Association of v-myc protein with chromatin.

abstract：:Inactivation of the tumor suppressor NF2/merlin underlies neurofibromatosis type 2 (NF2) and some sporadic tumors. Previous studies have established that merlin mediates contact inhibition of proliferation; however, the exact mechanisms remain obscure and multiple pathways have been implicated. We have previously repo...

journal_title：Oncogene

authors： Cui Y,Groth S,Troutman S,Carlstedt A,Sperka T,Riecken LB,Kissil JL,Jin H,Morrison H

更新日期：2019-09-01 00:00:00

abstract：:Human basal cell cancer (BCC) has unique growth characteristics with virtual inability to metastasize. We investigated clonality and genetic progression using p53 mutations as marker. Sampling was done through microdissection of frozen immunohistochemically stained 16 microm slices of tumors. From 11 BCC tumors 78 sam...

journal_title：Oncogene

authors： Pontén F,Berg C,Ahmadian A,Ren ZP,Nistér M,Lundeberg J,Uhlén M,Pontén J

更新日期：1997-08-28 00:00:00

abstract：:The p53 tumor suppressor protein activates transcription and induces cell death. A close homologue of p53, termed p73, is expressed in transactivating (TA) forms that induce growth arrest and apoptosis much like p53. However, the p73 gene contains a second promoter, giving rise to the expression of p73 Delta N, a spec...

journal_title：Oncogene

authors： Kartasheva NN,Contente A,Lenz-Stöppler C,Roth J,Dobbelstein M

更新日期：2002-07-18 00:00:00

abstract：:Ovarian cancer (OvCa) is characterized by widespread and rapid metastasis in the peritoneal cavity. Visceral adipocytes promote this process by providing fatty acids (FAs) for tumour growth. However, the exact mechanism of FA transfer from adipocytes to cancer cells remains unknown. This study shows that OvCa cells co...

journal_title：Oncogene

authors： Ladanyi A,Mukherjee A,Kenny HA,Johnson A,Mitra AK,Sundaresan S,Nieman KM,Pascual G,Benitah SA,Montag A,Yamada SD,Abumrad NA,Lengyel E

更新日期：2018-04-01 00:00:00

abstract：:Using a combination of raf and myc oncogenes co-expressed by the recombinant retrovirus J-2 we have generated and characterized a cell line which very efficiently supports the growth of B-cells and B-cell hybridomas. Murine spleen cells were cultured under in vitro immunization conditions favoring the short term proli...

journal_title：Oncogene

authors： Mischak H,Kolch W,Hofer F,Weissinger E,Gessl A,Davidson WF,Aiello FB,Blaas D,Rapp UR

更新日期：1990-09-01 00:00:00

abstract：:The antifolates were the first class of antimetabolites to enter the clinics more than 50 years ago. Over the following decades, a full understanding of their mechanisms of action and chemotherapeutic potential evolved along with the mechanisms by which cells develop resistance to these drugs. These principals served ...

journal_title：Oncogene

authors： Zhao R,Goldman ID

更新日期：2003-10-20 00:00:00

abstract：:Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa metastasis to lymph n...

journal_title：Oncogene

authors： Jin JK,Tien PC,Cheng CJ,Song JH,Huang C,Lin SH,Gallick GE

更新日期：2015-04-02 00:00:00

abstract：:The p53 protein is a multifunctional transcription factor which orchestrates cellular responses to DNA damage, so helping to conserve genomic stability. It may also regulate genes involved in intercellular signalling, such as thrombospondin, a negative regulator of angiogenesis and metastatic spread. Activation of p53...

journal_title：Oncogene

authors： Rolley N,Butcher S,Milner J

更新日期：1995-08-17 00:00:00

abstract：:Two alternatively spliced mouse lymphocyte and brain ltk cDNAs predict small transmembrane tyrosine kinases that use CUG translational start codons and that differ upstream of their transmembrane segment. A recently isolated human neuroblastoma ltk cDNA, in contrast, includes a regular AUG start codon and predicts a m...

journal_title：Oncogene

authors： Snijders AJ,Haase VH,Bernards A

更新日期：1993-01-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progressi...

journal_title：Oncogene

authors： Stieglitz D,Lamm S,Braig S,Feuerer L,Kuphal S,Dietrich P,Arndt S,Echtenacher B,Hellerbrand C,Karrer S,Bosserhoff AK

更新日期：2019-01-01 00:00:00

abstract：:c-Abl is a nuclear and cytoplasmic tyrosine kinase involved in a variety of cellular growth and differentiation processes. In contrast to its oncogenic counterparts, like BCR-Abl, c-Abl is not constitutively tyrosine phosphorylated and its catalytic activity is very low. Here we report tyrosine phosphorylation of endo...

journal_title：Oncogene

authors： Dorey K,Engen JR,Kretzschmar J,Wilm M,Neubauer G,Schindler T,Superti-Furga G

更新日期：2001-12-06 00:00:00

abstract：:Friend virus-induced erythroleukemia involves two members of the ETS family of transcriptional regulators, both activated via proviral insertion in the corresponding loci. Spi-1/PU.1 is expressed in the disease induced by the original Friend virus SFFV(F-MuLV) complex in adult mice. In contrast, FLI-1 is overexpressed...

journal_title：Oncogene

authors： Pereira R,Quang CT,Lesault I,Dolznig H,Beug H,Ghysdael J

更新日期：1999-02-25 00:00:00

abstract：:Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (...

journal_title：Oncogene

authors： Schoeneberger H,Belz K,Schenk B,Fulda S

更新日期：2015-07-30 00:00:00

abstract：:A Rho GTPase-activating protein (RhoGAP), deleted in liver cancer 1 (DLC1), is known to function as a tumor suppressor in various cancer types; however, whether DLC1 is a tumor-suppressor gene or an oncogene in melanoma remains to be clarified. Here we revealed that high DLC1 expression was detected in most of the mel...

journal_title：Oncogene

authors： Yang X,Hu F,Liu JA,Yu S,Cheung MPL,Liu X,Ng IO,Guan XY,Wong KKW,Sharma R,Lung HL,Jiao Y,Lee LTO,Cheung M

更新日期：2020-05-01 00:00:00

abstract：:The ARF tumour suppressor protein plays a critical role in the activation of p53 in response to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2. However, several lines of evidence indicate that this is not the only way of action of ARF, and alternative mechanisms must exist. p33ING1 is a...

journal_title：Oncogene

authors： González L,Freije JM,Cal S,López-Otín C,Serrano M,Palmero I

更新日期：2006-08-24 00:00:00

abstract：:Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin rec...

journal_title：Oncogene

authors： Langlais P,Dong LQ,Hu D,Liu F

更新日期：2000-06-08 00:00:00

abstract：:Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...

journal_title：Oncogene

authors： Lee Y,Kim SJ,Park HD,Park EH,Huang SM,Jeon SB,Kim JM,Lim DS,Koh SS

更新日期：2010-01-07 00:00:00

abstract：:We have studied the relationship between ras-GAP and G protein coupled receptors in a proliferative setting comprised of NIH3T3 expressing transfected muscarinic receptors (mAChRs). GAP expression plasmids were engineered to encode wild-type GAP, its carboxyl-terminal catalytic domain, a mutant lacking a portion of th...

journal_title：Oncogene

authors： Xu N,McCormick F,Gutkind JS

更新日期：1994-02-01 00:00:00

abstract：:Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an important role in the development of cancer, including HPV-related tum...

journal_title：Oncogene

authors： Peta E,Sinigaglia A,Masi G,Di Camillo B,Grassi A,Trevisan M,Messa L,Loregian A,Manfrin E,Brunelli M,Martignoni G,Palù G,Barzon L

更新日期：2018-03-01 00:00:00

abstract：:Mouse malignant T-lymphoma CS-21 cells grow in vitro in the presence of CA-12 lymph node stromal cells, but they undergo apoptotic cell death when separated from CA-12 stromal cells. In the course of examining the nursing effects of CA-12 stromal cells, we found that these cells provided some soluble factors that supp...

journal_title：Oncogene

authors： Lee SH,Fujita N,Mashima T,Tsuruo T

更新日期：1996-11-21 00:00:00

abstract：:The transcription factor activator protein-1 (AP-1) has been implicated in a large variety of biological processes including cell differentiation, proliferation, apoptosis and oncogenic transformation. It is thought that the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced AP-1 activity is because of the activation ...

journal_title：Oncogene

authors： Li J,Ma C,Huang Y,Luo J,Huang C

更新日期：2003-01-16 00:00:00

abstract：:As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional co-activator, whereas the SSX proteins are thought to act as transcriptional co...

journal_title：Oncogene

authors： de Bruijn DR,van Dijk AH,Willemse MP,van Kessel AG

更新日期：2008-01-24 00:00:00

abstract：:The forkhead transcription factor FOXO1, a downstream target of phosphatidylinositol-3-kinase/Akt signalling pathway, regulates cyclic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis is unknown. Screening of endometrial cancer cell lines demonstrated that FOXO1 is expres...

journal_title：Oncogene

authors： Goto T,Takano M,Albergaria A,Briese J,Pomeranz KM,Cloke B,Fusi L,Feroze-Zaidi F,Maywald N,Sajin M,Dina RE,Ishihara O,Takeda S,Lam EW,Bamberger AM,Ghaem-Maghami S,Brosens JJ

更新日期：2008-01-03 00:00:00

abstract：:Tumor suppressor p53 forms a homo-tetramer through its COOH-terminal oligomerization domain and acts as a sequence-specific transcription factor. We have analysed the interrelation among the transcriptional activities, the structure and the cancer-related mutations in the oligomerization domain by using a comprehensiv...

journal_title：Oncogene

authors： Kawaguchi T,Kato S,Otsuka K,Watanabe G,Kumabe T,Tominaga T,Yoshimoto T,Ishioka C

更新日期：2005-10-20 00:00:00

abstract：:Increased glucose consumption is a hallmark of cancer cells. The increased consumption and subsequent metabolism of glucose during proliferation creates the need for a constant supply of NAD, a co-factor in glycolysis. Regeneration of the NAD required to support enhanced glycolysis has been attributed to the terminal ...

journal_title：Oncogene

authors： Hanse EA,Ruan C,Kachman M,Wang D,Lowman XH,Kelekar A

更新日期：2017-07-06 00:00:00

abstract：:MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, are involved in many complex cellular processes. Several miRNAs are differentially expressed in hematopoietic tissues and play important roles in normal differentiation, but, when aberrantly regulated, contribute to the abn...

journal_title：Oncogene

authors： Pelosi A,Careccia S,Lulli V,Romania P,Marziali G,Testa U,Lavorgna S,Lo-Coco F,Petti MC,Calabretta B,Levrero M,Piaggio G,Rizzo MG

更新日期：2013-08-01 00:00:00

abstract：:BRCA1 is a tumour suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. We have generated cell lines with inducible expression of BRCA1 to evaluate its role in mediating the cellular response to various chemotherapeutic drugs commonly used in the treatment of breast and ovarian can...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Gilmore PM,McWilliams S,Andrews H,Gervin C,McCabe N,McKenna S,White P,Song YH,Maheswaran S,Liu E,Haber DA,Johnston PG,Harkin DP

更新日期：2001-09-27 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a malignant hematopoietic disorder whose proliferative component is a result of RAS pathway deregulation caused by somatic mutation in the RAS or PTPN11 oncogenes or in patients with underlying neurofibromatosis type 1 (NF-1), by loss of NF1 gene function. To search for poten...

journal_title：Oncogene

authors： Flotho C,Steinemann D,Mullighan CG,Neale G,Mayer K,Kratz CP,Schlegelberger B,Downing JR,Niemeyer CM

更新日期：2007-08-23 00:00:00

abstract：:Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppre...

journal_title：Oncogene

authors： Umeda Y,Hasegawa Y,Otsuka M,Ariki S,Takamiya R,Saito A,Uehara Y,Saijo H,Kuronuma K,Chiba H,Ohnishi H,Sakuma Y,Takahashi H,Kuroki Y,Takahashi M

更新日期：2017-11-16 00:00:00

abstract：:Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...

journal_title：Oncogene

authors： Varga AE,Stourman NV,Zheng Q,Safina AF,Quan L,Li X,Sossey-Alaoui K,Bakin AV

更新日期：2005-07-28 00:00:00