Retrospective analysis of ras gene activation in myeloid leukemic cells.

abstract：:Cyclin D1, encoded by the gene CCND1, is a major regulator of the cell cycle transition from G1 phase to S phase. A CCND1 polymorphism (G to A) at codon 242, the boundary of exon 4 and intron 4, affects splicing such that exon 5 is not expressed in the A allele. Since exon 5 is involved in rapid turnover, the variant ...

journal_title：Oncogene

authors： Pakakasama S,Chen TT,Frawley W,Muller CY,Douglass EC,Lee R,Pollock BH,Tomlinson GE

更新日期：2004-06-10 00:00:00

abstract：:Seventy lung tumors from 53 patients were analysed for alterations of myc family oncogenes, c-myc, N-myc and L-myc, to evaluate when activation of these genes occurs during tumor development. The 53 cases were 17 small cell carcinomas (SCCs), 18 adenocarcinomas, 12 squamous cell carcinomas (SqCs), 4 large cell carcino...

journal_title：Oncogene

authors： Yokota J,Wada M,Yoshida T,Noguchi M,Terasaki T,Shimosato Y,Sugimura T,Terada M

更新日期：1988-06-01 00:00:00

abstract：:Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis. Aberrant STC1 expression has been reported in breast, ovarian and prostate cancers, but the significance of this is not well understood. Here, we report that oxidative stress caused a 40-...

journal_title：Oncogene

authors： Nguyen A,Chang AC,Reddel RR

更新日期：2009-05-07 00:00:00

abstract：:We have determined the genomic structure of the mouse fra-1 gene, which consists of four exons and three introns at positions also found in the other members of the fos gene family. Fra-1 is expressed rather highly in the brain and testes of adult mice, and at low levels in most other tissues. Absence of c-Fos leads t...

journal_title：Oncogene

authors： Schreiber M,Poirier C,Franchi A,Kurzbauer R,Guenet JL,Carle GF,Wagner EF

更新日期：1997-09-04 00:00:00

abstract：:Like other types of pre-malignant lesions and carcinoma, angiogenesis is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular endothelial cell growth factor (VEGF) is known to be one of the most important inducers of angiogenesis and is upregulated in carcinoma of ...

journal_title：Oncogene

authors： López-Ocejo O,Viloria-Petit A,Bequet-Romero M,Mukhopadhyay D,Rak J,Kerbel RS

更新日期：2000-09-21 00:00:00

abstract：:The clonality of lymphomas that originate in myc/pim-1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy. To isolate genes that cooperate with both myc and pim-1, we have used provirus tagging with E mu L-myc/pim-1 double tra...

journal_title：Oncogene

authors： Zörnig M,Schmidt T,Karsunky H,Grzeschiczek A,Möröy T

更新日期：1996-04-18 00:00:00

abstract：:Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa metastasis to lymph n...

journal_title：Oncogene

authors： Jin JK,Tien PC,Cheng CJ,Song JH,Huang C,Lin SH,Gallick GE

更新日期：2015-04-02 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis protein family and has an essential role in mitosis. Survivin is overexpressed in a large variety of human cancers and represents an attractive target for cancer therapy. Epidermal growth factor receptor and Her/neu-transformed human tumors in particular exhibit high ...

journal_title：Oncogene

authors： Berezov A,Cai Z,Freudenberg JA,Zhang H,Cheng X,Thompson T,Murali R,Greene MI,Wang Q

更新日期：2012-04-12 00:00:00

abstract：:The FoxO family of Forkhead transcription factors plays an important role in longevity and tumor suppression by upregulating target genes involved in stress resistance, metabolism, cell cycle arrest and apoptosis. FoxO transcription factors translate a variety of environmental stimuli, including insulin, growth factor...

journal_title：Oncogene

authors： Calnan DR,Brunet A

更新日期：2008-04-07 00:00:00

abstract：:Solid tumors frequently contain hypoxic subregions due to insufficient blood supply. In these domains, cells can undergo p53-dependent apoptosis. Therefore, hypoxia has been implicated as a physiological stimulus for p53 accumulation and activation. In such an environment, p53 mutant cells exhibit a selective growth a...

journal_title：Oncogene

authors： Pan Y,Oprysko PR,Asham AM,Koch CJ,Simon MC

更新日期：2004-06-24 00:00:00

abstract：:Apoptin has been described to induce apoptosis in various human cancer cell lines, but not in normal cells, thus making it an interesting candidate for the development of novel therapeutic strategies. Apoptin was generated and cloned into several mammalian expression vectors. Transfection or microinjection of apoptin ...

journal_title：Oncogene

authors： Guelen L,Paterson H,Gäken J,Meyers M,Farzaneh F,Tavassoli M

更新日期：2004-02-05 00:00:00

abstract：:SIAH-1 and SIAH-2 are the human members of an evolutionary highly conserved E3 ligase family. SIAH-1 is a p53 and p21(Waf-1/Cip-1) induced gene during apoptosis and tumor suppression. In stable-transfected clones of MCF-7 cells, SIAH-1 overexpression was associated with apoptosis, mitotic alterations and p21(Waf-1/Cip...

journal_title：Oncogene

authors： Germani A,Prabel A,Mourah S,Podgorniak MP,Di Carlo A,Ehrlich R,Gisselbrecht S,Varin-Blank N,Calvo F,Bruzzoni-Giovanelli H

更新日期：2003-12-04 00:00:00

abstract：:Histone deacetylase inhibitors (HDACis) are a promising class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought to identify genes associated with HDACi resistance in gastric cancer. Treating a panel of 17 gastric...

journal_title：Oncogene

authors： Zhu Y,Das K,Wu J,Lee MH,Tan P

更新日期：2014-03-20 00:00:00

abstract：:In the course of our study on the amplification of 11q13 sequences in human breast cancer, we have investigated the amplification status of the anonymous DNA fragment D11S97 in a series of 125 mammary tumors. Our results indicate that, as with bladder carcinomas, D11S97 can be amplified separately from BCL1. In additi...

journal_title：Oncogene

authors： Szepetowski P,Courseaux A,Carle GF,Theillet C,Gaudray P

更新日期：1992-04-01 00:00:00

abstract：:Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) and mutation of the p53 are both commonly detected in human prostate cancer cells. We sought to investigate whether there is functional regulation of Stat3 by wild-type (wt) p53. Our results demonstrate that expression of wt p53 ...

journal_title：Oncogene

authors： Lin J,Tang H,Jin X,Jia G,Hsieh JT

更新日期：2002-05-02 00:00:00

abstract：:Injection of the human neurotropic polyomavirus, JCV, into neonatal hamsters causes tumors of glial origin. Previously, a rapidly proliferating cell line, HJC-15, which expresses high levels of the viral T-antigen, had been established from JCV-induced hamster glial tumors. In our analyses of the mechanisms involved i...

journal_title：Oncogene

authors： Raj GV,Ansari SA,Khalili K

更新日期：1996-03-21 00:00:00

abstract：:We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concen...

journal_title：Oncogene

authors： Kristjuhan A,Jaks V,Rimm I,Tooming T,Maimets T

更新日期：1998-05-07 00:00:00

abstract：:Although TGF-beta1, a growth inhibitor, is known to also induce apoptosis, the molecular mechanism of this apoptosis is largely undefined. Here, we identify the mechanism of TGF-beta1-induced apoptosis in SNU-16 human gastric cancer cells. Cell cycle and TUNEL analysis showed that, upon TGF-beta1 treatment, cells were...

journal_title：Oncogene

authors： Kim SG,Kim SN,Jong HS,Kim NK,Hong SH,Kim SJ,Bang YJ

更新日期：2001-03-08 00:00:00

abstract：:The temperature-sensitive mutant tsp53val135 accumulates in the cytoplasm of cells kept at the non-permissive temperature (39 degrees C), but is rapidly transported into the cell nucleus at the permissive temperature (30 degrees C). tsp53 thus may serve as a model for analysing cellular parameters influencing the subc...

journal_title：Oncogene

authors： Klotzsche O,Etzrodt D,Hohenberg H,Bohn W,Deppert W

更新日期：1998-07-02 00:00:00

abstract：:Breast carcinoma invasion is associated with prominent alterations in stromal fibroblasts. Carcinoma-associated fibroblasts (CAF) support and promote tumorigenesis, whereas normal mammary fibroblasts (NF) are thought to suppress tumor progression. Little is known about the difference in gene expression between CAF and...

journal_title：Oncogene

authors： Bauer M,Su G,Casper C,He R,Rehrauer W,Friedl A

更新日期：2010-03-25 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) is highly subjected to alternative pre-mRNA splicing that generates several splice variants. The VEGFxxx and VEGFxxxb families encode splice variants of VEGF-A that differ only at the level of six amino acids in their C-terminal part. The expression level of VEGFxxx splice...

journal_title：Oncogene

authors： Boudria A,Abou Faycal C,Jia T,Gout S,Keramidas M,Didier C,Lemaître N,Manet S,Coll JL,Toffart AC,Moro-Sibilot D,Albiges-Rizo C,Josserand V,Faurobert E,Brambilla C,Brambilla E,Gazzeri S,Eymin B

更新日期：2019-02-01 00:00:00

abstract：:Protein kinases are known to undergo phosphorylation to regulate their activity. To determine whether the protein kinase activity of p37v-mos was similarly regulated, we investigated the influence of two well known protein kinases, namely protein kinase C and protein kinase A, on the activity of p37v-mos in vivo. NIH3...

journal_title：Oncogene

authors： al-Bagdadi F,Singh B,Arlinghaus RB

更新日期：1990-08-01 00:00:00

abstract：:Clonogenic murine B cell precursors are normally ultrasensitive to apoptosis following genotoxic exposure in vitro but can be protected by expression of an E mu-BCL-2 transgene. Such exposures are likely to be mutagenic. This in turn suggests that a level of in vivo genotoxic exposure that usually has minimal patholog...

journal_title：Oncogene

authors： Gibbons DL,MacDonald D,McCarthy KP,Cleary HJ,Plumb M,Wright EG,Greaves MF

更新日期：1999-07-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are strongly immunosuppressive via producing nitric oxide (NO) and known to migrate into tumor sites to promote tumor growth, but the underlying mechanisms remain largely elusive. Here, we found that interferon alpha (IFNα)-secreting MSCs showed more dramatic inhibition effect on tumor...

journal_title：Oncogene

authors： Shou P,Chen Q,Jiang J,Xu C,Zhang J,Zheng C,Jiang M,Velletri T,Cao W,Huang Y,Yang Q,Han X,Zhang L,Wei L,Rabson AB,Chin YE,Wang Y,Shi Y

更新日期：2016-11-17 00:00:00

abstract：:Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endoplasmic reticulum (ER) stress. In this study, we have used small inter...

journal_title：Oncogene

authors： Rzymski T,Milani M,Pike L,Buffa F,Mellor HR,Winchester L,Pires I,Hammond E,Ragoussis I,Harris AL

更新日期：2010-08-05 00:00:00

abstract：:Epidermal squamous cell carcinoma (SCC) is a common and highly invasive form of cancer. SCC arises due to ultraviolet light exposure and is associated with increased expression of pro-cancer genes and reduced expression of cancer suppressors. Actin-Like Protein 6A (ACTL6A, BAF53a) is an important protein subunit of th...

journal_title：Oncogene

authors： Shrestha S,Adhikary G,Xu W,Kandasamy S,Eckert RL

更新日期：2020-09-01 00:00:00

abstract：:The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and -2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor. Loss of pVHL function results in c...

journal_title：Oncogene

authors： Rankin EB,Rha J,Unger TL,Wu CH,Shutt HP,Johnson RS,Simon MC,Keith B,Haase VH

更新日期：2008-09-11 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common and malignant carcinoma worldwide, and the incidence and mortality are increasing rapidly. Immunotherapy targeting programmed death 1/programmed death ligand 1 (PD-L1) signaling has shown prominent clinical effects in treating NSCLC; however, a poor understa...

journal_title：Oncogene

authors： Wang J,Jia Y,Zhao S,Zhang X,Wang X,Han X,Wang Y,Ma M,Shi J,Liu L

更新日期：2017-11-09 00:00:00

abstract：:The nucleolus is one of the functional nuclear compartments in which the ribosome biogenesis takes place. Proteomic analysis revealed a large number of nucleolar proteins that are involved in diverse cellular processes, including biogenesis of ribonucleoprotein particles, stress responses, cell proliferation and cell ...

journal_title：Oncogene

authors： Yao Z,Duan S,Hou D,Wang W,Wang G,Liu Y,Wen L,Wu M

更新日期：2010-03-25 00:00:00

abstract：:Trichostatin A (TSA), a histone deacetylase inhibitor, strongly increases acetylation of the N-terminal tails of histone H3. Many studies have correlated the function of TSA with the hyperacetylation of histone. Although histone H3 is known to be phosphorylated, the effect of acetylation on phosphorylation is not know...

journal_title：Oncogene

authors： Zhong S,Goto H,Inagaki M,Dong Z

更新日期：2003-08-14 00:00:00