Identification and analysis of the ret proto-oncogene promoter region in neuroblastoma cell lines and medullary thyroid carcinomas from MEN2A patients.

abstract：:SIAH-1 and SIAH-2 are the human members of an evolutionary highly conserved E3 ligase family. SIAH-1 is a p53 and p21(Waf-1/Cip-1) induced gene during apoptosis and tumor suppression. In stable-transfected clones of MCF-7 cells, SIAH-1 overexpression was associated with apoptosis, mitotic alterations and p21(Waf-1/Cip...

journal_title：Oncogene

authors： Germani A,Prabel A,Mourah S,Podgorniak MP,Di Carlo A,Ehrlich R,Gisselbrecht S,Varin-Blank N,Calvo F,Bruzzoni-Giovanelli H

更新日期：2003-12-04 00:00:00

abstract：:An adenovirus mutant lacking the expression of the large E1B protein (DeltaE1B) has been reported to replicate selectively in cells lacking the expression of functionally wild-type (wt) p53. Based on these results the DeltaE1B or ONYX-015 virus has been proposed to be an oncolytic virus which might be useful to treat ...

journal_title：Oncogene

authors： Steegenga WT,Riteco N,Bos JL

更新日期：1999-09-09 00:00:00

abstract：:The Neuregulins and their receptors, the ErbB/HER subfamily of receptor tyrosine kinases, have critical roles in animal physiology, and their deregulation is frequent in cancer. Here we report the identification of the guanine nucleotide exchange factor, phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger ...

journal_title：Oncogene

authors： Montero JC,Seoane S,Ocaña A,Pandiella A

更新日期：2011-03-03 00:00:00

abstract：:Growth arrest after u.v. damage was investigated in C3H mouse primary cultured hepatocytes, spontaneously immortalized liver epithelial cells and their H-ras-transformed derivatives. All cells except for one of the transformed lines had the wild type p53 gene considered necessary for the G1-S checkpoint. Growth arrest...

journal_title：Oncogene

authors： Kadohama T,Tsuji K,Ogawa K

更新日期：1994-10-01 00:00:00

abstract：:rho genes have been found in both lower and higher eucaryotes. They code for proteins of 21 kDa, highly conserved in evolution, which belong to the superfamily of ras GTPases. Among the members of this superfamily there are proteins with a regulatory function, such as ras, and proteins involved in vesicular traffickin...

journal_title：Oncogene

authors： Perona R,Esteve P,Jiménez B,Ballestero RP,Ramón y Cajal S,Lacal JC

更新日期：1993-05-01 00:00:00

abstract：:The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast cancer. ADM has been shown to be induced by tamoxifen in the endometrium and to be a growth factor for...

journal_title：Oncogene

authors： Oehler MK,Hague S,Rees MC,Bicknell R

更新日期：2002-04-25 00:00:00

abstract：:The NF-kappa B precursor p100 (lyt-10, p97, p98) generates after proteolytic processing a 52 kDa subunit, which can bind to kappa B-motifs. A deregulated form of the p100 gene, which is structurally altered by a t(10;14) translocation, has a potential oncogenic role in certain human B cell lymphomas. In this study p10...

journal_title：Oncogene

authors： Naumann M,Nieters A,Hatada EN,Scheidereit C

更新日期：1993-08-01 00:00:00

abstract：:Adenovirus contains two nuclear oncogenes, the EIA and EIB genes, which cooperatively can transform cells through mechanisms that are not understood. The transcriptional activities of the E1A gene (transactivation and repression) are well studied. Using transient expression assays, we show here that the 19,000-Da E1B ...

journal_title：Oncogene

authors： Herrmann CH,Dery CV,Mathews MB

更新日期：1987-01-01 00:00:00

abstract：:Expression of the p75 neurotrophin receptor (p75(NTR)) in primary melanomas is associated with deeply invasive lesions. In turn, there is expression of high levels of neurotrophins at the invasion front of normal tissue adjacent to brain metastases, thus implicating this growth factor-receptor system in melanoma tumor...

journal_title：Oncogene

authors： Shonukan O,Bagayogo I,McCrea P,Chao M,Hempstead B

更新日期：2003-06-05 00:00:00

abstract：:The past three decades have seen an unremitting quest to identify and understand gastrointestinal stem cells, their plasticity in differentiating across cell types, as well as their role in normal, regenerative, and cancer cells. A fascinating hallmark of stem cells is their ability to undergo assymetric cell division...

journal_title：Oncogene

authors： Mishra L,Shetty K,Tang Y,Stuart A,Byers SW

更新日期：2005-08-29 00:00:00

abstract：:Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired inte...

journal_title：Oncogene

authors： Högnäs G,Tuomi S,Veltel S,Mattila E,Murumägi A,Edgren H,Kallioniemi O,Ivaska J

更新日期：2012-08-02 00:00:00

abstract：:The mouse pancreatic amylase Amy-2.2 gene was fused to the structural gene for SV40 T antigen, and 51 independent transgenic founder mice carrying the fusion gene were generated. The majority of the founders and 100% of their offspring in the derived transgenic lines developed pancreatic acinar cell carcinomas and sto...

journal_title：Oncogene

authors： Ceci JD,Kovatch RM,Swing DA,Jones JM,Snow CM,Rosenberg MP,Jenkins NA,Copeland NG,Meisler MH

更新日期：1991-02-01 00:00:00

abstract：:Activation of the TAL1 (or SCL) gene, originally identified through its involvement by a recurrent chromosomal translocation, is the most frequent gain-of-function mutation recognized in T-cell acute lymphoblastic leukemia (T-ALL). The TAL1 proteins contain a basic helix - loop - helix (bHLH) motif characteristic of a...

journal_title：Oncogene

authors： Huang S,Qiu Y,Stein RW,Brandt SJ

更新日期：1999-09-02 00:00:00

abstract：:Hypoxic microenvironment supports cancer stem cell survival, causes poor response to anticancer therapy and tumor recurrence. Inhibition of Notch-1 signaling in adenocarcinoma of the lung (ACL) cells causes apoptosis specifically under hypoxia. Here, we found that Akt-1 activation is a key mediator of Notch-1 pro-surv...

journal_title：Oncogene

authors： Eliasz S,Liang S,Chen Y,De Marco MA,Machek O,Skucha S,Miele L,Bocchetta M

更新日期：2010-04-29 00:00:00

abstract：:We have previously demonstrated that daunorubicin (DNR) induces apoptosis in some leukemic myeloid cell lines. We investigated a potential protective role for Bcl-2 in apoptosis induced by DNR in two leukemic cell lines, one myeloid and one lymphoid, overexpressing the anti-apoptotic gene Bcl-2. Parental cells treated...

journal_title：Oncogene

authors： Allouche M,Bettaieb A,Vindis C,Rousse A,Grignon C,Laurent G

更新日期：1997-04-17 00:00:00

abstract：:Ataxia Telangiectasia Mutated (ATM) kinase, a central regulator of the DNA damage response, regulates the activity of several E3-ubiquitin ligases, and the ubiquitination-proteasome system is a consistent target of ATM. ITCH is an E3-ubiquitin ligase that modulates the ubiquitination of several targets, therefore part...

journal_title：Oncogene

authors： Santini S,Stagni V,Giambruno R,Fianco G,Di Benedetto A,Mottolese M,Pellegrini M,Barilà D

更新日期：2014-02-27 00:00:00

abstract：:Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77 translocation is induced by certain apoptotic stimuli, including the synthetic retinoid-related 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid...

journal_title：Oncogene

authors： Han YH,Cao X,Lin B,Lin F,Kolluri SK,Stebbins J,Reed JC,Dawson MI,Zhang XK

更新日期：2006-05-18 00:00:00

abstract：:The c-myc proto-oncogene has been shown to cause blockages to differentiation in many cell lineages. Although the mechanism by which c-Myc affects this process remains unknown, it is considered that it might result indirectly as an outcome of the continued cell-cycle progression invoked by c-Myc in cells which must gr...

journal_title：Oncogene

authors： Ryan KM,Birnie GD

更新日期：1997-06-12 00:00:00

abstract：:The most ominous development in tumor progression is the transition to an invasive and metastatic phenotype. Little is known, however, about the molecular alterations that cause a tumor to become invasive. In view of this, we have used microarray expression analysis to evaluate the expression profiles of a unique pane...

journal_title：Oncogene

authors： Manos EJ,Kim ML,Kassis J,Chang PY,Wells A,Jones DA

更新日期：2001-05-17 00:00:00

abstract：:c-Myc overexpression has been associated with several types of human cancers. To study the role of c-myc in epidermal differentiation and carcinogenesis, a transgenic mouse model was created to overexpress c-Myc in the epidermis. Human c-myc 2 cDNA was subcloned into a 6.5 kb mouse loricrin expression vector, ML.myc2....

journal_title：Oncogene

authors： Waikel RL,Wang XJ,Roop DR

更新日期：1999-08-26 00:00:00

abstract：:The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and -2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor. Loss of pVHL function results in c...

journal_title：Oncogene

authors： Rankin EB,Rha J,Unger TL,Wu CH,Shutt HP,Johnson RS,Simon MC,Keith B,Haase VH

更新日期：2008-09-11 00:00:00

abstract：:In chronic myelogenous leukemia (CML), the oncogene bcr-abl encodes a dysregulated tyrosine kinase that inhibits apoptosis. We showed previously that human erythroleukemia K562 cells are resistant to antineoplastic drug (taxol)-induced apoptosis through the atypical protein kinase C iota isozyme (PKC iota), a kinase d...

journal_title：Oncogene

authors： Lu Y,Jamieson L,Brasier AR,Fields AP

更新日期：2001-08-09 00:00:00

abstract：:Checkpoint kinase 2 (Chk2) is known to mediate diverse cellular responses to genotoxic stress. The fundamental role of Chk2 is to regulate the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both...

journal_title：Oncogene

authors： Park HU,Jeong SJ,Jeong JH,Chung JH,Brady JN

更新日期：2006-01-19 00:00:00

abstract：:SAG (Sensitive to Apoptosis Gene), also known as RBX2 or ROC2, is a RING protein required for the activity of Cullin-RING ligase (CRL). Our recent study showed that Sag total knockout caused embryonic lethality at E11.5-12.5 days with associated defects in vasculogenesis. Whether Sag is required for de novo vasculogen...

journal_title：Oncogene

authors： Tan M,Li H,Sun Y

更新日期：2014-10-30 00:00:00

abstract：:Apoptin, a small protein from the chicken anemia virus, has attracted attention because of its specificity in killing tumor cells. Localization of apoptin in the nucleus of tumor cells has been shown to be vital for proapoptotic activity, however, targeted expression of apoptin in the nucleus of normal cells does not ...

journal_title：Oncogene

authors： Maddika S,Wiechec E,Ande SR,Poon IK,Fischer U,Wesselborg S,Jans DA,Schulze-Osthoff K,Los M

更新日期：2008-05-08 00:00:00

abstract：:Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. The associations may arise because of short telomeres and/or alterations of chromatin structure. There is a growing consensus tha...

journal_title：Oncogene

authors： Pandita TK,Hall EJ,Hei TK,Piatyszek MA,Wright WE,Piao CQ,Pandita RK,Willey JC,Geard CR,Kastan MB,Shay JW

更新日期：1996-10-03 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) is highly subjected to alternative pre-mRNA splicing that generates several splice variants. The VEGFxxx and VEGFxxxb families encode splice variants of VEGF-A that differ only at the level of six amino acids in their C-terminal part. The expression level of VEGFxxx splice...

journal_title：Oncogene

authors： Boudria A,Abou Faycal C,Jia T,Gout S,Keramidas M,Didier C,Lemaître N,Manet S,Coll JL,Toffart AC,Moro-Sibilot D,Albiges-Rizo C,Josserand V,Faurobert E,Brambilla C,Brambilla E,Gazzeri S,Eymin B

更新日期：2019-02-01 00:00:00

abstract：:Apoptosis resistance is crucially involved in cancer development and progression, represents the leading cause for failure of anticancer therapy and is caused, for example, by downregulation of proapoptotic intracellular signaling molecules such as caspase-8. We found that the cytotoxic drugs methotrexate (MTX) and 5-...

journal_title：Oncogene

authors： Ehrhardt H,Häcker S,Wittmann S,Maurer M,Borkhardt A,Toloczko A,Debatin KM,Fulda S,Jeremias I

更新日期：2008-01-31 00:00:00

abstract：:Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; howev...

journal_title：Oncogene

authors： Sveen A,Kilpinen S,Ruusulehto A,Lothe RA,Skotheim RI

更新日期：2016-05-12 00:00:00

abstract：:The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor latency and accelerated tumor growth due to loss...

journal_title：Oncogene

authors： Dong H,Ma L,Gan J,Lin W,Chen C,Yao Z,Du L,Zheng L,Ke C,Huang X,Song H,Kumar R,Yeung SC,Zhang H

更新日期：2017-01-19 00:00:00