The consistent 13q14 translocation breakpoint seen in chronic B-cell leukaemia (BCLL) involves deletion of the D13S25 locus which lies distal to the retinoblastoma predisposition gene.

abstract：:Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms, including by mediating tumor-promoting inflammation. Immune modulation in the tumor microenvironment plays a central role in determining disease outcome. Howe...

journal_title：Oncogene

authors： Cohen N,Shani O,Raz Y,Sharon Y,Hoffman D,Abramovitz L,Erez N

更新日期：2017-08-01 00:00:00

abstract：:Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...

journal_title：Oncogene

authors： Sansom OJ,Griffiths DF,Reed KR,Winton DJ,Clarke AR

更新日期：2005-12-08 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first-line chemotherapeutic approach. Thus, there is a strong need for novel therapies, targeting more directly the molecular aberrations of...

journal_title：Oncogene

authors： Calabretta S,Bielli P,Passacantilli I,Pilozzi E,Fendrich V,Capurso G,Fave GD,Sette C

更新日期：2016-04-21 00:00:00

abstract：:The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...

journal_title：Oncogene

authors： Gutzman JH,Rugowski DE,Nikolai SE,Schuler LA

更新日期：2007-09-20 00:00:00

abstract：:Philadelphia chromosome (Ph)-positive leukaemia cells express the chimeric bcr/abl oncoprotein, whose deregulated protein tyrosine kinase (PTK) activity antagonizes the induction of apoptosis by DNA damaging agents. Treatment of Ph-positive K562, TOM 1 and KCL-22 cells with etoposide for 2d induced cytosolic vacuolati...

journal_title：Oncogene

authors： Riordan FA,Bravery CA,Mengubas K,Ray N,Borthwick NJ,Akbar AN,Hart SM,Hoffbrand AV,Mehta AB,Wickremasinghe RG

更新日期：1998-03-26 00:00:00

abstract：:Nerve growth factor (NGF)- and ras-induced neuronal differentiation of PC12 cells is accompanied by expression of transin, a secreted metalloproteinase. Retinoic acid (RA) is known to exert important effects on neural cell proliferation and differentiation. In this study we have analysed different PC12 sublines which ...

journal_title：Oncogene

authors： Cosgaya JM,Recio JA,Aranda A

更新日期：1997-04-10 00:00:00

abstract：:Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...

journal_title：Oncogene

authors： Chatain N,Ziegler P,Fahrenkamp D,Jost E,Moriggl R,Schmitz-Van de Leur H,Müller-Newen G

更新日期：2013-08-01 00:00:00

abstract：:Minichromosome maintenance (MCM) proteins 2-7 are important in DNA replication licensing. Functional roles beyond licensing are speculated. In addition, significances in medulloblastoma (MB) remain unclear. In this study, we showed the frequent deregulation of MCM2 and MCM3 expression in 7 MB cell lines and 31 clinica...

journal_title：Oncogene

authors： Lau KM,Chan QK,Pang JC,Li KK,Yeung WW,Chung NY,Lui PC,Tam YS,Li HM,Zhou L,Wang Y,Mao Y,Ng HK

更新日期：2010-10-07 00:00:00

abstract：:Following discovery of c-Cbl, a cellular form of the transforming retroviral protein v-Cbl, multiple Cbl-related proteins have been identified in vertebrate and invertebrate organisms. c-Cbl and its homologues are capable of interacting with numerous proteins involved in cell signaling, including various molecular ada...

journal_title：Oncogene

authors： Tsygankov AY,Teckchandani AM,Feshchenko EA,Swaminathan G

更新日期：2001-10-01 00:00:00

abstract：:In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...

journal_title：Oncogene

authors： Bosc DG,Goueli BS,Janknecht R

更新日期：2001-09-27 00:00:00

abstract：:Tumors of low malignant potential (LMP) represent 20% of epithelial ovarian cancers (EOCs) and are associated with a better prognosis than the invasive tumors (TOV). Defining the relationship between LMPs and TOVs remains an important goal towards understanding the molecular pathways that contribute to prognosis, as w...

journal_title：Oncogene

authors： Ouellet V,Provencher DM,Maugard CM,Le Page C,Ren F,Lussier C,Novak J,Ge B,Hudson TJ,Tonin PN,Mes-Masson AM

更新日期：2005-07-07 00:00:00

abstract：:eIF4E is essential for translation initiation, but its overexpression causes malignant transformation. Recent work demonstrated that eIF4E/F participates in exposing and locating alternate translation start codons during scanning. Translation initiation of several important protooncogenes and growth-regulators, such a...

journal_title：Oncogene

authors： Carter PS,Jarquin-Pardo M,De Benedetti A

更新日期：1999-07-29 00:00:00

abstract：:The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast cancer. ATM signalling is constitutively activated in early stages of diverse types of human malignancies and c...

journal_title：Oncogene

authors： Tommiska J,Bartkova J,Heinonen M,Hautala L,Kilpivaara O,Eerola H,Aittomäki K,Hofstetter B,Lukas J,von Smitten K,Blomqvist C,Ristimäki A,Heikkilä P,Bartek J,Nevanlinna H

更新日期：2008-04-10 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and comprises two major histological subtypes: alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS). Seventy-five percent of ARMS harbor reciprocal chromosomal translocations leading to fusion genes of the forkhead transcriptio...

journal_title：Oncogene

authors： Zibat A,Missiaglia E,Rosenberger A,Pritchard-Jones K,Shipley J,Hahn H,Fulda S

更新日期：2010-12-02 00:00:00

abstract：:Arg and c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases. The two proteins are composed of SH2, SH3, kinase and C-terminal domains. To examine Arg structure-function relationships we analysed a Gag-Arg fusion protein, analogous to the oncogenic Gag-Abl fusion protein o...

journal_title：Oncogene

authors： Mysliwiec T,Perego R,Kruh GD

更新日期：1996-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous disease comprising a large number of subtypes defined by specific chromosome abnormalities. One such subtype carries the t(6;9)(p22;q34) chromosome rearrangement, which leads to expression of the DEK-NUP214 chimeric gene, and has a particularly poor outcome. To provide a...

journal_title：Oncogene

authors： Qin H,Malek S,Cowell JK,Ren M

更新日期：2016-10-27 00:00:00

abstract：:We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH...

journal_title：Oncogene

authors： Martinerie C,Huff V,Joubert I,Badzioch M,Saunders G,Strong L,Perbal B

更新日期：1994-09-01 00:00:00

abstract：:We have isolated a gene (WS5) that is specifically expressed at the mRNA and protein level in avian fibroblasts transformed by the v-myc oncogene of avian acute leukemia virus MC29. In a conditional cell transformation system, WS5 gene expression was tightly correlated with v-myc activation. The WS5 gene contains 11 e...

journal_title：Oncogene

authors： Reiter F,Hartl M,Karagiannidis AI,Bister K

更新日期：2007-03-15 00:00:00

abstract：:c-myc is a proto-oncogene essential for cell growth. When activated, its expression can lead to uncontrolled cell proliferation, transformation and tumorigenesis. The cell line tEMmyc4 is a murine myelomonocytic cell line that was established following transformation by v-myc. It has a high level of v-myc expression a...

journal_title：Oncogene

authors： Dolnikov A,Ward RL,Hawkins NJ,Symonds G

更新日期：1996-03-21 00:00:00

abstract：:Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted therapy. We used microarray analysis to perform a pathway analysis of TNBC compared with non-triple negative breas...

journal_title：Oncogene

authors： Yang L,Wu X,Wang Y,Zhang K,Wu J,Yuan YC,Deng X,Chen L,Kim CC,Lau S,Somlo G,Yen Y

更新日期：2011-10-27 00:00:00

abstract：:The C3H/HeJ (C3H), A/J and BALB/cByJ (BALB) mouse strains are respectively resistant, sensitive and intermediate regarding the induction of lung tumors by urethane. The phenotypic difference between C3H and A/J is largely determined by the Pas1 (Pulmonary adenoma susceptibility 1) gene on chromosome 6, the A/J allele ...

journal_title：Oncogene

authors： Karasaki H,Obata M,Ogawa K,Lee GH

更新日期：1997-10-09 00:00:00

abstract：:The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...

journal_title：Oncogene

authors： La Rocca SA,Crouch DH,Gillespie DA

更新日期：1994-12-01 00:00:00

abstract：:The products of the proto-oncogenes c-jun and c-fos are known to form a complex in vivo. Complex formation appears to stabilize protein-DNA interactions and is thought to play an important functional role in transcriptional regulation. Here we show that the viral Jun oncoprotein, which differs structurally from cellul...

journal_title：Oncogene

authors： Bos TJ,Rauscher FJ 3rd,Curran T,Vogt PK

更新日期：1989-02-01 00:00:00

abstract：:TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5 (DR5). TRAIL preferentially induces apoptosis in transformed cells and the identification of mechanisms by which TRAIL-induced apoptosis can be enhanced may lead to novel cancer chemotherape...

journal_title：Oncogene

authors： Clarke P,Meintzer SM,Spalding AC,Johnson GL,Tyler KL

更新日期：2001-10-18 00:00:00

abstract：:Tumor recurrence following treatment remains a major clinical challenge in oral cavity cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been considered as the driving force of tumor recurrence and metastasis. However, it still remains unclear whether targeting CSCs in oral cancer is a cl...

journal_title：Oncogene

authors： Hu J,Mirshahidi S,Simental A,Lee SC,De Andrade Filho PA,Peterson NR,Duerksen-Hughes P,Yuan X

更新日期：2019-07-01 00:00:00

abstract：:The whey acidic protein (WAP) domain is a conserved motif, containing eight cysteines found in a characteristic 4-disulphide core arrangement, that is present in a number of otherwise unrelated proteins. WAP motifs are present in SLPI and elafin, two antiproteinases located on chromosome 20q12-13, in a locus rich in p...

journal_title：Oncogene

authors： Bingle L,Singleton V,Bingle CD

更新日期：2002-04-18 00:00:00

abstract：:Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress in the wound microenvironment, there has been no evidence of a similar e...

journal_title：Oncogene

authors： Tan EHP,Sng MK,How ISB,Chan JSK,Chen J,Tan CK,Wahli W,Tan NS

更新日期：2018-04-01 00:00:00

abstract：:Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...

journal_title：Oncogene

authors： Gooding AJ,Zhang B,Gunawardane L,Beard A,Valadkhan S,Schiemann WP

更新日期：2019-03-01 00:00:00

abstract：:Maspin has been demonstrated to be a suppressor of invasion and cell motility in vitro, whereas in vivo analyses have reported that increased expression of maspin is associated with malignant behavior. The present study examined maspin expression in normal lung and non-small-cell lung cancers. Only proximal airway cel...

journal_title：Oncogene

authors： Yatabe Y,Mitsudomi T,Takahashi T

更新日期：2004-05-20 00:00:00

abstract：:Bracken fern is the environmental co-carcinogen of BPV-4 in the induction of neoplasias of the upper alimentary canal of cattle. The flavonoid quercetin is one of the most potent and best characterised mutagens present in the fern. We have shown that transfection with BPV-4 DNA and exposure to a single dose of quercet...

journal_title：Oncogene

authors： Connolly JA,Morgan IM,Jackson ME,Campo MS

更新日期：1998-05-28 00:00:00