Abstract:
:The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and ALK receptor protein-tyrosine kinase. We used yeast two-hybrid screening to identify an adaptor protein Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target (SNT)-2 as a new partner that interacted with the cytoplasmic domain of ALK. Immunoprecipitation assay revealed that SNT-1 and SNT-2 interacted with NPM-ALK and kinase-negative NPM-ALK mutant. Y156, Y567 and a 19-amino-acid sequence (aa 631-649) of NPM-ALK were essential for this interaction. The interaction through Y156 and Y567 was dependent on phosphorylation of these tyrosines, whereas the interaction through the 19-amino-acid sequence was independent of phosphorylation. NPM-ALK mutant protein mutated at these three binding sites showed significantly reduced transforming activity. This transformation-defective NPM-ALK mutant still interacted with signal transducing proteins such as phospholipase C-gamma and phosphatidylinositol 3-kinase, which were previously reported to be relevant to NPM-ALK-dependent tumorigenesis. These observations indicate that the three SNT-binding sites of NPM-ALK are important for its transforming activity. This raises a possibility that SNT family proteins play significant roles in cellular transformation triggered by NPM-ALK, which though remains to be verified.
journal_name
Oncogenejournal_title
Oncogeneauthors
Chikamori M,Fujimoto J,Tokai-Nishizumi N,Yamamoto Tdoi
10.1038/sj.onc.1210095subject
Has Abstractpub_date
2007-05-03 00:00:00pages
2950-4issue
20eissn
0950-9232issn
1476-5594pii
1210095journal_volume
26pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Phosphorylation of linker histone H1(S)-3 (previously named H1b) and core histone H3 is elevated in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase (MAPK) kinase (MEK). H1(S)-3 phosphorylation is the only histone modification known to be dependent upon transcripti...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206029
更新日期:2002-12-05 00:00:00
abstract::Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein highly expressed in breast cancer that contributes to tumor progression through largely undefined mechanisms. By analyzing publicly available gene expression profiles of breast carcinomas, we found that MFG-E8 is highly expressed in primary and metastatic breast...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.356
更新日期:2012-03-22 00:00:00
abstract::c-Myc drives uncontrolled cell proliferation in various human cancers. However, in mouse embryo fibroblasts (MEFs), c-Myc also induces apoptosis by activating the p19Arf tumor suppressor pathway. Tbx2, a transcriptional repressor of p19Arf, can collaborate with c-Myc by suppressing apoptosis. MEFs overexpressing c-Myc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.294
更新日期:2008-11-20 00:00:00
abstract::In search of human homologues of the anti-apoptotic protein Nr-13, we have characterized a human EST clone that potentially encodes a protein, which is the closest homologue of Nr-13 among the Bcl-2 family members, to date known, in humans. Phylogenetic analyses suggest Human nrh, Mouse diva/boo and Quail nr-13 to be ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204740
更新日期:2001-09-13 00:00:00
abstract::Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0586-4
更新日期:2019-03-01 00:00:00
abstract::While advances in laboratory automation has dramatically increased throughout of compound screening efforts, development of robust cell-based assays in relevant disease models remain resource-intensive and time-consuming, presenting a bottleneck to drug discovery campaigns. To address this issue, we present a modified...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0274-4
更新日期:2018-08-01 00:00:00
abstract::Rac1-GTPases serve as intermediary cellular switches, which conduct transient and constitutive signals from upstream cues, including those from Ras oncoproteins. Although the sirtuin1 (SIRT1) deacetylase is overexpressed in several human cancers and has recently been linked to cancer cell motility as a context-depende...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.549
更新日期:2015-01-08 00:00:00
abstract::Topors was identified recently as a human protein that binds to topoisomerase I and p53. Topors contains a highly conserved RING domain and localizes in promyelocytic leukemia nuclear bodies. Relatively little is known regarding topors expression patterns or function. We now demonstrate that topors mRNA and protein ar...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207700
更新日期:2004-07-08 00:00:00
abstract::Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB recepto...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.220
更新日期:2016-03-24 00:00:00
abstract::The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino a...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::The tax gene product of the human T-cell leukemia virus type I (HTLV-I) induces the nuclear expression and biological function of the NF-kappa B/Rel family of host transcription factors although the underlying mechanism remains unclear. In the present study, we demonstrate that Tax-mediated activation of NF-kappa B/Re...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-09-07 00:00:00
abstract::Non-small cell lung carcinomas (NSCLCs) are typically resistant against apoptosis induced by standard chemotherapy. We evaluated the effects of the two potential antitumor agents of the lamellarin class on a highly apoptosis-resistant NSCLC cell line. Both the marine alkaloid lamellarin-D and its synthetic amino deriv...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210833
更新日期:2008-03-27 00:00:00
abstract::In the present study, we have analysed the effects of transforming growth factor-beta (TGF-beta) signaling on the growth behavior of pancreatic carcinoma cells in vitro and on their tumorigenicity in vivo. Ectopic expression of dominant-negative mutants of the TGF-beta type II receptor or type I receptor/activin recep...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210272
更新日期:2007-07-19 00:00:00
abstract::The Crk II adaptor protein encodes an SH2/SH3-domain containing adaptor protein with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The two SH3 domains are separated by a 54 amino acid linker region, whose length is highly conserved in xenopus, chicken, and mamalian Crk II proteins. To g...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204173
更新日期:2001-02-22 00:00:00
abstract::Altered expression of regulatory RNA-binding proteins (RBPs) in cancer leads to abnormal expression of mRNAs encoding many factors involved in cancer hallmarks. While conventional anticancer therapies usually target one pathway at a time, targeting key RBP would affect multiple genes and thus overcome drug resistance....
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0784-8
更新日期:2019-06-01 00:00:00
abstract::The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding act...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::The p53 tumor suppressor protein is frequently mutated in human tumors. It is thought that the p53 pathway is indirectly impaired in the remaining tumors, for example by overexpression of its important regulators Mdm2 and Mdm4, making them attractive targets for the development of anti-cancer agents. Recent studies ha...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.522
更新日期:2010-04-22 00:00:00
abstract::MicroRNAs (miRNAs) may function as either oncogenes or tumor suppressors in the malignant progression of different tumor types. MiR-663 was recently reported to be decreased and identified as a tumor suppressor in gastric cancer. We also verified its role in repressing cell proliferation of a gastric cancer cell line....
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.629
更新日期:2012-10-11 00:00:00
abstract::Dual specificity kinases that phosphorylate the Thr- and Tyr-residues within the TXY motif of MAP-kinases of play a central role in the regulation of various processes of cell growth. These dual specificity kinases also known as MAP kinase kinases are constituents of the sequential kinase signaling modules. Seven dist...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1202251
更新日期:1998-09-17 00:00:00
abstract::The genetic instability driving tumorigenesis is fueled by DNA damage and by errors made by the DNA replication. Upon DNA damage the cell organizes an integrated response not only by the classical DNA repair mechanisms but also involving mechanisms of replication, transcription, chromatin structure dynamics, cell cycl...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208570
更新日期:2005-06-09 00:00:00
abstract::Melanoma cells driven by mutant v-raf murine sarcoma viral oncogene homolog B1 (B-RAF) are highly resistant to chemotherapeutic treatments. Recent phase 1 results with PLX4032/RG7204/vemurafenib, which selectively inhibits B-RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)1...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.424
更新日期:2012-05-10 00:00:00
abstract::The RAD17 gene product of S. Pombe is an essential component of the checkpoint control pathway which responds to both DNA damage and disruption of replication. We have identified a human cDNA that encodes a polypeptide which is structurally conserved with the S. Pombe Rad17 protein. The human gene, designated hRAD17, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202469
更新日期:1999-03-04 00:00:00
abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Oncogene
pub_type: 已发布勘误
doi:10.1038/s41388-019-0835-1
更新日期:2019-07-01 00:00:00
abstract::wnt genes encode secretory glycoproteins that have been implicated in growth control and development in mice, frogs and insects. In this report we examine properties of two wnt genes recently identified in the nematode Caenorhabditis elegans. The first gene, Ce-wnt-1, was previously identified by a polymerase chain re...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::Colony-stimulating factors and other cytokines signal via their cognate receptors to regulate hematopoiesis. In many developmental systems, inductive signalling determines cell fate and, by analogy with this, it has been postulated that cytokines, signalling via their cognate receptors, may play an instructive role in...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210756
更新日期:2007-10-15 00:00:00
abstract::T-cell lymphoproliferative diseases are often associated with recurrent chromosomal translocations involving T cell receptor genes (TCR) and genes that are thought to play a role in the pathogenesis of these diseases. Whereas numerous such genes have already been identified in acute T cell leukemias, no candidate gene...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Mutations in mismatch repair (MMR) genes result in microsatellite instability (MSI) and early onset of colorectal cancer. To get mechanistic insights into the time scale, sequence and frequency of intestinal stem cell (ISC) transformation, we quantified MSI and growth characteristics of organoids of Msh2-deficient and...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.429
更新日期:2017-05-11 00:00:00
abstract::The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLr). Ubiquitin-dependent degradation of the PRLr that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLr on Ser349 followed by the recruitment of the beta-transducin ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209214
更新日期:2006-03-23 00:00:00
abstract::Ras genes are activated by point mutations at critical sites of their coding regions. Activated N-ras genes with transforming ability have been detected in patients with myelodysplastic syndromes (MDS), acute myelogenous leukemia (AML) and in human myeloid cell lines. We used polymerase chain reaction (PCR), different...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Fatty acid binding protein 4 (FABP4) is a fatty acid chaperone, which is induced during adipocyte differentiation. Previously we have shown that FABP4 in endothelial cells is induced by the NOTCH1 signalling pathway, the latter of which is involved in mechanisms of resistance to antiangiogenic tumour therapy. Here, we...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.256
更新日期:2017-02-16 00:00:00