Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma.

abstract：:We describe the cytogenetic and molecular characterization of a t(1;13)(q22;q12) constitutional rearrangement occurring in a patient with a relatively benign form of neuroblastoma, called ganglioneuroblastoma. Somatic cell hybrids were generated between mouse 3T3 cells and a lymphoblastoid cell line from this patient,...

journal_title：Oncogene

authors： Michalski AJ,Cotter FE,Cowell JK

更新日期：1992-08-01 00:00:00

abstract：:Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. BRCA1 is a 220-kDa protein that contains a tandem of two BRCA1 C-Terminal (BRCT) domains. Among missense and nonsense BRCA1 mutations responsible for family breast cancer, some are located into the BRCT tandem ...

journal_title：Oncogene

authors： Magnard C,Bachelier R,Vincent A,Jaquinod M,Kieffer S,Lenoir GM,Venezia ND

更新日期：2002-10-03 00:00:00

abstract：:Transcription from the rat transforming growth factor alpha (TGF-alpha) promoter initiates at multiple sites within a 200-bp G+C-rich region that lacks TATA and CAAT motifs but contains multiple potential binding sites for the transcription factor Sp1. In the present study, we used deletion analysis to establish the 5...

journal_title：Oncogene

authors： Chen X,Azizkhan JC,Lee DC

更新日期：1992-09-01 00:00:00

abstract：:A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma a...

journal_title：Oncogene

authors： Jacob AN,Kandpal G,Kandpal RP

更新日期：1996-07-04 00:00:00

abstract：:The Rel/NF-kappaB transcription factors regulate the expression of many genes. The activity of RelA, a member of the Rel/NF-kappaB transcription factor family, is constitutively activated in the majority of pancreatic adenocarcinomas and cell lines. We report that the urokinase-type plasminogen activator (uPA), one of...

journal_title：Oncogene

authors： Wang W,Abbruzzese JL,Evans DB,Chiao PJ

更新日期：1999-08-12 00:00:00

abstract：:We have recently identified ZNF185 as a gene that is downregulated in prostate cancer (PCa), in part via epigenetic alteration, and maybe associated with disease progression. In this study, we cloned the ZNF185 cDNA from normal human prostate tissues and investigated its biological function. We show that ZNF185 is a n...

journal_title：Oncogene

authors： Zhang JS,Gong A,Young CY

更新日期：2007-01-04 00:00:00

abstract：:The stress-activated protein kinases (SAPKs), also known as c-Jun amino-terminal kinases (JNKs), are activated in response to diverse stimuli including DNA damage, heat shock, interleukin-1, tumor necrosis factor-alpha and Fas. Although all these inducers cause apoptosis, whether SAPK/JNK activation is required for ap...

journal_title：Oncogene

authors： Chauhan D,Pandey P,Ogata A,Teoh G,Treon S,Urashima M,Kharbanda S,Anderson KC

更新日期：1997-08-14 00:00:00

abstract：:The management of pain and morbidity due to the spreading and growth of cancer within bone remains to be a paramount problem in clinical care. Cancer cells actively transform bone, however, the molecular requirements and mechanisms of this process remain unclear. This study shows that functional modulation of the alph...

journal_title：Oncogene

authors： McCabe NP,De S,Vasanji A,Brainard J,Byzova TV

更新日期：2007-09-13 00:00:00

abstract：:Genetic analysis of beta-catenin-induced oncogenic transformation in chicken embryo fibroblasts (CEF) revealed the following prerequisites for oncogenicity: (1) removal of the N terminal phosphorylation sites targeted by glycogen synthase kinase 3beta (GSK3beta), (2) retention of the N terminal transactivation domain,...

journal_title：Oncogene

authors： Aoki M,Sobek V,Maslyar DJ,Hecht A,Vogt PK

更新日期：2002-10-10 00:00:00

abstract：:During the evolution into castration or therapy resistance, prostate cancer cells reprogram the androgen responses to cope with the diminishing level of androgens, and undergo metabolic adaption to the nutritionally deprived and hypoxia conditions. AR (androgen receptor) and PKM2 (pyruvate kinase M2) have key roles in...

journal_title：Oncogene

authors： Wang HJ,Pochampalli M,Wang LY,Zou JX,Li PS,Hsu SC,Wang BJ,Huang SH,Yang P,Yang JC,Chu CY,Hsieh CL,Sung SY,Li CF,Tepper CG,Ann DK,Gao AC,Evans CP,Izumiya Y,Chuu CP,Wang WC,Chen HW,Kung HJ

更新日期：2019-01-01 00:00:00

abstract：:The Crk II adaptor protein encodes an SH2/SH3-domain containing adaptor protein with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The two SH3 domains are separated by a 54 amino acid linker region, whose length is highly conserved in xenopus, chicken, and mamalian Crk II proteins. To g...

journal_title：Oncogene

authors： Zvara A,Fajardo JE,Escalante M,Cotton G,Muir T,Kirsch KH,Birge RB

更新日期：2001-02-22 00:00:00

abstract：:The KLF6 gene encodes the Krüppel-like factor 6, a transcription factor that has been individualized as a tumor-suppressor gene involved in the regulation of cell proliferation and differentiation. Recently, high frequency (42%) of KLF6 mutations have been reported in colorectal cancers (CRC) as in prostate cancers, a...

journal_title：Oncogene

authors： Lièvre A,Landi B,Côté JF,Veyrie N,Zucman-Rossi J,Berger A,Laurent-Puig P

更新日期：2005-11-03 00:00:00

abstract：:Two rare cases of chronic lymphocytic leukemia (CLL) in children, patients AS and LH, have been found to be associated with a unique chromosomal translocation, t(2;14)(p13;q32). Previous studies have shown the breakpoints of this translocation to be in the gamma 2 switch region of the Ig heavy-chain locus on chromosom...

journal_title：Oncogene

authors： Richardson AL,Humphries CG,Tucker PW

更新日期：1992-05-01 00:00:00

abstract：:We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concen...

journal_title：Oncogene

authors： Kristjuhan A,Jaks V,Rimm I,Tooming T,Maimets T

更新日期：1998-05-07 00:00:00

abstract：:The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic deletions have been demonstrated at other chromosomal intervals. Since loss of heterozygosity (LOH) at distal 4p has been observed in about 20-29% of neuroblastomas, ...

journal_title：Oncogene

authors： Perri P,Longo L,Cusano R,McConville CM,Rees SA,Devoto M,Conte M,Ferrara GB,Seri M,Romeo G,Tonini GP

更新日期：2002-11-28 00:00:00

abstract：:Signal transducers and activators of transcription (Stats) are known to transduce signals from the cell surface to the nucleus in cytokine receptor signaling. We examined the capacity of platelet-derived growth factor (PDGF) receptor to interact with and activate Stat molecules. Activation of the PDGF beta-receptor le...

journal_title：Oncogene

authors： Valgeirsdóttir S,Paukku K,Silvennoinen O,Heldin CH,Claesson-Welsh L

更新日期：1998-01-29 00:00:00

abstract：:Embryonic stem (ES) cells have provided a valid model to understand early events of mammalian lineage specification and differentiation, leading to important insights into the mechanisms that control embryogenesis at the molecular and cellular levels. Furthermore, ES cells have recently evoked great scientific interes...

journal_title：Oncogene

authors： Minchiotti G

更新日期：2005-08-29 00:00:00

abstract：:Drosophila tumor suppressor WARTS (Wts) is an evolutionally conserved serine / threonine kinase and participates in a signaling complex that regulates both proliferation and apoptosis to ensure the proper size and shape of the fly. Human counterparts of this complex have been found to be frequently downregulated or mu...

journal_title：Oncogene

authors： Kuninaka S,Nomura M,Hirota T,Iida S,Hara T,Honda S,Kunitoku N,Sasayama T,Arima Y,Marumoto T,Koja K,Yonehara S,Saya H

更新日期：2005-08-11 00:00:00

abstract：:Many lines of evidence indicate that connexin genes expressing gap junction (GJ) proteins inhibit tumor cell proliferation. However, the precise molecular mechanisms remain unclear. In this study, we show that overexpression of connexin43 (Cx43) suppressed proliferation of human osteosarcoma U2OS cells through inhibit...

journal_title：Oncogene

authors： Zhang YW,Morita I,Ikeda M,Ma KW,Murota S

更新日期：2001-07-12 00:00:00

abstract：:Alpha-fetoprotein (AFP) producing gastric cancer (AFP-GC) is very malignant and highly metastatic compared with common gastric cancer. However, the causal relationship between AFP production and the high malignancy of AFP-GC is unclear. We investigated AFP gene regulation in AFP-GC by an active transcription factor, H...

journal_title：Oncogene

authors： Kataoka H,Miura Y,Joh T,Seno K,Tada T,Tamaoki T,Nakabayashi H,Kawaguchi M,Asai K,Kato T,Itoh M

更新日期：2001-02-15 00:00:00

abstract：:Helicobacter pylori induces a strong motogenic response in infected gastric epithelial host cells, which is enhanced by translocation of the pathogenic factor cytotoxin-associated gene A (CagA) into host cells via a specialized type IV secretion system. Once injected into the cytosol CagA is rapidly tyrosine phosphory...

journal_title：Oncogene

authors： Poppe M,Feller SM,Römer G,Wessler S

更新日期：2007-05-24 00:00:00

abstract：:Overexpression of the nuclear phosphoprotein p53 has been detected in many different transformed human cell lines and primary adult tumors. Elevated steady-state levels of p53 appear to be the result of an increase in the stability of the protein and, in adult cancers, high levels of the protein are associated with mu...

journal_title：Oncogene

authors： Davidoff AM,Pence JC,Shorter NA,Iglehart JD,Marks JR

更新日期：1992-01-01 00:00:00

abstract：:Nerve growth factor induces differentiation and survival of rat PC12 pheochromocytoma cells. The activation of the erk cascade has been implicated in transducing the multitude of signals induced by NGF. In order to explore the role of this signaling cascade in NGF mediated survival, differentiation and proliferation, ...

journal_title：Oncogene

authors： Klesse LJ,Meyers KA,Marshall CJ,Parada LF

更新日期：1999-03-25 00:00:00

abstract：:Protection from detachment-induced cell death, termed anoikis, facilitates metastasis. Though anoikis is largely attributed to the loss of integrin-related 'outside-in' survival signals, Terada and colleagues demonstrate a novel 'inside-out' attachment sensing role for the adapter protein p66(Shc) in promoting anoikis...

journal_title：Oncogene

authors： Debnath J

更新日期：2010-10-14 00:00:00

abstract：:Cell migration is essential to cancer invasion and metastasis and is spatially and temporally integrated through transcriptionally dependent and independent mechanisms. As cell migration is studied in vitro, it is important to identify genes that both drive cell migration and are biologically relevant in promoting inv...

journal_title：Oncogene

authors： Wu Y,Siadaty MS,Berens ME,Hampton GM,Theodorescu D

更新日期：2008-11-06 00:00:00

abstract：:Somatic mitochondrial DNA (mtDNA) mutations have been increasingly observed in primary human cancers. As each cell contains many mitochondria with multiple copies of mtDNA, it is possible that wild-type and mutant mtDNA can co-exist in a state called heteroplasmy. During cell division, mitochondria are randomly distri...

journal_title：Oncogene

authors： Chatterjee A,Mambo E,Sidransky D

更新日期：2006-08-07 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...

journal_title：Oncogene

authors： Leung N,Turbide C,Olson M,Marcus V,Jothy S,Beauchemin N

更新日期：2006-09-07 00:00:00

abstract：:With the development of a specific anti-rab2 antiserum, p23rab2, a ras-like GTPase with a -GGGCC C-terminus, has been localized mainly to the particulate (P100) fraction in NIH3T3 cells, although a small amount of this protein also appears in the soluble fraction. The endogenous p23rab2 is isoprenylated in intact cell...

journal_title：Oncogene

authors： Wei C,Lutz R,Sinensky M,Macara IG

更新日期：1992-03-01 00:00:00

abstract：:A series of primary human breast tumors was analysed by immunoblotting with anti-neu antibodies. Overproduction of the neu protein-tyrosine kinase, p185neu, was observed in 23 of 56 malignant tumor samples. 29 of these tumors were also immunoblotted with antiphosphotyrosine antibodies. A single prominent phosphotyrosi...

journal_title：Oncogene

authors： Wildenhain Y,Pawson T,Blackstein ME,Andrulis IL

更新日期：1990-06-01 00:00:00

abstract：:Phosphorylation of linker histone H1(S)-3 (previously named H1b) and core histone H3 is elevated in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase (MAPK) kinase (MEK). H1(S)-3 phosphorylation is the only histone modification known to be dependent upon transcripti...

journal_title：Oncogene

authors： Chadee DN,Peltier CP,Davie JR

更新日期：2002-12-05 00:00:00