Abstract:
:Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment.
journal_name
Oncogenejournal_title
Oncogeneauthors
Stieglitz D,Lamm S,Braig S,Feuerer L,Kuphal S,Dietrich P,Arndt S,Echtenacher B,Hellerbrand C,Karrer S,Bosserhoff AKdoi
10.1038/s41388-018-0475-xsubject
Has Abstractpub_date
2019-01-01 00:00:00pages
609-621issue
5eissn
0950-9232issn
1476-5594pii
10.1038/s41388-018-0475-xjournal_volume
38pub_type
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