Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos.

abstract：:The Rel/NF-kappaB transcription factors regulate the expression of many genes. The activity of RelA, a member of the Rel/NF-kappaB transcription factor family, is constitutively activated in the majority of pancreatic adenocarcinomas and cell lines. We report that the urokinase-type plasminogen activator (uPA), one of...

journal_title：Oncogene

authors： Wang W,Abbruzzese JL,Evans DB,Chiao PJ

更新日期：1999-08-12 00:00:00

abstract：:Maf b-Zip transcription factors are involved in both terminal differentiation and oncogenesis. To investigate this apparent contradiction, we used two different primary cell types and performed an extensive analysis of transformation parameters induced by Maf proteins. We show that MafA and c-Maf are potent oncogenes ...

journal_title：Oncogene

authors： Pouponnot C,Sii-Felice K,Hmitou I,Rocques N,Lecoin L,Druillennec S,Felder-Schmittbuhl MP,Eychène A

更新日期：2006-03-02 00:00:00

abstract：:Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional respon...

journal_title：Oncogene

authors： Choudhry H,Albukhari A,Morotti M,Haider S,Moralli D,Smythies J,Schödel J,Green CM,Camps C,Buffa F,Ratcliffe P,Ragoussis J,Harris AL,Mole DR

更新日期：2015-08-20 00:00:00

abstract：:The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully characterized, and the mechanisms of DAB2 dysregulation in lung cancer are not defined. Here we show that low D...

journal_title：Oncogene

authors： Du L,Zhao Z,Ma X,Hsiao TH,Chen Y,Young E,Suraokar M,Wistuba I,Minna JD,Pertsemlidis A

更新日期：2014-08-21 00:00:00

abstract：:Cyr61 is a secreted, cysteine-rich, heparin-binding protein that mediates diverse functions including extracellular matrix formation, differentiation, cell proliferation, adhesion, migration, survival, as well as angiogenesis and tumorigenesis. In this study, we found that Cyr61 gene expression is significantly downre...

journal_title：Oncogene

authors： Wang B,Ren J,Ooi LL,Chong SS,Lee CG

更新日期：2005-06-02 00:00:00

abstract：:Mutations of the RET proto-oncogene are found in the majority of patients with the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN 2). A minority of cases, however, have no detectable RET mutation and there is considerable phenotypic variation within and among MEN 2 families with the same RET mutati...

journal_title：Oncogene

authors： Vanhorne JB,Andrew SD,Harrison KJ,Taylor SA,Thomas B,McDonald TJ,Ainsworth PJ,Mulligan LM

更新日期：2005-02-03 00:00:00

abstract：:Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...

journal_title：Oncogene

authors： Healy E,Belgaid C,Takata M,Harrison D,Zhu NW,Burd DA,Rigby HS,Matthews JN,Rees JL

更新日期：1998-04-30 00:00:00

abstract：:The human ret proto-oncogene (proto-ret), encoding a receptor tyrosine kinase, is highly expressed in neuroblastomas, medullary thyroid carcinomas (MTCs) and pheochromocytomas, which are all tumors of cells originating from the neural crest. In studies on the transcription mechanism of proto-ret, we identified the tra...

journal_title：Oncogene

authors： Itoh F,Ishizaka Y,Tahira T,Yamamoto M,Miya A,Imai K,Yachi A,Takai S,Sugimura T,Nagao M

更新日期：1992-06-01 00:00:00

abstract：:Loss of p53 function is associated with the acquisition of cisplatin resistance in the human ovarian adenocarcinoma A2780 cell line. Selection for cisplatin resistance of A2780 cells was used to isolate genetic suppressor elements (GSEs) from a retroviral library expressing random fragments of human or murine TP53 cDN...

journal_title：Oncogene

authors： Gallagher WM,Cairney M,Schott B,Roninson IB,Brown R

更新日期：1997-01-16 00:00:00

abstract：:Activation of the mitogen-activated protein kinase (MAPK) cascade is a well documented mechanism for the G-protein-coupled receptors. Here, we have analysed the requirements for ERKs and p38 MAPK activation by thrombin in Jurkat T cells. We show that thrombin-mediated ERKs activation requires both PTK and PKC activiti...

journal_title：Oncogene

authors： Maulon L,Mari B,Bertolotto C,Ricci JE,Luciano F,Belhacene N,Deckert M,Baier G,Auberger P

更新日期：2001-04-12 00:00:00

abstract：:ERM is a member of the ETS transcription factor family. High levels of the corresponding mRNA are detected in a variety of human breast cancer cell lines, as well as in aggressive human breast tumors. As ERM protein is almost undetectable in these cells, high degradation of this transcription factor has been postulate...

journal_title：Oncogene

authors： Baert JL,Beaudoin C,Monte D,Degerny C,Mauen S,de Launoit Y

更新日期：2007-01-18 00:00:00

abstract：:NUP98 has been involved in multiple recurrent chromosome rearrangements in leukemia. We identified a novel fusion between NUP98 and IQ motif containing G (IQCG) gene from a de novo acute T-lymphoid/myeloid leukemia harboring t(3;11)(q29q13;p15)del(3)(q29). IQCG has two putative coiled-coil domains and one IQ domain. T...

journal_title：Oncogene

authors： Pan Q,Zhu YJ,Gu BW,Cai X,Bai XT,Yun HY,Zhu J,Chen B,Weng L,Chen Z,Xue YQ,Chen SJ

更新日期：2008-05-29 00:00:00

abstract：:Several motifs are conserved in the extracellular domain of the cloned chains of the recently described cytokine receptor superfamily. One of them, usually close to the transmembrane region, is the 'WS motif'. Its function remains unknown, but it has been recently shown that the integrity of this motif is essential fo...

journal_title：Oncogene

authors： Bénit L,Charon M,Cocault L,Wendling F,Gisselbrecht S

更新日期：1993-03-01 00:00:00

abstract：:Mutations in epidermal growth factor receptor (EGFR) kinase domain associate with clinical responses to EGFR inhibitors and are frequently observed in non-small cell lung cancer (NSCLC) patients in East Asian populations. Clinically identified EGFR mutations cause constitutive receptor activation. The activating mecha...

journal_title：Oncogene

authors： Fu YN,Yeh CL,Cheng HH,Yang CH,Tsai SF,Huang SF,Chen YR

更新日期：2008-02-07 00:00:00

abstract：:YAP (Yes-associated protein) oncogene has been found to form a stable complex with members of the Angiomotin (Amot) family of proteins, which bind WW domains of YAP and sequester the protein in the cytoplasm and junctional complexes. The Amot-mediated retention of YAP in the cytoplasm results in the inhibition of its ...

journal_title：Oncogene

authors： Oka T,Schmitt AP,Sudol M

更新日期：2012-01-05 00:00:00

abstract：:Understanding how disruption of differentiation contributes to the cancer cell phenotype is required to identify alterations essential for malignant transformation and provide experimental basis for their correction. We investigated whether primary quail neuroretina cells, transformed by a conditional v-Src mutant (QN...

journal_title：Oncogene

authors： Mateos S,Amarir S,Laugier D,Marx M,Calothy G

更新日期：2007-05-17 00:00:00

abstract：:The expression of the cyclin-dependent kinase inhibitor p15INK4B in normal cells after induction with TGF-beta1, or following overexpression from an adenovirus-encoded cDNA, appears on an SDS-polyacrylamide gel as a doublet. Here, the underlying mechanism behind the synthesis of the two species has been studied. By ex...

journal_title：Oncogene

authors： Fuxe J,Raschperger E,Pettersson RF

更新日期：2000-03-23 00:00:00

abstract：:The expression of the monocyte-chemoattractant-protein-1 (MCP-1) is closely linked with a non-tumorigenic phenotype in somatic cell hybrids made between the human papillomavirus type 18 (HPV 18) positive cervical carcinoma cell line HeLa and normal human fibroblasts. In contrast, MCP-1 transcription is absent in tumor...

journal_title：Oncogene

authors： Finzer P,Soto U,Delius H,Patzelt A,Coy JF,Poustka A,zur Hausen H,Rösl F

更新日期：2000-07-06 00:00:00

abstract：:Appropriate expression of HTLV-1 genes requires transcriptional transactivation by Tax and post-transcriptional regulation by Rex, both mediated by LTR encoded RNA sequences. Using a combination of deletion mutagenesis, Rex-reporter CAT assays, fluorescence in situ hybridization (FISH) and confocal laser scanning micr...

journal_title：Oncogene

authors： King JA,Bridger JM,Löchelt M,Lichter P,Schulz TF,Schirrmacher V,Khazaie K

更新日期：1998-06-25 00:00:00

abstract：:The E6 proteins originating from the tumour-associated Human Papillomavirus (HPV) types 16 and 18 have been shown to bind to and target the tumour suppressor protein, p53, for ubiquitin-mediated degradation. However, in cell lines derived from cervical neoplasias, the predominant early region transcripts are spliced a...

journal_title：Oncogene

authors： Pim D,Massimi P,Banks L

更新日期：1997-07-17 00:00:00

abstract：:Activation of hypoxia-inducible factor (HIF) is due to loss of von Hippel-Lindau protein (pVHL) function in most clear cell renal cell carcinomas (ccRCCs). Here we describe a novel pVHL-independent mechanism of HIF regulation and identify nuclear factor (NF)-κB essential modulator (NEMO) as a hitherto unknown oncogeni...

journal_title：Oncogene

authors： Nowicka AM,Häuselmann I,Borsig L,Bolduan S,Schindler M,Schraml P,Heikenwalder M,Moch H

更新日期：2016-06-16 00:00:00

abstract：:The RBTN1 and RBTN2 genes are activated by distinct translocations involving chromosome 11 in some T cell acute leukaemias. The RBTN proteins belong to the LIM family which comprises proteins with one, two or three cysteine-rich LIM domains, sometimes together with homeodomains or protein kinase domains. The RBTN1 and...

journal_title：Oncogene

authors： Sánchez-García I,Axelson H,Rabbitts TH

更新日期：1995-04-06 00:00:00

abstract：:Heat shock protein 70 (HSP70) can inhibit apoptosis by neutralizing and interacting with apoptosis-inducing factor (AIF), a mitochondrial flavoprotein that translocates upon apoptosis induction to the nucleus, via the cytosol. Here, we show that only members of the HSP70 family interact with AIF. Systematic deletion m...

journal_title：Oncogene

authors： Gurbuxani S,Schmitt E,Cande C,Parcellier A,Hammann A,Daugas E,Kouranti I,Spahr C,Pance A,Kroemer G,Garrido C

更新日期：2003-10-02 00:00:00

abstract：:FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis and confer resistance to FLT3 inhibitors. To explore activation mechanism of FLT3 TKD mutation, we analysed critical tyrosine residues for the constitutive act...

journal_title：Oncogene

authors： Ishiko J,Mizuki M,Matsumura I,Shibayama H,Sugahara H,Scholz G,Serve H,Kanakura Y

更新日期：2005-12-08 00:00:00

abstract：:Ovarian cancer is the leading cause of death among all gynecological malignancies due to the development of acquired chemoresistance and disease relapse. Although the role of cancer stem cells (CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therapeutic resistance is beginning...

journal_title：Oncogene

authors： Ramadoss S,Sen S,Ramachandran I,Roy S,Chaudhuri G,Farias-Eisner R

更新日期：2017-03-01 00:00:00

abstract：:Colon cancer is the third leading cause of death from cancer worldwide with less than 10% survival rate at the late stage. Although mutations of certain genes have been implicated in familial colon cancer development, the etiology of the majority of colon cancer remains unknown. Herein, we identified TYRO3 as a potent...

journal_title：Oncogene

authors： Chien CW,Hou PC,Wu HC,Chang YL,Lin SC,Lin SC,Lin BW,Lee JC,Chang YJ,Sun HS,Tsai SJ

更新日期：2016-11-10 00:00:00

abstract：:The naked mole rat (nmr) is cancer resistant due to the abundant production of extremely high-molecular-weight hyaluronan (EHMW-HA). However, whether EHMW-HA has similar anti-cancer effects in mice and humans remains to be determined. The present study used breast cancer cells to clarify the effect of EHMW-HA on breas...

journal_title：Oncogene

authors： Zhao Y,Qiao S,Hou X,Tian H,Deng S,Ye K,Nie Y,Chen X,Yan H,Tian W

更新日期：2019-05-01 00:00:00

abstract：:PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor regulates a variety of cellular processes including cell proliferation, growth, migration and death. This master regulator itself is also under deliberative regulation. Although the evidence for PTEN regulation and its significance in norm...

journal_title：Oncogene

authors： Wang X,Jiang X

更新日期：2008-09-18 00:00:00

abstract：:Plexin C1 is a type I transmembrane receptor with intrinsic R-Ras GTPase activity, which regulates cytoskeletal remodeling and adhesion in normal human melanocytes. Melanocytes are pigment-producing cells of the epidermis, precursors for melanoma, and express high levels of Plexin C1, which is lost in melanoma in vitr...

journal_title：Oncogene

authors： Chen Y,Soong J,Mohanty S,Xu L,Scott G

更新日期：2013-10-10 00:00:00

abstract：:Expression of polyomavirus middle-T antigen (middle-T) is involved in the formation of various tumors in vivo, e.g. hemangiomas and mammary gland tumors. Several genes have been shown to be activated in middle-T-expressing cells, but the underlying mechanisms have only been partially elucidated. Among the genes regula...

journal_title：Oncogene

authors： Besser D,Urich M,Sakaue M,Messerschmitt A,Ballmer-Hofer K,Nagamine Y

更新日期：1995-12-07 00:00:00