Abstract:
:ERM is a member of the ETS transcription factor family. High levels of the corresponding mRNA are detected in a variety of human breast cancer cell lines, as well as in aggressive human breast tumors. As ERM protein is almost undetectable in these cells, high degradation of this transcription factor has been postulated. Here we have investigated whether ERM degradation might depend on the proteasome pathway. We show that endogenous and ectopically expressed ERM protein is short-lived protein and undergoes proteasome-dependent degradation. Deletion mutagenesis studies indicate that the 61 C-terminal amino acids of ERM are critical for its proteolysis and serve as a degradation signal. Although ERM conjugates with ubiquitin, this post-translational modification does not depend on the C-terminal domain. We have used an Ets-responsive ICAM-1 reporter plasmid to show that the ubiquitin-proteasome pathway can affect transcriptional function of ERM. Thus, ERM is subject to degradation via the 26S proteasome pathway, and this pathway probably plays an important role in regulating ERM transcriptional activity.
journal_name
Oncogenejournal_title
Oncogeneauthors
Baert JL,Beaudoin C,Monte D,Degerny C,Mauen S,de Launoit Ydoi
10.1038/sj.onc.1209801subject
Has Abstractpub_date
2007-01-18 00:00:00pages
415-24issue
3eissn
0950-9232issn
1476-5594pii
1209801journal_volume
26pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Sam68 phosphorylation correlates with Fyn but not Lck expression in T cells. This substrate has been used here to explore the possible basis of the specificity of Fyn versus Lck. We show that this specificity is not based on a spatial segregation of the two kinases, since a chimeric Lck molecule containing the membran...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205929
更新日期:2002-10-17 00:00:00
abstract::Previously, we showed that the BRCA1 protein interacts directly and functionally with estrogen receptor-alpha (ER-alpha), resulting in the inhibition of estradiol (E2)-stimulated ER-alpha transcriptional activity. The interaction sites were mapped to the N-terminus of BRCA1 (within amino acids (aa) 1-302) and the liga...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208190
更新日期:2005-03-10 00:00:00
abstract::Ectopic expression of the intracellular domain of NOTCH-4/INT-3 leads to tumorigenesis in the mouse mammary gland. This results from a gain-of-function mutation. To evaluate gain-of-function NOTCH-4/INT-3 activity in human cancers we have surveyed human breast, lung, and colon carcinoma tissue culture cell lines for e...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203295
更新日期:2000-01-13 00:00:00
abstract::The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210454
更新日期:2007-09-20 00:00:00
abstract::Oncoprotein C-MYC is overexpressed in human metastatic melanomas and melanoma-derived cells where it is required for the suppression of oncogene-induced senescence (OIS). The genetic events that maintain high levels of C-MYC in melanoma cells and their role in OIS are unknown. Here we report that C-MYC in cells from s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.339
更新日期:2012-03-22 00:00:00
abstract::Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205382
更新日期:2002-04-25 00:00:00
abstract::Small cell lung cancer (SCLC) invades locally and metastasizes distantly extremely early when compared with nonsmall cell lung cancer (NSCLC). The underlying molecular mechanisms, however, have not been elucidated. Accumulating evidence suggests that downregulation of several members of tetraspanins is associated with...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206106
更新日期:2003-02-06 00:00:00
abstract::O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inversely linked to hypermethylation of the CpG island in the promoter r...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207183
更新日期:2003-12-04 00:00:00
abstract::The cdk2 gene has been identified as a human cdc2/CDC28-related gene that encodes a protein kinase essential for the G1/S transition in mammalian cells, but not for the G2/M transition, which requires Cdk1, another p34cdc2/CDC28 homolog. Novel potential functions of Cdk2 have been uncovered by using two potent and spe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203103
更新日期:1999-12-09 00:00:00
abstract::TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5 (DR5). TRAIL preferentially induces apoptosis in transformed cells and the identification of mechanisms by which TRAIL-induced apoptosis can be enhanced may lead to novel cancer chemotherape...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204842
更新日期:2001-10-18 00:00:00
abstract::Stimulator of interferon genes (STING) is a cellular sensor that controls cytosolic DNA-activated innate immune signaling. We have previously demonstrated that STING-deficient mice are resistant to carcinogen-induced skin cancer, similar to myeloid differentiation primary response gene 88 (MyD88) deficient mice, since...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.457
更新日期:2015-10-08 00:00:00
abstract::Our previous studies suggested that chromosome 8p deletion is associated with metastasis of hepatocellular carcinoma (HCC), in which some novel metastasis suppressor genes might be harbored. The present study aimed to identify the metastatic suppressor gene(s). A cDNA chip was constructed with the expressed sequence t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209191
更新日期:2006-03-16 00:00:00
abstract::Damage induced in the DNA after exposure of cells to ionizing radiation activates checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and induce a transient delay in the progression through S phase. Checkpoints together with repair and apoptosis are integrated in a circuitry that determi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206682
更新日期:2003-09-01 00:00:00
abstract::Small-molecule agonists at Toll-like receptor 7 (TLR7) and TLR8 have sparked a vivid interest in cancer research owing to their profound antitumoral activity. The lead compound of the imidazoquinoline family, imiquimod, is marketed as a topical formulation. It is efficacious against many primary skin tumors and cutane...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210913
更新日期:2008-01-07 00:00:00
abstract::Cytokinesis is the final step of cell division. Increasing evidence suggests failure of cytokinesis might contribute to the development of cancer. Here, we demonstrate that the serologically defined colon cancer antigen-3 (SDCCAG3) forms a complex with PTPN13, a protein tyrosine phosphatase known to be involved in the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.485
更新日期:2013-09-26 00:00:00
abstract::Each step in the synthesis of functional transcript by RNA polymerase II provides a level at which gene expression can be regulated. Control over the elongation phase of transcription is a recognized regulatory mechanism in prokaryotes; however, only recently have examples of conditional transcription elongation block...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:
更新日期:1990-06-01 00:00:00
abstract::Hepatitis B virus (HBV)-induced liver necrosis takes great part in liver cirrhosis progression. However, less is known about whether hepatitis B virus X protein (HBx) has effect on liver fibrosis. Here, we report that HBV leads to liver fibrosis and hepatocarcinogenesis through miR-30e targeting P4HA2. HBV transgenic ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.291
更新日期:2017-12-14 00:00:00
abstract::Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a histori...
journal_title:Oncogene
pub_type: 历史文章,杂志文章,评审
doi:10.1038/onc.2011.576
更新日期:2012-09-06 00:00:00
abstract::Bone metastatic prostate cancer provokes extensive osteogenesis by driving the recruitment and osteoblastic differentiation of mesenchymal stromal cells (MSCs). The resulting lesions greatly contribute to patient morbidity and mortality, underscoring the need for defining how prostate metastases subvert the MSC-osteob...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0913-4
更新日期:2019-10-01 00:00:00
abstract::Lung cancer is one of the major causes of cancer death and clarification of its molecular pathology is highly prioritized. The physiological importance of mRNA degradation through the CCR4-NOT deadenylase has recently been highlighted. For example, mutation in CNOT3, a gene coding for CNOT3 subunit of the CCR4-NOT com...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0603-7
更新日期:2019-04-01 00:00:00
abstract::Colon cancer is the third leading cause of death from cancer worldwide with less than 10% survival rate at the late stage. Although mutations of certain genes have been implicated in familial colon cancer development, the etiology of the majority of colon cancer remains unknown. Herein, we identified TYRO3 as a potent...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.120
更新日期:2016-11-10 00:00:00
abstract::The T-box transcription factor TBX3 has been implicated in the patterning and differentiation of a number of tissues during embryonic development, and is overexpressed in a variety of cancers; however, the precise function of TBX3 in papillary thyroid carcinoma (PTC) development remains to be determined. In the curren...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0090-2
更新日期:2018-05-01 00:00:00
abstract::The viability of rat embryo cells immortalized by thermosensitive mutants of SV40 or polyoma Large T antigen is impaired at the non-permissive temperature thus demonstrating that the immortal phenotype is dominantly maintained by Large T antigens. We have observed that exposing these cells to the restrictive temperatu...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::A mutation in codon 122 of the mouse p53 gene resulting in a T to L amino acid substitution (T122-->L) is frequently associated with skin cancer in UV-irradiated mice that are both homozygous mutant for the nucleotide excision repair (NER) gene Xpc (Xpc(-/-)) and hemizygous mutant for the p53 gene. We investigated the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205779
更新日期:2002-08-22 00:00:00
abstract::The RBTN1 and RBTN2 genes are activated by distinct translocations involving chromosome 11 in some T cell acute leukaemias. The RBTN proteins belong to the LIM family which comprises proteins with one, two or three cysteine-rich LIM domains, sometimes together with homeodomains or protein kinase domains. The RBTN1 and...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-04-06 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and remains incurable with conventional chemotherapy treatment approaches. CLL as a disease entity is defined by a relatively parsimonious set of diagnostic criteria and therefore likely constitutes an umbrella term for multiple relate...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.411
更新日期:2013-06-06 00:00:00
abstract::Brn-3a is a transcription factor belonging to the class IV of POU domain transcription factors. It is expressed throughout the peripheral nervous system but especially in postmitotic sensory neurons of dorsal root ganglia. Brn-3a is known to regulate different genes involved in neuronal differentiation and survival. I...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206635
更新日期:2003-08-21 00:00:00
abstract::Loss of heterozygosity on chromosome 10p was observed frequently in human prostate cancers. Studies have demonstrated that the introduction of the short arm of human chromosome 10 into a human prostate cancer cell line, PPC-1, by microcell-mediated chromosome transfer (MMCT), suppressed the malignant phenotype, sugges...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204079
更新日期:2001-01-18 00:00:00
abstract::The MRN (MRE11-RAD50-NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts with PIH1D1, a subun...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.99
更新日期:2017-08-24 00:00:00
abstract::Many p53 mutants found in human cancer have an altered ability to bind DNA and transactivate gene expression. Re-expression of functional p53 in cells in which the endogenous TP53 gene is inactivated has been demonstrated to restore a non-tumorigenic phenotype. Pharmacological modulation of p53 mutant conformation may...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204428
更新日期:2001-06-14 00:00:00