The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer.

abstract：:Endothelial cells expressing fibroblast growth factor receptor-1 (FGFR-1) migrate and proliferate in response to treatment with FGF. We analysed ligand-induced migration and proliferation of porcine aortic endothelial cells expressing wild-type FGFR-1, point-mutated Y766F FGFR-1, unable to activate phospholipase C-gam...

journal_title：Oncogene

authors： Landgren E,Klint P,Yokote K,Claesson-Welsh L

更新日期：1998-07-23 00:00:00

abstract：:Our previous studies suggested that chromosome 8p deletion is associated with metastasis of hepatocellular carcinoma (HCC), in which some novel metastasis suppressor genes might be harbored. The present study aimed to identify the metastatic suppressor gene(s). A cDNA chip was constructed with the expressed sequence t...

journal_title：Oncogene

authors： Wu X,Jia HL,Wang YF,Ren N,Ye QH,Sun HC,Wang L,Liu YK,Tang ZY,Qin LX

更新日期：2006-03-16 00:00:00

abstract：:Mutation induction in directly exposed cells is currently regarded as the main component of the genetic risk of ionizing radiation for humans. However, recent data on the transgenerational increases in mutation rates in the offspring of irradiated parents indicate that the genetic risk could be greater than predicted ...

journal_title：Oncogene

authors： Barber RC,Hickenbotham P,Hatch T,Kelly D,Topchiy N,Almeida GM,Jones GD,Johnson GE,Parry JM,Rothkamm K,Dubrova YE

更新日期：2006-11-30 00:00:00

abstract：:Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; howev...

journal_title：Oncogene

authors： Sveen A,Kilpinen S,Ruusulehto A,Lothe RA,Skotheim RI

更新日期：2016-05-12 00:00:00

abstract：:Myc promotes both normal cell proliferation and oncogenic transformation through the activation and repression of target genes. The c-Myc-S protein is a truncated form of c-Myc that is produced in some cells from translation initiation at an internal AUG codon. We report that c-Myc-S and a similar truncated form of N-...

journal_title：Oncogene

authors： Cowling VH,Cole MD

更新日期：2008-02-21 00:00:00

abstract：:Type I interferon (IFN) enhances the transcription of the tumor suppressor gene p53. To elucidate the molecular mechanism mediating IFN-induced apoptosis, we analysed programmed cell death in response to type I (IFNalpha) or type II (IFNgamma) treatment in relation to p53 status. In two cell lines (MCF-7, SKNSH), IFNa...

journal_title：Oncogene

authors： Porta C,Hadj-Slimane R,Nejmeddine M,Pampin M,Tovey MG,Espert L,Alvarez S,Chelbi-Alix MK

更新日期：2005-01-20 00:00:00

abstract：:REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the transcription of c-fos gene has been found to be downregulated. To elucidate the mechanisms of c-fos downregulation in E1A+cHa-ras transformants, we studied th...

journal_title：Oncogene

authors： Kukushkin AN,Abramova MV,Svetlikova SB,Darieva ZA,Pospelova TV,Pospelov VA

更新日期：2002-01-24 00:00:00

abstract：:Death receptor 5 (DR5) is a receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). TRAIL is a promising candidate for cancer therapeutics due to its ability to induce apoptosis selectively in cancer cells. Here, we report that histone deacetylase inhibitors (HDACIs) such as trichostatin A (TSA),...

journal_title：Oncogene

authors： Nakata S,Yoshida T,Horinaka M,Shiraishi T,Wakada M,Sakai T

更新日期：2004-08-19 00:00:00

abstract：:Amplification and rearrangements of the epidermal growth factor receptor (EGFR) gene are frequently found in glioblastoma multiforme (GBM). The most common variant is EGFR variant III (EGFRvIII). Research suggests that EGFRvIII could be a marker for a cancer stem cell or tumor-initiating population. If amplification a...

journal_title：Oncogene

authors： Del Vecchio CA,Giacomini CP,Vogel H,Jensen KC,Florio T,Merlo A,Pollack JR,Wong AJ

更新日期：2013-05-23 00:00:00

abstract：:The motility of cancer cells in 3D matrices is of two types: mesenchymal motility, in which the cells are elongated and amoeboid motility, in which the cells are round. Amoeboid motility is driven by an actomyosin-based contractile force, which is regulated by the Rho/ROCK pathway. However, the molecular mechanisms un...

journal_title：Oncogene

authors： Yamazaki D,Kurisu S,Takenawa T

更新日期：2009-04-02 00:00:00

abstract：:Clonogenic murine B cell precursors are normally ultrasensitive to apoptosis following genotoxic exposure in vitro but can be protected by expression of an E mu-BCL-2 transgene. Such exposures are likely to be mutagenic. This in turn suggests that a level of in vivo genotoxic exposure that usually has minimal patholog...

journal_title：Oncogene

authors： Gibbons DL,MacDonald D,McCarthy KP,Cleary HJ,Plumb M,Wright EG,Greaves MF

更新日期：1999-07-01 00:00:00

abstract：:Transcription factor PAX8 expression is upregulated in several types of cancers. However, little is known about the function of PAX8 in the progression of hepatoma and its regulatory mechanisms. Here, we show that PAX8 silencing inhibits the proliferation and clonogenicity of hepatoma cells and its growth in vivo. The...

journal_title：Oncogene

authors： Wang J,Li N,Huang ZB,Fu S,Yu SM,Fu YM,Zhou PC,Chen RC,Zhou RR,Huang Y,Hu XW,Fan XG

更新日期：2019-10-01 00:00:00

abstract：:Maspin has been demonstrated to be a suppressor of invasion and cell motility in vitro, whereas in vivo analyses have reported that increased expression of maspin is associated with malignant behavior. The present study examined maspin expression in normal lung and non-small-cell lung cancers. Only proximal airway cel...

journal_title：Oncogene

authors： Yatabe Y,Mitsudomi T,Takahashi T

更新日期：2004-05-20 00:00:00

abstract：:Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresistant tumors. Downregulation or inhibition of antiapoptotic proteins might result in the sensitization of cancer cells to chemothe...

journal_title：Oncogene

authors： Nouvion AL,Thibaut J,Lohez OD,Venet S,Colas P,Gillet G,Lalle P

更新日期：2007-02-01 00:00:00

abstract：:Different diagnostic and prognostic groups of colorectal carcinoma (CRC) have been defined. However, accurate diagnosis and prediction of survival are sometimes difficult. Gene expression profiling might improve these classifications and bring new insights into underlying molecular mechanisms. We profiled 50 cancerous...

journal_title：Oncogene

authors： Bertucci F,Salas S,Eysteries S,Nasser V,Finetti P,Ginestier C,Charafe-Jauffret E,Loriod B,Bachelart L,Montfort J,Victorero G,Viret F,Ollendorff V,Fert V,Giovaninni M,Delpero JR,Nguyen C,Viens P,Monges G,Birnbaum D,

更新日期：2004-02-19 00:00:00

abstract：:The membrane-anchored MMP-regulator RECK is down regulated in many solid tumors; the extent of RECK down regulation correlates with poor prognosis. Forced expression of RECK in tumor cells results in suppression of angiogenesis, invasion, and metastasis. Studies on the roles and the mechanisms of regulation of the REC...

journal_title：Oncogene

authors： Echizenya M,Kondo S,Takahashi R,Oh J,Kawashima S,Kitayama H,Takahashi C,Noda M

更新日期：2005-09-01 00:00:00

abstract：:Nerve growth factor induces differentiation and survival of rat PC12 pheochromocytoma cells. The activation of the erk cascade has been implicated in transducing the multitude of signals induced by NGF. In order to explore the role of this signaling cascade in NGF mediated survival, differentiation and proliferation, ...

journal_title：Oncogene

authors： Klesse LJ,Meyers KA,Marshall CJ,Parada LF

更新日期：1999-03-25 00:00:00

abstract：:There is an increasing interest in determining the role of ribosomal proteins (RPs) in the regulation of MDM2-p53 pathway in coordinating cellular response to stress. Herein, we report a novel regulatory role of ribosomal protein S25 (RPS25) in MDM2-mediated p53 degradation and a feedback regulation of S25 by p53. We ...

journal_title：Oncogene

authors： Zhang X,Wang W,Wang H,Wang MH,Xu W,Zhang R

更新日期：2013-05-30 00:00:00

abstract：:A Rho GTPase-activating protein (RhoGAP), deleted in liver cancer 1 (DLC1), is known to function as a tumor suppressor in various cancer types; however, whether DLC1 is a tumor-suppressor gene or an oncogene in melanoma remains to be clarified. Here we revealed that high DLC1 expression was detected in most of the mel...

journal_title：Oncogene

authors： Yang X,Hu F,Liu JA,Yu S,Cheung MPL,Liu X,Ng IO,Guan XY,Wong KKW,Sharma R,Lung HL,Jiao Y,Lee LTO,Cheung M

更新日期：2020-05-01 00:00:00

abstract：:Loss-of-function mutations in the LKB1 (STK11) serine-threonine kinase gene cause Peutz-Jeghers syndrome, which is associated with inherited susceptibility to colorectal and other cancers. No downstream targets of LKB1 kinase activity have been identified. Here we show that LKB1 can direct the phosphorylation of the s...

journal_title：Oncogene

authors： Spicer J,Rayter S,Young N,Elliott R,Ashworth A,Smith D

更新日期：2003-07-24 00:00:00

abstract：:Unique transcriptional transactivation by the human immunodeficiency virus type 1 (HIV-1) Tat protein of long terminal repeat (LTR)-driven RNA expression, in the absence of the transactivator responsive element (TAR), was previously demonstrated in central nervous system (CNS)-derived astrocytic cell-lines, including ...

journal_title：Oncogene

authors： Niikura M,Dornadula G,Zhang H,Mukhtar M,Lingxun D,Khalili K,Bagasra O,Pomerantz RJ

更新日期：1996-07-18 00:00:00

abstract：:Transcription from the rat TGF alpha promoter initiates at two predominant sites (-188 and -58) in a G+C-rich region that does not contain TATA or CAAT motifs. Previous studies using transfected reporter constructs implicated the transcription factor Sp1 in active expression from the promoter, particularly from the -5...

journal_title：Oncogene

authors： Chen X,Wright KL,Berkowitz EA,Azizkhan JC,Ting JP,Lee DC

更新日期：1994-11-01 00:00:00

abstract：:Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...

journal_title：Oncogene

authors： Hsieh HY,Jou YC,Tung CL,Tsai YS,Wang YH,Chi CL,Lin RI,Hung SK,Chuang YM,Wu SF,Li C,Shen CH,Chan MWY,Hsu CD

更新日期：2018-02-01 00:00:00

abstract：:Omi is a mammalian serine protease that is localized in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the X-chromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies o...

journal_title：Oncogene

authors： Junqueira D,Cilenti L,Musumeci L,Sedivy JM,Zervos AS

更新日期：2003-05-08 00:00:00

abstract：:Arg and c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases. The two proteins are composed of SH2, SH3, kinase and C-terminal domains. To examine Arg structure-function relationships we analysed a Gag-Arg fusion protein, analogous to the oncogenic Gag-Abl fusion protein o...

journal_title：Oncogene

authors： Mysliwiec T,Perego R,Kruh GD

更新日期：1996-02-01 00:00:00

abstract：:The rel oncogene from the avian reticuloendotheliosis virus strain T is a 59 kd phosphoprotein localized primarily to the cytoplasm of transformed cells. Recently, the v-rel protein was shown to associate with several cellular proteins with molecular weights of 124 kd, 115 kd, and 36 kd. We have analysed the subcellul...

journal_title：Oncogene

authors： Morrison LE,Kabrun N,Mudri S,Hayman MJ,Enrietto PJ

更新日期：1989-06-01 00:00:00

abstract：:After publication of this Article, the Authors noticed errors in some of the Figures. In Figures 2e, 2f-g, 4a, 4j, 5a and 6b, unmatched β-actin was inadvertently used as loading control for the immunoblots. These have been corrected using repeat data from a similar set of samples and the revised Figures containing mat...

journal_title：Oncogene

authors： Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

更新日期：2020-10-01 00:00:00

abstract：:A cDNA encoding a complete human c-fos protein was isolated and inserted into two different murine MoMuLV-derived recombinant retroviruses allowing expression of c-fos protein in different cell types. One c-fos-expressing retrovirus, chosen for its ability to express high levels of proteins in fibroblast-like cells, w...

journal_title：Oncogene

authors： Roux P,Verrier B,Klein B,Niccolino M,Marty L,Alexandre C,Piechaczyk M

更新日期：1991-11-01 00:00:00

abstract：:We previously described the isolation of non-tumorigenic revertants from mutagenized populations of v-fos-transformed Rat-1 cells (Zarbl et al., 1987). In the present study we examined the possibility that the revertant phenotype resulted from mutations that altered the expression or activities of the c-jun or junB pr...

journal_title：Oncogene

authors： Van Amsterdam JR,Wang Y,Sullivan RC,Zarbl H

更新日期：1994-10-01 00:00:00

abstract：:ErbB-2 is an orphan receptor that belongs to a family of tyrosine kinase receptors for either epidermal growth factor (EGF) or Neu differentiation factor (NDF/neuregulin). Because overexpression of the erbB-2 proto-oncogene is frequently associated with an aggressive clinical course of certain human adenocarcinomas, t...

journal_title：Oncogene

authors： Klapper LN,Vaisman N,Hurwitz E,Pinkas-Kramarski R,Yarden Y,Sela M

更新日期：1997-05-01 00:00:00