Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates.

abstract：:The metastasis-associated protein 1 (MTA1) is overexpressed in various human cancers and is closely connected with aggressive phenotypes; however, little is known about the transcriptional regulation of the MTA1 gene. This study identified the MTA1 gene as a target of p53-mediated transrepression. The MTA1 promoter co...

journal_title：Oncogene

authors： Lee MH,Na H,Kim EJ,Lee HW,Lee MO

更新日期：2012-12-06 00:00:00

abstract：:PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase activity in a guanine nucleotide-dependent manner. PIKE-A is one of the components of the CDK4 amplicon that is amplified in numerous human cancers. However, whether ...

journal_title：Oncogene

authors： Liu X,Hu Y,Hao C,Rempel SA,Ye K

更新日期：2007-07-26 00:00:00

abstract：:Mammalian heparanase (endo-beta-glucuronidase) degrades heparan sulfate proteoglycans and is an important modulator of the extracellular matrix and associated factors. The enzyme is preferentially expressed in neoplastic tissues and contributes to tumour metastasis and angiogenesis. To investigate the epigenetic regul...

journal_title：Oncogene

authors： Shteper PJ,Zcharia E,Ashhab Y,Peretz T,Vlodavsky I,Ben-Yehuda D

更新日期：2003-10-30 00:00:00

abstract：:PSP94, for prostatic secretory protein of 94 amino acids, is secreted by the prostate gland and functions as a suppressor of tumor growth and metastasis. The expression of PSP94 is lost in advanced, hormone-refractory prostate cancer and this correlates with an increased expression of the Polycomb protein EZH2 (enhanc...

journal_title：Oncogene

authors： Beke L,Nuytten M,Van Eynde A,Beullens M,Bollen M

更新日期：2007-07-05 00:00:00

abstract：:We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog (hTERT), and the presence of reverse transcriptase and telomerase specific motifs. Furthermore, we show functional interchangeability with hTERT in in vitro telomeras...

journal_title：Oncogene

authors： Greenberg RA,Allsopp RC,Chin L,Morin GB,DePinho RA

更新日期：1998-04-02 00:00:00

abstract：:Recently, we identified Insulinoma-Glucagonoma clone 20 (IG20) that can render cells more susceptible to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. In addition, it can slow cell proliferation, and enhance drug- and radiation-induced cell death. TNF-related apoptosis-inducing ligand (TRAIL) can selectiv...

journal_title：Oncogene

authors： Ramaswamy M,Efimova EV,Martinez O,Mulherkar NU,Singh SP,Prabhakar BS

更新日期：2004-08-12 00:00:00

abstract：:In order to examine the role of p53 expression on the sensitivity of cells to radiation-induced reproductive failure, we examined the radiosensitivity of a human diploid fibroblast cell strain (AG1521) before and after transfection with the E6 or E6/E7 genes of human papillomavirus 16 (HPV16)3. HPV E6 binds to p53, pr...

journal_title：Oncogene

authors： Tsang NM,Nagasawa H,Li C,Little JB

更新日期：1995-06-15 00:00:00

abstract：:Growing evidence demonstrates that hepatitis B virus (HBV) integration and resulting insertional mutagenesis play an important role in cell growth or maintenance in hepatocellular carcinomas (HCCs). To determine if HBV integration occurs and affects cellular genes at such a stage of infection, we analysed viral-host j...

journal_title：Oncogene

authors： Minami M,Daimon Y,Mori K,Takashima H,Nakajima T,Itoh Y,Okanoue T

更新日期：2005-06-23 00:00:00

abstract：:Understanding the molecular mechanisms that underlie the aggressive behavior and relapse of breast cancer may help in the development of novel therapeutic interventions. CUB-domain-containing protein 1 (CDCP1), a transmembrane adaptor protein, is highly maintained and required in the context of cellular metastatic pot...

journal_title：Oncogene

authors： Cui YH,Kim H,Lee M,Yi JM,Kim RK,Uddin N,Yoo KC,Kang JH,Choi MY,Cha HJ,Kwon OS,Bae IH,Kim MJ,Kaushik N,Lee SJ

更新日期：2018-10-01 00:00:00

abstract：:Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins...

journal_title：Oncogene

authors： Li Y,Jaramillo-Lambert AN,Yang Y,Williams R,Lee NH,Zhu W

更新日期：2012-02-02 00:00:00

abstract：:Interleukin-6 (IL-6) inhibits the growth of melanocytes and of early stage melanoma cells, but not that of advanced melanoma cells. The in vitro IL-6 response can be restored in the highly metastatic melanoma B16-F10.9 by addition of recombinant soluble IL-6 receptor alpha-chain (sIL-6R). The F10.9 cells then undergo ...

journal_title：Oncogene

authors： Oh JW,Katz A,Harroch S,Eisenbach L,Revel M,Chebath J

更新日期：1997-07-31 00:00:00

abstract：:Inhibitor of growth (ING)4, member of a gene family encoding potential tumor suppressors, is implicated as a repressor of angiogenesis and tumor growth and suppresses loss of contact inhibition in vitro. Here, we report that ING4 undergoes alternative splicing. Expression analysis identified novel ING4 spliced variant...

journal_title：Oncogene

authors： Raho G,Miranda C,Tamborini E,Pierotti MA,Greco A

更新日期：2007-08-09 00:00:00

abstract：:We have studied the role of the HPV-16 E5 protein in apoptosis, using HaCaT cell lines stably transfected with either E5 (HaCaT/E5) or the empty vector (HaCaT/pMSG) as control. When subjected to a hyperosmolar concentration of sorbitol, HaCaT/E5 cells respond with cytochrome c release, activation of caspase-3, -8, and...

journal_title：Oncogene

authors： Kabsch K,Alonso A

更新日期：2002-01-31 00:00:00

abstract：:Structural rearrangements involving chromosome 13 are frequently seen in B-cell chronic lymphocytic leukaemia. The presence of reciprocal translocations involving 13q14 in 10-15% of cases pinpoints the location of a gene important in leukaemogenesis. In order to characterise the exact location of the 13q14 breakpoint,...

journal_title：Oncogene

authors： Hawthorn LA,Chapman R,Oscier D,Cowell JK

更新日期：1993-06-01 00:00:00

abstract：:TGF-β is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-β signaling are process-and stage-dependent, and it is not uncommon that TGF-β exerts distinct and sometimes opposing effects on a di...

journal_title：Oncogene

authors： Muppala S,Xiao R,Krukovets I,Verbovetsky D,Yendamuri R,Habib N,Raman P,Plow E,Stenina-Adognravi O

更新日期：2017-09-07 00:00:00

abstract：:Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally expos...

journal_title：Oncogene

authors： Napolitano A,Pellegrini L,Dey A,Larson D,Tanji M,Flores EG,Kendrick B,Lapid D,Powers A,Kanodia S,Pastorino S,Pass HI,Dixit V,Yang H,Carbone M

更新日期：2016-04-14 00:00:00

abstract：:Heregulins are a group of growth factors that play diverse and critical roles in the signaling network of the human epidermal growth factor receptor (HER or EGFR) superfamily. Our earlier studies have shown that recombinant heregulinbeta1 (HRG) induces apoptosis in SKBr3 breast cancer cells that overexpress HER2. Here...

journal_title：Oncogene

authors： Le XF,Marcelli M,McWatters A,Nan B,Mills GB,O'Brian CA,Bast RC Jr

更新日期：2001-12-13 00:00:00

abstract：:Epstein-Barr virus (EBV) transforms resting primary human B lymphocytes into indefinitely proliferating lymphoblastoid cell lines in vitro and is associated with several human malignancies in vivo. Recombinant EBV genetic analyses combined with in vitro B lymphocyte transformation assays demonstrate that latent infect...

journal_title：Oncogene

authors： Cahir McFarland ED,Izumi KM,Mosialos G

更新日期：1999-11-22 00:00:00

abstract：:The ability of glioma cells to migrate great distances from a primary tumor mass is the primary cause of tumor recurrence. The urokinase-type plasminogen activator (uPA) is a serine protease that can initiate proteolytic cascades, which result in remodeling of extracellular matrix and basement membrane, allowing cells...

journal_title：Oncogene

authors： Chandrasekar N,Mohanam S,Gujrati M,Olivero WC,Dinh DH,Rao JS

更新日期：2003-01-23 00:00:00

abstract：:Ras is a major signaling molecule activated by interleukin-6. There have been no published reports, however, that specifically examine the kinetics and percentage of Ras activation in response to IL-6. Model cell lines were used to study activation of N- and K-ras induced by IL-6. All of the myeloma cell lines we test...

journal_title：Oncogene

authors： Rowley M,Van Ness B

更新日期：2002-12-12 00:00:00

abstract：:Type I interferon (IFN) enhances the transcription of the tumor suppressor gene p53. To elucidate the molecular mechanism mediating IFN-induced apoptosis, we analysed programmed cell death in response to type I (IFNalpha) or type II (IFNgamma) treatment in relation to p53 status. In two cell lines (MCF-7, SKNSH), IFNa...

journal_title：Oncogene

authors： Porta C,Hadj-Slimane R,Nejmeddine M,Pampin M,Tovey MG,Espert L,Alvarez S,Chelbi-Alix MK

更新日期：2005-01-20 00:00:00

abstract：:Resistance of pancreatic cancer to current treatments including radiotherapy remains a major challenge in oncology and may be caused by defects in apoptosis programs. Since 'inhibitor of apoptosis proteins' (IAPs) block apoptosis at the core of the apoptotic machinery by inhibiting caspases, therapeutic modulation of ...

journal_title：Oncogene

authors： Giagkousiklidis S,Vellanki SH,Debatin KM,Fulda S

更新日期：2007-10-25 00:00:00

abstract：:Diffuse intrinsic pontine glioma (or DIPG) are pediatric high-grade gliomas associated with a dismal prognosis. They harbor specific substitution in histone H3 at position K27 that induces major epigenetic dysregulations. Most clinical trials failed so far to increase survival, and radiotherapy remains the most effici...

journal_title：Oncogene

authors： Silva-Evangelista C,Barret E,Ménez V,Merlevede J,Kergrohen T,Saccasyn A,Oberlin E,Puget S,Beccaria K,Grill J,Castel D,Debily MA

更新日期：2019-09-01 00:00:00

abstract：:The RAS/RAF mitogen-activated protein kinase pathway (MAPK) is highly active in many tumor types including the majority of high-grade gliomas and expression of activated RAS or RAF in neural progenitor cells combined with either AKT activation or Ink4a/Arf loss leads to the development of high-grade gliomas in vivo. T...

journal_title：Oncogene

authors： Robinson JP,Vanbrocklin MW,Lastwika KJ,McKinney AJ,Brandner S,Holmen SL

更新日期：2011-03-17 00:00:00

abstract：:Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2. Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BRCA2 loss. This holds true for multiple DNA repair genes, and suggests...

journal_title：Oncogene

authors： van Gijn SE,Wierenga E,van den Tempel N,Kok YP,Heijink AM,Spierings DCJ,Foijer F,van Vugt MATM,Fehrmann RSN

更新日期：2019-02-01 00:00:00

abstract：:Immunopurified mouse p53 proteins were used to gain experimental access to the mechanisms underlying nonprimate p53 directed suppression of SV40 origin directed DNA replication in vivo. In replication competent HeLa cell extracts containing exogenous T antigen, mouse p53 blocks T antigen dependent DNA synthesis as in ...

journal_title：Oncogene

authors： Stürzbecher HW,Brain R,Maimets T,Addison C,Rudge K,Jenkins JR

更新日期：1988-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of critical cell processes such as apoptosis, cell proliferation and differentiation. A small set of miRNAs is differentially expressed in hematopoietic cells and seemingly has an important role in granulopoiesis and lineage differentiation. In th...

journal_title：Oncogene

authors： Careccia S,Mainardi S,Pelosi A,Gurtner A,Diverio D,Riccioni R,Testa U,Pelosi E,Piaggio G,Sacchi A,Lavorgna S,Lo-Coco F,Blandino G,Levrero M,Rizzo MG

更新日期：2009-11-12 00:00:00

abstract：:Intrinsic and acquired resistance to anti-EGFR antibody therapy, frequently mediated by a mutant or amplified KRAS oncogene, is a significant challenge in the treatment of colorectal cancer (CRC). However, the mechanism of KRAS-mediated therapeutic resistance is not well understood. In this study, we demonstrate that ...

journal_title：Oncogene

authors： Knickelbein K,Tong J,Chen D,Wang YJ,Misale S,Bardelli A,Yu J,Zhang L

更新日期：2018-08-01 00:00:00

abstract：:The human tumor suppressor gene ataxia telangiectasia mutated (ATM) encodes a 3056 amino-acid protein kinase that regulates cell cycle checkpoints. ATM is defective in the neurodegenerative and cancer predisposition syndrome ataxia-telangiectasia. ATM protein kinase is activated by DNA damage and responds by phosphory...

journal_title：Oncogene

authors： Llorca O,Rivera-Calzada A,Grantham J,Willison KR

更新日期：2003-06-19 00:00:00

abstract：:The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pe...

journal_title：Oncogene

authors： Khan KA,Naylor AJ,Khan A,Noy PJ,Mambretti M,Lodhia P,Athwal J,Korzystka A,Buckley CD,Willcox BE,Mohammed F,Bicknell R

更新日期：2017-11-02 00:00:00