A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors.

abstract：:Squamous cell carcinoma (SCC) cells of the head and neck specifically express collagenase-3 (matrix metalloproteinase-13 (MMP-13)), the expression of which correlates with their invasion capacity. Transforming growth factor-beta (TGF-beta) enhances MMP-13 and collagenase-1 (MMP-1) expression and invasion of SCC cells ...

journal_title：Oncogene

authors： Leivonen SK,Ala-Aho R,Koli K,Grénman R,Peltonen J,Kähäri VM

更新日期：2006-04-27 00:00:00

abstract：:Dysregulation of cellular signaling pathways can lead to colon cancer. However, research on the key signaling effectors or regulators in colon carcinogenesis is limited. Casein kinase-2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is crucial during adult bone formation and is a promising drug target for osteo...

journal_title：Oncogene

authors： Nie J,Liu L,Xing G,Zhang M,Wei R,Guo M,Li X,Xie P,Li L,He F,Han W,Zhang L

更新日期：2014-07-10 00:00:00

abstract：:Large cancer projects measure somatic mutations in thousands of samples, gradually assembling a catalog of recurring mutations in cancer. Many methods analyze these data jointly with auxiliary information with the aim of identifying subtype-specific results. Here, we show that somatic gene mutations alone can reliably...

journal_title：Oncogene

authors： Amar D,Izraeli S,Shamir R

更新日期：2017-06-15 00:00:00

abstract：:Murine double minute (MDM2) binding protein (MTBP) has been implicated in cancer progression. Here, we demonstrate one mechanism by which MTBP inhibits cancer metastasis. Overexpression of MTBP in human osteosarcoma cell lines lacking wild-type p53 did not alter primary tumor growth in mice, but significantly inhibite...

journal_title：Oncogene

authors： Agarwal N,Adhikari AS,Iyer SV,Hekmatdoost K,Welch DR,Iwakuma T

更新日期：2013-01-24 00:00:00

abstract：:Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting ~80% of women, and symptomatic in 25%, UFs bring tremendous suffering and are an economic burden worldwide; they cause severe pain and bleeding, an...

journal_title：Oncogene

authors： Cao T,Jiang Y,Wang Z,Zhang N,Al-Hendy A,Mamillapalli R,Kallen AN,Kodaman P,Taylor HS,Li D,Huang Y

更新日期：2019-07-01 00:00:00

abstract：:Chronic infection by hepatitis C virus (HCV) is a major risk factor for the onset and development of hepatocellular carcinoma (HCC), although the underlying mechanisms are unclear. The c-Myc oncogene contributes to the genesis of many types of cancers, including HCC, partly via the induction of genetic damage and the ...

journal_title：Oncogene

authors： Higgs MR,Lerat H,Pawlotsky JM

更新日期：2013-09-26 00:00:00

abstract：:Our recent study showed critical roles of Dmp1 as a sensor of oncogenic Ras, HER2/neu signaling and activation of the Arf-p53 pathway. To elucidate the role of human DMP1 (hDMP1) in breast cancer, one hundred and ten pairs of human breast cancer specimen were studied for the alterations of the hDMP1-ARF-Hdm2-p53 pathw...

journal_title：Oncogene

authors： Maglic D,Zhu S,Fry EA,Taneja P,Kai F,Kendig RD,Sugiyama T,Miller LD,Willingham MC,Inoue K

更新日期：2013-08-29 00:00:00

abstract：:Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed t...

journal_title：Oncogene

authors： Howlin J,McBryan J,Napoletano S,Lambe T,McArdle E,Shioda T,Martin F

更新日期：2006-03-09 00:00:00

abstract：:Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used...

journal_title：Oncogene

authors： Hsu CC,Chiang CW,Cheng HC,Chang WT,Chou CY,Tsai HW,Lee CT,Wu ZH,Lee TY,Chao A,Chow NH,Ho CL

更新日期：2011-02-10 00:00:00

abstract：:The tax gene product of the human T-cell leukemia virus type I (HTLV-I) induces the nuclear expression and biological function of the NF-kappa B/Rel family of host transcription factors although the underlying mechanism remains unclear. In the present study, we demonstrate that Tax-mediated activation of NF-kappa B/Re...

journal_title：Oncogene

authors： Maggirwar SB,Harhaj E,Sun SC

更新日期：1995-09-07 00:00:00

abstract：:Targeting Bruton tyrosine kinase (BTK) by ibrutinib is an effective treatment for patients with relapsed/refractory mantle cell lymphoma (MCL). However, both primary and acquired resistance to ibrutinib have developed in a significant number of these patients. A combinatory strategy targeting multiple oncogenic pathwa...

journal_title：Oncogene

authors： Li Y,Bouchlaka MN,Wolff J,Grindle KM,Lu L,Qian S,Zhong X,Pflum N,Jobin P,Kahl BS,Eickhoff JC,Wuerzberger-Davis SM,Miyamoto S,Thomas CJ,Yang DT,Capitini CM,Rui L

更新日期：2016-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for...

journal_title：Oncogene

authors： Trang P,Weidhaas JB,Slack FJ

更新日期：2008-12-01 00:00:00

abstract：:Recurrent and hormone-refractory prostate cancer (PCA) exhibits aggressive behaviors while current therapeutic approaches show little effect of prolonging the survival of patients with PCA. Thus, a deeper understanding of the patho-molecular mechanisms underlying the disease progression in PCA is crucial to identify n...

journal_title：Oncogene

authors： Pai VC,Hsu CC,Chan TS,Liao WY,Chuu CP,Chen WY,Li CR,Lin CY,Huang SP,Chen LT,Tsai KK

更新日期：2019-02-01 00:00:00

abstract：:We previously reported that overexpression of the 24 kDa basic fibroblast factor (or FGF-2) isoform provides protection from the cytotoxic effect of ionizing radiation (IR). DNA double-strand breaks (DSB), the IR-induced lethal lesions, are mainly repaired in human cells by non-homologous end joining system (NHEJ). NH...

journal_title：Oncogene

authors： Ader I,Muller C,Bonnet J,Favre G,Cohen-Jonathan E,Salles B,Toulas C

更新日期：2002-09-19 00:00:00

abstract：:Serine 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells. However, the mechanism for dephosphorylating c-Myc is not well understood. In this study, we identified carboxyl-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (SCP1) as a novel phosphatase specifically dephosph...

journal_title：Oncogene

authors： Wang W,Liao P,Shen M,Chen T,Chen Y,Li Y,Lin X,Ge X,Wang P

更新日期：2016-01-28 00:00:00

abstract：:To identify potential microRNA (miRNA) links between Smad3, a mediator of TGF-β (transforming growth factor-β) signaling, and E-cadherin, we characterized the miRNA profiles of two gastric cancer cell lines: SNU484-LPCX, which does not express Smad3, and SNU484-Smad3, in which Smad3 is overexpressed. We found that amo...

journal_title：Oncogene

authors： Ahn SM,Cha JY,Kim J,Kim D,Trang HT,Kim YM,Cho YH,Park D,Hong S

更新日期：2012-06-21 00:00:00

abstract：:Human basal-like breast cancer (BLBC) is an enigmatic and aggressive malignancy with a poor prognosis. There is an urgent need to identify therapeutic targets for BLBC, because current treatment modalities are limited and not effective. The forkhead box transcription factor FOXC1 has recently been identified as a crit...

journal_title：Oncogene

authors： Wang J,Ray PS,Sim MS,Zhou XZ,Lu KP,Lee AV,Lin X,Bagaria SP,Giuliano AE,Cui X

更新日期：2012-11-08 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non-PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. We examined characteristic cytokines and growth factors that ...

journal_title：Oncogene

authors： Totani H,Shinjo K,Suzuki M,Katsushima K,Mase S,Masaki A,Ito A,Ri M,Kusumoto S,Komatsu H,Ishida T,Inagaki H,Iida S,Kondo Y

更新日期：2020-08-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved process regulating cellular homeostasis via digestion of dysfunctional proteins and whole cellular organelles by mechanisms, involving their enclosure into double-membrane vacuoles that are subsequently fused to lysosomes. Glioma stem cells utilize autophagy as a main mechanism...

journal_title：Oncogene

authors： Kaverina NV,Kadagidze ZG,Borovjagin AV,Karseladze AI,Kim CK,Lesniak MS,Miska J,Zhang P,Baryshnikova MA,Xiao T,Ornelles D,Cobbs C,Khramtsov A,Ulasov IV

更新日期：2018-11-01 00:00:00

abstract：:We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer da...

journal_title：Oncogene

authors： Cai L,Lin S,Girard L,Zhou Y,Yang L,Ci B,Zhou Q,Luo D,Yao B,Tang H,Allen J,Huffman K,Gazdar A,Heymach J,Wistuba I,Xiao G,Minna J,Xie Y

更新日期：2019-04-01 00:00:00

abstract：:All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell maintenance, implicating that...

journal_title：Oncogene

authors： Lessard J,Faubert A,Sauvageau G

更新日期：2004-09-20 00:00:00

abstract：:The balance of activities between the proto-oncogene phosphoinositide 3-kinase (PI3K) and the tumour suppressor gene PTEN has been shown to affect cellular growth and proliferation, as well as tumorigenesis. Previously, PTEN expression in the PTEN-null Jurkat T cell leukaemia line was shown to cause reduced proliferat...

journal_title：Oncogene

authors： Seminario MC,Precht P,Wersto RP,Gorospe M,Wange RL

更新日期：2003-11-06 00:00:00

abstract：:RING-finger proteins play crucial roles in ubiquitination events involved in diverse cellular processes including signal transduction, differentiation and apoptosis. Most of the RING-finger proteins have E3-ubiquitin ligase activity. RNF11 is a small RING-finger protein and harbors a RING-H2 domain and a PY motif that...

journal_title：Oncogene

authors： Li H,Seth A

更新日期：2004-03-11 00:00:00

abstract：:Resistance of pancreatic cancer to current treatments including radiotherapy remains a major challenge in oncology and may be caused by defects in apoptosis programs. Since 'inhibitor of apoptosis proteins' (IAPs) block apoptosis at the core of the apoptotic machinery by inhibiting caspases, therapeutic modulation of ...

journal_title：Oncogene

authors： Giagkousiklidis S,Vellanki SH,Debatin KM,Fulda S

更新日期：2007-10-25 00:00:00

abstract：:Recent genetic investigations have established that RhoB gain-of-function is sufficient to mediate the antitransforming effects of farnesyltransferase inhibitors (FTIs) in H-Ras-transformed fibroblast systems. In this study, we addressed the breadth and mechanism of RhoB action in epithelial cells transformed by oncop...

journal_title：Oncogene

authors： Zeng PY,Rane N,Du W,Chintapalli J,Prendergast GC

更新日期：2003-02-27 00:00:00

abstract：:We report here the nucleic acid sequence and deduced amino acid sequence of a cDNA for TIS7, a gene induced by mitogens in 3T3 cells and by nerve growth factor in PC12 pheochromocytoma cells. A fragment of the TIS7 gene has previously been cloned from murine fibroblast cells infected with Newcastle Disease Virus. The ...

journal_title：Oncogene

authors： Varnum BC,Lim RW,Herschman HR

更新日期：1989-10-01 00:00:00

abstract：:Mechanisms underlying multidrug resistance (MDR), one of the major causes of cancer treatment failure, are still poorly understood. We selected the osteosarcoma MDR HosDXR150 cell line by culturing Hos cells in the presence of increasing doxorubicin doses and showed that it is crossresistant to vinblastine. Similarly ...

journal_title：Oncogene

authors： La Sala D,Macaluso M,Trimarchi C,Giordano A,Cinti C

更新日期：2003-06-05 00:00:00

abstract：:The molecular basis for the resistance of tumor cells to cell-mediated cytotoxicity remains poorly understood and thus poses a major challenge for cancer immunotherapy. The present study was designed to determine whether the WNT1-inducible signaling pathway protein 2 (WISP2, also referred to as CCN5), a key regulator ...

journal_title：Oncogene

authors： Akalay I,Tan TZ,Kumar P,Janji B,Mami-Chouaib F,Charpy C,Vielh P,Larsen AK,Thiery JP,Sabbah M,Chouaib S

更新日期：2015-04-23 00:00:00

abstract：:The extracellular matrix glycoprotein, fibronectin, influences a variety of cellular functions including adhesion, migration, survival, differentiation, and growth. Fibronectin has also been shown to increase the migration and proliferation of human lung carcinoma cells. However, the role of fibronectin in controlling...

journal_title：Oncogene

authors： Han SW,Roman J

更新日期：2006-07-20 00:00:00

abstract：:The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of Rad1 on checkpoint function and on DNA replication in mammalian cells. We show that RAD1 is an essential gene f...

journal_title：Oncogene

authors： Bao S,Lu T,Wang X,Zheng H,Wang LE,Wei Q,Hittelman WN,Li L

更新日期：2004-07-22 00:00:00