Cytokine receptors and hematopoietic differentiation.

abstract：:Several cytokines, growth factors and the HIV transactivator Tat were shown to be involved in the pathogenesis of Kaposi's sarcoma. BKV/tat transgenic mice develop Kaposi's sarcoma-like lesions, and spindle-shaped cells (TTB) have been derived from these lesions. Here we show that TTB cells co-express hepatocyte growt...

journal_title：Oncogene

authors： Maier J,Mariotti M,Comoglio PM,Soria MR

更新日期：1996-09-05 00:00:00

abstract：:P53 is a tumor suppressor gene that plays a crucial role in suppressing tumorigenesis by inducing either cell cycle arrest or apoptosis in cells with DNA damage. In more than 50% of tumors p53 is inactivated by gene mutations. However, there have also been reports of tumor cells in which p53 remains wild type and is p...

journal_title：Oncogene

authors： Mayelzadeh F,Martinez JD

更新日期：2007-05-10 00:00:00

abstract：:By direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron junctions. By homology search in the database of the Washington University Genome Sequence Center (GSC), we identified one a...

journal_title：Oncogene

authors： Duh FM,Scherer SW,Tsui LC,Lerman MI,Zbar B,Schmidt L

更新日期：1997-09-25 00:00:00

abstract：:Members of the ErbB family of receptors have been implicated in regulation of androgen receptor (AR) activity. Ebp1, an ErbB-3 binding protein recently cloned in our laboratory, possesses an LXXLL motif important in mediating interactions with nuclear hormone receptors. Therefore, we sought to determine if Ebp1 could ...

journal_title：Oncogene

authors： Zhang Y,Fondell JD,Wang Q,Xia X,Cheng A,Lu ML,Hamburger AW

更新日期：2002-08-15 00:00:00

abstract：:Glioblastoma (GBM) is a highly malignant glioma, which has the propensity to infiltrate throughout the brain in contrast to pilocytic astrocytoma (PA) of the posterior fossa, which does not spread and can be cured by surgery. We have used Suppression Subtractive Hybridization to define markers that better delineate th...

journal_title：Oncogene

authors： Colin C,Baeza N,Bartoli C,Fina F,Eudes N,Nanni I,Martin PM,Ouafik L,Figarella-Branger D

更新日期：2006-05-04 00:00:00

abstract：:G2A is a heptahelical cell surface protein that has recently been described as a potential tumor suppressor, based on its ability to counteract transformation of pre-B cells and fibroblasts by Bcr-Abl, an oncogenic tyrosine kinase. We have isolated cDNAs encoding G2A in the course of screening libraries for clones tha...

journal_title：Oncogene

authors： Zohn IE,Klinger M,Karp X,Kirk H,Symons M,Chrzanowska-Wodnicka M,Der CJ,Kay RJ

更新日期：2000-08-10 00:00:00

abstract：:Inhibitor of growth (ING)4, member of a gene family encoding potential tumor suppressors, is implicated as a repressor of angiogenesis and tumor growth and suppresses loss of contact inhibition in vitro. Here, we report that ING4 undergoes alternative splicing. Expression analysis identified novel ING4 spliced variant...

journal_title：Oncogene

authors： Raho G,Miranda C,Tamborini E,Pierotti MA,Greco A

更新日期：2007-08-09 00:00:00

abstract：:Density-enhanced protein-tyrosine phosphatase-1 (DEP-1 also CD148) is a transmembrane molecule with a single intracellular PTP domain. It has recently been proposed to function as a tumor suppressor. We have previously shown that DEP-1 dephosphorylates the activated platelet-derived growth factor (PDGF) beta-receptor ...

journal_title：Oncogene

authors： Jandt E,Denner K,Kovalenko M,Ostman A,Böhmer FD

更新日期：2003-07-03 00:00:00

abstract：:Heterozygous germline mutations in PHOX2B, a transcriptional regulator of sympathetic neuronal differentiation, predispose to diseases of the sympathetic nervous system, including neuroblastoma and congenital central hypoventilation syndrome (CCHS). Although the PHOX2B variants in CCHS largely involve expansions of th...

journal_title：Oncogene

authors： Wang W,Zhong Q,Teng L,Bhatnagar N,Sharma B,Zhang X,Luther W 2nd,Haynes LP,Burgoyne RD,Vidal M,Volchenboum S,Hill DE,George RE

更新日期：2014-06-19 00:00:00

abstract：:The E2F1 transcription factor binds to sites within the promoters of a number of cell cycle regulated genes through a basic-helix-loop-helix motif (bHLH). It is shown here that the basic region of E2F1 is distinct from that of all other bHLH proteins. The center of the basic region contains a helix breaking proline-gl...

journal_title：Oncogene

authors： Jordan KL,Haas AR,Logan TJ,Hall DJ

更新日期：1994-04-01 00:00:00

abstract：:We have previously reported that carboxyl terminal truncations of the normal human fyn gene, a member of the src subfamily, can transform immortal mouse fibroblasts to full malignancy. In search of evidence which suggests the possible activation of the human fyn gene, we have screened DNAs and RNAs from a number of hu...

journal_title：Oncogene

authors： Kawakami Y,Furue M,Kawakami T

更新日期：1989-03-01 00:00:00

abstract：:Accumulating evidences have shown the association between aberrantly expressed microRNAs (miRs) and cancer, where these small regulatory RNAs appear to dictate the cell fate by regulating all the main biological processes. We demonstrated the responsibility of the circuitry connecting the oncomiR-221&222 with the tumo...

journal_title：Oncogene

authors： Felli N,Errico MC,Pedini F,Petrini M,Puglisi R,Bellenghi M,Boe A,Felicetti F,Mattia G,De Feo A,Bottero L,Tripodo C,Carè A

更新日期：2016-06-09 00:00:00

abstract：:beta-catenin activation, and subsequent upregulation of Wnt-signaling, is an important event in the development of certain human and rodent cancers. Recently, mutations in the beta-catenin gene in the region of the serine-threonine glycogen kinase (GSK)-3beta phosphorylation target sites have been identified in hepato...

journal_title：Oncogene

authors： Devereux TR,Anna CH,Foley JF,White CM,Sills RC,Barrett JC

更新日期：1999-08-19 00:00:00

abstract：:Genomic instability is a hallmark feature of cancer cells, and can be caused by defective DNA repair, for instance due to inactivation of BRCA2. Paradoxically, loss of Brca2 in mice results in embryonic lethality, whereas cancer cells can tolerate BRCA2 loss. This holds true for multiple DNA repair genes, and suggests...

journal_title：Oncogene

authors： van Gijn SE,Wierenga E,van den Tempel N,Kok YP,Heijink AM,Spierings DCJ,Foijer F,van Vugt MATM,Fehrmann RSN

更新日期：2019-02-01 00:00:00

abstract：:The tumor microenvironment plays a critical role in prostate cancer (PC) development and progression. Inappropriate activation of the stroma potentiates the growth and transformation of epithelial tumor cells. Here, we show that upregulation of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine...

journal_title：Oncogene

authors： Li J,Pu T,Yin L,Li Q,Liao CP,Wu BJ

更新日期：2020-04-01 00:00:00

abstract：:Activating the protein-tyrosine kinase activity of v-Src rapidly induced expression of the two 'primary response' genes, TIS10 and Egr-1, in Balb/c 3T3 cells. Depleting cells of protein kinase C (PKC) by prolonged exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA), blocked v-Src-induced TIS10 expression, but had n...

journal_title：Oncogene

authors： Qureshi SA,Joseph CK,Rim M,Maroney A,Foster DA

更新日期：1991-06-01 00:00:00

abstract：:Skeletrophin (mindbomb homolog 2 (MIB2)) is a RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands. A previous immunohistochemical study demonstrated that skeletrophin was downregulated in many melanomas. In the present study, we have identified ...

journal_title：Oncogene

authors： Takeuchi T,Adachi Y,Sonobe H,Furihata M,Ohtsuki Y

更新日期：2006-11-09 00:00:00

abstract：:It has recently been shown that an adenovirus mutant lacking expression of the large E1B protein (deltaE1B) selectively replicates in p53 deficient cells. However, apart from the large E1B protein the adenovirus early region encodes the E1A and E4orf6 proteins which also have been reported to affect p53 expression as ...

journal_title：Oncogene

authors： Steegenga WT,Riteco N,Jochemsen AG,Fallaux FJ,Bos JL

更新日期：1998-01-22 00:00:00

abstract：:Exposure of cells to DNA damaging agents results in a G2 arrest. Exposure of HeLa cells to camptothecin, etoposide or nitrogen mustard for 1 h in S phase resulted in delayed expression of cyclin B1 mRNA during the G2 arrest. Initially the levels of cyclin B1 protein were low as well; however, with extended time the ce...

journal_title：Oncogene

authors： Maity A,Hwang A,Janss A,Phillips P,McKenna WG,Muschel RJ

更新日期：1996-10-17 00:00:00

abstract：:Mutations in epidermal growth factor receptor (EGFR) kinase domain associate with clinical responses to EGFR inhibitors and are frequently observed in non-small cell lung cancer (NSCLC) patients in East Asian populations. Clinically identified EGFR mutations cause constitutive receptor activation. The activating mecha...

journal_title：Oncogene

authors： Fu YN,Yeh CL,Cheng HH,Yang CH,Tsai SF,Huang SF,Chen YR

更新日期：2008-02-07 00:00:00

abstract：:Neuroendocrine prostate cancer (NEPC) has increasingly become a clinical challenge. The mechanisms by which neuroendocrine (NE) cells arises from prostate adenocarcinoma cells are poorly understood. FOXA1 is a transcription factor of the forkhead family that is required for prostate epithelial differentiation. In this...

journal_title：Oncogene

authors： Kim J,Jin H,Zhao JC,Yang YA,Li Y,Yang X,Dong X,Yu J

更新日期：2017-07-13 00:00:00

abstract：:p73 is a member of the p53 family. Recent studies have shown that DNA damage can stabilize p73 protein and enhance p73-mediated apoptosis in a c-Abl dependent manner. To determine what regulates p73 transcriptionally, we analysed the expression of p73 in several cell lines following genotoxic stresses. We found that p...

journal_title：Oncogene

authors： Chen X,Zheng Y,Zhu J,Jiang J,Wang J

更新日期：2001-02-08 00:00:00

abstract：:Normal human melanocytes are interspersed singly among keratinocytes along the basement membrane of the epidermis, whereas melanoma cells readily adhere to each other during invasion of the dermis or distant organs. The tumorigenic and metastatic phenotype of melanoma cells often correlates with increased expression o...

journal_title：Oncogene

authors： Satyamoorthy K,Muyrers J,Meier F,Patel D,Herlyn M

更新日期：2001-08-02 00:00:00

abstract：:The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLr). Ubiquitin-dependent degradation of the PRLr that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLr on Ser349 followed by the recruitment of the beta-transducin ...

journal_title：Oncogene

authors： Li Y,Clevenger CV,Minkovsky N,Kumar KG,Raghunath PN,Tomaszewski JE,Spiegelman VS,Fuchs SY

更新日期：2006-03-23 00:00:00

abstract：:We have analysed the importance of proper substrate methylation by S-adenosylmethionine-dependent methyltransferases for cell survival and cell cycle progression. We show that treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) causes cell cycle arrest and death in different cell types....

journal_title：Oncogene

authors： Schwerk C,Schulze-Osthoff K

更新日期：2005-10-27 00:00:00

abstract：:Trichostatin A (TSA), a histone deacetylase inhibitor, strongly increases acetylation of the N-terminal tails of histone H3. Many studies have correlated the function of TSA with the hyperacetylation of histone. Although histone H3 is known to be phosphorylated, the effect of acetylation on phosphorylation is not know...

journal_title：Oncogene

authors： Zhong S,Goto H,Inagaki M,Dong Z

更新日期：2003-08-14 00:00:00

abstract：:Epidermal squamous cell carcinoma (SCC) is a common and highly invasive form of cancer. SCC arises due to ultraviolet light exposure and is associated with increased expression of pro-cancer genes and reduced expression of cancer suppressors. Actin-Like Protein 6A (ACTL6A, BAF53a) is an important protein subunit of th...

journal_title：Oncogene

authors： Shrestha S,Adhikary G,Xu W,Kandasamy S,Eckert RL

更新日期：2020-09-01 00:00:00

abstract：:The molecular interactions implicated in the mammalian G1/S cell cycle phase transition comprise a highly nonlinear network which can produce seemingly paradoxical results and make intuitive interpretations unreliable. A new approach to this problem is presented, consisting of (1) a convention of unambiguous reaction ...

journal_title：Oncogene

authors： Kohn KW

更新日期：1998-02-26 00:00:00

abstract：:Type I interferon (IFN) enhances the transcription of the tumor suppressor gene p53. To elucidate the molecular mechanism mediating IFN-induced apoptosis, we analysed programmed cell death in response to type I (IFNalpha) or type II (IFNgamma) treatment in relation to p53 status. In two cell lines (MCF-7, SKNSH), IFNa...

journal_title：Oncogene

authors： Porta C,Hadj-Slimane R,Nejmeddine M,Pampin M,Tovey MG,Espert L,Alvarez S,Chelbi-Alix MK

更新日期：2005-01-20 00:00:00

abstract：:Activation of the mitogen-activated protein kinase (MAPK) cascade is a well documented mechanism for the G-protein-coupled receptors. Here, we have analysed the requirements for ERKs and p38 MAPK activation by thrombin in Jurkat T cells. We show that thrombin-mediated ERKs activation requires both PTK and PKC activiti...

journal_title：Oncogene

authors： Maulon L,Mari B,Bertolotto C,Ricci JE,Luciano F,Belhacene N,Deckert M,Baier G,Auberger P

更新日期：2001-04-12 00:00:00