Abstract：
:The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and -2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor. Loss of pVHL function results in constitutive activation of HIF-1 and HIF-2 and is associated with the development of highly vascularized tumors in multiple organs. We have used a conditional gene-targeting approach to investigate the relative contributions of HIF-1 and HIF-2 to VHL-associated vascular tumorigenesis in a mouse model of liver hemangiomas. Here we demonstrate genetically that conditional inactivation of HIF-2alpha suppressed the development of VHL-associated liver hemangiomas and that angiogenic gene expression in hepatocytes is predominantly regulated by HIF-2 and not by HIF-1. These findings suggest that HIF-2 is the dominant HIF in the pathogenesis of VHL-associated vascular tumors and that pharmacologic targeting of HIF-2 may be an effective strategy for their treatment.
journal_name
Oncogenejournal_title
Oncogeneauthors
Rankin EB,Rha J,Unger TL,Wu CH,Shutt HP,Johnson RS,Simon MC,Keith B,Haase VHdoi
10.1038/onc.2008.160subject
Has Abstractpub_date
2008-09-11 00:00:00pages
5354-8issue
40eissn
0950-9232issn
1476-5594pii
onc2008160journal_volume
27pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Fallopian tube carcinoma (FTC) is a rare, poorly studied and aggressive cancer, associated with poor survival. Since tumorigenesis is related to the acquisition of genetic changes, we used genome-wide array comparative genomic hybridization to analyse copy number aberrations occurring in FTC in order to obtain a bette...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206621
更新日期：2003-07-03 00:00:00
abstract：:Tuberin is the protein product of the tuberous sclerosis-2 (TSC2) gene, which is associated with tuberous sclerosis (TSC), a human genetic syndrome characterized by the development of tumors in a variety of tissues. We have previously shown that tuberin is a widely expressed 180 kDa protein which exhibits specific GTP...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-09-05 00:00:00
abstract：:Here we show that pemetrexed-treated mesothelioma cells undergo accelerated senescence. This is characterized by the secretion of proinflammatory and mitogenic cytokines, reminiscent of an SASP (senescence-associated secretory phenotype). Conditioned media from senescent MPM (malignant pleural mesothelioma) cells trig...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.485
更新日期：2012-06-28 00:00:00
abstract：:Mcl-1 is a critical antiapoptotic survival factor for human multiple myeloma (MM). We examined the importance of IL-6 for Mcl-1 expression in five MM cell lines and in primary MM cells from 14 patients. While culture of MM.1S cells in IL-6 did induce Mcl-1 expression, four other MM cell lines exhibited high levels of ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206358
更新日期：2003-03-27 00:00:00
abstract：:E1A of human adenovirus type 5 (Ad5) encodes proteins of 289 and 243 residues (289R and 243R) which differ only by the 46 amino acid CR3 region known to activate expression of certain cellular and early viral genes. E1A proteins also induce DNA synthesis and cell transformation, but as well can stimulate apoptosis. Tw...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-08-03 00:00:00
abstract：:Oncogenic forms of the c-myb protein (Myb) often exhibit amino-terminal and/or carboxyl-terminal truncations. When the transcriptional activity of these proteins was examined it was found that carboxyl-truncated Myb is more effective as a transcriptional activator than full-length or amino-truncated Myb. In order to d...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Identifying novel and known genes that are differentially expressed in breast cancer has important implications in understanding the biology of breast tumorigenesis and developing new diagnostic and therapeutic agents. In this study we have combined two powerful technologies, PCR-based cDNA subtraction and cDNA microa...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205278
更新日期：2002-03-28 00:00:00
abstract：:Sam68 phosphorylation correlates with Fyn but not Lck expression in T cells. This substrate has been used here to explore the possible basis of the specificity of Fyn versus Lck. We show that this specificity is not based on a spatial segregation of the two kinases, since a chimeric Lck molecule containing the membran...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205929
更新日期：2002-10-17 00:00:00
abstract：:The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1200972
更新日期：1997-03-27 00:00:00
abstract：:We have characterized a novel chicken c-myb exon whose sequences are specifically expressed in thymic cells. In situ hybridization experiments indicate that this thymus-specific coding exon is localized on a small chromosome, distinct from the large acrocentric chromosome 3 on which we recently mapped the bulk of 15 e...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:The precise genetic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable colorectal cancer (CRC) has yet to be elucidated. We employed cDNA microarray to identify patterns of gene expression among CRC cell lines and to compare directly lines with and without microsatellite in...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206609
更新日期：2003-09-18 00:00:00
abstract：:cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues with a calculated molecular weight of 29,413 and showed 90% similarity with rat fra-1 protein...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:SHPTP2 is a ubiquitously-expressed SH2-containing tyrosine phosphatase that is tyrosine phosphorylated in response to activation of various receptor and nonreceptor tyrosine kinases. SHPTP2 associates with the platelet-derived growth factor (PDGF) receptor after ligand stimulation, and binding of SHPTP2 to this recept...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-04-04 00:00:00
abstract：:In the published version of this paper the author Shu-Pin Huang's surname was incorrectly given as Hwang instead of Huang. This has now been corrected in the HTML and PDF versions of the paper. ...
journal_title：Oncogene
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41388-018-0561-0
更新日期：2019-02-01 00:00:00
abstract：:We analysed breast tumors and breast cancer cell lines for the expression of beta-parvin (ParvB), an adaptor protein that binds to the integrin-linked kinase (ILK). Quantitative RT-PCR indicated that ParvB mRNA was downregulated, by at least 60%, in four of nine breast tumors, relative to patient-matched normal mammar...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208112
更新日期：2004-11-25 00:00:00
abstract：:We have examined the possibility that the E7 proteins of the high-risk human papillomavirus (HPV) type 16 and 18 and the oncogenic adenovirus (Ad) type 12 E1A protein share the ability to down-regulate the expression of components of the antigen processing and presentation pathway, as a common strategy in the evasion ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203860
更新日期：2000-10-05 00:00:00
abstract：:We previously described the isolation of non-tumorigenic revertants from mutagenized populations of v-fos-transformed Rat-1 cells (Zarbl et al., 1987). In the present study we examined the possibility that the revertant phenotype resulted from mutations that altered the expression or activities of the c-jun or junB pr...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Angiogenesis is essential for tumor growth and blocking this process might be a valid tool for the control of cancer growth. We showed previously that tumor angiogenesis in integrin alpha1-null mice is reduced compared to that of wild type animals and that over-expression of matrix metalloproteinase 9 (MMP-9) in the a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205045
更新日期：2002-01-10 00:00:00
abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in neuroblastoma, a devastating pediatric cancer of the sympathetic nervous system. Germline and somatically acquired ALK aberrations induce increased autophosphorylation, constitutive ALK activation and increased downstream signaling....
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.647
更新日期：2012-11-15 00:00:00
abstract：:Although TGF-beta1, a growth inhibitor, is known to also induce apoptosis, the molecular mechanism of this apoptosis is largely undefined. Here, we identify the mechanism of TGF-beta1-induced apoptosis in SNU-16 human gastric cancer cells. Cell cycle and TUNEL analysis showed that, upon TGF-beta1 treatment, cells were...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204203
更新日期：2001-03-08 00:00:00
abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1209872
更新日期：2006-09-25 00:00:00
abstract：:Prostate stem cell antigen (PSCA) is a recently defined homologue of the Thy-1/Ly-6 family of glycosylphosphatidylinositol (GPI)-anchored cell surface antigens. PSCA mRNA is expressed in the basal cells of normal prostate and in more than 80% of prostate cancers. The purpose of the present study was to examine PSCA pr...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203426
更新日期：2000-03-02 00:00:00
abstract：:Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaire...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-020-01547-x
更新日期：2021-01-01 00:00:00
abstract：:A series of primary human breast tumors was analysed by immunoblotting with anti-neu antibodies. Overproduction of the neu protein-tyrosine kinase, p185neu, was observed in 23 of 56 malignant tumor samples. 29 of these tumors were also immunoblotted with antiphosphotyrosine antibodies. A single prominent phosphotyrosi...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Three-dimensional explant cultures of muscle tissue were used to characterize secreted proteins regulated by endogenous levels of the angiogenesis modulator thrombospondin (TSP)-1. Explants from TSP1 null mice exhibit enhanced neovascularization associated with increased endothelial outgrowth but decreased outgrowth o...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209069
更新日期：2006-01-26 00:00:00
abstract：:Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by overexpression of cyclin D1 due to the t(11;14) chromosomal translocation. While expression of cyclin D1 correlates with MCL development, expression of wild-type (WT) cyclin D1 transgene in murine lymphocytes is unable to drive B-cell lymphoma. As cyclin...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209147
更新日期：2006-02-16 00:00:00
abstract：:Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not. Serine, glutamic acid, and prolin...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:The p53 gene is frequently mutated in cancers and it is vital for cell cycle control, homeostasis and carcinogenesis. We describe a novel p53 mutational spectrum, different to those generally observed in human and murine tumors. Our study shows a high prevalence of nonsense mutations in the p53 N terminus of 2-acetyla...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.552
更新日期：2011-04-14 00:00:00
abstract：:Low molecular weight protein tyrosine phosphatases (LMW-PTPs) are an enzyme family that plays a key role in cell proliferation control by dephosphorylating/inactivating both tyrosine kinase receptors (such as PDGF, insulin, and ephrin receptors) and docking proteins (such, as beta-catenin) endowed with both adhesion a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207508
更新日期：2004-05-13 00:00:00
abstract：:The efficacy of anticancer therapy is limited by the development of drug resistance. While the role of p53 in the intrinsic sensitivity of human cancer cells to paclitaxel (PTX) remains controversial, its role in acquired paclitaxel resistance has never been addressed. In this study we examined the p53 status of three...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203642
更新日期：2000-06-22 00:00:00
