Abstract:
:The E6 proteins originating from the tumour-associated Human Papillomavirus (HPV) types 16 and 18 have been shown to bind to and target the tumour suppressor protein, p53, for ubiquitin-mediated degradation. However, in cell lines derived from cervical neoplasias, the predominant early region transcripts are spliced and encode truncated forms of E6, termed E6*. We report here that HPV-18 E6* protein will interact both with the full-length E6 proteins from HPV-16 and HPV-18 and also with E6-AP, and subsequently blocks the association of full length E6 protein with p53. We also show that, as a result of this block, E6* can inhibit E6-mediated degradation of p53 both in vitro and in vivo. The biological consequences of this are increased transcriptional activity on p53-responsive promoters and an inhibition of cell growth in cells transfected with E6*. This is the first report of a potential biological function for this polypeptide and may represent a means by which HPV is able to modulate the activity of the full-length E6 protein with respect to p53 during viral infection.
journal_name
Oncogenejournal_title
Oncogeneauthors
Pim D,Massimi P,Banks Ldoi
10.1038/sj.onc.1201202subject
Has Abstractpub_date
1997-07-17 00:00:00pages
257-64issue
3eissn
0950-9232issn
1476-5594journal_volume
15pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic transformation. Although in most instances Stat3 is growth-promoting, the impact of cell density on Stat3 act...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207378
更新日期:2004-04-08 00:00:00
abstract::Mitochondrial membrane permeabilization is a critical event in the process leading to physiological or chemotherapy-induced apoptosis. This permeabilization event is at least in part under the control of the permeability transition pore complex (PTPC), which interacts with oncoproteins from the Bcl-2 family as well as...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203299
更新日期:2000-01-13 00:00:00
abstract::P53 is a tumor suppressor gene that plays a crucial role in suppressing tumorigenesis by inducing either cell cycle arrest or apoptosis in cells with DNA damage. In more than 50% of tumors p53 is inactivated by gene mutations. However, there have also been reports of tumor cells in which p53 remains wild type and is p...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210110
更新日期:2007-05-10 00:00:00
abstract::Previous studies have shown that the adenovirus E1A oncoprotein can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300. In this study, wild-type E1A12S or two deletion mutants (delN, which binds pRb but not CBP/p300; delCR2, which binds to CBP/p300 bu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205050
更新日期:2002-02-07 00:00:00
abstract::The zinc-finger transcription factor Krox24 was analysed for its role in differentiation in P19 embryonal carcinoma cells. Reciprocal dominant negative mutants consisting of Krox24 deleted for a crucial region of the zinc-finger domain (delta Krox24) or of the zinc-finger region alone (delta Krox24Zf) abolished the ac...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202166
更新日期:1998-11-12 00:00:00
abstract::Loss of PTEN tumor suppressor enhances metastatic risk in breast cancer, although the underlying mechanisms are poorly defined. We report that homozygous deletion of PTEN in mammary epithelial cells induces tubulin-based microtentacles (McTNs) that facilitate cell reattachment and homotypic aggregation. Treatment with...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.234
更新日期:2013-04-25 00:00:00
abstract::The naevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple developmental defects and cancer susceptibility, in particular to basal cell carcinomas (BCCs). Medulloblastomas, primitive neuroectodermal tumours (PNETs) arising in childhood, occur in about 3-5% of NBCCS pa...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201340
更新日期:1997-07-17 00:00:00
abstract::Degradation of cellular proteins through ubiquitination is a fundamental strategy for regulating biological pathways. De-ubiquitination, i.e. the removal of ubiquitin from proteins and peptides to which ubiquitin is attached, is catalyzed by processing proteases known as de-ubiquitinating enzymes. We are studying the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204553
更新日期:2001-06-28 00:00:00
abstract::Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202694
更新日期:1999-06-17 00:00:00
abstract::Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205416
更新日期:2002-05-09 00:00:00
abstract::Pin1 regulates a subset of phosphoproteins by isomerizing phospho-Ser/Thr-Pro motifs via a 'post-phosphorylation' mechanism. Here, we characterize TR3 as a novel Pin1 substrate, and the mitogenic function of TR3 depends on Pin1-induced isomerization. There are at least three phospho-Ser-Pro motifs on TR3 that bind to ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.463
更新日期:2012-06-07 00:00:00
abstract::The alternative nuclear factor-kappaB (NF-κB) -activation pathway proceeds via inducible p100 processing, leading to the activation of RelB-containing dimers. This pathway is aberrantly activated in several types of tumors; however, a direct role for RelB in the control of cell proliferation is still largely unexplore...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.282
更新日期:2013-05-23 00:00:00
abstract::Ataxia telangiectasia (AT) is a human hereditary syndrome whose underlying gene product, ataxia telangiectasia mutated (ATM) protein kinase, is involved in multiple intracellular signaling pathways. We demonstrated previously that AT fibroblasts are defective in intracellular Ca(2+) mobilization in response to both st...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206167
更新日期:2003-01-23 00:00:00
abstract::Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted therapy. We used microarray analysis to perform a pathway analysis of TNBC compared with non-triple negative breas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.145
更新日期:2011-10-27 00:00:00
abstract::High-risk papillomavirus type 18 (HPV18) is one of the less represented HPV types in low-grade lesions of the anogenital tract, whereas it occupies the second place in cervical cancer, where it can be found in 16% of the cases worldwide, after HPV16 present in 54% of them. These epidemiological data indicate that HPV1...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.246
更新日期:2010-09-09 00:00:00
abstract::We described previously the characterization of a novel oncogene, cph, activated in primary Syrian hamster embryo fibroblasts by exposure to 3-methylcholanthrene (Velasco et al., Oncogene 9:2065-2069, 1994). The present report describes the participation in the neoplastic conversion of cph-expressing (81C39) hamster f...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-03-02 00:00:00
abstract::The p53 tumor suppressor gene continues to be distinguished as the most frequently mutated gene in human cancer; this gene can be found mutated in up to 50% of human tumors of diverse histological type. It is generally accepted that the ability of p53 to induce either growth arrest or programmed cell death in response...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1209367
更新日期:2006-03-13 00:00:00
abstract::We identified IFIX as a new member of the hematopoietic interferon (IFN)-inducible nuclear protein with the 200-amino-acid repeat (HIN-200) family. Six different alternatively spliced forms of mRNA are transcribed from the IFIX gene, which are predicted to encode six different isoforms of IFIX proteins (IFIXalpha1, al...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207592
更新日期:2004-06-03 00:00:00
abstract::The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of tumors, particularly in aggressive tumors and tumors resistant to conventional chemotherapy. BMI1/Bmi1 is also crucially involved in cancer-initiating cell maintenance, and is recurrently upregulated in mantle cell lymphoma (MCL), espe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.177
更新日期:2014-04-24 00:00:00
abstract::p73 is a member of the p53 family. Recent studies have shown that DNA damage can stabilize p73 protein and enhance p73-mediated apoptosis in a c-Abl dependent manner. To determine what regulates p73 transcriptionally, we analysed the expression of p73 in several cell lines following genotoxic stresses. We found that p...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204149
更新日期:2001-02-08 00:00:00
abstract::The requirement for cis-acting DNA sequences for transcriptional activity of the human lck type I promoter was investigated in two human cell lines that express type I transcripts, the leukemic T-cell line, Jurkat, and the colon carcinoma line, SW620. Transient transfection assays in Jurkat and SW620 cells revealed ne...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::A new class of nontransformed revertant cells has been isolated from the ras-transformed cell line DT using cis-4-hydroxy-L-proline (CHP) as a selective agent. The new revertants, CHP 9CJ and CHP CB4, each contain two copies of the v-Ki-ras gene, elevated levels of phosphorylated p21ras protein, and rescuable transfor...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207440
更新日期:2004-04-15 00:00:00
abstract::The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. The retinoblastoma family includes three members, Rb/p105, p107 ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1209615
更新日期:2006-08-28 00:00:00
abstract::ErbB-2 is an orphan receptor that belongs to a family of tyrosine kinase receptors for either epidermal growth factor (EGF) or Neu differentiation factor (NDF/neuregulin). Because overexpression of the erbB-2 proto-oncogene is frequently associated with an aggressive clinical course of certain human adenocarcinomas, t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201029
更新日期:1997-05-01 00:00:00
abstract::Migration and invasion inhibitory protein (MIIP) is recently identified as an inhibitor in tumor development. However, the regulatory mechanism and biological contributions of MIIP in pancreatic cancer (PC) have been not elucidated. In this study, we demonstrated a negative feedback of MIIP and hypoxia-induced factor-...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0082-2
更新日期:2018-03-01 00:00:00
abstract::The tumor-stroma crosstalk is a dynamic process fundamental in tumor development. In hepatocellular carcinoma (HCC), the progression of malignant hepatocytes frequently depends on transforming growth factor (TGF)-beta provided by stromal cells. TGF-beta induces an epithelial to mesenchymal transition (EMT) of oncogeni...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.253
更新日期:2009-11-12 00:00:00
abstract::Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE) is clearly occupied in a cyclic manner in vivo, whereas the 3' eleme...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203017
更新日期:1999-11-04 00:00:00
abstract::Defining apoptosis-regulatory cascades of the epithelium is important for understanding carcinogenesis, since cancer cells are considered to arise as a result of the collapse of the cascades. We previously reported that a novel gene GASDERMIN (GSDM) is expressed in the stomach but suppressed in gastric cancer cell lin...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210475
更新日期:2007-10-04 00:00:00
abstract::We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207046
更新日期:2003-10-30 00:00:00