COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer.

abstract：:Deletions involving chromosome 9 occur in more than 50% of human bladder cancers of all grades and stages. Most involve loss of the whole chromosome or of an entire chromosome arm but some small deletions are found which can be used to define critical regions which may contain tumour suppressor genes. We have localize...

journal_title：Oncogene

authors： Hornigold N,Devlin J,Davies AM,Aveyard JS,Habuchi T,Knowles MA

更新日期：1999-04-22 00:00:00

abstract：:GRIM-19 (Gene associated with Retinoid-Interferon-induced Mortality 19) is a novel tumor suppressor regulated by interferon/retinoid combination. We have recently shown that GRIM-19 inhibits v-Src-induced oncogenic transformation and metastatic behavior of cells. Oncogenic v-Src induces cell motility by cytoskeletal r...

journal_title：Oncogene

authors： Sun P,Nallar SC,Kalakonda S,Lindner DJ,Martin SS,Kalvakolanu DV

更新日期：2009-03-12 00:00:00

abstract：:Previous studies have shown that the adenovirus E1A oncoprotein can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300. In this study, wild-type E1A12S or two deletion mutants (delN, which binds pRb but not CBP/p300; delCR2, which binds to CBP/p300 bu...

journal_title：Oncogene

authors： Chen Q,Ash JD,Branton P,Fromm L,Overbeek PA

更新日期：2002-02-07 00:00:00

abstract：:The Ov/Br septin gene, which is also a fusion partner of MLL in acute myeloid leukaemia, is a member of a family of novel GTP binding proteins that have been implicated in cytokinesis and exocytosis. In this study, we describe the genomic and transcriptional organization of this gene, detailing seventeen exons distrib...

journal_title：Oncogene

authors： McIlhatton MA,Burrows JF,Donaghy PG,Chanduloy S,Johnston PG,Russell SE

更新日期：2001-09-13 00:00:00

abstract：:Hedgehog pathway activity has been demonstrated in malignant glioma. However, its role in tumor growth has not been determined. Here we demonstrate that pharmacological inhibition of the Hedgehog pathway in established orthotopic malignant glioma xenografts confers a survival advantage. Pathway inhibition is measured ...

journal_title：Oncogene

authors： Sarangi A,Valadez JG,Rush S,Abel TW,Thompson RC,Cooper MK

更新日期：2009-10-01 00:00:00

abstract：:Ataxia telangiectasia (AT) is a human hereditary syndrome whose underlying gene product, ataxia telangiectasia mutated (ATM) protein kinase, is involved in multiple intracellular signaling pathways. We demonstrated previously that AT fibroblasts are defective in intracellular Ca(2+) mobilization in response to both st...

journal_title：Oncogene

authors： Famulski KS,Al-Hijailan RS,Dobler K,Pienkowska M,Al-Mohanna F,Paterson MC

更新日期：2003-01-23 00:00:00

abstract：:Transforming Growth Factor-beta1 (TGF-beta1) inhibits the proliferation of most cells, but stimulates some mesenchymal cell types, including murine NIH3T3 fibroblasts. We show here that TGF-beta1 growth stimulation of NIH3T3 fibroblasts is reversed when these cells are transformed by SV40 or are transfected with a pla...

journal_title：Oncogene

authors： Dkhissi F,Raynal S,Jullien P,Lawrence DA

更新日期：1999-01-21 00:00:00

abstract：:High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and role of specific epigenetic targets has not been undertaken. Using a two-step, in vitro/in vivo epigenomic shRNA...

journal_title：Oncogene

authors： Green AL,DeSisto J,Flannery P,Lemma R,Knox A,Lemieux M,Sanford B,O'Rourke R,Ramkissoon S,Jones K,Perry J,Hui X,Moroze E,Balakrishnan I,O'Neill AF,Dunn K,DeRyckere D,Danis E,Safadi A,Gilani A,Hubbell-Engler B,Nus

更新日期：2020-03-01 00:00:00

abstract：:The Cbl family proteins Cbl, Cbl-b, and Cbl-c/Cbl-3 are thought to regulate signaling through protein-tyrosine kinases, positively as scaffold proteins and negatively as ubiquitin ligases. However, the precise signaling pathways and target proteins for each Cbl family member are not well understood. Here we show that ...

journal_title：Oncogene

authors： Kim M,Tezuka T,Tanaka K,Yamamoto T

更新日期：2004-03-04 00:00:00

abstract：:A selective switch from expression of Shc1 gene to Shc3 occurs with maturation of neuronal precursors into postmitotic neurons. Previous studies showed that in the embryo, Shc1 is maximally expressed in dividing CNS stem cells while it is silenced in mature neurons, where it is replaced by Shc3. Under normal condition...

journal_title：Oncogene

authors： Magrassi L,Conti L,Lanterna A,Zuccato C,Marchionni M,Cassini P,Arienta C,Cattaneo E

更新日期：2005-08-04 00:00:00

abstract：:Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally expos...

journal_title：Oncogene

authors： Napolitano A,Pellegrini L,Dey A,Larson D,Tanji M,Flores EG,Kendrick B,Lapid D,Powers A,Kanodia S,Pastorino S,Pass HI,Dixit V,Yang H,Carbone M

更新日期：2016-04-14 00:00:00

abstract：:Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC). To study the genetic basis for these tumors, we microdissected MTC specimens or obtaine...

journal_title：Oncogene

authors： Coxon AB,Ward JM,Geradts J,Otterson GA,Zajac-Kaye M,Kaye FJ

更新日期：1998-09-24 00:00:00

abstract：:Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that is mutated in the Simpson-Golabi-Behmel syndrome. This is an X-linked condition characterized by overgrowth, and various visceral and skeletal dysmorphisms. The phenotype of the Simpson-Golabi-Behmel syndrome patients and GPC3-deficient mice, as w...

journal_title：Oncogene

authors： Xiang YY,Ladeda V,Filmus J

更新日期：2001-11-01 00:00:00

abstract：:The c-Jun NH2-terminal kinase (JNK) pathway represents one subgroup of MAP kinases that are activated primarily by cytokines and exposure to environmental stress. Autophagy is a protein-degradation system characterized by the formation of double-membrane vacuoles termed autophagosomes. Autophagy-related gene beclin 1 ...

journal_title：Oncogene

authors： Li DD,Wang LL,Deng R,Tang J,Shen Y,Guo JF,Wang Y,Xia LP,Feng GK,Liu QQ,Huang WL,Zeng YX,Zhu XF

更新日期：2009-02-12 00:00:00

abstract：:Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitosis leading to the generation of lagging chromosomes during anaphase as a major form of mitotic errors in human...

journal_title：Oncogene

authors： Schmidt AK,Pudelko K,Boekenkamp JE,Berger K,Kschischo M,Bastians H

更新日期：2021-01-01 00:00:00

abstract：:The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas. As cat mammary tumours have been proposed as a suitable model for aggressive human breast cancer, we identified the feline stk g...

journal_title：Oncogene

authors： De Maria R,Maggiora P,Biolatti B,Prat M,Comoglio PM,Castagnaro M,Di Renzo MF

更新日期：2002-03-07 00:00:00

abstract：:Solid tumors frequently contain hypoxic subregions due to insufficient blood supply. In these domains, cells can undergo p53-dependent apoptosis. Therefore, hypoxia has been implicated as a physiological stimulus for p53 accumulation and activation. In such an environment, p53 mutant cells exhibit a selective growth a...

journal_title：Oncogene

authors： Pan Y,Oprysko PR,Asham AM,Koch CJ,Simon MC

更新日期：2004-06-24 00:00:00

abstract：:The tumor suppressor gene Pdcd4 (programmed cell death gene 4) has drawn considerable attention because its downregulation is involved in the development of several types of cancer. Because Pdcd4 interacts with the translation initiation factor eIF4A and inhibits its helicase activity, Pdcd4 has been implicated in the...

journal_title：Oncogene

authors： Biyanee A,Ohnheiser J,Singh P,Klempnauer KH

更新日期：2015-03-12 00:00:00

abstract：:Signet-ring cell carcinoma is classified in poorly differentiated adenocarcinoma with an aggressive nature and a poor prognosis. We have shown that the activation of PI 3-kinase in highly differentiated adenocarcinomas induces loss of cell-cell contact and formation of vacuoles, giving phenotypes similar to those of s...

journal_title：Oncogene

authors： Xu Q,Karouji Y,Kobayashi M,Ihara S,Konishi H,Fukui Y

更新日期：2003-08-28 00:00:00

abstract：:Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) and mutation of the p53 are both commonly detected in human prostate cancer cells. We sought to investigate whether there is functional regulation of Stat3 by wild-type (wt) p53. Our results demonstrate that expression of wt p53 ...

journal_title：Oncogene

authors： Lin J,Tang H,Jin X,Jia G,Hsieh JT

更新日期：2002-05-02 00:00:00

abstract：:Appropriate expression of HTLV-1 genes requires transcriptional transactivation by Tax and post-transcriptional regulation by Rex, both mediated by LTR encoded RNA sequences. Using a combination of deletion mutagenesis, Rex-reporter CAT assays, fluorescence in situ hybridization (FISH) and confocal laser scanning micr...

journal_title：Oncogene

authors： King JA,Bridger JM,Löchelt M,Lichter P,Schulz TF,Schirrmacher V,Khazaie K

更新日期：1998-06-25 00:00:00

abstract：:Post-translational acetylation of lysines is most extensively studied in histones, but this modification is also found in many other proteins and is implicated in a wide range of biological processes in both the cell nucleus and the cytoplasm. Like phosphorylation, acetylation patterns and levels are often altered in ...

journal_title：Oncogene

authors： Farria A,Li W,Dent SY

更新日期：2015-09-17 00:00:00

abstract：:Provirus modifications which can occur in tumors may lead to tumor antigenic variants. To investigate this possibility we compared the restriction fragment length patterns of mouse mammary tumor virus (MMTV), murine leukemia virus and xenotropic and mink cell-focus inducing (MCF)-related sequences, using Southern blot...

journal_title：Oncogene

authors： Colombo MP,Ferrari G,Parmiani G,Wettstein PJ

更新日期：1988-04-01 00:00:00

abstract：:Colorectal cancer is a major cause of cancer deaths in Western countries, but epidemiological data suggest that dietary modification might reduce these by as much as 90%. Cyclo-oxygenase 2 (COX2), an inducible isoform of prostaglandin H synthase, which mediates prostaglandin synthesis during inflammation, and which is...

journal_title：Oncogene

authors： Plummer SM,Holloway KA,Manson MM,Munks RJ,Kaptein A,Farrow S,Howells L

更新日期：1999-10-28 00:00:00

abstract：:The NF-kappaB signaling pathway has particular relevance to several liver diseases including hepatitis (liver infection by Helicobacter, viral hepatitis induced by HBV and HCV), liver fibrosis and cirrhosis and hepatocellular carcinoma. Furthermore, the NF-kappaB signaling pathway is a potential target for development...

journal_title：Oncogene

authors： Sun B,Karin M

更新日期：2008-10-20 00:00:00

abstract：:Non small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the United States and worldwide. Unfortunately, standard therapies remain inadequate. An increased understanding of the molecular biology of lung cancer biology is required to develop more effective new therapies. In this report, we show that ...

journal_title：Oncogene

authors： Uematsu K,He B,You L,Xu Z,McCormick F,Jablons DM

更新日期：2003-10-16 00:00:00

abstract：:Most human lymphomas originate from transformed germinal center (GC) B lymphocytes. While activating mutations and translocations of MYC, BCL2 and BCL6 promote specific GC lymphoma subtypes, other genetic and epigenetic modifications that contribute to malignant progression in the GC remain poorly defined. Recently, a...

journal_title：Oncogene

authors： Dawson DW,Hong JS,Shen RR,French SW,Troke JJ,Wu YZ,Chen SS,Gui D,Regelson M,Marahrens Y,Morse HC 3rd,Said J,Plass C,Teitell MA

更新日期：2007-06-21 00:00:00

abstract：:The subnuclear distribution of proteins encoded by v-myb and v-myc was analysed in a cell-line of AMV-transformed chicken myeloblasts superinfected by the myc-containing retrovirus MC29. p45v-myb and p110gag-myc, co-expressed in these cells, were released in similar fashion when nuclei were treated with salt or DNAase...

journal_title：Oncogene

authors： Klempnauer KH

更新日期：1989-01-01 00:00:00

abstract：:Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB recepto...

journal_title：Oncogene

authors： Humtsoe JO,Pham E,Louie RJ,Chan DA,Kramer RH

更新日期：2016-03-24 00:00:00

abstract：:ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...

journal_title：Oncogene

authors： Li Y,Zhou Z,Alimandi M,Chen C

更新日期：2009-08-20 00:00:00