mesenchymal subtype (MES). Moreover, ...

journal_title：Oncogene

authors： Wang Z,Shi Y,Ying C,Jiang Y,Hu J

更新日期：2021-01-08 00:00:00

abstract：:Constitutive telomerase activity maintains telomere length and confers immortal phenotypes to human cancers. The prevalence of telomerase, rather than a homologous recombination-based mechanism, in telomere length maintenance suggests that telomerase also has auxiliary roles in tumorigenesis. Here, we investigate grow...

journal_title：Oncogene

authors： Fleisig HB,Wong JM

更新日期：2012-02-23 00:00:00

abstract：:Activation of the EGF receptor (c-erbB) tyrosine kinase has been implicated in tumorigenesis, either by overexpression of the normal receptor in the presence of EGF, or through expression of a truncated receptor lacking the EGF binding domain as in the viral oncogene v-erbB. Here, normal and truncated human EGF recept...

journal_title：Oncogene

authors： Haley JD,Hsuan JJ,Waterfield MD

更新日期：1989-03-01 00:00:00

abstract：:Centromeric instability is characterized by dynamic formation of centromeric breaks, deletions, isochromosomes and translocations, which are commonly observed in cancer. So far, however, the mechanisms of centromeric instability in cancer cells are still poorly understood. In this study, we tested the hypothesis that ...

journal_title：Oncogene

authors： Deng W,Tsao SW,Mak GW,Tsang CM,Ching YP,Guan XY,Huen MS,Cheung AL

更新日期：2011-03-17 00:00:00

abstract：:The NF-kappaB signaling pathway has particular relevance to several liver diseases including hepatitis (liver infection by Helicobacter, viral hepatitis induced by HBV and HCV), liver fibrosis and cirrhosis and hepatocellular carcinoma. Furthermore, the NF-kappaB signaling pathway is a potential target for development...

journal_title：Oncogene

authors： Sun B,Karin M

更新日期：2008-10-20 00:00:00

abstract：:Hypoxia induces transcription of a range of physiologically important genes including erythropoietin and vascular endothelial growth factor. The transcriptional activation is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric member of the basic helix-loop-helix PAS family, composed of alpha and beta ...

journal_title：Oncogene

authors： Krieg M,Haas R,Brauch H,Acker T,Flamme I,Plate KH

更新日期：2000-11-16 00:00:00

abstract：:In colorectal tumorigenesis, loss of function of the mismatch repair genes is closely associated with genomic instability at the nucleotide level whereas p53 deficiency has been linked with gross chromosomal instability. We have addressed the contribution of these two forms of genetic instability to tumorigenesis usin...

journal_title：Oncogene

authors： Toft NJ,Curtis LJ,Sansom OJ,Leitch AL,Wyllie AH,te Riele H,Arends MJ,Clarke AR

更新日期：2002-09-12 00:00:00

abstract：:SIAH-1 and SIAH-2 are the human members of an evolutionary highly conserved E3 ligase family. SIAH-1 is a p53 and p21(Waf-1/Cip-1) induced gene during apoptosis and tumor suppression. In stable-transfected clones of MCF-7 cells, SIAH-1 overexpression was associated with apoptosis, mitotic alterations and p21(Waf-1/Cip...

journal_title：Oncogene

authors： Germani A,Prabel A,Mourah S,Podgorniak MP,Di Carlo A,Ehrlich R,Gisselbrecht S,Varin-Blank N,Calvo F,Bruzzoni-Giovanelli H

更新日期：2003-12-04 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...

journal_title：Oncogene

authors： Altieri DC

更新日期：2003-11-24 00:00:00

abstract：:Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure-activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and Q, led to the discovery of Cuc Q, which inhibits the activation of STAT3 but not JAK2; Cuc A which inhibits J...

journal_title：Oncogene

authors： Sun J,Blaskovich MA,Jove R,Livingston SK,Coppola D,Sebti SM

更新日期：2005-05-05 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation (PARylation). However, it remains largely unclear how PARP1 activity is regulated. Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitate...

journal_title：Oncogene

authors： Hsu PC,Gopinath RK,Hsueh YA,Shieh SY

更新日期：2019-02-01 00:00:00

abstract：:Expression of neurotrophin receptors of the tyrosine kinase receptor (Trk) family is an important prognostic factor in solid tumors including neuroblastoma. High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastoma...

journal_title：Oncogene

authors： Schulte JH,Schramm A,Klein-Hitpass L,Klenk M,Wessels H,Hauffa BP,Eils J,Eils R,Brodeur GM,Schweigerer L,Havers W,Eggert A

更新日期：2005-01-06 00:00:00

abstract：:We analysed 30 primary invasive oral and laryngeal squamous carcinomas (SC), with concurrent dysplastic lesions, for genetic alterations at 15 microsatellite loci on the short arm of chromosome 8. Overall, loss of heterozygosity (LOH) was observed, in at least one informative locus, in 27% of the dysplastic lesions an...

journal_title：Oncogene

authors： El-Naggar AK,Coombes MM,Batsakis JG,Hong WK,Goepfert H,Kagan J

更新日期：1998-06-11 00:00:00

abstract：:Friend virus-induced erythroleukemia involves two members of the ETS family of transcriptional regulators, both activated via proviral insertion in the corresponding loci. Spi-1/PU.1 is expressed in the disease induced by the original Friend virus SFFV(F-MuLV) complex in adult mice. In contrast, FLI-1 is overexpressed...

journal_title：Oncogene

authors： Pereira R,Quang CT,Lesault I,Dolznig H,Beug H,Ghysdael J

更新日期：1999-02-25 00:00:00

abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Harkin DP

更新日期：2006-09-25 00:00:00

abstract：:Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction by the generation of t...

journal_title：Oncogene

authors： Kretschmer C,Murphy C,Biesinger B,Beckers J,Fickenscher H,Kirchner T,Fleckenstein B,Rüther U

更新日期：1996-04-18 00:00:00

abstract：:Our recent study showed critical roles of Dmp1 as a sensor of oncogenic Ras, HER2/neu signaling and activation of the Arf-p53 pathway. To elucidate the role of human DMP1 (hDMP1) in breast cancer, one hundred and ten pairs of human breast cancer specimen were studied for the alterations of the hDMP1-ARF-Hdm2-p53 pathw...

journal_title：Oncogene

authors： Maglic D,Zhu S,Fry EA,Taneja P,Kai F,Kendig RD,Sugiyama T,Miller LD,Willingham MC,Inoue K

更新日期：2013-08-29 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non-PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that ...

journal_title：Oncogene

authors： Totani H,Shinjo K,Suzuki M,Katsushima K,Mase S,Masaki A,Ito A,Ri M,Kusumoto S,Komatsu H,Ishida T,Inagaki H,Iida S,Kondo Y

更新日期：2020-08-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cell...

journal_title：Oncogene

authors： Nakamura N,Fujii M,Tsukahara T,Arai M,Ohashi T,Wakao H,Kannagi M,Yamamoto N

更新日期：1999-04-29 00:00:00

abstract：:The alternative nuclear factor-kappaB (NF-κB) -activation pathway proceeds via inducible p100 processing, leading to the activation of RelB-containing dimers. This pathway is aberrantly activated in several types of tumors; however, a direct role for RelB in the control of cell proliferation is still largely unexplore...

journal_title：Oncogene

authors： Jacque E,Billot K,Authier H,Bordereaux D,Baud V

更新日期：2013-05-23 00:00:00

abstract：:Undifferentiated cells and embryos express high levels of endogenous non-telomerase reverse transcriptase (RT) of retroposon/retroviral origin. We previously found that RT inhibitors modulate cell growth and differentiation in several cell lines. We have now sought to establish whether high levels of RT activity are d...

journal_title：Oncogene

authors： Sciamanna I,Landriscina M,Pittoggi C,Quirino M,Mearelli C,Beraldi R,Mattei E,Serafino A,Cassano A,Sinibaldi-Vallebona P,Garaci E,Barone C,Spadafora C

更新日期：2005-06-02 00:00:00

abstract：:With the development of a specific anti-rab2 antiserum, p23rab2, a ras-like GTPase with a -GGGCC C-terminus, has been localized mainly to the particulate (P100) fraction in NIH3T3 cells, although a small amount of this protein also appears in the soluble fraction. The endogenous p23rab2 is isoprenylated in intact cell...

journal_title：Oncogene

authors： Wei C,Lutz R,Sinensky M,Macara IG

更新日期：1992-03-01 00:00:00

abstract：:Retinoids have been shown to inhibit the growth of a number of human tumor cells, including several ovarian adenocarcinoma cell lines. All-trans retinoic acid (RA) is an effective growth suppressor of CA-OV3 cells but not SK-OV3 cells. Since the effects of RA are known to be mediated via the nuclear receptors (RARs an...

journal_title：Oncogene

authors： Wu S,Zhang D,Zhang ZP,Soprano DR,Soprano KJ

更新日期：1998-12-03 00:00:00

abstract：:The genetically heterogeneous triple-negative breast cancer (TNBC) continues to be an intractable disease, due to lack of effective targeted therapies. Gene amplification is a major event in tumorigenesis. Genes with amplification-dependent expression are being explored as therapeutic targets for cancer treatment. In ...

journal_title：Oncogene

authors： He J,McLaughlin RP,van der Beek L,Canisius S,Wessels L,Smid M,Martens JWM,Foekens JA,Zhang Y,van de Water B

更新日期：2020-05-01 00:00:00

abstract：:Activation of the p53 tumor suppressor protein can lead to either cell cycle arrest or apoptosis. Several functional domains necessary for mediating cell cycle arrest and apoptosis in p53 have been mapped, e.g., the proline-rich domain. The proline-rich domain is located within residues 60-90, which comprise five PXXP...

journal_title：Oncogene

authors： Zhu J,Jiang J,Zhou W,Zhu K,Chen X

更新日期：1999-03-25 00:00:00

abstract：:c-Abl is a nuclear and cytoplasmic tyrosine kinase involved in a variety of cellular growth and differentiation processes. In contrast to its oncogenic counterparts, like BCR-Abl, c-Abl is not constitutively tyrosine phosphorylated and its catalytic activity is very low. Here we report tyrosine phosphorylation of endo...

journal_title：Oncogene

authors： Dorey K,Engen JR,Kretzschmar J,Wilm M,Neubauer G,Schindler T,Superti-Furga G

更新日期：2001-12-06 00:00:00

abstract：:Signal transduction and activator of transcription 3(STAT3) signaling is constitutively activated in various tumors, and is involved in cell survival and proliferation during oncogenesis. There are few reports, however, on the role of STAT3 signaling in gastric cancer. The aim of the present study was to clarify the r...

journal_title：Oncogene

authors： Kanda N,Seno H,Konda Y,Marusawa H,Kanai M,Nakajima T,Kawashima T,Nanakin A,Sawabu T,Uenoyama Y,Sekikawa A,Kawada M,Suzuki K,Kayahara T,Fukui H,Sawada M,Chiba T

更新日期：2004-06-17 00:00:00

abstract：:A33 antigen is a membrane-bound protein that is expressed only in intestinal epithelium and in most human colon cancers. Thus, A33 antigen has been explored as a potential therapeutic target for the treatment of colon cancers. However, little is known about the mechanism responsible for the tissue-specific pattern of ...

journal_title：Oncogene

authors： Mao Z,Song S,Zhu Y,Yi X,Zhang H,Shang Y,Tong T

更新日期：2003-07-10 00:00:00