Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny.

abstract：:SPARC, also termed osteonectin, BM-40 and 43K protein, is an acidic, cysteine-rich component of the extracellular matrix that has been shown to be directly regulated by progesterone and dexamethasone and indirectly by cytokines. By RNA fingerprinting technique, we cloned a SPARC homolog from the normal human ovarian s...

journal_title：Oncogene

authors： Mok SC,Chan WY,Wong KK,Muto MG,Berkowitz RS

更新日期：1996-05-02 00:00:00

abstract：:Mutations of the RET proto-oncogene are found in the majority of patients with the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN 2). A minority of cases, however, have no detectable RET mutation and there is considerable phenotypic variation within and among MEN 2 families with the same RET mutati...

journal_title：Oncogene

authors： Vanhorne JB,Andrew SD,Harrison KJ,Taylor SA,Thomas B,McDonald TJ,Ainsworth PJ,Mulligan LM

更新日期：2005-02-03 00:00:00

abstract：:We have previously shown (Smith et al., 1994) that antibodies raised against the growth arrest and DNA damage inducible protein Gadd45 co-precipitate proliferating cell nuclear antigen (PCNA), a protein involved in DNA replication and repair. Here we demonstrate that Gadd45 can directly bind to PCNA using a Far-wester...

journal_title：Oncogene

authors： Chen IT,Smith ML,O'Connor PM,Fornace AJ Jr

更新日期：1995-11-16 00:00:00

abstract：:In classical Hodgkin lymphoma the malignant Hodgkin/Reed-Sternberg (HRS) cells characteristically constitute only a small minority of the tumour load. Their origin has been debated for decades, but on the basis of rearrangement and somatic hypermutations of their immunoglubulin (Ig) genes, HRS cells are now ascribed t...

journal_title：Oncogene

authors： Hertel CB,Zhou XG,Hamilton-Dutoit SJ,Junker S

更新日期：2002-07-25 00:00:00

abstract：:Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaire...

journal_title：Oncogene

authors： Sari IN,Yang YG,Wijaya YT,Jun N,Lee S,Kim KS,Bajaj J,Oehler VG,Kim SH,Choi SY,Park SH,Kim DW,Reya T,Han J,Kwon HY

更新日期：2021-01-01 00:00:00

abstract：:The NF-kappaB signaling pathway has particular relevance to several liver diseases including hepatitis (liver infection by Helicobacter, viral hepatitis induced by HBV and HCV), liver fibrosis and cirrhosis and hepatocellular carcinoma. Furthermore, the NF-kappaB signaling pathway is a potential target for development...

journal_title：Oncogene

authors： Sun B,Karin M

更新日期：2008-10-20 00:00:00

abstract：:Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...

journal_title：Oncogene

authors： Zhang CC,Yang JM,White E,Murphy M,Levine A,Hait WN

更新日期：1998-03-26 00:00:00

abstract：:Most human lymphomas originate from transformed germinal center (GC) B lymphocytes. While activating mutations and translocations of MYC, BCL2 and BCL6 promote specific GC lymphoma subtypes, other genetic and epigenetic modifications that contribute to malignant progression in the GC remain poorly defined. Recently, a...

journal_title：Oncogene

authors： Dawson DW,Hong JS,Shen RR,French SW,Troke JJ,Wu YZ,Chen SS,Gui D,Regelson M,Marahrens Y,Morse HC 3rd,Said J,Plass C,Teitell MA

更新日期：2007-06-21 00:00:00

abstract：:The steady-state levels of p53 mRNA and protein were barely detectable by Northern and Western blot analysis in spontaneously immortalized (10)3 and (10)7 murine embryo fibroblast (MEF) cells. But when cells were treated with cycloheximide (CHX) or emetine, expression levels were restored to those observed in primary ...

journal_title：Oncogene

authors： Kim H,You S,Farris J,Foster LK,Foster DN

更新日期：2001-05-31 00:00:00

abstract：:Genetic suppression of the neoplastic phenotype has been demonstrated in somatic cell hybrids between tumor and normal cells. Suppression in whole-cell and microcell hybrids cannot, as yet, be attributed to specific elements defined at the molecular level. To identify a gene capable of suppressing the neoplastic pheno...

journal_title：Oncogene

authors： Schäfer R,Nirkko AC,Ambühl PM,Grzeschik KH,Schwarte-Waldhoff I

更新日期：1991-12-01 00:00:00

abstract：:Blockade of the mitogen-activated protein (MAP) kinase pathway suppresses growth of colon cancer in vivo. Here we demonstrate a direct link between the extracellular signal-regulated kinase ERK2 and the growth-promoting cell adhesion molecule, integrin alphavbeta6, in colon cancer cells. Down-regulation of beta6 integ...

journal_title：Oncogene

authors： Ahmed N,Niu J,Dorahy DJ,Gu X,Andrews S,Meldrum CJ,Scott RJ,Baker MS,Macreadie IG,Agrez MV

更新日期：2002-02-21 00:00:00

abstract：:Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...

journal_title：Oncogene

authors： Xu X,Ehdaie B,Ohara N,Yoshino T,Deng CX

更新日期：2010-02-04 00:00:00

abstract：:Two distinct pathways for completion of base excision repair (BER) have been discovered in eukaryotes: the DNA polymerase beta (Pol beta)-dependent short-patch pathway that involves the replacement of a single nucleotide and the long-patch pathway that entails the resynthesis of 2-6 nucleotides and requires PCNA. We h...

journal_title：Oncogene

authors： Stucki M,Pascucci B,Parlanti E,Fortini P,Wilson SH,Hübscher U,Dogliotti E

更新日期：1998-08-20 00:00:00

abstract：:The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying cause of this dysregulation, however, remains a subject of discussion, as the majority of cancer patients do not present with activating mutations in c-Met recept...

journal_title：Oncogene

authors： Szabo R,Rasmussen AL,Moyer AB,Kosa P,Schafer JM,Molinolo AA,Gutkind JS,Bugge TH

更新日期：2011-04-28 00:00:00

abstract：:Epidermal squamous cell carcinoma (SCC) is a common and highly invasive form of cancer. SCC arises due to ultraviolet light exposure and is associated with increased expression of pro-cancer genes and reduced expression of cancer suppressors. Actin-Like Protein 6A (ACTL6A, BAF53a) is an important protein subunit of th...

journal_title：Oncogene

authors： Shrestha S,Adhikary G,Xu W,Kandasamy S,Eckert RL

更新日期：2020-09-01 00:00:00

abstract：:The retinoblastoma suppressor gene product Rb has been assigned a critical role in cell cycle regulation, the induction of differentiation, and inhibition of oncogenic transformation. Inheritance of a mutant RB allele in humans is responsible for bilateral retinoblastoma, a malignant tumor of the retina. Trilateral re...

journal_title：Oncogene

authors： Vooijs M,te Riele H,van der Valk M,Berns A

更新日期：2002-07-11 00:00:00

abstract：:The programmed cell death 4 (PDCD4) gene was originally identified as a tumor-related gene in humans and acts as a tumor-suppressor in mouse epidermal carcinoma cells. However, its function and regulatory mechanisms of expression in human cancer remain to be elucidated. We therefore investigated the expression of PDCD...

journal_title：Oncogene

authors： Zhang H,Ozaki I,Mizuta T,Hamajima H,Yasutake T,Eguchi Y,Ideguchi H,Yamamoto K,Matsuhashi S

更新日期：2006-10-05 00:00:00

abstract：:Amplification and overexpression of the E2F3 gene at 6p22 in human bladder cancer is associated with increased tumour stage, grade and proliferation index, and in prostate cancer E2F3 overexpression is linked to tumour aggressiveness. We first used small interfering RNA technology to confirm the potential importance o...

journal_title：Oncogene

authors： Olsson AY,Feber A,Edwards S,Te Poele R,Giddings I,Merson S,Cooper CS

更新日期：2007-02-15 00:00:00

abstract：:As leukemic transformation of myeloproliferative neoplasms (MPNs) worsens the clinical outcome, reducing the inherent risk of the critical event in MPN cases could be beneficial. Among genetic alterations concerning the transformation, the frequent one is TP53 mutation. Here we show that retroviral overexpression of J...

journal_title：Oncogene

authors： Tsuruta-Kishino T,Koya J,Kataoka K,Narukawa K,Sumitomo Y,Kobayashi H,Sato T,Kurokawa M

更新日期：2017-06-08 00:00:00

abstract：:Expression of neurotrophin receptors of the tyrosine kinase receptor (Trk) family is an important prognostic factor in solid tumors including neuroblastoma. High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastoma...

journal_title：Oncogene

authors： Schulte JH,Schramm A,Klein-Hitpass L,Klenk M,Wessels H,Hauffa BP,Eils J,Eils R,Brodeur GM,Schweigerer L,Havers W,Eggert A

更新日期：2005-01-06 00:00:00

abstract：:The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...

journal_title：Oncogene

authors： Gutzman JH,Rugowski DE,Nikolai SE,Schuler LA

更新日期：2007-09-20 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) all signal through the transmembrane receptor tyrosine kinase RET. The signalling complex consists of GFLs, GPI-anchored ligand binding GDNF family receptor alphas (GFRalphas) and RET. Signalling via RET is required for the development of the ner...

journal_title：Oncogene

authors： Yang J,Runeberg-Roos P,Leppänen VM,Saarma M

更新日期：2007-05-31 00:00:00

abstract：:Constitutive telomerase activity maintains telomere length and confers immortal phenotypes to human cancers. The prevalence of telomerase, rather than a homologous recombination-based mechanism, in telomere length maintenance suggests that telomerase also has auxiliary roles in tumorigenesis. Here, we investigate grow...

journal_title：Oncogene

authors： Fleisig HB,Wong JM

更新日期：2012-02-23 00:00:00

abstract：:The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pe...

journal_title：Oncogene

authors： Khan KA,Naylor AJ,Khan A,Noy PJ,Mambretti M,Lodhia P,Athwal J,Korzystka A,Buckley CD,Willcox BE,Mohammed F,Bicknell R

更新日期：2017-11-02 00:00:00

abstract：:Integrins are adhesion receptors that mediate both cell-extracellular matrix and cell-cell interactions. It has also been reported that the loss of integrin alpha4 expression might be associated with metastasis in several cancers. However, the molecular mechanism for loss of their expression in cancers has not been ex...

journal_title：Oncogene

authors： Park J,Song SH,Kim TY,Choi MC,Jong HS,Kim TY,Lee JW,Kim NK,Kim WH,Bang YJ

更新日期：2004-04-22 00:00:00

abstract：:Polyoma virus (Py) causes neoplastic transformation in vitro and multiple tumors in vivo. The role played by large and middle T antigens (LT, MT) and their mechanisms of action are focused here. Py-transformed Balb-3T3 cells become independent of platelet-derived growth factor (PDGF) for growth. JE, c-fos, c-jun and c...

journal_title：Oncogene

authors： Rameh LE,Armelin MC

更新日期：1991-06-01 00:00:00

abstract：:We compared the regulation of gamma-glutamyl transferase (gamma GT) and glutathione-S-transferase-P (GST-P) expression in rat liver epithelial cells (228 cells) and a line derived from them (C5 cells) by stable transfection with a metallothionein-activated ras fusion gene (MTrasT24). Earlier studies demonstrated that ...

journal_title：Oncogene

authors： Li YC,Lieberman MW

更新日期：1989-06-01 00:00:00

abstract：:Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27. These pivotal epigenetic marks are altered in many cancers, including melanoma, as a result of EZH2 overexpression. Here, we show that the non-canonical-NF-kB pathway accounts for mo...

journal_title：Oncogene

authors： De Donatis GM,Le Pape E,Pierron A,Cheli Y,Hofman V,Hofman P,Allegra M,Zahaf K,Bahadoran P,Rocchi S,Bertolotto C,Ballotti R,Passeron T

更新日期：2016-05-01 00:00:00

abstract：:Overexpressed or activated hepatocyte growth factor receptor, encoded by the MET proto-oncogene, was found in the majority of colorectal carcinomas (CRCs), whose stepwise progression to malignancy requires transcriptional activation of beta-catenin. We here demonstrate that a functional crosstalk between Met and beta-...

journal_title：Oncogene

authors： Rasola A,Fassetta M,De Bacco F,D'Alessandro L,Gramaglia D,Di Renzo MF,Comoglio PM

更新日期：2007-02-15 00:00:00

abstract：:The retinoblastoma (Rb) tumor suppressor gene and its close relatives p107 and p130 are best known for their function in the control of cell cycle progression. In recent years, however, a new role for these proteins has been emerging as they have been linked with regulation of terminal differentiation of many tissues ...

journal_title：Oncogene

authors： Lipinski MM,Jacks T

更新日期：1999-12-20 00:00:00