Abstract:
:Persistent infection with hepatitis B virus (HBV) is one of the primary risk factors for human hepatocellular carcinoma (HCC). In a human ecological study, we have shown that, in addition to HBV, animal food consumption also significantly contributes to the variance of HCC. To test the interacting effect of HBV and animal food consumption on the development of HCC, we investigated HBV expression in HBV transgenic mice fed three levels of casein diet. HBV expression in transgenic animals was substantially inhibited when dietary casein was reduced from the traditional level of 22% to the level of 6%. Northern analysis revealed that suppression of HBV was derived from both the upstream albumin promoter and the internal HBV promoter. Immunochemical staining of liver sections indicated that only a few hepatocytes around the central vein expressed viral surface antigen (HBsAg) in the 6% casein animals, whereas virtually all hepatocytes stained positively for HBsAg in the 22% dietary casein animals. Serum HBsAg concentrations at 4 months were increased by 1.6-, 2.1-, and 5.1- fold over baseline for animals fed the 6%, 14%, and 22% casein diets, respectively. Correspondingly, liver injury was much less severe in animals fed 6% casein diet than in those fed 14% and 22% casein diets. These results demonstrate that a low casein diet is a potent suppresser of HBV transgene and HBV-induced liver injury, suggesting that diet management may be a practical means to aid in the control HBV infection.
journal_name
Oncogenejournal_title
Oncogeneauthors
Hu JF,Cheng Z,Chisari FV,Vu TH,Hoffman AR,Campbell TCdoi
10.1038/sj.onc.1201444subject
Has Abstractpub_date
1997-12-04 00:00:00pages
2795-801issue
23eissn
0950-9232issn
1476-5594journal_volume
15pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::The etiology of cancers appears to be complex and multifactorial. Peyton Rous and others demonstrated the process of co-carcinogenesis by exposing rabbits to a virus and tars. Epidemiologists have proposed virus-chemical interactions to cause several cancers. For example, one might propose that the etiology of cervica...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207822
更新日期:2004-08-23 00:00:00
abstract::Burkitt's lymphoma cells are characterized by chromosomal translocations involving the proto-oncogene c-myc on chromosome 8 and one of the immunoglobulin gene loci on chromosome 2, 14 or 22. The translocated c-myc allele is transcriptionally activated, shows a preferential usage of promoter P1 over P2 (promoter shift)...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-04-06 00:00:00
abstract::LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204112
更新日期:2001-01-25 00:00:00
abstract::Integrins are adhesion receptors that mediate both cell-extracellular matrix and cell-cell interactions. It has also been reported that the loss of integrin alpha4 expression might be associated with metastasis in several cancers. However, the molecular mechanism for loss of their expression in cancers has not been ex...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207470
更新日期:2004-04-22 00:00:00
abstract::We have cloned and characterised the murine gene encoding c-Mpl, a receptor for thrombopoietin and member of the hematopoietin receptor superfamily. The gene encompasses 15 kb of the mouse genome and the organisation of its 12 exons conforms closely to the pattern observed for the genes of other hematopoietin receptor...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-02-16 00:00:00
abstract::The transcription factor Cdx1 regulates intestine-specific gene expression and enterocyte differentiation. It has been hypothesized to play a role in regulating intestinal cell proliferation; however, the mechanism for this effect remains elusive. In a prior study, we demonstrated that Cdx1 expression reduced the prol...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206770
更新日期:2003-09-25 00:00:00
abstract::Histone deacetylases (HDACs) catalyse the removal of acetyl groups from the N-terminal tails of histones. All known HDACs can be categorized into one of four classes (I-IV). The class III HDAC or silencing information regulator 2 (Sir2) family exhibits characteristics consistent with a distinctive role in regulation o...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210617
更新日期:2007-08-13 00:00:00
abstract::Junctional adhesion molecule-A (JAM-A) is a membranous cell-cell adhesion protein involved in tight-junction formation in epithelial and endothelial cells. Its overexpression in breast tumors has recently been linked with increased risk of metastasis. We sought to identify if JAM-A overexpression was associated with s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.276
更新日期:2013-05-30 00:00:00
abstract::An altered protein expression of Ca(2+)-dependent protein kinase C (PKC) isoforms and a point mutation in the PKC alpha cDNA (position 908 of the nucleotide sequence, position 294 of the amino acid sequence, substitution of an aspartic acid by a glycine) have been previously described in a subpopulation of human pitui...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-08-17 00:00:00
abstract::Elucidating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation (IR) treatments while minimizing injury to surrounding normal tissue is an important clinical goal. Due to their sequence-derived specificity and properties as gene regulators in IR-affected pathways, microRNAs (miRNAs) coul...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.222
更新日期:2017-01-26 00:00:00
abstract::We have analysed the immortalizing function of Human Papillomavirus type 16 (HPV16) in a rat cell line which has been derived by immortalizing rat embryo fibroblasts with a thermolabile SV40 large T antigen and is temperature sensitive for growth. Introduction of wild type SV40 large T antigen or the adenovirus E1a 12...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
abstract::Ataxia telangiectasia mutated and RAD3 related (ATR) protein kinase plays critical roles in ensuring DNA replication, DNA repair, and cell cycle control in response to replication stress, making ATR inhibition a promising therapeutic strategy for cancer treatment. To identify genes whose loss makes tumor cells hyperse...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0606-4
更新日期:2019-04-01 00:00:00
abstract::TSG101 has been identified as a candidate tumor suppressor gene and abnormal transcripts have been identified in a substantial fraction of breast cancers. To determine whether TSG101 expression is commonly altered in other tumors, a series of 15 primary and metastatic prostate cancers were analysed by reverse transcri...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201521
更新日期:1997-12-18 00:00:00
abstract::Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cance...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0114-y
更新日期:2018-04-01 00:00:00
abstract::We have recently isolated the erythroleukemic cell line, HB60-5, that proliferates in the presence of erythropoietin (Epo) and stem cell factor (SCF), but undergoes terminal differentiation in the presence of Epo alone. Ectopic expression of the ets related transcription factor Fli-1 in these cells resulted in the est...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203590
更新日期:2000-05-04 00:00:00
abstract::Dependence receptors (DRs) now form a family of more than a dozen membrane receptors that are not linked by their structure, but by common functional traits. The most notable is their ability to trigger two opposite signaling pathways: in the presence of ligand, these receptors activate classic signaling pathways impl...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2010.13
更新日期:2010-04-01 00:00:00
abstract::Induction of apoptosis by adenovirus E1A in rodent cells is stimulated by wild type (wt) p53 but completely suppressed by mutated p53. The suppression is overcome by coexpression with Id proteins (Ids). The cells expressing E1A and Ids undergo apoptosis after accumulation in S phase, suggesting that S phase events are...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203063
更新日期:1999-08-26 00:00:00
abstract::Bone morphogenetic proteins (BMPs) are known to play an important role in melanoma development and progression. However, the downstream targets of BMPs have not been investigated thus far. Therefore, we treated melanoma cell lines with the Smad-specific BMP inhibitor Dorsomorphin and performed a cDNA microarray. We id...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.115
更新日期:2013-02-14 00:00:00
abstract::Intrachromosomal rearrangements involving the RET and the adjacent H4 or ELE1 gene are very frequent events in thyroid cancer of children from Belarus after the Chernobyl reactor accident (Klugbauer et al., 1995). The fusion product between ELE1 and RET (RET/ PTC3) seems to be the prevailing type of rearrangement as s...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-09-05 00:00:00
abstract::Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial-mesenchymal transition (EMT) with cells exhibiting enhanced migration and invasion potential in vit...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01563-x
更新日期:2020-12-15 00:00:00
abstract::Each step in the synthesis of functional transcript by RNA polymerase II provides a level at which gene expression can be regulated. Control over the elongation phase of transcription is a recognized regulatory mechanism in prokaryotes; however, only recently have examples of conditional transcription elongation block...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:
更新日期:1990-06-01 00:00:00
abstract::The human c-rel gene (REL), encoding an NF-kappaB transcription factor, is amplified or mutated in several human B-cell lymphomas and can transform chicken lymphoid cells in vitro. We have previously shown that certain deletions of C-terminal transactivation sequences enhance REL's transforming ability in chicken sple...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208902
更新日期:2005-11-10 00:00:00
abstract::To investigate Mad1 function in vivo, transgenic mice were generated that express a Mad1 transgene in T lineage cells under the control of the proximal lck promoter. Thymus size in lck-Mad1 transgenic mice is drastically reduced although representation of the various thymocyte sub populations appears normal. To invest...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204196
更新日期:2001-03-08 00:00:00
abstract::Pilocytic astrocytomas (PAs, WHO grade I) are the most common brain tumors in the pediatric and adolescent population, accounting for approximately one-fifth of central nervous system tumors. Because few consistent molecular alterations have been identified in PAs compared to higher grade gliomas, we performed array c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.110
更新日期:2008-08-07 00:00:00
abstract::The role of the hepatitis B virus protein HBx in liver cell proliferation and apoptosis remains controversial. Using a transgenic mouse model, we have recently shown that HBx stimulates the apoptotic turnover of hepatocytes, independently of p53. In this paper, we tested whether the proapoptotic function of HBx can in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205110
更新日期:2002-01-17 00:00:00
abstract::The diverse checkpoint responses to DNA damage may reflect differential sensitivities by molecular components of the damage-signalling network to the type and amount of lesions. Here, we determined the kinetics of activation of the checkpoint kinases ATM and Chk2 (the latter substrate of ATM) in relation to the initia...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207986
更新日期:2004-10-07 00:00:00
abstract::A single heat shock factor (HSF), mediating the heat shock response, exists from yeast to Drosophila, whereas several related HSFs have been found in mammals. This raises the question of the specific or redundant functions of the different members of the HSF family and in particular of HSF1 and HSF2, which are both ub...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.171
更新日期:2010-07-22 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) signaling is dependent on the heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Activated TbetaRI then mediates TGF-beta signals by inducing the phosphorylation of Smad2 and/or Smad3, which separately hetetorodimerize ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202909
更新日期:1999-09-23 00:00:00
abstract::TrkA is the receptor tyrosine kinase (RTK) for nerve growth factor (NGF) and stimulates NGF-dependent cell survival and differentiation in primary neurons. TrkA expression in neuronal tumors also supports NGF-dependent differentiation of neuroblastomas and apoptosis of medulloblastomas. Phosphorylation of the activati...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203330
更新日期:2000-01-20 00:00:00
abstract::Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200203
更新日期:1998-04-30 00:00:00