Abstract:
:Two alternatively spliced mouse lymphocyte and brain ltk cDNAs predict small transmembrane tyrosine kinases that use CUG translational start codons and that differ upstream of their transmembrane segment. A recently isolated human neuroblastoma ltk cDNA, in contrast, includes a regular AUG start codon and predicts a more conventional receptor kinase with a larger N-terminal segment. This raised the suggestion that previous mouse cDNAs may have been aberrantly spliced or incomplete and questioned the significance of a recent study that localized the lymphoid ltk protein to the endoplasmic reticulum. Here we show that mice tissue-specifically express four ltk mRNAs. In addition to the two previously described lymphoid and brain mRNAs, we now describe two mRNAs from C1300 neuroblastoma cells that start with five exons which are absent from lymphoid or brain transcripts. The pair of C1300 mRNAs differ by the same alternatively spliced exon that distinguishes brain from lymphoid mRNAs and predict much larger receptor-type kinases that use regular AUG start codons. Our results also show that at least one of the larger, more conventional C1300 ltk receptors shares the endoplasmic reticulum localization of the shorter lymphoid protein.
journal_name
Oncogenejournal_title
Oncogeneauthors
Snijders AJ,Haase VH,Bernards Asubject
Has Abstractpub_date
1993-01-01 00:00:00pages
27-35issue
1eissn
0950-9232issn
1476-5594journal_volume
8pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::We previously reported that overexpression of the 24 kDa basic fibroblast factor (or FGF-2) isoform provides protection from the cytotoxic effect of ionizing radiation (IR). DNA double-strand breaks (DSB), the IR-induced lethal lesions, are mainly repaired in human cells by non-homologous end joining system (NHEJ). NH...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205838
更新日期:2002-09-19 00:00:00
abstract::Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81 results in hypersensitivity to DNA-damaging agents, defects on both t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.16
更新日期:2016-09-15 00:00:00
abstract::Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27. These pivotal epigenetic marks are altered in many cancers, including melanoma, as a result of EZH2 overexpression. Here, we show that the non-canonical-NF-kB pathway accounts for mo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.331
更新日期:2016-05-01 00:00:00
abstract::The natural phytoalexin resveratrol (3, 5, 4'-trihydroxystilbene) exhibits both chemopreventive and antitumor activities through a variety of mechanisms. We have shown previously that resveratrol-induced apoptosis of a human colon cancer cell line involved the redistribution of CD95 (Fas/Apo-1) into lipid rafts. Here,...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208086
更新日期:2004-11-25 00:00:00
abstract::The t(8;21) is associated with 12-15% of acute myelogenous leukemias of the M2 subtype. The translocation results in the fusion of two genes, AML1 (CBFA2) on chromosome 21 and ETO (MTG8) on chromosome 8. AML1 encodes a DNA binding factor; the ETO protein product is less well characterized, but is thought to be a trans...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202412
更新日期:1999-02-11 00:00:00
abstract::Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.70
更新日期:2017-08-01 00:00:00
abstract::The most common mutations in the familial breast and ovarian cancer susceptibility gene BRCA1 are frameshift and nonsense mutations, which lead to the synthesis of truncated proteins. On this ground, we have analysed BRCA1 exon 11, which includes about 61% of coding region, in germline DNA from 70 Italian breast and/o...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-09-19 00:00:00
abstract::We have previously reported on the identification of a cDNA (placenta growth factor, PlGF) coding for a novel angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). Biochemical and functional characterization of PlGF derived from t...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-10-17 00:00:00
abstract::The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1209872
更新日期:2006-09-25 00:00:00
abstract::Tuftelin1 (TUFT1), an acidic protein constituent of developing and mineralizing tooth tissues, is regulated by hypoxia and the Hedgehog signaling pathway. We investigated the role of TUFT1 in hepatocellular carcinoma (HCC). qRT-PCR, immunohistochemistry and western blot were employed to evaluate TUFT1 level in HCC. MT...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0505-8
更新日期:2019-02-01 00:00:00
abstract::Although there is indirect genetic evidence that MEN1, the gene for multiple endocrine neoplasia type 1, is a tumor suppressor gene, little is known about the MEN1-encoded protein, menin. Menin was stably overexpressed in a well-characterized murine tumor cell line, (valine-12)-RAS-transformed NIH3T3 cells. Menin over...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203005
更新日期:1999-10-21 00:00:00
abstract::Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development of aggressive prostate cancer (PrCa) is pivotal in developing new therapies. Using a systems biology approach, we interrogated the AR-regulated proteome and identified PDZ binding kinase (PBK) as a novel AR-re...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0501-z
更新日期:2019-02-01 00:00:00
abstract::A flow cytometric assay was developed to examine the expression of the cellular myc oncogene in relation to cell cycle in individual cells. C-myc-oncoprotein was detected by indirect immunofluorescence using a purified sheep polyclonal antibody, anti-human-myc. Specific binding of anti-human-myc was measured by flow c...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Cancer cells show deviant behavior that induces apoptotic signaling. To survive, cancer cells typically acquire changes enabling evasion of death signals. One way they do this is by increasing the expression of anti-apoptotic BCL-2 proteins. Anti-apoptotic BCL-2 family proteins antagonize death signaling by forming he...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2009.52
更新日期:2008-12-01 00:00:00
abstract::The tumor suppressor gene Pdcd4 (programmed cell death gene 4) has drawn considerable attention because its downregulation is involved in the development of several types of cancer. Because Pdcd4 interacts with the translation initiation factor eIF4A and inhibits its helicase activity, Pdcd4 has been implicated in the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.83
更新日期:2015-03-12 00:00:00
abstract::In Dictyostelium discoideum, three ras genes (rasD, rasG and rasB) and one ras-related gene (rap1) have been previously isolated and characterized, and the deduced amino acid sequence of their predicted protein products share at least 50% sequence identity with the human H-Ras protein. We have now cloned and character...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::Pretreatment of cells with 0.5 mM sodium arsenite (but not other activators of stress-activated MAP kinase cascades) prevents the activation of p21Ras and strongly suppresses the activation of c-Raf and the MAP kinase cascade by a variety of growth factors. Arsenite appears to exert its effect by preventing the guanin...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202168
更新日期:1998-07-09 00:00:00
abstract::Diminished expression of the metastasis suppressor protein RKIP was previously reported in a number of cancers. The underlying mechanism remains unknown. Here, we show that the expression of RKIP negatively correlates with that of Snail zinc-transcriptional repressor, a key modulator of normal and neoplastic epithelia...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210860
更新日期:2008-04-03 00:00:00
abstract::Wild-type p53 is stabilized and accumulates in the nucleus of DNA damaged cells. The effect of stabilizing p53 is to inhibit cell growth, either through a G1 cell cycle arrest or apoptotic cell death. MDM2 can inhibit p53 activity, in part, by promoting its rapid degradation through the ubiquitin proteolysis pathway. ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203980
更新日期:2000-11-30 00:00:00
abstract::In chronic myelogenous leukemia (CML), the oncogene bcr-abl encodes a dysregulated tyrosine kinase that inhibits apoptosis. We showed previously that human erythroleukemia K562 cells are resistant to antineoplastic drug (taxol)-induced apoptosis through the atypical protein kinase C iota isozyme (PKC iota), a kinase d...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204607
更新日期:2001-08-09 00:00:00
abstract::Vascular endothelial growth factor-A (VEGF-A) is highly subjected to alternative pre-mRNA splicing that generates several splice variants. The VEGFxxx and VEGFxxxb families encode splice variants of VEGF-A that differ only at the level of six amino acids in their C-terminal part. The expression level of VEGFxxx splice...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0486-7
更新日期:2019-02-01 00:00:00
abstract::Activation of the EGF receptor (c-erbB) tyrosine kinase has been implicated in tumorigenesis, either by overexpression of the normal receptor in the presence of EGF, or through expression of a truncated receptor lacking the EGF binding domain as in the viral oncogene v-erbB. Here, normal and truncated human EGF recept...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::c-Abl is a nuclear and cytoplasmic tyrosine kinase involved in a variety of cellular growth and differentiation processes. In contrast to its oncogenic counterparts, like BCR-Abl, c-Abl is not constitutively tyrosine phosphorylated and its catalytic activity is very low. Here we report tyrosine phosphorylation of endo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205017
更新日期:2001-12-06 00:00:00
abstract::An altered protein expression of Ca(2+)-dependent protein kinase C (PKC) isoforms and a point mutation in the PKC alpha cDNA (position 908 of the nucleotide sequence, position 294 of the amino acid sequence, substitution of an aspartic acid by a glycine) have been previously described in a subpopulation of human pitui...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-08-17 00:00:00
abstract::The chromosomal translocation t(8;21) is associated with 10-15% of all cases of acute myeloid leukaemia (AML). The resultant fusion protein AML1/MTG8 interferes with haematopoietic gene expression and is an important regulator of leukaemogenesis. We studied the effects of small interfering RNA (siRNA)-mediated AML1/MT...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209638
更新日期:2006-10-05 00:00:00
abstract::Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation (PARylation). However, it remains largely unclear how PARP1 activity is regulated. Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitate...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0506-7
更新日期:2019-02-01 00:00:00
abstract::The vast majority of cancer cells have defective checkpoints that permit the cell cycle to progress in the presence of double-strand DNA breaks (DSBs) caused by ionizing radiation (IR) and radiomimetic drugs. ATR (ataxia telangiectasia-mutated and Rad3-related) has recently been shown to be activated by DSBs, although...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210049
更新日期:2007-04-19 00:00:00
abstract::Loss of p53 function is associated with the acquisition of cisplatin resistance in the human ovarian adenocarcinoma A2780 cell line. Selection for cisplatin resistance of A2780 cells was used to isolate genetic suppressor elements (GSEs) from a retroviral library expressing random fragments of human or murine TP53 cDN...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200813
更新日期:1997-01-16 00:00:00
abstract::Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202290
更新日期:1999-01-14 00:00:00