Abstract：
:Although there is indirect genetic evidence that MEN1, the gene for multiple endocrine neoplasia type 1, is a tumor suppressor gene, little is known about the MEN1-encoded protein, menin. Menin was stably overexpressed in a well-characterized murine tumor cell line, (valine-12)-RAS-transformed NIH3T3 cells. Menin overexpression reverted the morphology of the RAS-transformed NIH3T3 cells towards the more flattened and more spread, fibroblastic shape of wild type NIH3T3 cells. The proliferation rate of the RAS-transformed cells in 0.5% calf serum was also slower with menin overexpression. Menin overexpression reduced the RAS-induced clonogenicity in soft agar. Menin also reduced tumor growth after injection of cells in nude mice. In conclusion, stable overexpression of MEN1 suppressed partially the RAS-mediated tumor phenotype in vitro and in vivo. Overexpressed menin protein had biological effects, directly supporting MEN1 gene function as a tumor suppressor.
journal_name
Oncogenejournal_title
Oncogeneauthors
Kim YS,Burns AL,Goldsmith PK,Heppner C,Park SY,Chandrasekharappa SC,Collins FS,Spiegel AM,Marx SJdoi
10.1038/sj.onc.1203005subject
Has Abstractpub_date
1999-10-21 00:00:00pages
5936-42issue
43eissn
0950-9232issn
1476-5594journal_volume
18pub_type
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