Abstract:
:VEGFR-1 (Flt-1), VEGFR-2 (KDR) and VEGFR-3 (Flt4) are endothelial specific receptor tyrosine kinases, regulated by members of the vascular endothelial growth factor family. VEGFRs are indispensable for embryonic vascular development, and are involved in the regulation of many aspects of physiological and pathological angiogenesis. VEGF-C and VEGF-D, as ligands for VEGFR-3 are also capable of stimulating lymphangiogenesis and at least VEGF-C can enhance lymphatic metastasis. Recent studies have shown that missense mutations within the VEGFR-3 tyrosine kinase domain are associated with human hereditary lymphedema, suggesting an important role for this receptor in the development of the lymphatic vasculature.
journal_name
Oncogenejournal_title
Oncogeneauthors
Karkkainen MJ,Petrova TVdoi
10.1038/sj.onc.1203855subject
Has Abstractpub_date
2000-11-20 00:00:00pages
5598-605issue
49eissn
0950-9232issn
1476-5594journal_volume
19pub_type
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